Chemical and Biophysical Signatures of the Protein Corona in Nanomedicine

Opsonin-Deficient Nucleoproteic Corona Endows UnPEGylated Liposomes with Stealth Properties In Vivo

(2022) Francesca Giulimondi et al.   ACS Nano

Understanding Nanomaterial–Liver Interactions to Facilitate the Development of Safer Nanoapplications

(2022) Jiulong Li et al.   ADVANCED MATERIALS

Drug delivery systems for RNA therapeutics

(2022) Kalina Paunovska et al.   NATURE REVIEWS GENETICS

Membrane engineering of cell membrane biomimetic nanoparticles for nanoscale therapeutics

(2021) Minghai Zhang et al.   Clinical and Translational Medicine

Composition of Intracellular Protein Corona around Nanoparticles during Internalization

(2021) Chuan Wang et al.   ACS Nano

Molybdenum derived from nanomaterials incorporates into molybdenum enzymes and affects their activities in vivo

(2021) Mingjing Cao et al.   Nature Nanotechnology

Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets

(2021) Michael P. Vincent et al.   Nature Communications

Development of a Cancer Vaccine Using In Vivo Click‐Chemistry‐Mediated Active Lymph Node Accumulation for Improved Immunotherapy

(2021) Hao Qin et al.   ADVANCED MATERIALS

The protein corona hampers the transcytosis of transferrin-modified nanoparticles through blood–brain barrier and attenuates their targeting ability to brain tumor

(2021) Wei Xiao et al.   BIOMATERIALS

Quantitative Measurement of Multiprotein Nanoparticle Interactions Using NMR Spectroscopy

(2021) Joanna Xiuzhu Xu et al.   ANALYTICAL CHEMISTRY

The Underlying Function and Structural Organization of the Intracellular Protein Corona on Graphdiyne Oxide Nanosheet for Local Immunomodulation

(2021) Mengyu Guo et al.   NANO LETTERS

Nanotoxicology and nanomedicine: The Yin and Yang of nano-bio interactions for the new decade

(2021) Olesja Bondarenko et al.   Nano Today

Solution NMR of Nanoparticles in Serum: Protein Competition Influences Binding Thermodynamics and Kinetics

(2021) Joanna Xiuzhu Xu et al.   Frontiers in Physiology

Detection of Circulating Serum Protein Biomarkers of Non-Muscle Invasive Bladder Cancer after Protein Corona-Silver Nanoparticles Analysis by SWATH-MS

(2021) Benito Blanco Gómez et al.   Nanomaterials

A Framework of Paracellular Transport via Nanoparticles‐Induced Endothelial Leakiness

(2021) Myeongsang Lee et al.   Advanced Science

Unusual zymogen activation patterns in the protein corona of Ca-zeolites

(2021) Xiaoqiang Shang et al.   Nature Catalysis

Quantitative Analysis of Protein Corona on Precoated Protein Nanoparticles and Determined Nanoparticles with Ultralow Protein Corona and Efficient Targeting in Vivo

(2021) Zicheng Zhong et al.   ACS Applied Materials & Interfaces

Protein-Cloaked Nanoparticles for Enhanced Cellular Association and Controlled Pathophysiology via Immunosurveillance Escape

(2021) Aqib Iqbal Dar et al.   ACS Applied Materials & Interfaces

Dynamic Protein Corona of Gold Nanoparticles with an Evolving Morphology

(2021) Aparna Nandakumar et al.   ACS Applied Materials & Interfaces

Nanoprotein Interaction Atlas Reveals the Transport Pathway of Gold Nanoparticles across Epithelium and Its Association with Wnt/β-Catenin Signaling

(2021) Jian Zhang et al.   ACS Nano

The ancillary effects of nanoparticles and their implications for nanomedicine

(2021) Evan P. Stater et al.   Nature Nanotechnology

On the mechanism of tissue-specific mRNA delivery by selective organ targeting nanoparticles

(2021) Sean A. Dilliard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gold Nanostars with Reduced Fouling Facilitate Small Molecule Detection in the Presence of Protein

(2021) Anastasiia Tukova et al.   Nanomaterials

On the growth of the soft and hard protein corona of mesoporous silica particles with varying morphology

(2021) Inga Kuschnerus et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Protein Binding Affinity of Polymeric Nanoparticles as a Direct Indicator of Their Pharmacokinetics

