Origins of Parkinson’s Disease in Brain Development: Insights From Early and Persistent Effects of LRRK2-G2019S on Striatal Circuits

Are we listening to everything the PARK genes are telling us?

(2019) Deanna L. Benson et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Network abnormalities among non-manifesting Parkinson disease related LRRK2 mutation carriers

(2019) Yael Jacob et al.   HUMAN BRAIN MAPPING

Repeated social defeat in female mice induces anxiety-like behavior associated with enhanced myelopoiesis and increased monocyte accumulation in the brain

(2019) Wenyuan Yin et al.   BRAIN BEHAVIOR AND IMMUNITY

The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human

(2018) Rafeeq Mir et al.   BIOCHEMICAL JOURNAL

Altered reward-related neural responses in non-manifesting carriers of the Parkinson disease related LRRK2 mutation

(2018) Avner Thaler et al.   Brain Imaging and Behavior

Presynaptic origins of distinct modes of neurotransmitter release

(2018) Natali L Chanaday et al.   CURRENT OPINION IN NEUROBIOLOGY

LRRK2 G2019S Induces Anxiety/Depression-like Behavior before the Onset of Motor Dysfunction with 5-HT1AReceptor Upregulation in Mice

(2018) Juhee Lim et al.   JOURNAL OF NEUROSCIENCE

Bidirectional and long-lasting control of alcohol-seeking behavior by corticostriatal LTP and LTD

(2018) Tengfei Ma et al.   NATURE NEUROSCIENCE

Dopamine D2 receptor activation potently inhibits striatal glutamatergic transmission in a G2019S LRRK2 genetic model of Parkinson's disease

(2018) Alessandro Tozzi et al.   NEUROBIOLOGY OF DISEASE

Parkinson's Disease-linked LRRK2-G2019S mutation alters synaptic plasticity and promotes resilience to chronic social stress in young adulthood

(2018) Bridget A. Matikainen-Ankney et al.   JOURNAL OF NEUROSCIENCE

Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4

(2018) Isabella Russo et al.   Journal of Neuroinflammation

Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson’s disease

(2017) Cynthia Sandor et al.   HUMAN MOLECULAR GENETICS

LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network

(2017) Zhiyong Liu et al.   HUMAN MOLECULAR GENETICS

Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons

(2017) Ping-Yue Pan et al.   JOURNAL OF NEUROSCIENCE

The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning

(2017) Zikai Zhou et al.   NATURE NEUROSCIENCE

Non-motor features of Parkinson disease

(2017) Anthony H.V. Schapira et al.   NATURE REVIEWS NEUROSCIENCE

The Retromer Supports AMPA Receptor Trafficking During LTP

(2017) Paul Temkin et al.   NEURON

Neural Substrates of Depression and Resilience

(2017) Ming-Hu Han et al.   Neurotherapeutics

Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice

(2017) Mattia Volta et al.   eLife

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis

(2017) Martin Steger et al.   eLife

LRRK2BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function

(2016) Max Sloan et al.   HUMAN MOLECULAR GENETICS

Altered Development of Synapse Structure and Function in Striatum Caused by Parkinson's Disease-Linked LRRK2-G2019S Mutation

(2016) B. A. Matikainen-Ankney et al.   JOURNAL OF NEUROSCIENCE

LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate

(2016) Elisa Belluzzi et al.   Molecular Neurodegeneration

Early hyperactivity and precocious maturation of corticostriatal circuits in Shank3B−/− mice

(2016) Rui T Peixoto et al.   NATURE NEUROSCIENCE

Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington’s disease

(2016) Aldrin E. Molero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction

(2016) Jay Penney et al.   Nature Communications

Endocannabinoid-Mediated Plasticity in Nucleus Accumbens Controls Vulnerability to Anxiety after Social Defeat Stress

(2016) Clémentine Bosch-Bouju et al.   Cell Reports

Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNA-Seq

(2016) Ozgun Gokce et al.   Cell Reports

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

(2016) Martin Steger et al.   eLife

LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts

(2016) Tomoki Kuwahara et al.   Scientific Reports

Hyperactivity and lack of social discrimination in the adolescent Fmr1 knockout mouse

(2015) Emilie M. Sørensen et al.   BEHAVIOURAL PHARMACOLOGY

Nucleus Accumbens Medium Spiny Neuron Subtypes Mediate Depression-Related Outcomes to Social Defeat Stress

(2015) T. Chase Francis et al.   BIOLOGICAL PSYCHIATRY

The Parkinson's Disease-Associated Mutation LRRK2-G2019S Impairs Synaptic Plasticity in Mouse Hippocampus

(2015) E. S. Sweet et al.   JOURNAL OF NEUROSCIENCE

Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice

(2015) M. Yue et al.   NEUROBIOLOGY OF DISEASE

Depression and subsequent risk of Parkinson disease: A nationwide cohort study

(2015) H. Gustafsson et al.   NEUROLOGY

Chronic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release

(2015) Mattia Volta et al.   PARKINSONISM & RELATED DISORDERS

Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease

(2015) Matthieu F. Bastide et al.   PROGRESS IN NEUROBIOLOGY

Adult cortical plasticity depends on an early postnatal critical period

(2015) S. D. Greenhill et al.   SCIENCE

Deregulation of protein translation control, a potential game-changing hypothesis for Parkinson's disease pathogenesis

(2015) Jean-Marc Taymans et al.   TRENDS IN MOLECULAR MEDICINE

Psychiatric diseases predated the occurrence of Parkinson disease: a retrospective cohort study

(2014) Hsiu-Li Lin et al.   ANNALS OF EPIDEMIOLOGY

Ribosomal Protein s15 Phosphorylation Mediates LRRK2 Neurodegeneration in Parkinson’s Disease

(2014) Ian Martin et al.   CELL

Abberant protein synthesis in G2019S LRRK2DrosophilaParkinson disease-related phenotypes

(2014) Ian Martin et al.   FLY

Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson's disease VPS35 mutation p.D620N

(2014) L. N. Munsie et al.   HUMAN MOLECULAR GENETICS

LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory

(2014) Dayne A. Beccano-Kelly et al.   HUMAN MOLECULAR GENETICS

LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism

(2014) A. M. Arranz et al.   JOURNAL OF CELL SCIENCE

Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents

(2014) Andrew B. West et al.   JOURNAL OF COMPARATIVE NEUROLOGY

LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity

(2014) Loukia Parisiadou et al.   NATURE NEUROSCIENCE

(G2019S) LRRK2 causes early-phase dysfunction of SNpc dopaminergic neurons and impairment of corticostriatal long-term depression in the PD transgenic mouse

(2014) Jun-Shiao Chou et al.   NEUROBIOLOGY OF DISEASE

Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging

(2014) Francesco Longo et al.   NEUROBIOLOGY OF DISEASE

Reorganization of corticostriatal circuits in healthy G2019S LRRK2 carriers

(2014) R. C. Helmich et al.   NEUROLOGY

Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress

(2014) Georgia E. Hodes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice

(2014) Dayne A. Beccano-Kelly et al.   Frontiers in Cellular Neuroscience

Parkinson’s disease: animal models and dopaminergic cell vulnerability

(2014) Javier Blesa et al.   Frontiers in Neuroanatomy

Investigating habits: strategies, technologies and models

(2014) Kyle S. Smith et al.   Frontiers in Behavioral Neuroscience

Neural correlates of executive functions in healthy G2019S LRRK2 mutation carriers

(2013) Avner Thaler et al.   CORTEX

Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies

(2013) David J. Irwin et al.   NATURE REVIEWS NEUROSCIENCE

Expression Analysis of Lrrk1, Lrrk2 and Lrrk2 Splice Variants in Mice

(2013) Florian Giesert et al.   PLoS One

Anatomic and Molecular Development of Corticostriatal Projection Neurons in Mice

(2012) U. Shivraj Sohur et al.   CEREBRAL CORTEX

Recurrent network activity drives striatal synaptogenesis

(2012) Yevgenia Kozorovitskiy et al.   NATURE

Exaggerated translation causes synaptic and behavioural aberrations associated with autism

(2012) Emanuela Santini et al.   NATURE

Lower cognitive performance in healthy G2019S LRRK2 mutation carriers

(2012) A. Thaler et al.   NEUROLOGY

LRRK2 Controls an EndoA Phosphorylation Cycle in Synaptic Endocytosis

(2012) Samer Matta et al.   NEURON

Stress, depression and Parkinson's disease

(2011) Ann M. Hemmerle et al.   EXPERIMENTAL NEUROLOGY

LRRK2 Controls Synaptic Vesicle Storage and Mobilization within the Recycling Pool

(2011) G. Piccoli et al.   JOURNAL OF NEUROSCIENCE

 -Adrenergic Receptor Antagonism Prevents Anxiety-Like Behavior and Microglial Reactivity Induced by Repeated Social Defeat

(2011) E. S. Wohleb et al.   JOURNAL OF NEUROSCIENCE

A standardized protocol for repeated social defeat stress in mice

(2011) Sam A Golden et al.   Nature Protocols

When Does Parkinson Disease Start?

(2010) Rodolfo Savica et al.   ARCHIVES OF NEUROLOGY

Acquisition and Performance of Goal-Directed Instrumental Actions Depends on ERK Signaling in Distinct Regions of Dorsal Striatum in Rats

(2010) M. W. Shiflett et al.   JOURNAL OF NEUROSCIENCE

Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors

(2010) Michael J Higley et al.   NATURE NEUROSCIENCE

ΔFosB in brain reward circuits mediates resilience to stress and antidepressant responses

(2010) Vincent Vialou et al.   NATURE NEUROSCIENCE

Genetic Animal Models of Parkinson's Disease

(2010) Ted M. Dawson et al.   NEURON

LRRK2 regulates synaptic vesicle endocytosis

(2008) Narae Shin et al.   EXPERIMENTAL CELL RESEARCH

Striatal Plasticity and Basal Ganglia Circuit Function

(2008) Anatol C. Kreitzer et al.   NEURON

Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson’s disease

(2008) M. Westerlund et al.   NEUROSCIENCE

Dichotomous Dopaminergic Control of Striatal Synaptic Plasticity

(2008) W. Shen et al.   SCIENCE