Using the Ubiquitin-modified Proteome to Monitor Distinct and Spatially Restricted Protein Homeostasis Dysfunction

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis

(2015) Daniel J. Anderson et al.   CANCER CELL

The Unfolded Protein Response Triggers Site-Specific Regulatory Ubiquitylation of 40S Ribosomal Proteins

(2015) Reneé Higgins et al.   MOLECULAR CELL

Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response

(2015) Andrew E.H. Elia et al.   MOLECULAR CELL

Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

(2015) Jan Krönke et al.   NATURE

Targeting the translation machinery in cancer

(2015) Mamatha Bhat et al.   NATURE REVIEWS DRUG DISCOVERY

The TOPCONS web server for consensus prediction of membrane protein topology and signal peptides

(2015) Konstantinos D. Tsirigos et al.   NUCLEIC ACIDS RESEARCH

Advances in high-resolution accurate mass spectrometry application to targeted proteomics

(2015) Antoine Lesur et al.   PROTEOMICS

Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit

(2015) I. Das et al.   SCIENCE

Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy

(2014) Raymond J Deshaies   BMC BIOLOGY

Differential Scales of Protein Quality Control

(2014) Suzanne Wolff et al.   CELL

Protecting the proteome: Eukaryotic cotranslational quality control pathways

(2014) Jens Lykke-Andersen et al.   JOURNAL OF CELL BIOLOGY

The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis

(2014) H. Meyer et al.   JOURNAL OF CELL SCIENCE

Identification of Candidate Substrates for the Golgi Tul1 E3 Ligase Using Quantitative diGly Proteomics in Yeast

(2014) Zongtian Tong et al.   MOLECULAR & CELLULAR PROTEOMICS

Cleaning up in the endoplasmic reticulum: ubiquitin in charge

(2014) John C Christianson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration

(2014) R. Ishimura et al.   SCIENCE

Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer

(2014) J.-P. P. Theurillat et al.   SCIENCE

Phase 2 dose-expansion study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma

(2013) M. Wang et al.   BLOOD

Lessons from the Cancer Genome

(2013) Levi A. Garraway et al.   CELL

The Ubiquitin Proteasome System as a Potential Target for the Treatment of Neurodegenerative Diseases

(2013) Zheng Ying et al.   CURRENT PHARMACEUTICAL DESIGN

The ubiquitin code and its decoding machinery in the endocytic pathway

(2013) H. Tanno et al.   JOURNAL OF BIOCHEMISTRY

False start: Cotranslational protein ubiquitination and cytosolic protein quality control

(2013) Sophie A. Comyn et al.   Journal of Proteomics

Using the Ubiquitin-modified Proteome to Monitor Protein Homeostasis Function

(2013) Andrea C. Carrano et al.   MOLECULAR & CELLULAR PROTEOMICS

The Colossus of Ubiquitylation: Decrypting a Cellular Code

(2013) Adam Williamson et al.   MOLECULAR CELL

A Cotranslational Ubiquitination Pathway for Quality Control of Misfolded Proteins

(2013) Feng Wang et al.   MOLECULAR CELL

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

(2013) Shireen A. Sarraf et al.   NATURE

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death

(2013) Paola Magnaghi et al.   Nature Chemical Biology

Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells

(2013) J. Kronke et al.   SCIENCE

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Regulation of Pluripotency and Cellular Reprogramming by the Ubiquitin-Proteasome System

(2012) Shannon M. Buckley et al.   Cell Stem Cell

Design Principles of Protein Biosynthesis-Coupled Quality Control

(2012) Monica C. Rodrigo-Brenni et al.   DEVELOPMENTAL CELL

Methods for Quantification ofin vivoChanges in Protein Ubiquitination following Proteasome and Deubiquitinase Inhibition

(2012) Namrata D. Udeshi et al.   MOLECULAR & CELLULAR PROTEOMICS

Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass

(2012) Lou K. Povlsen et al.   NATURE CELL BIOLOGY

Global Identification of Modular Cullin-RING Ligase Substrates

(2011) Michael J. Emanuele et al.   CELL

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways

(2011) T.-F. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein homeostasis and aging: The importance of exquisite quality control

(2010) Hiroshi Koga et al.   AGEING RESEARCH REVIEWS

Illuminating the ubiquitin/proteasome system

(2010) Florian A. Salomons et al.   EXPERIMENTAL CELL RESEARCH

Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling

(2010) Guoqiang Xu et al.   NATURE BIOTECHNOLOGY

Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets

(2010) Lynn Bedford et al.   NATURE REVIEWS DRUG DISCOVERY

Stressing the ubiquitin-proteasome system

(2009) N. P. Dantuma et al.   CARDIOVASCULAR RESEARCH

A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration

(2009) J. Chu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Proteins for Destruction by the Ubiquitin System: Implications for Human Pathobiology

(2008) Alan L. Schwartz et al.   Annual Review of Pharmacology and Toxicology