Neuronal replacement: Concepts, achievements, and call for caution

CRISPR-Mediated Induction of Neuron-Enriched Mitochondrial Proteins Boosts Direct Glia-to-Neuron Conversion

(2021) Gianluca L. Russo et al.   Cell Stem Cell

Defining the Adult Neural Stem Cell Niche Proteome Identifies Key Regulators of Adult Neurogenesis

(2020) Jacob Kjell et al.   Cell Stem Cell

Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease

(2020) Zheng Wu et al.   Nature Communications

Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice

(2020) Haibo Zhou et al.   CELL

Transplanted Embryonic Neurons Improve Functional Recovery by Increasing Activity in Injured Cortical Circuits

(2020) Evgenia Andreoli et al.   CEREBRAL CORTEX

Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson’s Disease

(2020) Jeffrey S. Schweitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Activity in grafted human iPS cell–derived cortical neurons integrated in stroke-injured rat brain regulates motor behavior

(2020) Sara Palma-Tortosa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease

(2020) Katarína Tiklová et al.   Nature Communications

Srebf1 Controls Midbrain Dopaminergic Neurogenesis

(2020) Enrique M. Toledo et al.   Cell Reports

Reversing a model of Parkinson’s disease with in situ converted nigral neurons

(2020) Hao Qian et al.   NATURE

CRISPR-tools for physiology & cell state changes - potential of transcriptional engineering and epigenome editing

(2020) Christopher Breunig et al.   PHYSIOLOGICAL REVIEWS

Midbrain Dopaminergic Neuron Development at the Single Cell Level: In vivo and in Stem Cells

(2020) Emilía Sif Ásgrímsdóttir et al.   Frontiers in Cell and Developmental Biology

Neuronal Reprogramming for Brain Repair: Challenges and Perspectives

(2020) Riccardo Bocchi et al.   TRENDS IN MOLECULAR MEDICINE

Direct Reprogramming of Human Fetal- and Stem Cell-Derived Glial Progenitor Cells into Midbrain Dopaminergic Neurons

(2020) Sara Nolbrant et al.   Stem Cell Reports

Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion

(2019) Taito Matsuda et al.   NEURON

In vivo direct reprogramming of glial linage to mature neurons after cerebral ischemia

(2019) Toru Yamashita et al.   Scientific Reports

A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair after Ischemic Injury through In Vivo Astrocyte-to-Neuron Conversion

(2019) Yu-Chen Chen et al.   MOLECULAR THERAPY

Inducing Different Neuronal Subtypes from Astrocytes in the Injured Mouse Cerebral Cortex

(2019) Nicola Mattugini et al.   NEURON

hESC-Derived Dopaminergic Transplants Integrate into Basal Ganglia Circuitry in a Preclinical Model of Parkinson’s Disease

(2019) Andrew F. Adler et al.   Cell Reports

Strategies for in vivo reprogramming

(2019) Andreas Ofenbauer et al.   CURRENT OPINION IN CELL BIOLOGY

Target-specific forebrain projections and appropriate synaptic inputs of hESC-derived dopamine neurons grafted to the midbrain of parkinsonian rats

(2018) Tiago Cardoso et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

New approaches for brain repair—from rescue to reprogramming

(2018) Roger A. Barker et al.   NATURE

Single-cell mapping of lineage and identity in direct reprogramming

(2018) Brent A. Biddy et al.   NATURE

In vivo modeling of human neuron dynamics and Down syndrome

(2018) Raquel Real et al.   SCIENCE

Phenotypic Reprogramming of Striatal Neurons into Dopaminergic Neuron-like Cells in the Adult Mouse Brain

(2018) Wenze Niu et al.   Stem Cell Reports

Synthetic AAV/CRISPR vectors for blocking HIV-1 expression in persistently infected astrocytes

(2017) Christine Kunze et al.   GLIA

Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model

(2017) Pia Rivetti di Val Cervo et al.   NATURE BIOTECHNOLOGY

Electromagnetized gold nanoparticles mediate direct lineage reprogramming into induced dopamine neurons in vivo for Parkinson's disease therapy

(2017) Junsang Yoo et al.   Nature Nanotechnology

Direct Reprogramming of Resident NG2 Glia into Neurons with Properties of Fast-Spiking Parvalbumin-Containing Interneurons

(2017) Maria Pereira et al.   Stem Cell Reports

Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells

(2016) Gioele La Manno et al.   CELL

Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

(2016) Sergio Gascón et al.   Cell Stem Cell

Transplanted embryonic neurons integrate into adult neocortical circuits

(2016) Susanne Falkner et al.   NATURE

In vivo reprogramming reactive glia into iPSCs to produce new neurons in the cortex following traumatic brain injury

(2016) Xiang Gao et al.   Scientific Reports

Reactive astrocytes as neural stem or progenitor cells: In vivo lineage, In vitro potential, and Genome-wide expression analysis

(2015) Magdalena Götz et al.   GLIA

Ascl1 Converts Dorsal Midbrain Astrocytes into Functional Neurons In Vivo

(2015) Y. Liu et al.   JOURNAL OF NEUROSCIENCE

The neocortical circuit: themes and variations

(2015) Kenneth D Harris et al.   NATURE NEUROSCIENCE

In Vivo Reprogramming of Striatal NG2 Glia into Functional Neurons that Integrate into Local Host Circuitry

(2015) Olof Torper et al.   Cell Reports

Monosynaptic Tracing using Modified Rabies Virus Reveals Early and Extensive Circuit Integration of Human Embryonic Stem Cell-Derived Neurons

(2015) Shane Grealish et al.   Stem Cell Reports

SOX2 Reprograms Resident Astrocytes into Neural Progenitors in the Adult Brain

(2015) Wenze Niu et al.   Stem Cell Reports

Transduction efficiency of neurons and glial cells by AAV-1, -5, -9, -rh10 and -hu11 serotypes in rat spinal cord following contusion injury

(2014) H A Petrosyan et al.   GENE THERAPY

Sox2-Mediated Conversion of NG2 Glia into Induced Neurons in the Injured Adult Cerebral Cortex

(2014) Christophe Heinrich et al.   Stem Cell Reports

In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model

(2013) Ziyuan Guo et al.   Cell Stem Cell

In vivo reprogramming of astrocytes to neuroblasts in the adult brain

(2013) Wenze Niu et al.   NATURE CELL BIOLOGY

Generation of induced neurons via direct conversion in vivo

(2013) O. Torper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Environmental impact on direct neuronal reprogramming in vivo in the adult brain

(2013) Andrew Grande et al.   Nature Communications

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

(2011) Sonja Kriks et al.   NATURE

Age-specific progression of nigrostriatal dysfunction in Parkinson's disease

(2010) Raúl de la Fuente-Fernández et al.   ANNALS OF NEUROLOGY

Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

(2008) Kevin D Foust et al.   NATURE BIOTECHNOLOGY