p53 induces a survival transcriptional response after nucleolar stress

The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning

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The rRNA synthesis inhibitor CX-5461 may induce autophagy that inhibits anticancer drug-induced cell damage to leukemia cells

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First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematological Cancers: Results of a Phase I Dose Escalation Study

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The Targeting of RNA Polymerase I Transcription Using CX-5461 in Combination with Radiation Enhances Tumour Cell Killing Effects in Human Solid Cancers

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Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer

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CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

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Mammalian Autophagy: How Does It Work?

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The p53 family orchestrates the regulation of metabolism: physiological regulation and implications for cancer therapy

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Tumor-associated mutant p53 promotes cancer cell survival upon glutamine deprivation through p21 induction

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CX-5461 induces autophagy and inhibits tumor growth via mammalian target of rapamycin-related signaling pathways in osteosarcoma

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The BMI1 polycomb protein represses cyclin G2-induced autophagy to support proliferation in chronic myeloid leukemia cells

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Coordinated Ribosomal ITS2 RNA Processing by the Las1 Complex Integrating Endonuclease, Polynucleotide Kinase, and Exonuclease Activities

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Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains

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Eukaryotic rRNA Modification by Yeast 5-Methylcytosine-Methyltransferases and Human Proliferation-Associated Antigen p120

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Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex

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Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms

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Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses

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Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells

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The 5S RNP Couples p53 Homeostasis to Ribosome Biogenesis and Nucleolar Stress

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Characterization of the p53 Cistrome – DNA Binding Cooperativity Dissects p53's Tumor Suppressor Functions

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Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

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Suprainduction of p53 by disruption of 40S and 60S ribosome biogenesis leads to the activation of a novel G2/M checkpoint

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Las1 interacts with Grc3 polynucleotide kinase and is required for ribosome synthesis in Saccharomyces cerevisiae

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Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress

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Nucleolar Localization of a Netrin-1 Isoform Enhances Tumor Cell Proliferation

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Regulation of lipid metabolism by p53 – fighting two villains with one sword

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The Evolutionarily Conserved Protein LAS1 Is Required for Pre-rRNA Processing at Both Ends of ITS2

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LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis

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AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer

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Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth

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Stimulation of autophagy by the p53 target gene Sestrin2

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Defects in 18 S or 28 S rRNA Processing Activate the p53 Pathway

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Perturbation of 60 S Ribosomal Biogenesis Results in Ribosomal Protein L5- and L11-dependent p53 Activation

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Las1L Is a Nucleolar Protein Required for Cell Proliferation and Ribosome Biogenesis

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Ribosomal Protein S7 Is Both a Regulator and a Substrate of MDM2

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Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction

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TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4

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p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

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Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

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A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

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