Astrocytic transcription factor REST upregulates glutamate transporter EAAT2, protecting dopaminergic neurons from manganese-induced excitotoxicity

REST protects dopaminergic neurons from mitochondrial and α-synuclein oligomer pathology in an alpha synuclein overexpressing BAC-transgenic mouse model

(2021) BJ Ryan et al.   JOURNAL OF NEUROSCIENCE

Cerebral ischemia-reperfusion causes a down regulation of HCN1 expression via enhancing the nuclear NRSF-HDAC4 gathering that contributes to neuron damage

(2020) Pan Luo et al.   BRAIN RESEARCH BULLETIN

The transcription factor REST up-regulates tyrosine hydroxylase and antiapoptotic genes and protects dopaminergic neurons against manganese toxicity

(2020) Edward Pajarillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Astrocyte-specific deletion of the transcription factor Yin Yang 1 in murine substantia nigra mitigates manganese-induced dopaminergic neurotoxicity

(2020) Edward Pajarillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: Potential targets for neurotherapeutics

(2019) Edward Pajarillo et al.   NEUROPHARMACOLOGY

REST/NRSF transcription factor is overexpressed in hippocampus of patients with drug-resistant mesial temporal lobe epilepsy

(2019) Victor Navarrete-Modesto et al.   EPILEPSY & BEHAVIOR

Loss of nuclear REST/NRSF in aged-dopaminergic neurons in Parkinson’s disease patients

(2019) Miwako Kawamura et al.   NEUROSCIENCE LETTERS

Regulation of lifespan by neural excitation and REST

(2019) Joseph M. Zullo et al.   NATURE

The deficiency of NRSF/REST enhances the pro-inflammatory function of astrocytes in a model of Parkinson's disease

(2019) Heng Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Sodium Para-aminosalicylic Acid Reverses Changes of Glutamate Turnover in Manganese-Exposed Rats

(2019) Zhao-Cong Li et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

17β-estradiol and tamoxifen protect mice from manganese-induced dopaminergic neurotoxicity

(2018) Edward Pajarillo et al.   NEUROTOXICOLOGY

Valproic acid attenuates manganese-induced reduction in expression of GLT-1 and GLAST with concomitant changes in murine dopaminergic neurotoxicity

(2018) James Johnson et al.   NEUROTOXICOLOGY

Ceftriaxone reduces L -dopa-induced dyskinesia severity in 6-hydroxydopamine parkinson's disease model

(2017) Tanya Chotibut et al.   MOVEMENT DISORDERS

Transcriptional Mechanisms of Proneural Factors and REST in Regulating Neuronal Reprogramming of Astrocytes

(2015) Giacomo Masserdotti et al.   Cell Stem Cell

Transcriptional Regulation of the Astrocytic Excitatory Amino Acid Transporter 1 (EAAT1) via NF-κB and Yin Yang 1 (YY1)

(2015) Pratap Karki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

REST-Governed Gene Expression Profiling in a Neuronal Cell Model Reveals Novel Direct and Indirect Processes of Repression and Up-Regulation

(2015) Jose M. Garcia-Manteiga et al.   Frontiers in Cellular Neuroscience

Yin Yang 1 Is a Repressor of Glutamate Transporter EAAT2, and It Mediates Manganese-Induced Decrease of EAAT2 Expression in Astrocytes

(2014) P. Karki et al.   MOLECULAR AND CELLULAR BIOLOGY

REST and stress resistance in ageing and Alzheimer’s disease

(2014) Tao Lu et al.   NATURE

Dopamine Reduction in the Substantia Nigra of Parkinson's Disease Patients Confirmed by In Vivo Magnetic Resonance Spectroscopic Imaging

(2014) Adriane Gröger et al.   PLoS One

Nitric Oxide-Induced Neuronal to Glial Lineage Fate-Change Depends on NRSF/REST Function in Neural Progenitor Cells

(2014) Maria Bergsland et al.   STEM CELLS

cAMP Response Element-binding Protein (CREB) and Nuclear Factor κB Mediate the Tamoxifen-induced Up-regulation of Glutamate Transporter 1 (GLT-1) in Rat Astrocytes

(2013) Pratap Karki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NRSF/REST neuronal deficient mice are more vulnerable to the neurotoxin MPTP

(2012) Mei Yu et al.   NEUROBIOLOGY OF AGING

REST/NRSF governs the expression of dense-core vesicle gliosecretion in astrocytes

(2011) Ilaria Prada et al.   JOURNAL OF CELL BIOLOGY

Chromatin structure and expression of the AMPA receptor subunit Glur2 in human glioma cells: Major regulatory role of REST and Sp1

(2011) Myriam Ekici et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Master Negative Regulator REST/NRSF Controls Adult Neurogenesis by Restraining the Neurogenic Program in Quiescent Stem Cells

(2011) Z. Gao et al.   JOURNAL OF NEUROSCIENCE

Regulation of the NRSF/REST gene by methylation and CREB affects the cellular phenotype of small-cell lung cancer

(2010) A Kreisler et al.   ONCOGENE

Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases

(2009) Xiao-xia Dong et al.   ACTA PHARMACOLOGICA SINICA

Turning REST/NRSF Dysfunction in Huntingtons Disease into a Pharmaceutical Target

(2009) Dorotea Rigamonti et al.   CURRENT PHARMACEUTICAL DESIGN

Protective effects of MK-801 on manganese-induced glutamate metabolism disorder in rat striatum

(2009) Bin Xu et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Functional diversity for REST (NRSF) is defined by in vivo binding affinity hierarchies at the DNA sequence level

(2009) A. W. Bruce et al.   GENOME RESEARCH

Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia

(2009) Gregg D. Stanwood et al.   JOURNAL OF NEUROCHEMISTRY

Estrogen and tamoxifen reverse manganese-induced glutamate transporter impairment in astrocytes

(2009) Eun-Sook Y. Lee et al.   JOURNAL OF NEUROCHEMISTRY

Differential Deployment of REST and CoREST Promotes Glial Subtype Specification and Oligodendrocyte Lineage Maturation

(2009) Joseph J. Abrajano et al.   PLoS One

Transcription of the chicken Grin1 gene is regulated by the activity of SP3 and NRSF in undifferentiated cells and neurons

(2008) Gabriel Moreno-González et al.   BIOSCIENCE REPORTS

Molecular mechanism of manganese exposure-induced dopaminergic toxicity

(2008) K. Prabhakaran et al.   BRAIN RESEARCH BULLETIN

Downregulation of glial glutamate transporters after dopamine denervation in the striatum of 6-hydroxydopamine-lesioned rats

(2008) E.K.Y. Chung et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Yin yang 1 directly regulates the transcription of RE-1 silencing transcription factor

(2007) Lichun Jiang et al.   JOURNAL OF NEUROSCIENCE RESEARCH