Here, there, and everywhere: The importance of ER membrane contact sites

Molecular basis for sterol transport by StART‐like lipid transfer domains

(2018) Florian A Horenkamp et al.   EMBO JOURNAL

Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions

(2018) Dijin Xu et al.   JOURNAL OF CELL BIOLOGY

Structural basis of sterol recognition and nonvesicular transport by lipid transfer proteins anchored at membrane contact sites

(2018) Junsen Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells

(2018) Marina Besprozvannaya et al.   eLife

Vps13-Mcp1 interact at vacuole–mitochondria interfaces and bypass ER–mitochondria contact sites

(2017) Arun T. John Peter et al.   JOURNAL OF CELL BIOLOGY

Defects in ER–endosome contacts impact lysosome function in hereditary spastic paraplegia

(2017) Rachel Allison et al.   JOURNAL OF CELL BIOLOGY

VAPs and ACBD5 tether peroxisomes to the ER for peroxisome maintenance and lipid homeostasis

(2017) Rong Hua et al.   JOURNAL OF CELL BIOLOGY

ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER

(2017) Joseph L. Costello et al.   JOURNAL OF CELL BIOLOGY

Functional characterisation of peroxisomal β-oxidation disorders in fibroblasts using lipidomics

(2017) Katharina Herzog et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Applying systems-level spectral imaging and analysis to reveal the organelle interactome

(2017) Alex M. Valm et al.   NATURE

Crystal structures of Mmm1 and Mdm12–Mmm1 reveal mechanistic insight into phospholipid trafficking at ER-mitochondria contact sites

(2017) Hanbin Jeong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contacts between the endoplasmic reticulum and other membranes in neurons

(2017) Yumei Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid transport by TMEM24 at ER–plasma membrane contacts regulates pulsatile insulin secretion

(2017) Joshua A. Lees et al.   SCIENCE

ER-mitochondria tethering by PDZD8 regulates Ca2+dynamics in mammalian neurons

(2017) Yusuke Hirabayashi et al.   SCIENCE

Coupling organelle inheritance with mitosis to balance growth and differentiation

(2017) Amma Asare et al.   SCIENCE

Constriction of the mitochondrial inner compartment is a priming event for mitochondrial division

(2017) Bongki Cho et al.   Nature Communications

Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P

(2016) Rui Dong et al.   CELL

Seipin regulates ER–lipid droplet contacts and cargo delivery

(2016) Veijo T Salo et al.   EMBO JOURNAL

Crystal structure of Mdm12 reveals the architecture and dynamic organization of the ERMES complex

(2016) Hanbin Jeong et al.   EMBO REPORTS

An inducible ER–Golgi tether facilitates ceramide transport to alleviate lipotoxicity

(2016) Li-Ka Liu et al.   JOURNAL OF CELL BIOLOGY

Cooperative and independent roles of the Drp1 adaptors Mff, MiD49 and MiD51 in mitochondrial fission

(2016) Laura D. Osellame et al.   JOURNAL OF CELL SCIENCE

Multiple dynamin family members collaborate to drive mitochondrial division

(2016) Jason E. Lee et al.   NATURE

Control of plasma membrane lipid homeostasis by the extended synaptotagmins

(2016) Yasunori Saheki et al.   NATURE CELL BIOLOGY

Junctophilin-4, a component of the endoplasmic reticulum–plasma membrane junctions, regulates Ca2+dynamics in T cells

(2016) Jin Seok Woo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells

(2016) Samantha C. Lewis et al.   SCIENCE

Seipin is required for converting nascent to mature lipid droplets

(2016) Huajin Wang et al.   eLife

Critical Role of Intracellular RyR1 Calcium Release Channels in Skeletal Muscle Function and Disease

(2016) Erick O. Hernández-Ochoa et al.   Frontiers in Physiology

A phospholipid transfer function of ER-mitochondria encounter structure revealed in vitro

(2016) Rieko Kojima et al.   Scientific Reports

Phosphatidylinositol-Phosphatidic Acid Exchange by Nir2 at ER-PM Contact Sites Maintains Phosphoinositide Signaling Competence

(2015) Yeun Ju Kim et al.   DEVELOPMENTAL CELL

Triggered Ca2+ influx is required for extended synaptotagmin 1-induced ER-plasma membrane tethering