(2020) Zhi-Ting Cao et al.   ACS Nano

The entry of nanoparticles into solid tumours

(2020) Shrey Sindhwani et al.   NATURE MATERIALS

Intracellular Activation of Bioorthogonal Nanozymes through Endosomal Proteolysis of the Protein Corona

(2020) Xianzhi Zhang et al.   ACS Nano

Immunological Responses Induced by Blood Protein Coronas on Two-Dimensional MoS2 Nanosheets

(2020) Didar Baimanov et al.   ACS Nano

An Analysis of the Binding Function and Structural Organization of the Protein Corona

(2020) Yuwei Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Influence of Nanoparticle Shape on Protein Corona Formation

(2020) Rahul Madathiparambil Visalakshan et al.   Small

Protein-polymer bioconjugates via a versatile oxygen tolerant photoinduced controlled radical polymerization approach

(2020) Alexis Theodorou et al.   Nature Communications

Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver

(2020) Lei Miao et al.   Nature Communications

Personalized Graphene Oxide-Protein Corona in the Human Plasma of Pancreatic Cancer Patients

(2020) Riccardo Di Santo et al.   Frontiers in Bioengineering and Biotechnology

Tracing the In Vivo Fate of Nanoparticles with a “Non-Self” Biological Identity

(2020) Hossein Mohammad-Beigi et al.   ACS Nano

In Situ Analysis of Weakly Bound Proteins Reveals Molecular Basis of Soft Corona Formation

(2020) Daniel Sanchez-Guzman et al.   ACS Nano

Blood circulation of soft nanomaterials is governed by dynamic remodeling of protein opsonins at nano-biointerface

(2020) Srinivas Abbina et al.   Nature Communications

Protein Nanoparticle Charge and Hydrophobicity Govern Protein Corona and Macrophage Uptake

(2020) Samantha M. Pustulka et al.   ACS Applied Materials & Interfaces

Polymer Topology Determines the Formation of Protein Corona on Core–Shell Nanoparticles

(2020) Martina Schroffenegger et al.   ACS Nano

Cloaking Silica Nanoparticles with Functional Protein Coatings for Reduced Complement Activation and Cellular Uptake

(2020) Jae Hyeon Park et al.   ACS Nano

Quantitative Protein Corona Composition and Dynamics on Carbon Nanotubes in Biological Environments

(2020) Rebecca L Pinals et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure of soft and hard protein corona around polystyrene nanoplastics—Particle size and protein types

(2020) Shinji Kihara et al.   Biointerphases

Mapping and identification of soft corona proteins at nanoparticles and their impact on cellular association

(2020) Hossein Mohammad-Beigi et al.   Nature Communications

Monodispersity of Poly(ethylene glycol) Matters for Low-Fouling Coatings

(2020) Peiyu Zhang et al.   ACS Macro Letters

Amyloidosis inhibition, a new frontier of the protein corona

(2020) Pengyu Chen et al.   Nano Today

The Nano–Bio Interactions of Nanomedicines: Understanding the Biochemical Driving Forces and Redox Reactions

(2019) Yaling Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Stability of Ligands on Nanoparticles Regulating the Integrity of Biological Membranes at the Nano–Lipid Interface

(2019) Liming Wang et al.   ACS Nano

Protein-Nanoparticle interactions: What are the protein-corona thickness and organization?

(2019) Laurent Marichal et al.   LANGMUIR

Precision Nanomedicine Development Based on Specific Opsonization of Human Cancer Patient-Personalized Protein Coronas

(2019) Jiayu Ren et al.   NANO LETTERS

On the issue of transparency and reproducibility in nanomedicine

(2019) Hon S. Leong et al.   Nature Nanotechnology

Long-term pulmonary exposure to multi-walled carbon nanotubes promotes breast cancer metastatic cascades

(2019) Xuefei Lu et al.   Nature Nanotechnology

Protein Corona over Mesoporous Silica Nanoparticles: Influence of the Pore Diameter on Competitive Adsorption and Application to Prostate Cancer Diagnostics

(2019) Carla Vidaurre-Agut et al.   ACS Omega

Resolving Single-Nanoconstruct Dynamics during Targeting and Nontargeting Live-Cell Membrane Interactions

(2019) Debanjan Bhowmik et al.   ACS Nano

Elucidating the Role of Surface Coating in the Promotion or Prevention of Protein Corona around Quantum Dots

(2019) Woody Perng et al.   BIOCONJUGATE CHEMISTRY

Transcytosis at the blood–brain barrier

(2019) Swathi Ayloo et al.   CURRENT OPINION IN NEUROBIOLOGY

Zwitterionic polymer ligands: an ideal surface coating to totally suppress protein-nanoparticle corona formation?

