Semisynthetic and Enzyme-Mediated Conjugate Preparations Illuminate the Ubiquitination-Dependent Aggregation of Tau Protein

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases

(2019) Wenjuan Zhang et al.   eLife

Protein Semisynthesis Provides Access to Tau Disease-Associated Post-translational Modifications (PTMs) and Paves the Way to Deciphering the Tau PTM Code in Health and Diseased States

(2018) Mahmood Haj-Yahya et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tau-targeting therapies for Alzheimer disease

(2018) Erin E. Congdon et al.   Nature Reviews Neurology

Single Posttranslational Modifications in the Central Repeat Domains of Tau4 Impact its Aggregation and Tubulin Binding

(2018) Doris Ellmer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking

(2017) Youssra K. Al-Hilaly et al.   JOURNAL OF MOLECULAR BIOLOGY

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Semi-synthesis of a tag-freeO-GlcNAcylated tau protein by sequential chemoselective ligation

(2016) Sergej Schwagerus et al.   JOURNAL OF PEPTIDE SCIENCE

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice

(2015) Meaghan Morris et al.   NATURE NEUROSCIENCE

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

On the lag phase in amyloid fibril formation

(2015) Paolo Arosio et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Traceless Purification and Desulfurization of Tau Protein Ligation Products

(2014) Oliver Reimann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective chemical protein modification

(2014) Christopher D. Spicer et al.   Nature Communications

Mechanistic Basis of Phenothiazine-Driven Inhibition of Tau Aggregation

(2013) Elias Akoury et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tau degradation: The ubiquitin–proteasome system versus the autophagy-lysosome system

(2013) Min Jae Lee et al.   PROGRESS IN NEUROBIOLOGY

The Alzheimer’s Disease Related Tau Protein as a New Target for Chemical Protein Engineering

(2012) Malgorzata Broncel et al.   CHEMISTRY-A EUROPEAN JOURNAL

Semisynthetic, Site-Specific Ubiquitin Modification of α-Synuclein Reveals Differential Effects on Aggregation

(2012) Franziska Meier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

E2 Conjugating Enzyme Selectivity and Requirements for Function of the E3 Ubiquitin Ligase CHIP

(2011) Sarah E. Soss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Post-translational modifications of tau protein: Implications for Alzheimer's disease

(2011) Ludovic Martin et al.   NEUROCHEMISTRY INTERNATIONAL

Chemically ubiquitylated PCNA as a probe for eukaryotic translesion DNA synthesis

(2010) Junjun Chen et al.   Nature Chemical Biology

Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation

(2010) Champak Chatterjee et al.   Nature Chemical Biology