Huntington’s disease alters human neurodevelopment

Abnormal development of cerebellar-striatal circuitry in Huntington disease

(2020) Alexander V. Tereshchenko et al.   NEUROLOGY

Mutant ataxin1 disrupts cerebellar development in spinocerebellar ataxia type 1

(2018) Chandrakanth Reddy Edamakanti et al.   JOURNAL OF CLINICAL INVESTIGATION

Faulty neuronal determination and cell polarization are reverted by modulating HD early phenotypes

(2018) P. Conforti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstituting Corticostriatal Network on-a-Chip Reveals the Contribution of the Presynaptic Compartment to Huntington’s Disease

(2018) Amandine Virlogeux et al.   Cell Reports

Pseudostratified epithelia – cell biology, diversity and roles in organ formation at a glance

(2017) Caren Norden   JOURNAL OF CELL SCIENCE

Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice

(2017) Ryan G Lim et al.   NATURE NEUROSCIENCE

Huntingtin-Mediated Multipolar-Bipolar Transition of Newborn Cortical Neurons Is Critical for Their Postnatal Neuronal Morphology

(2017) Monia Barnat et al.   NEURON

Neural Progenitor Cell Polarity and Cortical Development

(2017) Yoko Arai et al.   Frontiers in Cellular Neuroscience

Postnatal and adult consequences of loss of huntingtin during development: Implications for Huntington's disease

(2016) Eduardo E. Arteaga-Bracho et al.   NEUROBIOLOGY OF DISEASE

The Biology of Huntingtin

(2016) Frédéric Saudou et al.   NEURON

Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington’s disease

(2016) Aldrin E. Molero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington’s disease

(2016) Xiaobei Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unraveling the Role of Huntingtin in Breast Cancer Metastasis

(2015) Morgane S. Thion et al.   JNCI-Journal of the National Cancer Institute

Regulation of cerebral cortical neurogenesis by the Pax6 transcription factor

(2015) Martine N. Manuel et al.   Frontiers in Cellular Neuroscience

Interkinetic nuclear migration generates and opposes ventricular-zone crowding: insight into tissue mechanics

(2015) Takaki Miyata et al.   Frontiers in Cellular Neuroscience

Huntingtin Is Required for Epithelial Polarity through RAB11A-Mediated Apical Trafficking of PAR3-aPKC

(2015) Salah Elias et al.   PLOS BIOLOGY

Unraveling the Role of Huntingtin in Breast Cancer Metastasis

(2015) Morgane S. Thion et al.   JNCI-Journal of the National Cancer Institute

Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington’s Disease Neural Stem Cells

(2015) Karen L. Ring et al.   Stem Cell Reports

The Cell Biology of Neurogenesis: Toward an Understanding of the Development and Evolution of the Neocortex

(2014) Elena Taverna et al.   Annual Review of Cell and Developmental Biology

Mutant Huntingtin Affects Cortical Progenitor Cell Division and Development of the Mouse Neocortex

(2014) M. Molina-Calavita et al.   JOURNAL OF NEUROSCIENCE

Huntingtin Is Required for Normal Excitatory Synapse Development in Cortical and Striatal Circuits

(2014) S. U. McKinstry et al.   JOURNAL OF NEUROSCIENCE

The Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signalling

(2013) Cristovão Moreira Sousa et al.   EMBO Molecular Medicine

Metabolic network as a progression biomarker of premanifest Huntington’s disease

(2013) Chris C. Tang et al.   JOURNAL OF CLINICAL INVESTIGATION

An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin

(2012) Valentina Lo Sardo et al.   NATURE NEUROSCIENCE

Measures of growth in children at risk for Huntington disease

(2012) J. K. Lee et al.   NEUROLOGY

A series of N-terminal epitope tagged Hdh knock-in alleles expressing normal and mutant huntingtin: their application to understanding the effect of increasing the length of normal huntingtin’s polyglutamine stretch on CAG140 mouse model pathogenesis

(2012) Shuqiu Zheng et al.   Molecular Brain

Basolateral rather than apical primary cilia on neuroepithelial cells committed to delamination

(2011) M. Wilsch-Brauninger et al.   DEVELOPMENT

Regulation of interkinetic nuclear migration by cell cycle-coupled active and passive mechanisms in the developing brain

(2011) Yoichi Kosodo et al.   EMBO JOURNAL

Neural stem and progenitor cells shorten S-phase on commitment to neuron production

(2011) Yoko Arai et al.   Nature Communications

Smaller intracranial volume in prodromal Huntington's disease: evidence for abnormal neurodevelopment

(2010) Peggy C. Nopoulos et al.   BRAIN

Mutant huntingtin-impaired degradation of β-catenin causes neurotoxicity in Huntington's disease

(2010) Juliette D Godin et al.   EMBO JOURNAL

Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis

(2010) Sarah J Tabrizi et al.   LANCET NEUROLOGY

Huntingtin Is Required for Mitotic Spindle Orientation and Mammalian Neurogenesis

(2010) Juliette D. Godin et al.   NEURON

Mammalian Par3 Regulates Progenitor Cell Asymmetric Division via Notch Signaling in the Developing Neocortex

(2009) Ronald S. Bultje et al.   NEURON

Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression

(2008) Asako Sakaue-Sawano et al.   CELL