Neuroregenerative gene therapy to treat temporal lobe epilepsy in a rat model

Revisiting astrocyte to neuron conversion with lineage tracing in vivo

(2021) Lei-Lei Wang et al.   CELL

In vivo confusion over in vivo conversion

(2021) Gong Chen   MOLECULAR THERAPY

Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease

(2020) Zheng Wu et al.   Nature Communications

Single-cell RNA-seq analysis revealed long-lasting adverse effects of tamoxifen on neurogenesis in prenatal and adult brains

(2020) Chia-Ming Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocyte function from information processing to cognition and cognitive impairment

(2019) Mirko Santello et al.   NATURE NEUROSCIENCE

Region-Restrict Astrocytes Exhibit Heterogeneous Susceptibility to Neuronal Reprogramming

(2019) Xin Hu et al.   Stem Cell Reports

Epilepsy gene therapy using an engineered potassium channel

(2019) Albert Snowball et al.   JOURNAL OF NEUROSCIENCE

A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair after Ischemic Injury through In Vivo Astrocyte-to-Neuron Conversion

(2019) Yu-Chen Chen et al.   MOLECULAR THERAPY

Biochemical autoregulatory gene therapy for focal epilepsy

(2018) Andreas Lieb et al.   NATURE MEDICINE

In vivo somatic cell reprogramming for tissue regeneration: the emerging role of the local microenvironment

(2018) Martina Pesaresi et al.   CURRENT OPINION IN CELL BIOLOGY

Diverse reprogramming codes for neuronal identity

(2018) Rachel Tsunemoto et al.   NATURE

Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration

(2018) Dinesh Upadhya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pluripotent stem cell-derived interneuron progenitors mature and restore memory deficits but do not suppress seizures in the epileptic mouse brain

(2018) Nickesha C. Anderson et al.   Stem Cell Research

Seizure frequency correlates with loss of dentate gyrus GABAergic neurons in a mouse model of temporal lobe epilepsy

(2017) Paul S. Buckmaster et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Molecular and Functional Properties of Regional Astrocytes in the Adult Brain

(2017) Lydie Morel et al.   JOURNAL OF NEUROSCIENCE

Resolving Astrocyte Heterogeneity in the CNS

(2017) W. Todd Farmer et al.   Frontiers in Cellular Neuroscience

Lineage Reprogramming of Astroglial Cells from Different Origins into Distinct Neuronal Subtypes

(2017) Malek Chouchane et al.   Stem Cell Reports

Direct Reprogramming of Resident NG2 Glia into Neurons with Properties of Fast-Spiking Parvalbumin-Containing Interneurons

(2017) Maria Pereira et al.   Stem Cell Reports

Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

(2016) Sergio Gascón et al.   Cell Stem Cell

Time course evaluation of behavioral impairments in the pilocarpine model of epilepsy

(2016) Mark William Lopes et al.   EPILEPSY & BEHAVIOR

In Vivo Reprogramming for CNS Repair: Regenerating Neurons from Endogenous Glial Cells

(2016) Hedong Li et al.   NEURON

GABA-ergic cell therapy for epilepsy: Advances, limitations and challenges

(2016) Ashok K. Shetty et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Newly generated neurons at 2 months post-status epilepticus are functionally integrated into neuronal circuitry in mouse hippocampus

(2015) Ming Hu et al.   EXPERIMENTAL NEUROLOGY

Ascl1 Converts Dorsal Midbrain Astrocytes into Functional Neurons In Vivo

(2015) Y. Liu et al.   JOURNAL OF NEUROSCIENCE

In vivo reprogramming for tissue repair

(2015) Christophe Heinrich et al.   NATURE CELL BIOLOGY

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline

(2015) Kyung-Ok Cho et al.   Nature Communications

In Vivo Reprogramming of Striatal NG2 Glia into Functional Neurons that Integrate into Local Host Circuitry

(2015) Olof Torper et al.   Cell Reports

hPSC-Derived Maturing GABAergic Interneurons Ameliorate Seizures and Abnormal Behavior in Epileptic Mice

(2014) Miles Cunningham et al.   Cell Stem Cell

Gene therapy in epilepsy—is it time for clinical trials?

(2014) Dimitri M. Kullmann et al.   Nature Reviews Neurology

Chemical–genetic attenuation of focal neocortical seizures

(2014) Dennis Kätzel et al.   Nature Communications

Sox2-Mediated Conversion of NG2 Glia into Induced Neurons in the Injured Adult Cerebral Cortex

(2014) Christophe Heinrich et al.   Stem Cell Reports

In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model

(2013) Ziyuan Guo et al.   Cell Stem Cell

Issues related to symptomatic and disease-modifying treatments affecting cognitive and neuropsychiatric comorbidities of epilepsy

(2013) Amy R. Brooks-Kayal et al.   EPILEPSIA

Early Activation of Ventral Hippocampus and Subiculum during Spontaneous Seizures in a Rat Model of Temporal Lobe Epilepsy

(2013) I. Toyoda et al.   JOURNAL OF NEUROSCIENCE

In vivo reprogramming of astrocytes to neuroblasts in the adult brain

(2013) Wenze Niu et al.   NATURE CELL BIOLOGY

Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation

(2013) Sophia Bardehle et al.   NATURE NEUROSCIENCE

GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior

(2013) Robert F Hunt et al.   NATURE NEUROSCIENCE

Environmental impact on direct neuronal reprogramming in vivo in the adult brain

(2013) Andrew Grande et al.   Nature Communications

On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy

(2013) Esther Krook-Magnuson et al.   Nature Communications

Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury

(2012) Jeanne T Paz et al.   NATURE NEUROSCIENCE

Selective induction of astrocytic gliosis generates deficits in neuronal inhibition

(2010) Pavel I Ortinski et al.   NATURE NEUROSCIENCE

Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies

(2009) Patrick Kwan et al.   EPILEPSIA

Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis

(2009) Tomoko Kuwabara et al.   NATURE NEUROSCIENCE

Neurod1 is essential for the survival and maturation of adult-born neurons

(2009) Zhengliang Gao et al.   NATURE NEUROSCIENCE

Hippocampal neurogenesis and neural stem cells in temporal lobe epilepsy

(2008) Ramkumar Kuruba et al.   EPILEPSY & BEHAVIOR

The pilocarpine model of temporal lobe epilepsy

(2008) Giulia Curia et al.   JOURNAL OF NEUROSCIENCE METHODS