The Crown and the Scepter: Roles of the Protein Corona in Nanomedicine

Human Biomolecular Corona of Liposomal Doxorubicin: The Overlooked Factor in Anticancer Drug Delivery

(2018) Giulio Caracciolo et al.   ACS Applied Materials & Interfaces

Surface-adaptive zwitterionic nanoparticles for prolonged blood circulation time and enhanced cellular uptake in tumor cells

(2018) Hanlin Ou et al.   Acta Biomaterialia

Nanocomposites based on graphene oxide and mesoporous silica nanoparticles: Preparation, characterization and nanobiointeractions with red blood cells and human plasma proteins

(2018) Leandro C. Fonseca et al.   APPLIED SURFACE SCIENCE

Targeting Endothelial Cell Junctions with Negatively Charged Gold Nanoparticles

(2018) Jinping Wang et al.   CHEMISTRY OF MATERIALS

Artificial apolipoprotein corona enables nanoparticle brain targeting

(2018) Roberta Dal Magro et al.   Nanomedicine-Nanotechnology Biology and Medicine

Human plasma proteome association and cytotoxicity of nano-graphene oxide grafted with stealth polyethylene glycol and poly(2-ethyl-2-oxazoline)

(2018) Miaoyi Wang et al.   Nanoscale

Pre-adsorption of antibodies enables targeting of nanocarriers despite a biomolecular corona

(2018) Manuel Tonigold et al.   Nature Nanotechnology

Progress and challenges towards targeted delivery of cancer therapeutics

(2018) Daniel Rosenblum et al.   Nature Communications

Toxicity of silicon dioxide nanoparticles with varying sizes on the cornea and protein corona as a strategy for therapy

(2018) Dayu Sun et al.   Science Bulletin

How Entanglement of Different Physicochemical Properties Complicates the Prediction of in Vitro and in Vivo Interactions of Gold Nanoparticles

(2018) Ming Xu et al.   ACS Nano

Nanoparticles-protein interaction: Role in protein aggregation and clinical implications

(2017) Romana Parveen et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Cargo-influences on the biodistribution of hollow mesoporous silica nanoparticles as studied by quantitative 19 F-magnetic resonance imaging

(2017) Alexander Pochert et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

An apolipoprotein-enriched biomolecular corona switches the cellular uptake mechanism and trafficking pathway of lipid nanoparticles

(2017) L. Digiacomo et al.   Nanoscale

Nanoparticle-induced oxidation of corona proteins initiates an oxidative stress response in cells

(2017) Dhanya T. Jayaram et al.   Nanoscale

Evolution of the nanoparticle corona

(2017) Marilena Hadjidemetriou et al.   Nature Nanotechnology

The Impact of Protein Corona Formation on the Macrophage Cellular Uptake and Biodistribution of Spherical Nucleic Acids

(2017) Alyssa B. Chinen et al.   Small

In situ detection of the protein corona in complex environments

(2017) Monica Carril et al.   Nature Communications

Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics

(2017) Nicolas Bertrand et al.   Nature Communications

Size-Dependent Facilitation of Cancer Cell Targeting by Proteins Adsorbed on Nanoparticles

(2016) Gaoxing Su et al.   ACS Applied Materials & Interfaces

Regulation of Macrophage Recognition through the Interplay of Nanoparticle Surface Functionality and Protein Corona

(2016) Krishnendu Saha et al.   ACS Nano

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

(2016) Jung Soo Suk et al.   ADVANCED DRUG DELIVERY REVIEWS

Clusterin in the protein corona plays a key role in the stealth effect of nanoparticles against phagocytes

(2016) Michihiko Aoyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Impact of protein pre-coating on the protein corona composition and nanoparticle cellular uptake

(2016) Vahid Mirshafiee et al.   BIOMATERIALS

Protein corona over silver nanoparticles triggers conformational change of proteins and drop in bactericidal potential of nanoparticles: Polyethylene glycol capping as preventive strategy

(2016) Deependra Kumar Ban et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Personalized liposome–protein corona in the blood of breast, gastric and pancreatic cancer patients

(2016) Valentina Colapicchioni et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mapping of Molecular Structure of the Nanoscale Surface in Bionanoparticles

(2016) Luciana M. Herda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tuning the Surface of Nanoparticles: Impact of Poly(2-ethyl-2-oxazoline) on Protein Adsorption in Serum and Cellular Uptake

(2016) Olga Koshkina et al.   MACROMOLECULAR BIOSCIENCE

Impact of mesoporous silica surface functionalization on human serum albumin interaction, cytotoxicity and antibacterial activity

(2016) Małgorzata Ferenc et al.   MICROPOROUS AND MESOPOROUS MATERIALS

Adsorbed plasma proteins modulate the effects of single-walled carbon nanotubes on neutrophils in blood

(2016) Irina I. Vlasova et al.   Nanomedicine-Nanotechnology Biology and Medicine

Protein source and choice of anticoagulant decisively affect nanoparticle protein corona and cellular uptake

(2016) S. Schöttler et al.   Nanoscale

A magnetic-dependent protein corona of tailor-made superparamagnetic iron oxides alters their biological behaviors

(2016) Ziyao Liu et al.   Nanoscale

Zwitterionic surface coating of quantum dots reduces protein adsorption and cellular uptake

(2016) Sumaira Ashraf et al.   Nanoscale

Drug delivery: Unravelling the stealth effect

(2016) Neville J. Butcher et al.   Nature Nanotechnology

Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo

(2016) Fangfang Chen et al.   Nature Nanotechnology

Protein adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)-coated nanocarriers

(2016) Susanne Schöttler et al.   Nature Nanotechnology

Brushed polyethylene glycol and phosphorylcholine for grafting nanoparticles against protein binding

(2016) Bo Wang et al.   Polymer Chemistry

Pathophysiologic mechanisms of biomedical nanomaterials

(2016) Liming Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

In situ characterization of nanoparticle biomolecular interactions in complex biological media by flow cytometry

(2016) Maria Cristina Lo Giudice et al.   Nature Communications

Dynamic protein coronas revealed as a modulator of silver nanoparticle sulphidation in vitro

(2016) Teodora Miclăuş et al.   Nature Communications

Analysis of nanoparticle delivery to tumours

(2016) Stefan Wilhelm et al.   Nature Reviews Materials

Monoclonal Antibody-Functionalized Multilayered Particles: Targeting Cancer Cells in the Presence of Protein Coronas

(2015) Qiong Dai et al.   ACS Nano

Use of Synchrotron Radiation-Analytical Techniques To Reveal Chemical Origin of Silver-Nanoparticle Cytotoxicity

(2015) Liming Wang et al.   ACS Nano

Tuning Endothelial Permeability with Functionalized Nanodiamonds

(2015) Magdiel I. Setyawati et al.   ACS Nano

Reduced Cytotoxicity of Graphene Nanosheets Mediated by Blood-Protein Coating

(2015) Yu Chong et al.   ACS Nano

Protein Corona Influences Cell-Biomaterial Interactions in Nanostructured Tissue Engineering Scaffolds

(2015) Vahid Serpooshan et al.   ADVANCED FUNCTIONAL MATERIALS

Protein Corona of Nanoparticles: Distinct Proteins Regulate the Cellular Uptake

(2015) Sandra Ritz et al.   BIOMACROMOLECULES

Comparative study of serum protein binding to three different carbon-based nanomaterials

(2015) Maja Sopotnik et al.   CARBON

Understanding and exploiting nanoparticles' intimacy with the blood vessel and blood

(2015) Magdiel Inggrid Setyawati et al.   CHEMICAL SOCIETY REVIEWS

Stealth Effect of Biomolecular Corona on Nanoparticle Uptake by Immune Cells

(2015) Giulio Caracciolo et al.   LANGMUIR

Reaction of human macrophages on protein corona covered TiO2 nanoparticles

(2015) Camila F. Borgognoni et al.   Nanomedicine-Nanotechnology Biology and Medicine

Innate immune humoral factors, C1q and factor H, with differential pattern recognition properties, alter macrophage response to carbon nanotubes

(2015) Kirsten M. Pondman et al.   Nanomedicine-Nanotechnology Biology and Medicine

Personalized disease-specific protein corona influences the therapeutic impact of graphene oxide

(2015) Mohammad Javad Hajipour et al.   Nanoscale

The functional dissection of the plasma corona of SiO2-NPs spots histidine rich glycoprotein as a major player able to hamper nanoparticle capture by macrophages

(2015) Chiara Fedeli et al.   Nanoscale

Utilizing the protein corona around silica nanoparticles for dual drug loading and release

(2015) Shakiba Shahabi et al.   Nanoscale

Destruction of amyloid fibrils by graphene through penetration and extraction of peptides

(2015) Zaixing Yang et al.   Nanoscale

Protein corona composition of gold nanoparticles/nanorods affects amyloid beta fibrillation process

(2015) Somayeh Mirsadeghi et al.   Nanoscale

BSA modification to reduce CTAB induced nonspecificity and cytotoxicity of aptamer-conjugated gold nanorods

(2015) Emir Yasun et al.   Nanoscale

Protein corona changes mediated by surface modification of amorphous silica nanoparticles suppress acute toxicity and activation of intrinsic coagulation cascade in mice

(2015) Tokuyuki Yoshida et al.   NANOTECHNOLOGY

Factors Ruling the Uptake of Silica Nanoparticles by Mesenchymal Stem Cells: Agglomeration Versus Dispersions, Absence Versus Presence of Serum Proteins

(2015) Federico Catalano et al.   Small

Plasma protein corona reduces the haemolytic activity of graphene oxide nano and micro flakes

(2015) M. Papi et al.   RSC Advances

Targeting Ability of Affibody-Functionalized Particles Is Enhanced by Albumin but Inhibited by Serum Coronas

(2015) Qiong Dai et al.   ACS Macro Letters

In Vitro Hemocompatibility and Toxic Mechanism of Graphene Oxide on Human Peripheral Blood T Lymphocytes and Serum Albumin

(2014) Zhijia Ding et al.   ACS Applied Materials & Interfaces

Impact of Shape and Pore Size of Mesoporous Silica Nanoparticles on Serum Protein Adsorption and RBCs Hemolysis

(2014) Zhifang Ma et al.   ACS Applied Materials & Interfaces

Cryptic Epitopes of Albumin Determine Mononuclear Phagocyte System Clearance of Nanomaterials

(2014) Gysell M. Mortimer et al.   ACS Nano

Secreted Biomolecules Alter the Biological Identity and Cellular Interactions of Nanoparticles

(2014) Alexandre Albanese et al.   ACS Nano

Forming Buried Junctions to Enhance the Photovoltage Generated by Cuprous Oxide in Aqueous Solutions

(2014) Pengcheng Dai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The effect of protein corona composition on the interaction of carbon nanotubes with human blood platelets

(2014) Silvia H. De Paoli et al.   BIOMATERIALS

Blood protein coating of gold nanoparticles as potential tool for organ targeting

(2014) Martin Schäffler et al.   BIOMATERIALS

Binding of Human Serum Albumin to Single-Walled Carbon Nanotubes Activated Neutrophils to Increase Production of Hypochlorous Acid, the Oxidant Capable of Degrading Nanotubes

(2014) Naihao Lu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Protein corona change the drug release profile of nanocarriers: The “overlooked” factor at the nanobio interface

(2014) Shahed Behzadi et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Monoclonal antibody conjugated magnetic nanoparticles could target MUC-1-positive cellsin vitrobut notin vivo

(2014) Saeed Shanehsazzadeh et al.   Contrast Media & Molecular Imaging

In situ generated thrombin in the protein corona of zeolites: Relevance of the functional proteins to its biological impact

(2014) Yunlong Li et al.   Nano Research

Targeted uptake of folic acid-functionalized iron oxide nanoparticles by ovarian cancer cells in the presence but not in the absence of serum

(2014) Annette Krais et al.   Nanomedicine-Nanotechnology Biology and Medicine

Diagnostic nanoparticle targeting of the EGF-receptor in complex biological conditions using single-domain antibodies

(2014) K. Zarschler et al.   Nanoscale

Personalized protein coronas: a “key” factor at the nanobiointerface

(2014) Mohammad J. Hajipour et al.   Biomaterials Science

Functionalization of Graphene Oxide Generates a Unique Interface for Selective Serum Protein Interactions

(2013) Xiaofang Tan et al.   ACS Applied Materials & Interfaces

Influence of Protein Corona on the Transport of Molecules into Cells by Mesoporous Silica Nanoparticles

(2013) Amauri J. Paula et al.   ACS Applied Materials & Interfaces

Optimizing the Properties of the Protein Corona Surrounding Nanoparticles for Tuning Payload Release

(2013) Anna Cifuentes-Rius et al.   ACS Nano

Differential Roles of the Protein Corona in the Cellular Uptake of Nanoporous Polymer Particles by Monocyte and Macrophage Cell Lines

(2013) Yan Yan et al.   ACS Nano

Preformed albumin corona, a protective coating for nanoparticles based drug delivery system

(2013) Qiang Peng et al.   BIOMATERIALS

The accelerated blood clearance (ABC) phenomenon: Clinical challenge and approaches to manage

(2013) Amr S. Abu Lila et al.   JOURNAL OF CONTROLLED RELEASE

Revealing the Binding Structure of the Protein Corona on Gold Nanorods Using Synchrotron Radiation-Based Techniques: Understanding the Reduced Damage in Cell Membranes

(2013) Liming Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nanoparticle Adhesion to the Cell Membrane and Its Effect on Nanoparticle Uptake Efficiency

(2013) Anna Lesniak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Surface chemistry of gold nanorods: origin of cell membrane damage and cytotoxicity

(2013) Liming Wang et al.   Nanoscale

Dynamic development of the protein corona on silica nanoparticles: composition and role in toxicity

(2013) Ninell P. Mortensen et al.   Nanoscale

Effect of polyethyleneglycol (PEG) chain length on the bio–nano-interactions between PEGylated lipid nanoparticles and biological fluids: from nanostructure to uptake in cancer cells

(2013) Daniela Pozzi et al.   Nanoscale

Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

(2013) Anna Salvati et al.   Nature Nanotechnology

Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

(2013) Stefan Tenzer et al.   Nature Nanotechnology

Titanium dioxide nanomaterials cause endothelial cell leakiness by disrupting the homophilic interaction of VE–cadherin

(2013) M.I. Setyawati et al.   Nature Communications

Cellular binding of anionic nanoparticles is inhibited by serum proteins independent of nanoparticle composition

(2013) Candace C. Fleischer et al.   Biomaterials Science

Protein coronas suppress the hemolytic activity of hydrophilic and hydrophobic nanoparticles

(2013) Krishnendu Saha et al.   Materials Horizons

Exploiting the Protein Corona around Gold Nanorods for Loading and Triggered Release

(2012) James Chen Yong Kah et al.   ACS Nano

Effects of the Presence or Absence of a Protein Corona on Silica Nanoparticle Uptake and Impact on Cells

(2012) Anna Lesniak et al.   ACS Nano

Hemolytic properties of synthetic nano- and porous silica particles: The effect of surface properties and the protection by the plasma corona

(2012) J. Shi et al.   Acta Biomaterialia

Delivery of membrane impermeable cargo into CHO cells by peptide nanoparticles targeted by a protein corona

(2012) Christian Dittrich et al.   BIOMATERIALS

Nanoparticle Surface Charge Mediates the Cellular Receptors Used by Protein–Nanoparticle Complexes

(2012) Candace C. Fleischer et al.   JOURNAL OF PHYSICAL CHEMISTRY B

PEGylated PRINT Nanoparticles: The Impact of PEG Density on Protein Binding, Macrophage Association, Biodistribution, and Pharmacokinetics

(2012) Jillian L. Perry et al.   NANO LETTERS

Ultrasmall fluorescent silver nanoclusters: Protein adsorption and its effects on cellular responses

(2012) Li Shang et al.   Nano Research

Effect of Functionalization of Carbon Nanotubes with Psychosine on Complement Activation and Protein Adsorption

(2011) Malgorzata J. Rybak-Smith et al.   Journal of Biomedical Nanotechnology

Albumin-based nanoparticles as potential controlled release drug delivery systems

(2011) Ahmed O. Elzoghby et al.   JOURNAL OF CONTROLLED RELEASE

Binding of blood proteins to carbon nanotubes reduces cytotoxicity

(2011) C. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hardening of the Nanoparticle-Protein Corona in Metal (Au, Ag) and Oxide (Fe3O4, CoO, and CeO2) Nanoparticles

(2011) Eudald Casals et al.   Small

Serum heat inactivation affects protein corona composition and nanoparticle uptake

(2010) Anna Lesniak et al.   BIOMATERIALS

Surface chemistry and aspect ratio mediated cellular uptake of Au nanorods

(2010) Yang Qiu et al.   BIOMATERIALS

Binding of Silver Nanoparticles to Bacterial Proteins Depends on Surface Modifications and Inhibits Enzymatic Activity

(2010) Nicholas S. Wigginton et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation

(2010) Zhou J. Deng et al.   Nature Nanotechnology

What does the cell see?

(2009) Iseult Lynch et al.   Nature Nanotechnology