Cellular and molecular mechanisms underlying presynapse formation

Maturation of active zone assembly byDrosophilaBruchpilot

(2016) Wernher Fouquet et al.   JOURNAL OF CELL BIOLOGY

Bassoon and Piccolo maintain synapse integrity by regulating protein ubiquitination and degradation

(2013) Clarissa L Waites et al.   EMBO JOURNAL

Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission

(2013) Samantha A. Spangler et al.   JOURNAL OF CELL BIOLOGY

Balance of Calcineurin A  and CDK5 Activities Sets Release Probability at Nerve Terminals

(2013) S. H. Kim et al.   JOURNAL OF NEUROSCIENCE

Intramolecular regulation of presynaptic scaffold protein SYD-2/liprin-α

(2013) Poh Hui Chia et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

mSYD1A, a Mammalian Synapse-Defective-1 Protein, Regulates Synaptogenic Signaling and Vesicle Docking

(2013) Corinna Wentzel et al.   NEURON

The Balance between Capture and Dissociation of Presynaptic Proteins Controls the Spatial Distribution of Synapses

(2013) Ye E. Wu et al.   NEURON

Drosophila cyfip Regulates Synaptic Development and Endocytosis by Suppressing Filamentous Actin Assembly

(2013) Lu Zhao et al.   PLoS Genetics

Kinesin-1 regulates dendrite microtubule polarity in Caenorhabditis elegans

(2013) Jing Yan et al.   eLife

Wnt Signaling Regulates Acetylcholine Receptor Translocation and Synaptic Plasticity in the Adult Nervous System

(2012) Michael Jensen et al.   CELL

Integration of a Retrograde Signal during Synapse Formation by Glia-Secreted TGF-β Ligand

(2012) Yuly Fuentes-Medel et al.   CURRENT BIOLOGY

Synaptic vesicle clustering requires a distinct MIG-10/Lamellipodin isoform and ABI-1 downstream from Netrin

(2012) A. K. H. Stavoe et al.   GENES & DEVELOPMENT

Mechanism of Evenness Interrupted (Evi)-Exosome Release at Synaptic Boutons

(2012) Kate Koles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The novel synaptogenic protein Farp1 links postsynaptic cytoskeletal dynamics and transsynaptic organization

(2012) Lucas Cheadle et al.   JOURNAL OF CELL BIOLOGY

Cyclin-Dependent Kinase 5 Regulates the Polarized Trafficking of Neuropeptide-Containing Dense-Core Vesicles in Caenorhabditis elegans Motor Neurons

(2012) P. R. Goodwin et al.   JOURNAL OF NEUROSCIENCE

Interleukin-1 Receptor Accessory Protein Organizes Neuronal Synaptogenesis as a Cell Adhesion Molecule

(2012) T. Yoshida et al.   JOURNAL OF NEUROSCIENCE

Formation of Golgi-Derived Active Zone Precursor Vesicles

(2012) C. Maas et al.   JOURNAL OF NEUROSCIENCE

Molecular Basis for Specific Regulation of Neuronal Kinesin-3 Motors by Doublecortin Family Proteins

(2012) Judy S. Liu et al.   MOLECULAR CELL

Lrp4 is a retrograde signal for presynaptic differentiation at neuromuscular synapses

(2012) Norihiro Yumoto et al.   NATURE

Teneurins instruct synaptic partner matching in an olfactory map

(2012) Weizhe Hong et al.   NATURE

Trans-synaptic Teneurin signalling in neuromuscular synapse organization and target choice

(2012) Timothy J. Mosca et al.   NATURE

Selective control of inhibitory synapse development by Slitrk3-PTPδ trans-synaptic interaction

(2012) Hideto Takahashi et al.   NATURE NEUROSCIENCE

NAB-1 instructs synapse assembly by linking adhesion molecules and F-actin to active zone proteins

(2012) Poh Hui Chia et al.   NATURE NEUROSCIENCE

Cooperation of Syd-1 with Neurexin synchronizes pre- with postsynaptic assembly

(2012) David Owald et al.   NATURE NEUROSCIENCE

Transsynaptic Signaling by Activity-Dependent Cleavage of Neuroligin-1

(2012) Rui T. Peixoto et al.   NEURON

Wnt proteins regulate acetylcholine receptor clustering in muscle cells

(2012) Bin Zhang et al.   Molecular Brain

Differential interactions of cerebellin precursor protein (Cbln) subtypes and neurexin variants for synapse formation of cortical neurons

(2011) Jae-Yeol Joo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions

(2011) Keiko Matsuda et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons

(2011) Jaewon Ko et al.   JOURNAL OF CELL BIOLOGY

Glutamate receptor δ1 induces preferentially inhibitory presynaptic differentiation of cortical neurons by interacting with neurexins through cerebellin precursor protein subtypes

(2011) Misato Yasumura et al.   JOURNAL OF NEUROCHEMISTRY

The Liprin Homology Domain Is Essential for the Homomeric Interaction of SYD-2/Liprin-  Protein in Presynaptic Assembly

(2011) H. Taru et al.   JOURNAL OF NEUROSCIENCE

Transsynaptic EphB/Ephrin-B Signaling Regulates Growth of Presynaptic Boutons Required for Classical Conditioning

(2011) W. Li et al.   JOURNAL OF NEUROSCIENCE

 -Pix Modulates Actin-Mediated Recruitment of Synaptic Vesicles to Synapses

(2011) Y. Sun et al.   JOURNAL OF NEUROSCIENCE

Neuroligin 2 Is Required for Synapse Development and Function at the Drosophila Neuromuscular Junction

(2011) M. Sun et al.   JOURNAL OF NEUROSCIENCE

Piccolo Regulates the Dynamic Assembly of Presynaptic F-Actin

(2011) C. L. Waites et al.   JOURNAL OF NEUROSCIENCE

The Presynaptic Dense Projection of the Caenorhabiditis elegans Cholinergic Neuromuscular Junction Localizes Synaptic Vesicles at the Active Zone through SYD-2/Liprin and UNC-10/RIM-Dependent Interactions

(2011) C. Stigloher et al.   JOURNAL OF NEUROSCIENCE

UNC-33 (CRMP) and ankyrin organize microtubules and localize kinesin to polarize axon-dendrite sorting

(2011) Tapan A Maniar et al.   NATURE NEUROSCIENCE

Hts/Adducin Controls Synaptic Elaboration and Elimination

(2011) Jan Pielage et al.   NEURON

β-Adducin Is Required for Stable Assembly of New Synapses and Improved Memory upon Environmental Enrichment

(2011) Ewa Bednarek et al.   NEURON

Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities

(2011) J.-P. Silva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo

(2011) G. J. Soler-Llavina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca2+/Calmodulin-dependent protein kinase II

(2011) L. Ciani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC

(2011) Hakan Kucukdereli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIM-Binding Protein, a Central Part of the Active Zone, Is Essential for Neurotransmitter Release

(2011) K. S. Y. Liu et al.   SCIENCE

The Translocation Selectivity of the Kinesins that Mediate Neuronal Organelle Transport

(2011) Chun-fang Huang et al.   TRAFFIC

Two Cyclin-Dependent Kinase Pathways Are Essential for Polarized Trafficking of Presynaptic Components

(2010) Chan-Yen Ou et al.   CELL

Trans-Synaptic Interaction of GluRδ2 and Neurexin through Cbln1 Mediates Synapse Formation in the Cerebellum

(2010) Takeshi Uemura et al.   CELL

Perisomatic GABAergic Innervation in Prefrontal Cortex Is Regulated by Ankyrin Interaction with the L1 Cell Adhesion Molecule

(2010) H. Guan et al.   CEREBRAL CORTEX

Increased Dentate Gyrus Excitability in Neuroligin-2-Deficient Mice in Vivo

(2010) P. Jedlicka et al.   CEREBRAL CORTEX

N-cadherin and Neuroligins Cooperate to Regulate Synapse Formation in Hippocampal Cultures