(2015) O. Idevall-Hagren et al.   EMBO JOURNAL

Ltc1 is an ER-localized sterol transporter and a component of ER–mitochondria and ER–vacuole contacts

(2015) Andrew Murley et al.   JOURNAL OF CELL BIOLOGY

ER–mitochondrial junctions can be bypassed by dominant mutations in the endosomal protein Vps13

(2015) Alexander B. Lang et al.   JOURNAL OF CELL BIOLOGY

The seipin complex Fld1/Ldb16 stabilizes ER–lipid droplet contact sites

(2015) Alexandra Grippa et al.   JOURNAL OF CELL BIOLOGY

Gating machinery of InsP3R channels revealed by electron cryomicroscopy

(2015) Guizhen Fan et al.   NATURE

Repeated ER–endosome contacts promote endosome translocation and neurite outgrowth

(2015) Camilla Raiborg et al.   NATURE

Proteomic mapping of ER–PM junctions identifies STIMATE as a regulator of Ca2+ influx

(2015) Ji Jing et al.   NATURE CELL BIOLOGY

Structure and function of ER membrane contact sites with other organelles

(2015) Melissa J. Phillips et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Three-dimensional architecture of extended synaptotagmin-mediated endoplasmic reticulum–plasma membrane contact sites

(2015) Rubén Fernández-Busnadiego et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TMEM110 regulates the maintenance and remodeling of mammalian ER–plasma membrane junctions competent for STIM–ORAI signaling

(2015) Ariel Quintana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conserved SMP domains of the ERMES complex bind phospholipids and mediate tether assembly

(2015) Andrew P. AhYoung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts

(2015) J. Chung et al.   SCIENCE

Lam6 Regulates the Extent of Contacts between Organelles

(2015) Yael Elbaz-Alon et al.   Cell Reports

A new family of StART domain proteins at membrane contact sites has a role in ER-PM sterol transport

(2015) Alberto T Gatta et al.   eLife

A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division

(2015) Uri Manor et al.   eLife

ER Contact Sites Define the Position and Timing of Endosome Fission

(2014) Ashley A. Rowland et al.   CELL

Peroxisomes: A Nexus for Lipid Metabolism and Cellular Signaling

(2014) Irfan J. Lodhi et al.   Cell Metabolism

A Dynamic Interface between Vacuoles and Mitochondria in Yeast

(2014) Yael Elbaz-Alon et al.   DEVELOPMENTAL CELL

Cellular Metabolism Regulates Contact Sites between Vacuoles and Mitochondria

(2014) Carina Hönscher et al.   DEVELOPMENTAL CELL

Control of lipid droplet size in budding yeast requires the collaboration between Fld1 and Ldb16

(2014) C.-W. Wang et al.   JOURNAL OF CELL SCIENCE

Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer

(2014) Curtis M. Schauder et al.   NATURE

Structure and Ca2+-Binding Properties of the Tandem C2 Domains of E-Syt2

(2014) Junjie Xu et al.   STRUCTURE

Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting

(2014) Florian Wilfling et al.   eLife

Microarchitecture of the dyad

(2013) David R.L. Scriven et al.   CARDIOVASCULAR RESEARCH

A Four-Step Cycle Driven by PI(4)P Hydrolysis Directs Sterol/PI(4)P Exchange by the ER-Golgi Tether OSBP

(2013) Bruno Mesmin et al.   CELL

PI(4,5)P2-Dependent and Ca2+-Regulated ER-PM Interactions Mediated by the Extended Synaptotagmins

(2013) Francesca Giordano et al.   CELL

Local Cytoskeletal and Organelle Interactions Impact Molecular-Motor-Driven Early Endosomal Trafficking

(2013) Allison L. Zajac et al.   CURRENT BIOLOGY

An ER-peroxisome tether exerts peroxisome population control in yeast

(2013) Barbara Knoblach et al.   EMBO JOURNAL

The phosphatidylinositol-transfer protein Nir2 binds phosphatidic acid and positively regulates phosphoinositide signalling

(2013) SoHui Kim et al.   EMBO REPORTS

Mcp1 and Mcp2, two novel proteins involved in mitochondrial lipid homeostasis

(2013) T. Tan et al.   JOURNAL OF CELL SCIENCE

STARD3 or STARD3NL and VAP form a novel molecular tether between late endosomes and the ER