(2019) Manon Debayle et al.   BIOMATERIALS

Brain-targeted drug delivery by manipulating protein corona functions

(2019) Zui Zhang et al.   Nature Communications

Tailoring the component of protein corona via simple chemistry

(2019) Xiang Lu et al.   Nature Communications

Corona of Thorns: The Surface Chemistry-Mediated Protein Corona Perturbs the Recognition and Immune Response of Macrophages

(2019) Rong Cai et al.   ACS Applied Materials & Interfaces

Control of Protein Conformation and Orientation on Graphene

(2019) Shuai Wei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Human Biomolecular Corona of Liposomal Doxorubicin: The Overlooked Factor in Anticancer Drug Delivery

(2018) Giulio Caracciolo et al.   ACS Applied Materials & Interfaces

Effect of Surface Chemistry and Associated Protein Corona on the Long-Term Biodegradation of Iron Oxide Nanoparticles In Vivo

(2018) Grazyna Stepien et al.   ACS Applied Materials & Interfaces

Profiling the Serum Protein Corona of Fibrillar Human Islet Amyloid Polypeptide

(2018) Emily H. Pilkington et al.   ACS Nano

Evolution of Nanoparticle Protein Corona across the Blood–Brain Barrier

(2018) Alysia Cox et al.   ACS Nano

Hydrophilicity Regulates the Stealth Properties of Polyphosphoester-Coated Nanocarriers

(2018) Johanna Simon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Walking the line: The fate of nanomaterials at biological barriers

(2018) Huan Meng et al.   BIOMATERIALS

Surface modification of polymer nanoparticles with native albumin for enhancing drug delivery to solid tumors

(2018) Hyesun Hyun et al.   BIOMATERIALS

Stealth Nanoparticles Grafted with Dense Polymer Brushes Display Adsorption of Serum Protein Investigated by Isothermal Titration Calorimetry

(2018) Noga Gal et al.   JOURNAL OF PHYSICAL CHEMISTRY B

In vivo formation of protein corona on gold nanoparticles. The effect of their size and shape

(2018) Rafaela García-Álvarez et al.   Nanoscale

Pre-adsorption of antibodies enables targeting of nanocarriers despite a biomolecular corona

(2018) Manuel Tonigold et al.   Nature Nanotechnology

Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

(2018) David Adams et al.   NEW ENGLAND JOURNAL OF MEDICINE

Probing Adsorption Behaviors of BSA onto Chiral Surfaces of Nanoparticles

(2018) Xinyi Wang et al.   Small

The in vivo fates of plant viral nanoparticles camouflaged using self-proteins: overcoming immune recognition

(2018) N. M. Gulati et al.   Journal of Materials Chemistry B

Carbon-Based Nanomaterials for Cancer Therapy via Targeting Tumor Microenvironment

(2018) Jabran Saleem et al.   Advanced Healthcare Materials

In situ low-immunogenic albumin-conjugating-corona guiding nanoparticles for tumor-targeting chemotherapy

(2018) Zhenbao Li et al.   Biomaterials Science

The Crown and the Scepter: Roles of the Protein Corona in Nanomedicine

(2018) Rong Cai et al.   ADVANCED MATERIALS

Interactions between Metal Oxides and Biomolecules: from Fundamental Understanding to Applications

(2018) Marion J. Limo et al.   CHEMICAL REVIEWS

Synthesis of Patient-Specific Nanomaterials

(2018) James Lazarovits et al.   NANO LETTERS

Cloaking nanoparticles with protein corona shield for targeted drug delivery

(2018) Jun Yong Oh et al.   Nature Communications

Protein Corona Liposomes Achieve Efficient Oral Insulin Delivery by Overcoming Mucus and Epithelial Barriers

(2018) Aohua Wang et al.   Advanced Healthcare Materials

Highly Heterogeneous Nature of the Native and Unfolded States of the B Domain of Protein A Revealed by Two-Dimensional Fluorescence Lifetime Correlation Spectroscopy

(2017) Takuhiro Otosu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Probing the modulated formation of gold nanoparticles–beta-lactoglobulin corona complexes and their applications

(2017) Jiang Yang et al.   Nanoscale

Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics

(2017) Nicolas Bertrand et al.   Nature Communications

Hyaluronic Acid Coated Chitosan Nanoparticles Reduced the Immunogenicity of the Formed Protein Corona

(2017) Abdulaziz Almalik et al.   Scientific Reports

Regulation of Macrophage Recognition through the Interplay of Nanoparticle Surface Functionality and Protein Corona

(2016) Krishnendu Saha et al.   ACS Nano

Controlling the Stealth Effect of Nanocarriers through Understanding the Protein Corona

(2016) Susanne Schöttler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The study of transient protein–nanoparticle interactions by solution NMR spectroscopy

(2016) Michael Assfalg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Impact of protein pre-coating on the protein corona composition and nanoparticle cellular uptake

(2016) Vahid Mirshafiee et al.   BIOMATERIALS

Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA

(2016) Sam Chen et al.   JOURNAL OF CONTROLLED RELEASE

A magnetic-dependent protein corona of tailor-made superparamagnetic iron oxides alters their biological behaviors

(2016) Ziyao Liu et al.   Nanoscale

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Development and application of bond cleavage reactions in bioorthogonal chemistry

(2016) Jie Li et al.   Nature Chemical Biology

Protein adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)-coated nanocarriers

(2016) Susanne Schöttler et al.   Nature Nanotechnology

Dynamic protein coronas revealed as a modulator of silver nanoparticle sulphidation in vitro

(2016) Teodora Miclăuş et al.   Nature Communications

Use of Synchrotron Radiation-Analytical Techniques To Reveal Chemical Origin of Silver-Nanoparticle Cytotoxicity

(2015) Liming Wang et al.   ACS Nano

Tuning PEGylation of mixed micelles to overcome intracellular and systemic siRNA delivery barriers

(2015) Martina Miteva et al.   BIOMATERIALS

Albumin corona on nanoparticles – a strategic approach in drug delivery

(2015) Jessy Mariam et al.   DRUG DELIVERY

Detecting and Quantifying Biomolecular Interactions of a Dendritic Polyglycerol Sulfate Nanoparticle Using Fluorescence Lifetime Measurements

(2015) Alexander Boreham et al.   MOLECULES

Reducing the cytotoxicity of ZnO nanoparticles by a pre-formed protein corona in a supplemented cell culture medium

(2015) Hong Yin et al.   RSC Advances

Targeting Ability of Affibody-Functionalized Particles Is Enhanced by Albumin but Inhibited by Serum Coronas

(2015) Qiong Dai et al.   ACS Macro Letters

Significance of surface charge and shell material of superparamagnetic iron oxide nanoparticle (SPION) based core/shell nanoparticles on the composition of the protein corona

(2015) Usawadee Sakulkhu et al.   Biomaterials Science

Size and Surface Functionalization of Iron Oxide Nanoparticles Influence the Composition and Dynamic Nature of Their Protein Corona

(2014) Jonathan Ashby et al.   ACS Applied Materials & Interfaces

Polyethylene Glycol Backfilling Mitigates the Negative Impact of the Protein Corona on Nanoparticle Cell Targeting

(2014) Qin Dai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Therapeutic Protein–Polymer Conjugates: Advancing Beyond PEGylation

(2014) Emma M. Pelegri-O’Day et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spatial Mapping and Quantification of Soft and Hard Protein Coronas at Silver Nanocubes

(2014) Teodora Miclăuş et al.   NANO LETTERS

Structure-based programming of lymph-node targeting in molecular vaccines

(2014) Haipeng Liu et al.   NATURE

Palladium-triggered deprotection chemistry for protein activation in living cells

(2014) Jie Li et al.   Nature Chemistry

Zwitterionic-Coated “Stealth” Nanoparticles for Biomedical Applications: Recent Advances in Countering Biomolecular Corona Formation and Uptake by the Mononuclear Phagocyte System

(2014) Karina Pombo García et al.   Small

Advanced nuclear analytical and related techniques for the growing challenges in nanotoxicology

(2013) Chunying Chen et al.   CHEMICAL SOCIETY REVIEWS

Conformational changes in human plasma proteins induced by metal oxide nanoparticles

(2013) Rosana Simón-Vázquez et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

GolP-CHARMM: First-Principles Based Force Fields for the Interaction of Proteins with Au(111) and Au(100)

(2013) Louise B. Wright et al.   Journal of Chemical Theory and Computation

Revealing the Binding Structure of the Protein Corona on Gold Nanorods Using Synchrotron Radiation-Based Techniques: Understanding the Reduced Damage in Cell Membranes

(2013) Liming Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biomolecular Adsorption at Aqueous Silver Interfaces: First-Principles Calculations, Polarizable Force-Field Simulations, and Comparisons with Gold

(2013) Zak E. Hughes et al.   LANGMUIR

Direct observation of a single nanoparticle–ubiquitin corona formation

(2013) Feng Ding et al.   Nanoscale

Effect of polyethyleneglycol (PEG) chain length on the bio–nano-interactions between PEGylated lipid nanoparticles and biological fluids: from nanostructure to uptake in cancer cells

(2013) Daniela Pozzi et al.   Nanoscale

Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

(2013) Anna Salvati et al.   Nature Nanotechnology

Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

(2013) Stefan Tenzer et al.   Nature Nanotechnology

Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor

(2013) D. T. Wiley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Titanium dioxide nanomaterials cause endothelial cell leakiness by disrupting the homophilic interaction of VE–cadherin

(2013) M.I. Setyawati et al.   Nature Communications

Peptide Adsorption on Silica Nanoparticles: Evidence of Hydrophobic Interactions

(2012) Valeria Puddu et al.   ACS Nano

Stem cell membrane engineering for cell rolling using peptide conjugation and tuning of cell–selectin interaction kinetics

(2012) Hao Cheng et al.   BIOMATERIALS

Chemistry of Aqueous Silica Nanoparticle Surfaces and the Mechanism of Selective Peptide Adsorption

(2012) Siddharth V. Patwardhan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent advances in stealth coating of nanoparticle drug delivery systems

(2012) Zohreh Amoozgar et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

The Evolution of the Protein Corona around Nanoparticles: A Test Study

(2011) Martin Lundqvist et al.   ACS Nano

Protein Corona-Mediated Mitigation of Cytotoxicity of Graphene Oxide

(2011) Wenbing Hu et al.   ACS Nano

The Shape Effect of Mesoporous Silica Nanoparticles on Biodistribution, Clearance, and Biocompatibility in Vivo

(2011) Xinglu Huang et al.   ACS Nano

Effect of gold nanoparticle morphology on adsorbed protein structure and function

(2011) Jennifer E. Gagner et al.   BIOMATERIALS

Understanding and controlling the interaction of nanomaterials with proteins in a physiological environment

(2011) Carl D. Walkey et al.   CHEMICAL SOCIETY REVIEWS

Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake

(2011) Carl D. Walkey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Gadolinium metallofullerenol nanoparticles inhibit cancer metastasis through matrix metalloproteinase inhibition: imprisoning instead of poisoning cancer cells

(2011) Huan Meng et al.   Nanomedicine-Nanotechnology Biology and Medicine

Palladium-mediated intracellular chemistry

(2011) Rahimi M. Yusop et al.   Nature Chemistry

Binding of blood proteins to carbon nanotubes reduces cytotoxicity

(2011) C. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zwitterion-Stabilized Silica Nanoparticles: Toward Nonstick Nano

(2010) Zaki G. Estephan et al.   LANGMUIR

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

Protein-binding assays in biological liquids using microscale thermophoresis

(2010) Christoph J. Wienken et al.   Nature Communications

Surface-enhanced Raman scattering for protein detection

(2009) Xiao X. Han et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function

(2009) Xinglu Huang et al.   BIOMATERIALS

Biodistribution of gold nanoparticles in mouse lung following intratracheal instillation

(2009) Evaldas Sadauskas et al.   Chemistry Central Journal

The role of apolipoprotein E in uptake of atovaquone into the brain in murine acute and reactivated toxoplasmosis

(2009) Hend M. Shubar et al.   JOURNAL OF DRUG TARGETING

Protein Resistance of PEG-Functionalized Dendronized Surfaces: Effect of PEG Molecular Weight and Dendron Generation

(2008) S. Rahima Benhabbour et al.   MACROMOLECULES

Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts

(2008) M. Lundqvist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA