Brain REST/NRSF Is Not Only a Silent Repressor but Also an Active Protector

Rest mutant zebrafish swim erratically and display atypical spatial preferences

(2015) Cara E. Moravec et al.   BEHAVIOURAL BRAIN RESEARCH

Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1

(2015) X. Du et al.   BIOCHEMICAL JOURNAL

Importance of gene dosage in controlling dendritic arbor formation during development

(2015) Tijana Copf   EUROPEAN JOURNAL OF NEUROSCIENCE

Sp3/REST/HDAC1/HDAC2 Complex Represses and Sp1/HIF-1/p300 Complex Activates ncx1 Gene Transcription, in Brain Ischemia and in Ischemic Brain Preconditioning, by Epigenetic Mechanism

(2015) L. Formisano et al.   JOURNAL OF NEUROSCIENCE

Steroid receptor coactivator-1 mediates letrozole induced downregulation of postsynaptic protein PSD-95 in the hippocampus of adult female rats

(2015) Mengying Liu et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

PDYN, a gene implicated in brain/mental disorders, is targeted by REST in the adult human brain

(2014) Richard Henriksson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Sex differences in Parkinson's disease and other movement disorders

(2014) Kara M. Smith et al.   EXPERIMENTAL NEUROLOGY

Sex differences in cognitive impairment and Alzheimer’s disease

(2014) Rena Li et al.   FRONTIERS IN NEUROENDOCRINOLOGY

The Gene Silencing Transcription Factor REST Represses miR-132 Expression in Hippocampal Neurons Destined to Die

(2014) Jee-Yeon Hwang et al.   JOURNAL OF MOLECULAR BIOLOGY

NRSF: an Angel or a Devil in Neurogenesis and Neurological Diseases

(2014) Zhiqi Song et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Casein Kinase 1 Suppresses Activation of REST in Insulted Hippocampal Neurons and Halts Ischemia-Induced Neuronal Death

(2014) N. Kaneko et al.   JOURNAL OF NEUROSCIENCE

REST/NRSF-induced changes of ChAT protein expression in the neocortex and hippocampus of the 3xTg-AD mouse model for Alzheimer's disease

(2014) E. Orta-Salazar et al.   LIFE SCIENCES

REST and stress resistance in ageing and Alzheimer’s disease

(2014) Tao Lu et al.   NATURE

The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes

(2014) Shawn McClelland et al.   eLife

Regulation of the neuronal transcription factor NPAS4 by REST and microRNAs

(2013) David C. Bersten et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

REST/NRSF-mediated intrinsic homeostasis protects neuronal networks from hyperexcitability

(2013) Davide Pozzi et al.   EMBO JOURNAL

High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes

(2013) Jérémie Charbord et al.   STEM CELLS

NRSF/REST is required for gastrulation and neurogenesis during zebrafish development

(2012) X. Wang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Regulation of gene expression during early neuronal differentiation: evidence for patterns conserved across neuron populations and vertebrate classes

(2012) Uwe Ernsberger   CELL AND TISSUE RESEARCH

Zebrafish rest regulates developmental gene expression but not neurogenesis

(2012) F. O. Kok et al.   DEVELOPMENT

Intronic miR-26b controls neuronal differentiation by repressing its host transcript, ctdsp2

(2012) H. Dill et al.   GENES & DEVELOPMENT

Neuron-restrictive Silencer Factor (NRSF) Represses Cocaine- and Amphetamine-regulated Transcript (CART) Transcription and Antagonizes cAMP-response Element-binding Protein Signaling through a Dual NRSE Mechanism

(2012) Jing Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

REST Controls Self-Renewal and Tumorigenic Competence of Human Glioblastoma Cells

(2012) Luciano Conti et al.   PLoS One

Elevated IKKα Accelerates the Differentiation of Human Neuronal Progenitor Cells and Induces MeCP2-Dependent BDNF Expression

(2012) Ali Khoshnan et al.   PLoS One

Neuron-restrictive silencer factor-mediated hyperpolarization-activated cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy

(2011) Shawn McClelland et al.   ANNALS OF NEUROLOGY

Cysteine 397 plays important roles in the folding of the neuron-restricted silencer factor/RE1-silencing transcription factor

(2011) Yan Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Alterations of steroid receptor coactivator-1 (SRC-1) immunoreactivities in specific brain regions of young and middle-aged female Sprague–Dawley rats

(2011) Dongmei Zhang et al.   BRAIN RESEARCH

A signaling loop of REST, TSC2 and  -catenin governs proliferation and function of PC12 neural cells

(2011) R. Tomasoni et al.   JOURNAL OF CELL SCIENCE

The Master Negative Regulator REST/NRSF Controls Adult Neurogenesis by Restraining the Neurogenic Program in Quiescent Stem Cells

(2011) Z. Gao et al.   JOURNAL OF NEUROSCIENCE

Cross-Regulation between an Alternative Splicing Activator and a Transcription Repressor Controls Neurogenesis

(2011) Bushra Raj et al.   MOLECULAR CELL

Non-Coding RNAs in Neural Networks, REST-Assured

(2011) Michael Rossbach   Frontiers in Genetics

Gene expression profiling in progressively MPTP-lesioned macaques reveals molecular pathways associated with sporadic Parkinson's disease

(2010) Tatsuya Ohnuki et al.   BRAIN RESEARCH

In PC12 Cells, Expression of Neurosecretion and Neurite Outgrowth are Governed by the Transcription Repressor REST/NRSF

(2010) Rosalba D’Alessandro et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

BMP-induced REST regulates the establishment and maintenance of astrocytic identity

(2010) Jun Kohyama et al.   JOURNAL OF CELL BIOLOGY

Corepressor for element-1-silencing transcription factor preferentially mediates gene networks underlying neural stem cell fate decisions

(2010) J. J. Abrajano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Remote control of activity-dependent BDNF gene promoter-I transcription mediated by REST/NRSF

(2009) Daichi Hara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NRSF downregulation induces neuronal differentiation in mouse embryonic stem cells

(2009) Shailesh Kumar Gupta et al.   DIFFERENTIATION

DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome

(2009) Aude-Marie Lepagnol-Bestel et al.   HUMAN MOLECULAR GENETICS

MicroRNA-mediated switching of chromatin-remodelling complexes in neural development

(2009) Andrew S. Yoo et al.   NATURE

Alteration of NRSF expression exacerbating 1-methyl-4-phenyl-pyridinium ion-induced cell death of SH-SY5Y cells

(2009) Mei Yu et al.   NEUROSCIENCE RESEARCH

REST and CoREST Modulate Neuronal Subtype Specification, Maturation and Maintenance

(2009) Joseph J. Abrajano et al.   PLoS One

Biological Studies on Alcohol-Induced Neuronal Damage

(2009) Masaru Tateno et al.   Psychiatry Investigation

Lithium-induced suppression of transcription repressor NRSF/REST: Effects on the dysfunction of neuronal differentiation by ethanol

(2008) Takao Ishii et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation

(2008) Thomas F. Westbrook et al.   NATURE