Xanthoceraside prevented synaptic loss and reversed learning-memory deficits in APP/PS1 transgenic mice

Lead, cadmium, arsenic, and mercury combined exposure disrupted synaptic homeostasis through activating the Snk-SPAR pathway

(2018) Fankun Zhou et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Xanthoceraside modulates neurogenesis to ameliorate cognitive impairment in APP/PS1 transgenic mice

(2017) Lin Zhu et al.   Journal of Physiological Sciences

Functional convergence of Akt protein with VEGFR-1 in human endothelial progenitor cells exposed to sera from patient with type 2 diabetes mellitus

(2017) Mehdi Hassanpour et al.   MICROVASCULAR RESEARCH

Antiangiogenic properties of caudatin in vitro and in vivo by suppression of VEGF-VEGFR2-AKT/FAK signal axis

(2017) Xinzhi Wang et al.   Molecular Medicine Reports

Neuroprotective effects of a novel peptide, FK18, under oxygen-glucose deprivation in SH-SY5Y cells and retinal ischemia in rats via the Akt pathway

(2017) Shuyu Xiong et al.   NEUROCHEMISTRY INTERNATIONAL

Activation of β2-adrenergic receptor promotes dendrite ramification and spine generation in APP/PS1 mice

(2017) Gao-shang Chai et al.   NEUROSCIENCE LETTERS

Xanthoceraside modulates NR2B-containing NMDA receptors at synapses and rescues learning-memory deficits in APP/PS1 transgenic mice

(2017) Lin Zhu et al.   PSYCHOPHARMACOLOGY

Hypertension-induced synapse loss and impairment in synaptic plasticity in the mouse hippocampus mimics the aging phenotype: implications for the pathogenesis of vascular cognitive impairment

(2017) Zsuzsanna Tucsek et al.   GeroScience

Neurotrophins Enhance CaMKII Activity and Rescue Amyloid-β-Induced Deficits in Hippocampal Synaptic Plasticity

(2017) Yan Zeng et al.   JOURNAL OF ALZHEIMERS DISEASE

Deficits in object-in-place but not relative recency performance in the APPswe/PS1dE9 mouse model of Alzheimer’s disease: Implications for object recognition

(2016) Charlotte Bonardi et al.   BEHAVIOURAL BRAIN RESEARCH

Early effects of Aβ 1-42 oligomers injection in mice: Involvement of PI3K/Akt/GSK3 and MAPK/ERK1/2 pathways

(2016) Fabiana Morroni et al.   BEHAVIOURAL BRAIN RESEARCH

Xanthoceras sorbifolia extracts ameliorate dendritic spine deficiency and cognitive decline via upregulation of BDNF expression in a rat model of Alzheimer's disease

(2016) Yinjie Li et al.   NEUROSCIENCE LETTERS

Degeneration and energy shortage in the suprachiasmatic nucleus underlies the circadian rhythm disturbance in ApoE−/− mice: implications for Alzheimer’s disease

(2016) Lan Zhou et al.   Scientific Reports

Neurobiology of Alzheimer’s Disease: Integrated Molecular, Physiological, Anatomical, Biomarker, and Cognitive Dimensions

(2015) Joel Raskin et al.   Current Alzheimer Research

Staining neurons with Golgi techniques in degenerative diseases of the brain

(2015) StavrosJ Baloyannis   Neural Regeneration Research

Pratensein ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels

(2015) Chunhong Liang et al.   NEUROSCIENCE LETTERS

Cognitive Enhancing Treatment with a PPARγ Agonist Normalizes Dentate Granule Cell Presynaptic Function in Tg2576 APP Mice

(2014) Miroslav N. Nenov et al.   JOURNAL OF NEUROSCIENCE

Altered synaptic structure in the hippocampus in a mouse model of Alzheimer’s disease with soluble amyloid-β oligomers and no plaque pathology

(2014) Katherine A Price et al.   Molecular Neurodegeneration

A Synaptotoxic Pathway from Aβ oligomer to Prion Protein to mGluR5 to F kinase in Alzheimer's Disease

(2014) Stephen Strittmatter et al.   NEUROBIOLOGY OF AGING

Xanthoceraside rescues learning and memory deficits through attenuating beta-amyloid deposition and tau hyperphosphorylation in APP mice

(2014) Ge Jin et al.   NEUROSCIENCE LETTERS

PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease

(2013) Cora O' Neill   EXPERIMENTAL GERONTOLOGY

Enhanced Phosphatidylinositol 3-kinase (PI3K)/Akt Signaling Has Pleiotropic Targets in Hippocampal Neurons Exposed to Iron-induced Oxidative Stress

(2013) Romina María Uranga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Xanthoceraside Inhibits Pro-inflammatory Cytokine Expression in Aβ25–35/IFN-γ–Stimulated Microglia Through the TLR2 Receptor, MyD88, Nuclear Factor-κB, and Mitogen-Activated Protein Kinase Signaling Pathways

(2013) Yue Qi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases

(2013) Bai Lu et al.   NATURE REVIEWS NEUROSCIENCE

Free and nanoencapsulated curcumin suppress β-amyloid-induced cognitive impairments in rats: Involvement of BDNF and Akt/GSK-3β signaling pathway

(2013) Juliana B. Hoppe et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

A role for tau at the synapse in Alzheimer's disease pathogenesis

(2013) Amy M. Pooler et al.   NEUROPHARMACOLOGY

Synaptic gene dysregulation within hippocampal CA1 pyramidal neurons in mild cognitive impairment

(2013) Scott E. Counts et al.   NEUROPHARMACOLOGY

Xanthoceraside attenuates learning and memory deficits via improving insulin signaling in STZ-induced AD rats

(2013) Peng Liu et al.   NEUROSCIENCE LETTERS

Stress and trauma: BDNF control of dendritic-spine formation and regression

(2013) M.R. Bennett et al.   PROGRESS IN NEUROBIOLOGY

Xanthoceraside attenuates tau hyperphosphorylation and cognitive deficits in intracerebroventricular-streptozotocin injected rats

(2013) Peng Liu et al.   PSYCHOPHARMACOLOGY

Curcumin protects organotypic hippocampal slice cultures from Aβ1–42-induced synaptic toxicity

(2013) Juliana Bender Hoppe et al.   TOXICOLOGY IN VITRO

Role of pro-brain-derived neurotrophic factor (proBDNF) to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapses

(2012) H. S. Je et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

(2011) M. J. Calkins et al.   HUMAN MOLECULAR GENETICS

Early development of social deficits in APP and APP-PS1 mice

(2011) Susanna Pietropaolo et al.   NEUROBIOLOGY OF AGING

Xanthoceraside attenuates amyloid β peptide25–35-induced learning and memory impairments in mice

(2011) Ping Lu et al.   PSYCHOPHARMACOLOGY

The novel squamosamide derivative FLZ enhances BDNF/TrkB/CREB signaling and inhibits neuronal apoptosis in APP/PS1 mice

(2010) Ning Li et al.   ACTA PHARMACOLOGICA SINICA

ADF/Cofilin-Actin Rods in Neurodegenerative Diseases

(2010) J.R. Bamburg et al.   Current Alzheimer Research

Ciliary Neurotrophic Factor Cell-Based Delivery Prevents Synaptic Impairment and Improves Memory in Mouse Models of Alzheimer's Disease

(2010) P. Garcia et al.   JOURNAL OF NEUROSCIENCE

Positive and Negative Symptoms in Schizophrenia: The NMDA Receptor Hypofunction Hypothesis, Neuregulin/ErbB4 and Synapse Regression

(2009) Maxwell Bennett   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Protective effects of xanthoceraside on learning and memory impairment induced by Aβ25–35in mice

(2009) Tian-Yan Chi et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Inhibition of PI3K-Akt Signaling Blocks Exercise-Mediated Enhancement of Adult Neurogenesis and Synaptic Plasticity in the Dentate Gyrus

(2009) Elodie Bruel-Jungerman et al.   PLoS One

New insights into brain BDNF function in normal aging and Alzheimer disease

(2008) Lucia Tapia-Arancibia et al.   BRAIN RESEARCH REVIEWS

Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats

(2008) S. Arancibia et al.   NEUROBIOLOGY OF DISEASE