Overexpression of REST Causes Neuronal Injury and Decreases Cofilin Phosphorylation in Mice

REST protects dopaminergic neurons from mitochondrial and α-synuclein oligomer pathology in an alpha synuclein overexpressing BAC-transgenic mouse model

(2021) BJ Ryan et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation induces synaptic scaling through IL-1β-mediated activation of the transcriptional repressor REST/NRSF

(2021) Federica Buffolo et al.   Cell Death & Disease

Astrocytic transcription factor REST upregulates glutamate transporter EAAT2, protecting dopaminergic neurons from manganese-induced excitotoxicity

(2021) Edward Pajarillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The transcription factor REST up-regulates tyrosine hydroxylase and antiapoptotic genes and protects dopaminergic neurons against manganese toxicity

(2020) Edward Pajarillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Memory trace interference impairs recall in a mouse model of Alzheimer’s disease

(2020) Stefanie Poll et al.   NATURE NEUROSCIENCE

Role of Cofilin in Alzheimer’s Disease

(2020) Qiang Wang et al.   Frontiers in Cell and Developmental Biology

Xanthoceraside prevented synaptic loss and reversed learning-memory deficits in APP/PS1 transgenic mice

(2019) Ge Jin et al.   Journal of Physiological Sciences

REST/NRSF transcription factor is overexpressed in hippocampus of patients with drug-resistant mesial temporal lobe epilepsy

(2019) Victor Navarrete-Modesto et al.   EPILEPSY & BEHAVIOR

WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs

(2019) Yuxing Liao et al.   NUCLEIC ACIDS RESEARCH

Cofilin, a Master Node Regulating Cytoskeletal Pathogenesis in Alzheimer’s Disease

(2019) David E. Kang et al.   JOURNAL OF ALZHEIMERS DISEASE

News about the Role of the Transcription Factor REST in Neurons: From Physiology to Pathology

(2019) Jose M. Garcia-Manteiga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

REST, a master transcriptional regulator in neurodegenerative disease

(2018) Jee-Yeon Hwang et al.   CURRENT OPINION IN NEUROBIOLOGY

Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer’s disease

(2018) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Kaempferol alleviates LPS-induced neuroinflammation and BBB dysfunction in mice via inhibiting HMGB1 release and down-regulating TLR4/MyD88 pathway

(2018) Xiao Cheng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Alzheimer’s Disease, Oligomers, and Inflammation

(2018) Gianluigi Forloni et al.   JOURNAL OF ALZHEIMERS DISEASE

Cofilin Rods and Aggregates Concur with Tau Pathology and the Development of Alzheimer's Disease

(2018) Tasnim Rahman et al.   JOURNAL OF ALZHEIMERS DISEASE

Inhibition of the Epigenetic Regulator REST Ameliorates Ischemic Brain Injury

(2018) Kahlilia C. Morris-Blanco et al.   MOLECULAR NEUROBIOLOGY

Alzheimer’s disease

(2018) Richard Hodson   NATURE

REST overexpression in mice causes deficits in spontaneous locomotion

(2018) Li Lu et al.   Scientific Reports

PP2A regulates SCF-induced cardiac stem cell migration through interaction with p38 MAPK

(2017) Ying Wang et al.   LIFE SCIENCES

Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

(2017) Ken Y Chan et al.   NATURE NEUROSCIENCE

Actin dynamics and cofilin-actin rods in alzheimer disease

(2016) James R. Bamburg et al.   Cytoskeleton

Brain REST/NRSF Is Not Only a Silent Repressor but Also an Active Protector

(2016) Yangang Zhao et al.   MOLECULAR NEUROBIOLOGY

Six alternative proteases for mass spectrometry–based proteomics beyond trypsin

(2016) Piero Giansanti et al.   Nature Protocols

Lim kinase, a bi-functional effector in injury-induced structural plasticity of synapses

(2016) Ellen Townes-Anderson et al.   Neural Regeneration Research

The ImageJ ecosystem: An open platform for biomedical image analysis

(2015) Johannes Schindelin et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

FunRich proteomics software analysis, let the fun begin!

(2015) Alberto Benito-Martin et al.   PROTEOMICS

RanBP9 at the intersection between cofilin and Aβ pathologies: rescue of neurodegenerative changes by RanBP9 reduction

(2015) J A Woo et al.   Cell Death & Disease

cytoHubba: identifying hub objects and sub-networks from complex interactome

(2014) Chia-Hao Chin et al.   BMC Systems Biology

A Receptor-interacting Protein 1 (RIP1)-independent Necrotic Death under the Control of Protein Phosphatase PP2A That Involves the Reorganization of Actin Cytoskeleton and the Action of Cofilin-1

(2014) Andrea Tomasella et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

REST/NRSF-induced changes of ChAT protein expression in the neocortex and hippocampus of the 3xTg-AD mouse model for Alzheimer's disease

(2014) E. Orta-Salazar et al.   LIFE SCIENCES

REST and stress resistance in ageing and Alzheimer’s disease

(2014) Tao Lu et al.   NATURE

Neural restrictive silencer factor and choline acetyltransferase expression in cerebral tissue of Alzheimer's Disease patients: a pilot study

(2013) Rocío E. González-Castañeda et al.   GENETICS AND MOLECULAR BIOLOGY

Human LilrB2 Is a  -Amyloid Receptor and Its Murine Homolog PirB Regulates Synaptic Plasticity in an Alzheimer's Model

(2013) T. Kim et al.   SCIENCE

p21-Activated kinase inhibitors: a patent review

(2012) James J Crawford et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Actin realignment and cofilin regulation are essential for barrier integrity during shear stress

(2012) Joshua B. Slee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Review: Systemic inflammation and Alzheimer's disease

(2012) C. Holmes   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease

(2011) Eric M. Blalock et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Gene expression changes in the course of normal brain aging are sexually dimorphic

(2008) N. C. Berchtold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons

(2008) W. S. Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA