Site-specific ubiquitination: Deconstructing the degradation tag

MaxQuant.Live Enables Enhanced Selectivity and Identification of Peptides Modified by Endogenous SUMO and Ubiquitin

(2021) Ivo A. Hendriks et al.   JOURNAL OF PROTEOME RESEARCH

BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1

(2021) Samuel R. Witus et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ubiquitylation of lipopolysaccharide by RNF213 during bacterial infection

(2021) Elsje G. Otten et al.   NATURE

Mechanistic basis for ubiquitin modulation of a protein energy landscape

(2021) Emma C. Carroll et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PROTACs technology for targeting non-oncoproteins: Advances and perspectives

(2021) Chao Wang et al.   BIOORGANIC CHEMISTRY

The ubiquitin proteoform problem

(2021) Kirandeep K. Deol et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Rewiring of the ubiquitinated proteome determines ageing in C. elegans

(2021) Seda Koyuncu et al.   NATURE

Site-specific ubiquitylation acts as a regulator of linker histone H1

(2021) Eva Höllmüller et al.   Nature Communications

Semisynthetic and Enzyme-Mediated Conjugate Preparations Illuminate the Ubiquitination-Dependent Aggregation of Tau Protein

(2020) Francesca Munari et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PROTACs: A novel strategy for cancer therapy

(2020) Jing Liu et al.   SEMINARS IN CANCER BIOLOGY

The proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for substrates

(2020) Kirby Martinez-Fonts et al.   Nature Communications

Strategy for Development of Site-Specific Ubiquitin Antibodies

(2020) Ila van Kruijsbergen et al.   Frontiers in Chemistry

Site-specific ubiquitination affects protein energetics and proteasomal degradation

(2020) Emma C. Carroll et al.   Nature Chemical Biology

A masked initiation region in retinoblastoma protein regulates its proteasomal degradation

(2020) Takuya Tomita et al.   Nature Communications

Histone H2A variants alpha1-extension helix directs RNF168-mediated ubiquitination

(2020) Jessica L. Kelliher et al.   Nature Communications

Identification and characterization of diverse OTU deubiquitinases in bacteria

(2020) Alexander F Schubert et al.   EMBO JOURNAL

Site-specific ubiquitination of pathogenic huntingtin attenuates its deleterious effects

(2020) Vicky Hakim-Eshed et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Native Mass Spectrometry Can Effectively Predict PROTAC Efficacy

(2020) Rebecca Beveridge et al.   ACS Central Science

KRAS ubiquitination at lysine 104 retains exchange factor regulation by dynamically modulating the conformation of the interface

(2020) Guowei Yin et al.   iScience

Site‐specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling

(2020) Lilian M Fennell et al.   EMBO JOURNAL

Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler

(2020) Joanna Liwocha et al.   Nature Chemical Biology

Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners

(2020) Xingyan Li et al.   Nature Communications

Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase

(2019) Blake E. Smith et al.   Nature Communications

Breaking the chains: deubiquitylating enzyme specificity begets function

(2019) Michael J. Clague et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The 26S Proteasome Utilizes a Kinetic Gateway to Prioritize Substrate Degradation

(2019) Jared A.M. Bard et al.   CELL

Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases

(2019) Matthew Ravalin et al.   Nature Chemical Biology

Structural basis of generic versus specific E2‐RING E3 interactions in protein ubiquitination

(2019) Mehmet Gundogdu et al.   PROTEIN SCIENCE

Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding

(2019) Edward C. Twomey et al.   SCIENCE

Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system

(2019) Laura Rinaldi et al.   Nature Communications

Remodeling Membrane Binding by Mono-Ubiquitylation

(2019) Neta Tanner et al.   Biomolecules

The Journey for the Total Chemical Synthesis of a 53 kDa Protein

(2019) Hao Sun et al.   ACCOUNTS OF CHEMICAL RESEARCH

Enzymatic Logic of Ubiquitin Chain Assembly

(2019) Kirandeep K. Deol et al.   Frontiers in Physiology

Programmed ubiquitin acetylation using genetic code expansion reveals altered ubiquitination patterns

(2019) Rachel E. Lacoursiere et al.   FEBS LETTERS

Allosteric mechanism for site-specific ubiquitination of FANCD2

(2019) Viduth K. Chaugule et al.   Nature Chemical Biology

Plasticity in binding confers selectivity in ligand-induced protein degradation

(2018) Radosław P. Nowak et al.   Nature Chemical Biology

K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains

(2018) Fumiaki Ohtake et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control

(2018) Rahul S. Samant et al.   NATURE

Repair or destruction-an intimate liaison between ubiquitin ligases and molecular chaperones in proteostasis

(2017) Éva Kevei et al.   FEBS LETTERS

StUbEx PLUS—A Modified Stable Tagged Ubiquitin Exchange System for Peptide Level Purification and In-Depth Mapping of Ubiquitination Sites

(2017) Vyacheslav Akimov et al.   JOURNAL OF PROTEOME RESEARCH

In Vivo Ubiquitin Linkage-type Analysis Reveals that the Cdc48-Rad23/Dsk2 Axis Contributes to K48-Linked Chain Specificity of the Proteasome

(2017) Hikaru Tsuchiya et al.   MOLECULAR CELL

Global profiling of lysine reactivity and ligandability in the human proteome

(2017) Stephan M. Hacker et al.   Nature Chemistry

Ubiquitin modifications

(2016) Kirby N Swatek et al.   CELL RESEARCH

Using the Ubiquitin-modified Proteome to Monitor Distinct and Spatially Restricted Protein Homeostasis Dysfunction

(2016) Joshua M. Gendron et al.   MOLECULAR & CELLULAR PROTEOMICS

Enhanced Purification of Ubiquitinated Proteins by Engineered Tandem Hybrid Ubiquitin-binding Domains (ThUBDs)

(2016) Yuan Gao et al.   MOLECULAR & CELLULAR PROTEOMICS

The increasing complexity of the ubiquitin code

(2016) Richard Yau et al.   NATURE CELL BIOLOGY

Structural insights into the catalysis and regulation of E3 ubiquitin ligases

(2016) Lori Buetow et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Numerous proteins with unique characteristics are degraded by the 26S proteasome following monoubiquitination

(2016) Ori Braten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of ubiquitylated-Rpn10 provides insight into its autoregulation mechanism

(2016) Tal Keren-Kaplan et al.   Nature Communications

Non-degradative Ubiquitination of Protein Kinases

(2016) K. Aurelia Ball et al.   PLoS Computational Biology

Global functional profiling of human ubiquitome identifies E3 ubiquitin ligase DCST1 as a novel negative regulator of Type-I interferon signaling

(2016) Sajith Nair et al.   Scientific Reports

Cdc48-independent proteasomal degradation coincides with a reduced need for ubiquitylation

(2015) Daniela Gödderz et al.   Scientific Reports

Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress

(2014) Nancy N. Fang et al.   NATURE CELL BIOLOGY

Lysine-targeting specificity in ubiquitin and ubiquitin-like modification pathways

(2014) Francesca Mattiroli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Challenge of Producing Ubiquitinated Proteins for Structural Studies

(2014) Serena Faggiano et al.   Cells

Non-canonical ubiquitylation: Mechanisms and consequences

(2013) Gary S. McDowell et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Intrinsic Disorder in Ubiquitination Substrates

(2011) Tzachi Hagai et al.   JOURNAL OF MOLECULAR BIOLOGY

Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome

(2009) Yasushi Saeki et al.   EMBO JOURNAL