Poly(ADP-Ribosyl) Glycohydrolase Prevents the Accumulation of Unusual Replication Structures during Unperturbed S Phase

PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress

(2014) Giuditta Illuzzi et al.   NUCLEIC ACIDS RESEARCH

Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease

(2013) Reza Sharifi et al.   EMBO JOURNAL

Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates

(2013) Kai J. Neelsen et al.   JOURNAL OF CELL BIOLOGY

Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition

(2013) Matteo Berti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Friedreich's ataxia–associated GAA repeats induce replication-fork reversal and unusual molecular junctions

(2013) Cindy Follonier et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation

(2013) WooKee Min et al.   Nature Communications

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

(2012) Katharina Schlacher et al.   CANCER CELL

The Intra-S Phase Checkpoint Targets Dna2 to Prevent Stalled Replication Forks from Reversing

(2012) Jiazhi Hu et al.   CELL

Inhibition of poly(ADP-ribose) glycohydrolase (PARG) specifically kills BRCA2-deficient tumor cells

(2012) Catherine Fathers et al.   CELL CYCLE

Silencing of Apoptosis-Inducing factor and poly(ADP-ribose) glycohydrolase reveals novel roles in breast cancer cell death after chemotherapy

(2012) Xiaoxing Feng et al.   Molecular Cancer

New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

(2012) Bryan A. Gibson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Topoisomerase I poisoning results in PARP-mediated replication fork reversal

(2012) Arnab Ray Chaudhuri et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase

(2011) Dea Slade et al.   NATURE

PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms

(2011) Oliver Mortusewicz et al.   NUCLEIC ACIDS RESEARCH

Poly(ADP-Ribose) Polymerase Inhibition: "Targeted" Therapy for Triple-Negative Breast Cancer

(2010) C. K. Anders et al.   CLINICAL CANCER RESEARCH

Replication protein A: directing traffic at the intersection of replication and repair

(2010) Greg et al.   Frontiers in Bioscience-Landmark

Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair

(2010) Eva Petermann et al.   MOLECULAR CELL

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

(2010) Yoshitami Hashimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dual role of poly(ADP-ribose) glycohydrolase in the regulation of cell death in oxidatively stressed A549 cells

(2009) Katalin Erdélyi et al.   FASEB JOURNAL

Poly (ADP-ribose) glycohydrolase (PARG) and its therapeutic potential

(2009) WooKee Min   Frontiers in Bioscience-Landmark

Radiation-induced mitotic catastrophe in PARG-deficient cells

(2009) J.-C. Ame et al.   JOURNAL OF CELL SCIENCE

Mono-galloyl glucose derivatives are potent poly(ADP-ribose) glycohydrolase (PARG) inhibitors and partially reduce PARP-1-dependent cell death

(2008) L Formentini et al.   BRITISH JOURNAL OF PHARMACOLOGY

Poly ADP-ribose polymerase-1: An international molecule of mystery

(2008) Bethany C. Woodhouse et al.   DNA REPAIR

Cytotoxicity and mutagenicity of endogenous DNA base lesions as potential cause of human aging

(2008) Mansour Akbari et al.   MECHANISMS OF AGEING AND DEVELOPMENT