(2013) F. Alpy et al.   JOURNAL OF CELL SCIENCE

Cholesterol-binding molecules MLN64 and ORP1L mark distinct late endosomes with transporters ABCA3 and NPC1

(2013) Rik van der Kant et al.   JOURNAL OF LIPID RESEARCH

Endoplasmic reticulum–endosome contact increases as endosomes traffic and mature

(2013) Jonathan R. Friedman et al.   MOLECULAR BIOLOGY OF THE CELL

Initial activation of STIM1, the regulator of store-operated calcium entry

(2013) Yubin Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An Actin-Dependent Step in Mitochondrial Fission Mediated by the ER-Associated Formin INF2

(2013) F. Korobova et al.   SCIENCE

ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast

(2013) Andrew Murley et al.   eLife

SARAF Inactivates the Store Operated Calcium Entry Machinery to Prevent Excess Calcium Refilling

(2012) Raz Palty et al.   CELL

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

ER-to-Plasma Membrane Tethering Proteins Regulate Cell Signaling and ER Morphology

(2012) Andrew G. Manford et al.   DEVELOPMENTAL CELL

The FATP1–DGAT2 complex facilitates lipid droplet expansion at the ER–lipid droplet interface

(2012) Ningyi Xu et al.   JOURNAL OF CELL BIOLOGY

A conserved membrane-binding domain targets proteins to organelle contact sites

(2012) A. Toulmay et al.   JOURNAL OF CELL SCIENCE

Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1)

(2012) S. Srikanth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1)

(2012) X. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Calcium Release-Activated Calcium Channel Orai

(2012) X. Hou et al.   SCIENCE

Gem1 and ERMES Do Not Directly Affect Phosphatidylserine Transport from ER to Mitochondria or Mitochondrial Inheritance

(2012) Tammy T. Nguyen et al.   TRAFFIC

Osh Proteins Regulate Phosphoinositide Metabolism at ER-Plasma Membrane Contact Sites

(2011) Christopher J. Stefan et al.   CELL

Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission

(2011) Jian Zhao et al.   EMBO JOURNAL

MiD49 and MiD51, new components of the mitochondrial fission machinery

(2011) Catherine S Palmer et al.   EMBO REPORTS

A 3D analysis of yeast ER structure reveals how ER domains are organized by membrane curvature

(2011) Matt West et al.   JOURNAL OF CELL BIOLOGY

Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers

(2011) Maud de Saint-Jean et al.   JOURNAL OF CELL BIOLOGY

Lipid droplets are functionally connected to the endoplasmic reticulum in Saccharomyces cerevisiae

(2011) N. Jacquier et al.   JOURNAL OF CELL SCIENCE

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

(2010) César Cárdenas et al.   CELL

Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells

(2010) Hidenori Otera et al.   JOURNAL OF CELL BIOLOGY

A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells

(2010) Sonal Srikanth et al.   NATURE CELL BIOLOGY

Membrane contacts between endosomes and ER provide sites for PTP1B–epidermal growth factor receptor interaction

(2010) Emily R. Eden et al.   NATURE CELL BIOLOGY

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

(2009) Chan Young Park et al.   CELL

Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7–RILP–p150Gluedand late endosome positioning

(2009) Nuno Rocha et al.   JOURNAL OF CELL BIOLOGY

Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response

(2009) Sebastian Schuck et al.   JOURNAL OF CELL BIOLOGY

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

(2009) Joseph P. Yuan et al.   NATURE CELL BIOLOGY

STIM1-induced precortical and cortical subdomains of the endoplasmic reticulum

(2009) L. Orci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

(2009) Benoît Kornmann et al.   SCIENCE

Structural and Mechanistic Insights into STIM1-Mediated Initiation of Store-Operated Calcium Entry

(2008) Peter B. Stathopulos et al.   CELL

Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast

(2008) Weihua Fei et al.   JOURNAL OF CELL BIOLOGY

Coordinated Lipid Transfer between the Endoplasmic Reticulum and the Golgi Complex Requires the VAP Proteins and Is Essential for Golgi-mediated Transport

(2008) Diego Peretti et al.   MOLECULAR BIOLOGY OF THE CELL

The Novel Tail-anchored Membrane Protein Mff Controls Mitochondrial and Peroxisomal Fission in Mammalian Cells

(2008) Shilpa Gandre-Babbe et al.   MOLECULAR BIOLOGY OF THE CELL

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE