γ-secretase promotes Drosophila postsynaptic development through the cleavage of a Wnt receptor

ALS2 regulates endosomal trafficking, postsynaptic development, and neuronal survival

(2021) Joohyung Kim et al.   JOURNAL OF CELL BIOLOGY

Circuitry Underlying Experience-Dependent Plasticity in the Mouse Visual System

(2020) Bryan M. Hooks et al.   NEURON

Origins of Parkinson’s Disease in Brain Development: Insights From Early and Persistent Effects of LRRK2-G2019S on Striatal Circuits

(2020) George W. Huntley et al.   Frontiers in Neuroscience

Breaking symmetry – cell polarity signaling pathways in growth cone guidance and synapse formation

(2020) Yimin Zou   CURRENT OPINION IN NEUROBIOLOGY

Synapse development and maturation at the drosophila neuromuscular junction

(2020) Vivian T. Chou et al.   Neural Development

Huntington’s disease alters human neurodevelopment

(2020) Monia Barnat et al.   SCIENCE

The substrate repertoire of γ-secretase/presenilin

(2020) Gökhan Güner et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Changes in synaptic proteins precede neurodegeneration markers in preclinical Alzheimer’s disease cerebrospinal fluid

(2019) Alberto Lleó et al.   MOLECULAR & CELLULAR PROTEOMICS

Nuclear import of the DSCAM‐cytoplasmic domain drives signaling capable of inhibiting synapse formation

(2019) Sonja M Sachse et al.   EMBO JOURNAL

Presenilin/γ-secretase-dependent EphA3 processing mediates axon elongation through non-muscle myosin IIA

(2019) Míriam Javier-Torrent et al.   eLife

Retrovirus-like Gag Protein Arc1 Binds RNA and Traffics across Synaptic Boutons

(2018) James Ashley et al.   CELL

Synapse-to-nucleus communication: from developmental disorders to Alzheimer's disease

(2018) Elena Marcello et al.   CURRENT OPINION IN NEUROBIOLOGY

Advances in Engineering the Fly Genome with the CRISPR-Cas System

(2018) Ethan Bier et al.   GENETICS

Neural circuits driving larval locomotion in Drosophila

(2018) Matthew Q. Clark et al.   Neural Development

Dedicated photoreceptor pathways in Drosophila larvae mediate navigation by processing either spatial or temporal cues

(2018) Tim-Henning Humberg et al.   Nature Communications

Advances in Engineering the Fly Genome with the CRISPR-Cas System

(2018) Ethan Bier et al.   GENETICS

Presenilin regulates retinotectal synapse formation through EphB2 receptor processing

(2018) Zhenyu Liu et al.   Developmental Neurobiology

Crystal structure of the Frizzled 4 receptor in a ligand-free state

(2018) Shifan Yang et al.   NATURE

Loss of canonical Wnt signaling is involved in the pathogenesis of Alzheimer's disease

(2018) NibaldoC Inestrosa et al.   Neural Regeneration Research

Synaptic dysfunction in neurodegenerative and neurodevelopmental diseases: an overview of induced pluripotent stem-cell-based disease models

(2018) Era Taoufik et al.   Open Biology

FlyBase 2.0: the next generation

(2018) Jim Thurmond et al.   NUCLEIC ACIDS RESEARCH

Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity

(2018) Gaël Barthet et al.   Nature Communications

Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production

(2017) Katarzyna Marta Zoltowska et al.   Molecular Neurodegeneration

Activity-dependent proteolytic cleavage of cell adhesion molecules regulates excitatory synaptic development and function

(2017) Sivapratha Nagappan-Chettiar et al.   NEUROSCIENCE RESEARCH

APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases

(2017) Hélène-Marie Lanoiselée et al.   PLOS MEDICINE

Presynaptic LRP4 promotes synapse number and function of excitatory CNS neurons

(2017) Timothy J Mosca et al.   eLife

Shank Modulates Postsynaptic Wnt Signaling to Regulate Synaptic Development

(2016) K. P. Harris et al.   JOURNAL OF NEUROSCIENCE

Spinal WNT pathway contributes to remifentanil induced hyperalgesia through regulating fractalkine and CX3CR1 in rats

(2016) Gu Gong et al.   NEUROSCIENCE LETTERS

FlyRNAi.org—the database of the Drosophila RNAi screening center and transgenic RNAi project: 2017 update

(2016) Yanhui Hu et al.   NUCLEIC ACIDS RESEARCH

Effect of Presenilin Mutations on APP Cleavage; Insights into the Pathogenesis of FAD

(2016) Nuomin Li et al.   Frontiers in Aging Neuroscience

A circuit mechanism for the propagation of waves of muscle contraction in Drosophila

(2016) Akira Fushiki et al.   eLife

Maturation of active zone assembly byDrosophilaBruchpilot

(2016) Wernher Fouquet et al.   JOURNAL OF CELL BIOLOGY

Transmission, Development, and Plasticity of Synapses

(2015) Kathryn P. Harris et al.   GENETICS

Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases

(2015) Daniel Fleck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An atomic structure of human γ-secretase

(2015) Xiao-chen Bai et al.   NATURE

The Intracellular Domain of the Frazzled/DCC Receptor Is a Transcription Factor Required for Commissural Axon Guidance

(2015) Alexandra Neuhaus-Follini et al.   NEURON

Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse

(2015) Soraia Barão et al.   Cell Reports

Transmission, Development, and Plasticity of Synapses

(2015) Kathryn P. Harris et al.   GENETICS

Shared mechanisms between Drosophila peripheral nervous system development and human neurodegenerative diseases

(2014) Wu-Lin Charng et al.   CURRENT OPINION IN NEUROBIOLOGY

Retrograde BMP Signaling Modulates Rapid Activity-Dependent Synaptic Growth via Presynaptic LIM Kinase Regulation of Cofilin

(2014) Z. D. Piccioli et al.   JOURNAL OF NEUROSCIENCE

Glial Wingless/Wnt Regulates Glutamate Receptor Clustering and Synaptic Physiology at the Drosophila Neuromuscular Junction

(2014) K. S. Kerr et al.   JOURNAL OF NEUROSCIENCE

Postsynaptic actin regulates active zone spacing and glutamate receptor apposition at the Drosophila neuromuscular junction

(2014) Aline D. Blunk et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Inhibition of the Polyamine System Counteracts β-Amyloid Peptide-Induced Memory Impairment in Mice: Involvement of Extrasynaptic NMDA Receptors

(2014) Guilherme Monteiro Gomes et al.   PLoS One

Synaptic function of nicastrin in hippocampal neurons

(2014) S. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the γ-secretase component nicastrin

(2014) Tian Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling

(2014) Pietro Fazzari et al.   eLife

Synaptic organization of the Drosophila antennal lobe and its regulation by the Teneurins

(2014) Timothy J Mosca et al.   eLife

Cellular and molecular mechanisms underlying presynapse formation

(2013) Poh Hui Chia et al.   JOURNAL OF CELL BIOLOGY

Perlecan regulates bidirectional Wnt signaling at theDrosophilaneuromuscular junction

(2013) Keisuke Kamimura et al.   JOURNAL OF CELL BIOLOGY

Neuroligin1 Drives Synaptic and Behavioral Maturation through Intracellular Interactions

(2013) J. L. Hoy et al.   JOURNAL OF NEUROSCIENCE

Synapse maturation by activity-dependent ectodomain shedding of SIRPα

(2013) Anna B Toth et al.   NATURE NEUROSCIENCE

Sensorimotor structure of Drosophila larva phototaxis

(2013) E. A. Kane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Presenilins and  -Secretase: Structure, Function, and Role in Alzheimer Disease

(2013) B. De Strooper et al.   Cold Spring Harbor Perspectives in Medicine

Pathogenic SYNGAP1 Mutations Impair Cognitive Development by Disrupting Maturation of Dendritic Spine Synapses

(2012) James P. Clement et al.   CELL

Nuclear Envelope Budding Enables Large Ribonucleoprotein Particle Export during Synaptic Wnt Signaling

(2012) Sean D. Speese et al.   CELL

Dendritic spines: from structure to in vivo function

(2012) Nathalie L Rochefort et al.   EMBO REPORTS

Regulation of retinal progenitor expansion by Frizzled receptors: implications for microphthalmia and retinal coloboma

(2012) Chunqiao Liu et al.   HUMAN MOLECULAR GENETICS

Trans-synaptic Teneurin signalling in neuromuscular synapse organization and target choice

(2012) Timothy J. Mosca et al.   NATURE

Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors

(2012) Gael Barthet et al.   NEUROBIOLOGY OF AGING

Transsynaptic Signaling by Activity-Dependent Cleavage of Neuroligin-1

(2012) Rui T. Peixoto et al.   NEURON

Activity-Dependent Proteolytic Cleavage of Neuroligin-1

(2012) Kunimichi Suzuki et al.   NEURON

EphBs: an integral link between synaptic function and synaptopathies

(2012) Sean I. Sheffler-Collins et al.   TRENDS IN NEUROSCIENCES

Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities

(2012) H. Y. Zoghbi et al.   Cold Spring Harbor Perspectives in Biology

Wnt signaling during synaptic development and plasticity

(2011) Vivian Budnik et al.   CURRENT OPINION IN NEUROBIOLOGY

MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes

(2011) Koen J T Venken et al.   NATURE METHODS

Genetic Manipulation of Genes and Cells in the Nervous System of the Fruit Fly

(2011) Koen J.T. Venken et al.   NEURON

Frizzled-5, a receptor for the synaptic organizer Wnt7a, regulates activity-mediated synaptogenesis

(2010) M. Sahores et al.   DEVELOPMENT

Importin- 11 Regulates Synaptic Phosphorylated Mothers Against Decapentaplegic, and Thereby Influences Synaptic Development and Function at the Drosophila Neuromuscular Junction

(2010) M. E. Higashi-Kovtun et al.   JOURNAL OF NEUROSCIENCE

Histone Deacetylase Rpd3 Regulates Olfactory Projection Neuron Dendrite Targeting via the Transcription Factor Prospero

(2010) J. S. Tea et al.   JOURNAL OF NEUROSCIENCE

In Vivo Reconstitution of  -Secretase in Drosophila Results in Substrate Specificity

(2010) D. Stempfle et al.   MOLECULAR AND CELLULAR BIOLOGY

The nuclear import of Frizzled2-C by Importins-β11 and α2 promotes postsynaptic development

(2010) Timothy J Mosca et al.   NATURE NEUROSCIENCE

Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors

(2010) Raik Rönicke et al.   NEUROBIOLOGY OF AGING

Drosophila Importin-α2 Is Involved in Synapse, Axon and Muscle Development

(2010) Timothy J. Mosca et al.   PLoS One

Trans-Synaptic Transmission of Vesicular Wnt Signals through Evi/Wntless

(2009) Ceren Korkut et al.   CELL

Synaptic activity prompts γ-secretase–mediated cleavage of EphA4 and dendritic spine formation

(2009) Eiji Inoue et al.   JOURNAL OF CELL BIOLOGY

Notch Signaling Is Required for Activity-Dependent Synaptic Plasticity at theDrosophilaNeuromuscular Junction

(2009) Benjamin Lovegren de Bivort et al.   JOURNAL OF NEUROGENETICS

Conditional Forebrain Inactivation of Nicastrin Causes Progressive Memory Impairment and Age-Related Neurodegeneration

(2009) K. Tabuchi et al.   JOURNAL OF NEUROSCIENCE

Presenilins are essential for regulating neurotransmitter release

(2009) Chen Zhang et al.   NATURE

γ-Secretase in biology and medicine

(2009) Michael S. Wolfe   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Glia and Muscle Sculpt Neuromuscular Arbors by Engulfing Destabilized Synaptic Boutons and Shed Presynaptic Debris

(2009) Yuly Fuentes-Medel et al.   PLOS BIOLOGY

Wnt Signaling in Neural Circuit Assembly

(2008) Patricia C. Salinas et al.   Annual Review of Neuroscience

Notch: from neural development to neurological disorders

(2008) Justin D. Lathia et al.   JOURNAL OF NEUROCHEMISTRY

Presynaptic Local Signaling by a Canonical Wingless Pathway Regulates Development of the Drosophila Neuromuscular Junction

(2008) C. Miech et al.   JOURNAL OF NEUROSCIENCE

An Essential Role for Frizzled5 in Neuronal Survival in the Parafascicular Nucleus of the Thalamus

(2008) C. Liu et al.   JOURNAL OF NEUROSCIENCE

Activity-dependent site-specific changes of glutamate receptor composition in vivo

(2008) Andreas Schmid et al.   NATURE NEUROSCIENCE

Rapid Activity-Dependent Modifications in Synaptic Structure and Function Require Bidirectional Wnt Signaling

(2008) Bulent Ataman et al.   NEURON

A Presynaptic Giant Ankyrin Stabilizes the NMJ through Regulation of Presynaptic Microtubules and Transsynaptic Cell Adhesion

(2008) Jan Pielage et al.   NEURON