Ubiquitination regulation of aerobic glycolysis in cancer

UCHL3 promotes aerobic glycolysis of pancreatic cancer through upregulating LDHA expression

(2021) Y. Fan et al.   Clinical & Translational Oncology

FOXO3A-induced LINC00926 suppresses breast tumor growth and metastasis through inhibition of PGK1-mediated Warburg effect

(2021) Zhong Chu et al.   MOLECULAR THERAPY

SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis

(2021) Xun Shangguan et al.   Nature Communications

Neddylation regulation of mitochondrial structure and functions

(2021) Qiyin Zhou et al.   Cell and Bioscience

Discovery and development of tumor glycolysis rate-limiting enzyme inhibitors

(2021) Xueyan Sun et al.   BIOORGANIC CHEMISTRY

Trim21-mediated HIF-1α degradation attenuates aerobic glycolysis to inhibit renal cancer tumorigenesis and metastasis

(2021) Xintian Chen et al.   CANCER LETTERS

Proteomic analysis of ubiquitination substrates reveals a CTLH E3 ligase complex‐dependent regulation of glycolysis

(2021) Matthew E. R. Maitland et al.   FASEB JOURNAL

Deubiquitinase PSMD14 promotes ovarian cancer progression by decreasing enzymatic activity of PKM2

(2021) Tianshui Sun et al.   Molecular Oncology

CSN5 upregulates glycolysis to promote hepatocellular carcinoma metastasis via stabilizing the HK2 protein

(2020) Mingwen Huang et al.   EXPERIMENTAL CELL RESEARCH

KDM4B facilitates colorectal cancer growth and glucose metabolism by stimulating TRAF6-mediated AKT activation

(2020) Haijie Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

A20 targets PFKL and glycolysis to inhibit the progression of hepatocellular carcinoma

(2020) Yilu Feng et al.   Cell Death & Disease

Mitochondrial MUL1 E3 ubiquitin ligase regulates Hypoxia Inducible Factor (HIF-1α) and metabolic reprogramming by modulating the UBXN7 cofactor protein

(2020) Lucia Cilenti et al.   Scientific Reports

Tanshinone IIA inhibits oral squamous cell carcinoma via reducing Akt-c-Myc signaling-mediated aerobic glycolysis

(2020) Ming Li et al.   Cell Death & Disease

Long noncoding RNA AGPG regulates PFKFB3-mediated tumor glycolytic reprogramming

(2020) Jia Liu et al.   Nature Communications

TRIM58 Interacts with Pyruvate Kinase M2 to Inhibit Tumorigenicity in Human Osteosarcoma Cells

(2020) Peng Yuan et al.   Biomed Research International

Circular RNA ITCH suppresses proliferation, invasion, and glycolysis of ovarian cancer cells by up-regulating CDH1 via sponging miR-106a

(2020) Chunli Lin et al.   Cancer Cell International

Sumoylation as an Emerging Target in Therapeutics against Cancer.

(2020) Sitong Liu et al.   CURRENT PHARMACEUTICAL DESIGN

TRIM59 knockdown blocks cisplatin resistance in A549/DDP cells through regulating PTEN/AKT/HK2

(2020) Rong He et al.   GENE

Caveolin-1 inhibits breast cancer stem cells via c-Myc-mediated metabolic reprogramming

(2020) Shengqi Wang et al.   Cell Death & Disease

Identification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer

(2020) Chengheng Liao et al.   Cancer Discovery

Protein Stability of Pyruvate Kinase Isozyme M2 Is Mediated by HAUSP

(2020) Hae-Seul Choi et al.   Cancers

Advances in Deubiquitinating Enzyme Inhibition and Applications in Cancer Therapeutics

(2020) Ainsley Mike Antao et al.   Cancers

Flavonoids against the Warburg phenotype—concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism

(2020) Marek Samec et al.   EPMA Journal

The deubiquitinase JOSD2 is a positive regulator of glucose metabolism

(2020) Lyudmila Krassikova et al.   CELL DEATH AND DIFFERENTIATION

CircECE1 activates energy metabolism in osteosarcoma by stabilizing c-Myc

(2020) Shuying Shen et al.   Molecular Cancer

TRAP1 enhances Warburg metabolism through modulation of PFK1 expression/activity and favors resistance to EGFR inhibitors in human colorectal carcinomas

(2020) Francesca Maddalena et al.   Molecular Oncology

Targeting SKA3 suppresses the proliferation and chemoresistance of laryngeal squamous cell carcinoma via impairing PLK1–AKT axis-mediated glycolysis

(2020) Wei Gao et al.   Cell Death & Disease

STK35 Is Ubiquitinated by NEDD4L and Promotes Glycolysis and Inhibits Apoptosis Through Regulating the AKT Signaling Pathway, Influencing Chemoresistance of Colorectal Cancer

(2020) Haojun Yang et al.   Frontiers in Cell and Developmental Biology

The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression

(2019) Peter Vaupel et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

PRMT5 enhances tumorigenicity and glycolysis in pancreatic cancer via the FBW7/cMyc axis

(2019) Yi Qin et al.   Cell Communication and Signaling

UHRF1 promotes aerobic glycolysis and proliferation via suppression of SIRT4 in pancreatic cancer

(2019) Qiangsheng Hu et al.   CANCER LETTERS

Overexpression of TRIM26 suppresses the proliferation, metastasis, and glycolysis in papillary thyroid carcinoma cells

(2019) Kefeng Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

TRIM11 promotes proliferation and glycolysis of breast cancer cells via targeting AKT/GLUT1 pathway

(2019) WenBo Song et al.   OncoTargets and Therapy

Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion

(2019) Hong-Jen Lee et al.   Nature Communications

PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1

(2019) Xu Qian et al.   MOLECULAR CELL

TRIM27 promotes the development of esophagus cancer via regulating PTEN/AKT signaling pathway

(2019) Liang Ma et al.   Cancer Cell International

USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by a HIF1α/USP22 positive feedback loop upon TP53 inactivation

(2019) Sunbin Ling et al.   GUT

LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc

(2019) Jiayin Tang et al.   Nature Communications

Cdh1-mediated Skp2 degradation by dioscin reprogrammes aerobic glycolysis and inhibits colorectal cancer cells growth

(2019) Li Zhou et al.   EBioMedicine

Ferrous glycinate regulates cell energy metabolism by restrictinghypoxia-induced factor-1α expression in human A549 cells

(2018) Yung-Ting Kuo et al.   FREE RADICAL RESEARCH

Ubiquitination: Friend and foe in cancer

(2018) Mohammed A. Mansour   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

BRCA1 through Its E3 Ligase Activity Regulates the Transcription Factor Oct1 and Carbohydrate Metabolism

(2018) Karina Vázquez-Arreguín et al.   MOLECULAR CANCER RESEARCH

Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism

(2018) Ryan J. Davis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains

(2018) Fumiaki Ohtake et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small ubiquitin-like modifier 1 modification of pyruvate kinase M2 promotes aerobic glycolysis and cell proliferation in A549 human lung cancer cells

(2018) Shuxian An et al.   OncoTargets and Therapy

BRD7 inhibits the Warburg effect and tumor progression through inactivation of HIF1α/LDHA axis in breast cancer

(2018) Weihong Niu et al.   Cell Death & Disease

Towards Computational Models of Identifying Protein Ubiquitination Sites

(2018) Lidong Wang et al.   CURRENT DRUG TARGETS

ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes

(2018) Juncheng Wei et al.   Nature Communications

Large-scale prediction of protein ubiquitination sites using a multimodal deep architecture

(2018) Fei He et al.   BMC Systems Biology

VBP1 represses cancer metastasis by enhancing HIF-1α degradation induced by pVHL

(2017) Ji Ae Kim et al.   FEBS Journal

XIAP upregulates expression of HIF target genes by targeting HIF1α for Lys63-linked polyubiquitination

(2017) Catherine V. Park et al.   NUCLEIC ACIDS RESEARCH

SALL4 promotes glycolysis and chromatin remodeling via modulating HP1α-Glut1 pathway

(2017) J Kim et al.   ONCOGENE

CHIP/Stub1 regulates the Warburg effect by promoting degradation of PKM2 in ovarian carcinoma

(2017) Y Shang et al.   ONCOGENE

Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis

(2017) Jong-Ho Lee et al.   Nature Communications

LMP1-mediated glycolysis induces myeloid-derived suppressor cell expansion in nasopharyngeal carcinoma

(2017) Ting-Ting Cai et al.   PLoS Pathogens

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Parkin Regulates the Activity of Pyruvate Kinase M2

(2016) Kun Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FLIPL is critical for aerobic glycolysis in hepatocellular carcinoma

(2016) Shixiong Lei et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Foxp3 enhances HIF-1α target gene expression in human bladder cancer through decreasing its ubiquitin-proteasomal degradation

(2016) Yeong-Chin Jou et al.   Oncotarget

SENP1 promotes proliferation of clear cell renal cell carcinoma through activation of glycolysis

(2016) Baijun Dong et al.   Oncotarget

Interactions between Myc and MondoA transcription factors in metabolism and tumourigenesis

(2015) Blake R Wilde et al.   BRITISH JOURNAL OF CANCER

WSB1 promotes tumor metastasis by inducing pVHL degradation

(2015) Jung Jin Kim et al.   GENES & DEVELOPMENT

Regulation of pyruvate kinase isozyme M2 is mediated by the ubiquitin-specific protease 20

(2015) SO-RA KIM et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

FBXW7 negatively regulates ENO1 expression and function in colorectal cancer

(2015) Panpan Zhan et al.   LABORATORY INVESTIGATION

NEDDylation in liver cancer: The regulation of the RNA binding protein Hu antigen R

(2015) David Fernández-Ramos et al.   PANCREATOLOGY

Metabolic reprogramming in cancer cells: glycolysis, glutaminolysis, and Bcl-2 proteins as novel therapeutic targets for cancer

(2015) Chunxia Li et al.   World Journal of Surgical Oncology

The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming

(2015) Liem Phan et al.   Nature Communications

Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer

(2015) Lucía Barbier-Torres et al.   Oncotarget

N-myc downstream-regulated gene 2 expression is associated with glucose transport and correlated with prognosis in breast carcinoma

(2014) Ji Ma et al.   BREAST CANCER RESEARCH

Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth

(2014) Nan Li et al.   GENES & DEVELOPMENT

USP37 directly deubiquitinates and stabilizes c-Myc in lung cancer

(2014) J Pan et al.   ONCOGENE

MYC Degradation

(2014) A. S. Farrell et al.   Cold Spring Harbor Perspectives in Medicine

Is Cancer a Metabolic Disease?

(2013) Hilary A. Coller   AMERICAN JOURNAL OF PATHOLOGY

GRIM-19 opposes reprogramming of glioblastoma cell metabolism via HIF1α destabilization

(2013) Qian Liu et al.   CARCINOGENESIS

mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc

(2013) Kenta Masui et al.   Cell Metabolism

Glucose Transporter-1 as a New Therapeutic Target in Laryngeal Carcinoma

(2013) X-M Luo et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Deubiquitylation and stabilization of PTEN by USP13

(2013) Jinsong Zhang et al.   NATURE CELL BIOLOGY

Cycles of Ubiquitination and Deubiquitination Critically Regulate Growth Factor-Mediated Activation of Akt Signaling

(2013) W.-L. Yang et al.   Science Signaling

The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis

(2012) Chia-Hsin Chan et al.   CELL

Ubiquitin-dependent Regulation of Phospho-AKT Dynamics by the Ubiquitin E3 Ligase, NEDD4-1, in the Insulin-like Growth Factor-1 Response

(2012) Chuan-Dong Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles of microRNA on cancer cell metabolism

(2012) Bing Chen et al.   Journal of Translational Medicine

Reduced survival of patients with hepatocellular carcinoma expressing hexokinase II

(2011) Lei Gong et al.   MEDICAL ONCOLOGY

Nonproteolytic Functions of Ubiquitin in Cell Signaling

(2009) Zhijian J. Chen et al.   MOLECULAR CELL

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

(2009) W.-L. Yang et al.   SCIENCE

A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression

(2008) Carolyn L. Buller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Reverse the curse—the role of deubiquitination in cell cycle control

(2008) Ling Song et al.   CURRENT OPINION IN CELL BIOLOGY

Atypical ubiquitin chains: new molecular signals. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Fumiyo Ikeda et al.   EMBO REPORTS