(2010) Mytyl Aiga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microtubule-associated Protein-like Binding of the Kinesin-1 Tail to Microtubules

(2010) Mark A. Seeger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trans-synaptic Adhesions between Netrin-G Ligand-3 (NGL-3) and Receptor Tyrosine Phosphatases LAR, Protein-tyrosine Phosphatase δ (PTPδ), and PTPσ via Specific Domains Regulate Excitatory Synapse Formation

(2010) Seok-Kyu Kwon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Syd-1 homologue regulates pre- and postsynaptic maturation inDrosophila

(2010) David Owald et al.   JOURNAL OF CELL BIOLOGY

Actin in dendritic spines: connecting dynamics to function

(2010) Pirta Hotulainen et al.   JOURNAL OF CELL BIOLOGY

Three Drosophila Liprins Interact to Control Synapse Formation

(2010) S. Astigarraga et al.   JOURNAL OF NEUROSCIENCE

Neuroligin-1 Deletion Results in Impaired Spatial Memory and Increased Repetitive Behavior

(2010) J. Blundell et al.   JOURNAL OF NEUROSCIENCE

Wnt-5a Modulates Recycling of Functional GABAA Receptors on Hippocampal Neurons

(2010) L. Cuitino et al.   JOURNAL OF NEUROSCIENCE

An Arf-like Small G Protein, ARL-8, Promotes the Axonal Transport of Presynaptic Cargoes by Suppressing Vesicle Aggregation

(2010) Matthew P. Klassen et al.   NEURON

Retrograde BMP Signaling Controls Synaptic Growth at the NMJ by Regulating Trio Expression in Motor Neurons

(2010) Robin W. Ball et al.   NEURON

CDK5 Serves as a Major Control Point in Neurotransmitter Release

(2010) Sung Hyun Kim et al.   NEURON

Drosophila Neuroligin 1 Promotes Growth and Postsynaptic Differentiation at Glutamatergic Neuromuscular Junctions

(2010) Daniel Banovic et al.   NEURON

Neurexin in Embryonic Drosophila Neuromuscular Junctions

(2010) Kaiyun Chen et al.   PLoS One

Essential cooperation of N-cadherin and neuroligin-1 in the transsynaptic control of vesicle accumulation

(2010) A. Stan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonneuronal cells regulate synapse formation in the vestibular sensory epithelium via erbB-dependent BDNF expression

(2010) M. E. Gomez-Casati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis

(2010) K. Mukherjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cbln1 Is a Ligand for an Orphan Glutamate Receptor  2, a Bidirectional Synapse Organizer

(2010) K. Matsuda et al.   SCIENCE

Many Paths to Synaptic Specificity

(2009) Joshua R. Sanes et al.   Annual Review of Cell and Developmental Biology

Trans-Synaptic Transmission of Vesicular Wnt Signals through Evi/Wntless

(2009) Ceren Korkut et al.   CELL

Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis

(2009) Çagla Eroglu et al.   CELL

The DLK-1 Kinase Promotes mRNA Stability and Local Translation in C. elegans Synapses and Axon Regeneration

(2009) Dong Yan et al.   CELL

The Mechanism of Ca2+-Dependent Regulation of Kinesin-Mediated Mitochondrial Motility

(2009) Xinnan Wang et al.   CELL

Rapid Assembly of Functional Presynaptic Boutons Triggered by Adhesive Contacts

(2009) A. L. Lucido et al.   JOURNAL OF NEUROSCIENCE

The N-Terminal Domain of GluD2 (GluR 2) Recruits Presynaptic Terminals and Regulates Synaptogenesis in the Cerebellum In Vivo

(2009) W. Kakegawa et al.   JOURNAL OF NEUROSCIENCE

Activity-Dependent Repression of Cbln1 Expression: Mechanism for Developmental and Homeostatic Regulation of Synapses in the Cerebellum

(2009) T. Iijima et al.   JOURNAL OF NEUROSCIENCE

Control of CNS Synapse Development by  -Protocadherin-Mediated Astrocyte-Neuron Contact

(2009) A. M. Garrett et al.   JOURNAL OF NEUROSCIENCE

A Protein Interaction Node at the Neurotransmitter Release Site: Domains of Aczonin/Piccolo, Bassoon, CAST, and Rim Converge on the N-Terminal Domain of Munc13-1

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Trans-synaptic adhesion between NGL-3 and LAR regulates the formation of excitatory synapses

(2009) Jooyeon Woo et al.   NATURE NEUROSCIENCE

Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1

(2009) Junyu Xu et al.   NATURE NEUROSCIENCE

Rab3 Dynamically Controls Protein Composition at Active Zones

(2009) Ethan R. Graf et al.   NEURON

An Unbiased Expression Screen for Synaptogenic Proteins Identifies the LRRTM Protein Family as Synaptic Organizers

(2009) Michael W. Linhoff et al.   NEURON

ELKS2α/CAST Deletion Selectively Increases Neurotransmitter Release at Inhibitory Synapses

(2009) Pascal S. Kaeser et al.   NEURON

Neuroligin 2 Drives Postsynaptic Assembly at Perisomatic Inhibitory Synapses through Gephyrin and Collybistin

(2009) Alexandros Poulopoulos et al.   NEURON

Wnt Signals Organize Synaptic Prepattern and Axon Guidance through the Zebrafish unplugged/MuSK Receptor

(2009) Lili Jing et al.   NEURON

LRRTM2 Interacts with Neurexin1 and Regulates Excitatory Synapse Formation

(2009) Joris de Wit et al.   NEURON

LRRTM2 Functions as a Neurexin Ligand in Promoting Excitatory Synapse Formation

(2009) Jaewon Ko et al.   NEURON

Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses

(2009) Andrew F. MacAskill et al.   NEURON

Postsynaptic Neuroligin1 regulates presynaptic maturation

(2009) N. Wittenmayer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mouse neurexin-1  deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments

(2009) M. R. Etherton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RSY-1 Is a Local Inhibitor of Presynaptic Assembly in C. elegans

(2009) M. R. Patel et al.   SCIENCE

Negative Regulation of Active Zone Assembly by a Newly Identified SR Protein Kinase

(2009) Ervin L. Johnson et al.   PLOS BIOLOGY

Molecular Mechanisms of Presynaptic Differentiation

(2008) Yishi Jin et al.   Annual Review of Cell and Developmental Biology

Lrp4 Is a Receptor for Agrin and Forms a Complex with MuSK

(2008) Natalie Kim et al.   CELL

Increased anxiety-like behavior in mice lacking the inhibitory synapse cell adhesion molecule neuroligin 2

(2008) J. Blundell et al.   GENES BRAIN AND BEHAVIOR

Wnt/β-Catenin Signaling Suppresses Rapsyn Expression and Inhibits Acetylcholine Receptor Clustering at the Neuromuscular Junction

(2008) Jia Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Regulation of Synaptic Plasticity and Cerebellar Motor Learning by the C-Terminal PDZ-Binding Motif of GluR 2

(2008) W. Kakegawa et al.   JOURNAL OF NEUROSCIENCE

Microtubules Have Opposite Orientation in Axons and Dendrites of Drosophila Neurons

(2008) Michelle C. Stone et al.   MOLECULAR BIOLOGY OF THE CELL

UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendrites

(2008) Vivian Y. Poon et al.   NATURE

Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy

(2008) Lorenzo A. Cingolani et al.   NATURE REVIEWS NEUROSCIENCE

LRP4 Serves as a Coreceptor of Agrin

(2008) Bin Zhang et al.   NEURON

Wnt signaling promotes AChR aggregation at the neuromuscular synapse in collaboration with agrin

(2008) J. P. Henriquez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA