TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling

p53 controls genomic stability and temporal differentiation of human neural stem cells and affects neural organization in human brain organoids

(2020) Ana Marin Navarro et al.   Cell Death & Disease

A global analysis of IFT-A function reveals specialization for transport of membrane-associated proteins into cilia

(2019) Tyler Picariello et al.   JOURNAL OF CELL SCIENCE

Context is everything: aneuploidy in cancer

(2019) Uri Ben-David et al.   NATURE REVIEWS GENETICS

Identification of Drivers of Aneuploidy in Breast Tumors

(2018) Katherine Pfister et al.   Cell Reports

Integrated Molecular Characterization of Testicular Germ Cell Tumors

(2018) Hui Shen et al.   Cell Reports

An Argonaute phosphorylation cycle promotes microRNA-mediated silencing

(2017) Ryan J. Golden et al.   NATURE

Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations

(2017) Florian T. Merkle et al.   NATURE

p53 Prohibits Propagation of Chromosome Segregation Errors that Produce Structural Aneuploidies

(2017) Mar Soto et al.   Cell Reports

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

(2016) Zuguang Gu et al.   BIOINFORMATICS

Aneuploid embryonic stem cells exhibit impaired differentiation and increased neoplastic potential

(2016) Meili Zhang et al.   EMBO JOURNAL

Primary Cilia and Mammalian Hedgehog Signaling

(2016) Fiona Bangs et al.   Cold Spring Harbor Perspectives in Biology

ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization

(2015) Guangchuang Yu et al.   BIOINFORMATICS

Modeling Familial Cancer with Induced Pluripotent Stem Cells

(2015) Dung-Fang Lee et al.   CELL

Sequential cancer mutations in cultured human intestinal stem cells

(2015) Jarno Drost et al.   NATURE

The anatomical distribution of genetic associations

(2015) Alan Wells et al.   NUCLEIC ACIDS RESEARCH

APTCH1Homolog Transcriptionally Activated by p53 Suppresses Hedgehog Signaling

(2014) Jon H. Chung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide

(2014) Qian He et al.   MOLECULAR BIOLOGY OF THE CELL

Dissecting neural differentiation regulatory networks through epigenetic footprinting

(2014) Michael J. Ziller et al.   NATURE

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Combined NGS Approaches Identify Mutations in the Intraflagellar Transport GeneIFT140in Skeletal Ciliopathies with Early Progressive Kidney Disease

(2013) Miriam Schmidts et al.   HUMAN MUTATION

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

The BBSome controls IFT assembly and turnaround in cilia

(2012) Qing Wei et al.   NATURE CELL BIOLOGY

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

p53 is balancing development, differentiation and de-differentiation to assure cancer prevention

(2010) A. Molchadsky et al.   CARCINOGENESIS

p53 directly transactivates Δ133p53α, regulating cell fate outcome in response to DNA damage

(2010) M Aoubala et al.   CELL DEATH AND DIFFERENTIATION

Modeling Disease in Human ESCs Using an Efficient BAC-Based Homologous Recombination System

(2010) Hoseok Song et al.   Cell Stem Cell

p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal

(2010) Z. Zhao et al.   GENES & DEVELOPMENT

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

The Ciliogenic Protein Oral-Facial-Digital 1 Regulates the Neuronal Differentiation of Embryonic Stem Cells

(2010) Julie Hunkapiller et al.   STEM CELLS AND DEVELOPMENT

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Mechanistic insights into Bardet-Biedl syndrome, a model ciliopathy

(2009) Norann A. Zaghloul et al.   JOURNAL OF CLINICAL INVESTIGATION

Linking the p53 tumour suppressor pathway to somatic cell reprogramming

(2009) Teruhisa Kawamura et al.   NATURE

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

(2009) Rosa M. Marión et al.   NATURE

Suppression of induced pluripotent stem cell generation by the p53–p21 pathway

(2009) Hyenjong Hong et al.   NATURE

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Dual and opposing roles of primary cilia in medulloblastoma development

(2009) Young-Goo Han et al.   NATURE MEDICINE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage

(2008) Y. Elkabetz et al.   GENES & DEVELOPMENT

Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery

(2008) Enko N. Kiprilov et al.   JOURNAL OF CELL BIOLOGY

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY