Cancer-associated fibroblasts and resistance to anticancer therapies: status, mechanisms, and countermeasures
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Title
Cancer-associated fibroblasts and resistance to anticancer therapies: status, mechanisms, and countermeasures
Authors
Keywords
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Journal
Cancer Cell International
Volume 22, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-04-29
DOI
10.1186/s12935-022-02599-7
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Note: Only part of the references are listed.- Role of cancer‐associated fibroblast subpopulations in immune infiltration, as a new means of treatment in cancer
- (2021) Rana Mhaidly et al. IMMUNOLOGICAL REVIEWS
- Cancer-Associated Fibroblast-Derived IL-6 Determines Unfavorable Prognosis in Cholangiocarcinoma by Affecting Autophagy-Associated Chemoresponse
- (2021) Suyanee Thongchot et al. Cancers
- PEGylated recombinant human hyaluronidase (PEGPH20) pre-treatment improves intra-tumour distribution and efficacy of paclitaxel in preclinical models
- (2021) Lavinia Morosi et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment
- (2021) Alba Nicolas-Boluda et al. eLife
- The transformation of cancer-associated fibroblasts: Current perspectives on the role of TGF-β in CAF mediated tumor progression and therapeutic resistance
- (2021) Bikash Chandra Jena et al. CANCER LETTERS
- Cancer‐associated fibroblasts that restrain cancer progression (rCAFs): hypotheses and perspectives
- (2020) Yuki Miyai et al. CANCER SCIENCE
- CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer
- (2020) Haiyang Zhang et al. Molecular Cancer
- Fibroblast Heterogeneity in the Pancreatic Tumor Microenvironment
- (2020) Erin Helms et al. Cancer Discovery
- Melanoma-associated fibroblasts impair CD8+ T cell function and modify expression of immune checkpoint regulators via increased arginase activity
- (2020) Barbara Érsek et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Single-cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer
- (2020) Yann Kieffer et al. Cancer Discovery
- Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer
- (2020) Lisa M. Becker et al. Cell Reports
- T-cell tumour exclusion and immunotherapy resistance: a role for CAF targeting
- (2020) Christopher J. Hanley et al. BRITISH JOURNAL OF CANCER
- Stress-induced upregulation of TNFSF4 in cancer-associated fibroblast facilitates chemoresistance of lung adenocarcinoma through inhibiting apoptosis of tumor cells
- (2020) Yan Li et al. CANCER LETTERS
- Fibroblast-derived IL-33 facilitates breast cancer metastasis by modifying the immune microenvironment and driving type-2 immunity
- (2020) Ophir Shani et al. CANCER RESEARCH
- Cancer-Associated Fibroblasts-Derived Exosomes Suppress Immune Cell Function in Breast Cancer via the miR-92/PD-L1 Pathway
- (2020) Dongwei Dou et al. Frontiers in Immunology
- Cancer associated fibroblast mediated chemoresistance: A paradigm shift in understanding the mechanism of tumor progression
- (2020) Bikash Chandra Jena et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Lactate modulates CD4+ T-cell polarization and induces an immunosuppressive environment, which sustains prostate carcinoma progression via TLR8/miR21 axis
- (2019) G. Comito et al. ONCOGENE
- Targeting the tumor stroma with an oncolytic adenovirus secreting a fibroblast activation protein-targeted bispecific T-cell engager
- (2019) Jana de Sostoa et al. Journal for ImmunoTherapy of Cancer
- Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling
- (2019) Fernanda G. Kugeratski et al. Science Signaling
- Blockade of fibroblast activation protein in combination with radiation treatment in murine models of pancreatic adenocarcinoma
- (2019) Andrew J. Gunderson et al. PLoS One
- Genome-wide association study of peripheral blood DNA methylation and conventional mammographic density measures
- (2019) Shuai Li et al. INTERNATIONAL JOURNAL OF CANCER
- Current perspectives of cancer-associated fibroblast in therapeutic resistance: potential mechanism and future strategy
- (2019) Dhruba Kadel et al. CELL BIOLOGY AND TOXICOLOGY
- Transforming Growth Factor-β Signaling in Immunity and Cancer
- (2019) Eduard Batlle et al. IMMUNITY
- CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer
- (2019) J. L. Hu et al. Molecular Cancer
- LOXL1 Is Regulated by Integrin α11 and Promotes Non-Small Cell Lung Cancer Tumorigenicity
- (2019) Cédric Zeltz et al. Cancers
- Exosomal miRNA-106b from cancer-associated fibroblast promotes gemcitabine resistance in pancreatic cancer
- (2019) Yuan Fang et al. EXPERIMENTAL CELL RESEARCH
- Subcellular compartmentalization of PKM2 identifies anti-PKM2 therapy response in vitro and in vivo mouse model of human non-small-cell lung cancer
- (2019) Akiko Suzuki et al. PLoS One
- Human Pancreatic Carcinoma-Associated Fibroblasts Promote Expression of Co-inhibitory Markers on CD4+ and CD8+ T-Cells
- (2019) Laia Gorchs et al. Frontiers in Immunology
- The Dark Side of Fibroblasts: Cancer-Associated Fibroblasts as Mediators of Immunosuppression in the Tumor Microenvironment
- (2019) Lea Monteran et al. Frontiers in Immunology
- Loss of Fibroblast-Dependent Androgen Receptor Activation in Prostate Cancer Cells is Involved in the Mechanism of Acquired Resistance to Castration
- (2019) Kenichiro Ishii et al. Journal of Clinical Medicine
- PD-L1 Induction by Cancer-Associated Fibroblast-Derived Factors in Lung Adenocarcinoma Cells
- (2019) Inoue et al. Cancers
- Clinical significance of PD-L1-positive cancer-associated fibroblasts in pN0M0 non-small cell lung cancer
- (2019) Koji Teramoto et al. LUNG CANCER
- Single-cell RNA sequencing reveals stromal evolution into LRRC15+ myofibroblasts as a determinant of patient response to cancer immunotherapy
- (2019) Claudia X Dominguez et al. Cancer Discovery
- Cancer-associated fibroblast-derived exosomal microRNA-98-5p promotes cisplatin resistance in ovarian cancer by targeting CDKN1A
- (2019) Hua Guo et al. Cancer Cell International
- Comparison of EMT mediated tyrosine kinase inhibitor resistance in NSCLC
- (2018) Tsatsral Iderzorig et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Cancer-associated fibroblasts promote epithelial-mesenchymal transition and EGFR-TKI resistance of non-small cell lung cancers via HGF/IGF-1/ANXA2 signaling
- (2018) Yanmei Yi et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Cancer-associated fibroblasts confer cisplatin resistance of tongue cancer via autophagy activation
- (2018) Juan-kun Liao et al. BIOMEDICINE & PHARMACOTHERAPY
- Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer
- (2018) Ana Costa et al. CANCER CELL
- CD10 + GPR77 + Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness
- (2018) Shicheng Su et al. CELL
- Targeting the IL-6/JAK/STAT3 signalling axis in cancer
- (2018) Daniel E. Johnson et al. Nature Reviews Clinical Oncology
- Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer
- (2018) Lucy Ireland et al. ONCOGENE
- Cancer-associated fibroblasts induce antigen-specific deletion of CD8+ T Cells to protect tumour cells
- (2018) Matthew A. Lakins et al. Nature Communications
- Cancer-Associated-Fibroblasts Promote the Chemo-Resistance in Gastric Cancer through Secreting IL-11 targeting JAK/STAT3/Bcl2 Pathway
- (2018) Jun Ma et al. Cancer Research and Treatment
- Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies
- (2018) Maria Apicella et al. Cell Metabolism
- Stromal epigenetic alterations drive metabolic and neuroendocrine prostate cancer reprogramming
- (2018) Rajeev Mishra et al. JOURNAL OF CLINICAL INVESTIGATION
- Complex formation between platelet-derived growth factor receptor β and transforming growth factor β receptor regulates the differentiation of mesenchymal stem cells into cancer-associated fibroblasts
- (2018) Kaori Aoto et al. Oncotarget
- FAP delineates heterogeneous and functionally divergent stromal cells in immune-excluded breast tumors
- (2018) Viviana Cremasco et al. Cancer Immunology Research
- An Oncolytic Virus Expressing a T-cell Engager Simultaneously Targets Cancer and Immunosuppressive Stromal Cells
- (2018) Joshua D. Freedman et al. CANCER RESEARCH
- Exosome as a Novel Shuttle for Delivery of Therapeutics across Biological Barriers
- (2018) Chandan Kanta Das et al. MOLECULAR PHARMACEUTICS
- Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance
- (2018) Fei Chen et al. Nature Communications
- Chemoresistance and the Self-Maintaining Tumor Microenvironment
- (2018) Gulcen Yeldag et al. Cancers
- Modulation of cancer-specific immune responses by amino acid degrading enzymes
- (2017) Elina Timosenko et al. Immunotherapy
- The Role of Tumor Microenvironment in Chemoresistance: To Survive, Keep Your Enemies Closer
- (2017) Dimakatso Alice Senthebane et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- High-mobility group box 1 released by autophagic cancer-associated fibroblasts maintains the stemness of luminal breast cancer cells
- (2017) Xi-Long Zhao et al. JOURNAL OF PATHOLOGY
- DNA damage response-initiated cytokine secretion in bone marrow stromal cells promotes chemoresistance of myeloma cells
- (2017) Hailong Tang et al. LEUKEMIA & LYMPHOMA
- JAK1/STAT3 Activation through a Proinflammatory Cytokine Pathway Leads to Resistance to Molecularly Targeted Therapy in Non–Small Cell Lung Cancer
- (2017) Kazuhiko Shien et al. MOLECULAR CANCER THERAPEUTICS
- Epithelial-to-mesenchymal transition transcription factors in cancer-associated fibroblasts
- (2017) Josep Baulida Molecular Oncology
- DNA methylation variations are required for epithelial-to-mesenchymal transition induced by cancer-associated fibroblasts in prostate cancer cells
- (2017) C Pistore et al. ONCOGENE
- Clinical Implications of Compounds Designed to Inhibit ECM-Modifying Metalloproteinases
- (2017) Sabrina Amar et al. PROTEOMICS
- Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane
- (2017) Alexandros Glentis et al. Nature Communications
- Obesity Enhances the Conversion of Adipose-Derived Stromal/Stem Cells into Carcinoma-Associated Fibroblast Leading to Cancer Cell Proliferation and Progression to an Invasive Phenotype
- (2017) Amy L. Strong et al. Stem Cells International
- Cancer-associated Fibroblasts Promote Irradiated Cancer Cell Recovery Through Autophagy
- (2017) Yongbin Wang et al. EBioMedicine
- A cancer stem cell model as the point of origin of cancer-associated fibroblasts in tumor microenvironment
- (2017) Neha Nair et al. Scientific Reports
- Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors
- (2016) Lucy Ireland et al. CANCER RESEARCH
- Autophagy protects ovarian cancer-associated fibroblasts against oxidative stress
- (2016) Qian Wang et al. CELL CYCLE
- Oxidative stress induced autophagy in cancer associated fibroblast enhances proliferation and metabolism of colorectal cancer cells
- (2016) Wenjing Zhou et al. CELL CYCLE
- Fibroblast Subtypes Regulate Responsiveness of Luminal Breast Cancer to Estrogen
- (2016) Heather M. Brechbuhl et al. CLINICAL CANCER RESEARCH
- The impact of hypoxia and its modification of the outcome of radiotherapy
- (2016) Michael R. Horsman et al. JOURNAL OF RADIATION RESEARCH
- Mesenchymal stromal cells derived from cervical cancer produce high amounts of adenosine to suppress cytotoxic T lymphocyte functions
- (2016) María de Lourdes Mora-García et al. Journal of Translational Medicine
- Cancer-associated fibroblasts mediated chemoresistance by a FOXO1/TGFβ1 signaling loop in esophageal squamous cell carcinoma
- (2016) Hongfang Zhang et al. MOLECULAR CARCINOGENESIS
- Cytoplasmic GPER translocation in cancer-associated fibroblasts mediates cAMP/PKA/CREB/glycolytic axis to confer tumor cells with multidrug resistance
- (2016) T Yu et al. ONCOGENE
- Neutrophils in the Tumor Microenvironment
- (2016) Davalyn R. Powell et al. TRENDS IN IMMUNOLOGY
- Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth
- (2016) Marco Gerling et al. Nature Communications
- Pancreatic Fibroblasts Stimulate the Motility of Pancreatic Cancer Cells through IGF1/IGF1R Signaling under Hypoxia
- (2016) Toshiki Hirakawa et al. PLoS One
- Immunosuppressive activity of cancer-associated fibroblasts in head and neck squamous cell carcinoma
- (2015) Hideyuki Takahashi et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells
- (2015) A. Lo et al. CANCER RESEARCH
- Cancer-associated fibroblast-targeted strategy enhances antitumor immune responses in dendritic cell-based vaccine
- (2015) Yasuhiko Ohshio et al. CANCER SCIENCE
- Stromal gene expression defines poor-prognosis subtypes in colorectal cancer
- (2015) Alexandre Calon et al. NATURE GENETICS
- Crosstalk with cancer-associated fibroblasts induces resistance of non-small cell lung cancer cells to epidermal growth factor receptor tyrosine kinase inhibition
- (2015) Chung Choe et al. OncoTargets and Therapy
- TGFβ1 secreted by cancer-associated fibroblasts induces epithelial-mesenchymal transition of bladder cancer cells through lncRNA-ZEB2NAT
- (2015) Junlong Zhuang et al. Scientific Reports
- Fibroblast-Derived Exosomes Contribute to Chemoresistance through Priming Cancer Stem Cells in Colorectal Cancer
- (2015) Yibing Hu et al. PLoS One
- Hedgehog Signaling Restrains Bladder Cancer Progression by Eliciting Stromal Production of Urothelial Differentiation Factors
- (2014) Kunyoo Shin et al. CANCER CELL
- Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival
- (2014) Berna C. Özdemir et al. CANCER CELL
- Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
- (2014) Andrew D. Rhim et al. CANCER CELL
- Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy
- (2014) Mara H. Sherman et al. CELL
- Overexpression of NRG1 promotes progression of gastric cancer by regulating the self-renewal of cancer stem cells
- (2014) Myoung-Eun Han et al. JOURNAL OF GASTROENTEROLOGY
- TGF- -inducible microRNA-183 silences tumor-associated natural killer cells
- (2014) S. S. Donatelli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Prognostic significance of Zinc finger E-box binding homeobox 1 (ZEB1) expression in cancer cells and cancer-associated fibroblasts in pancreatic head cancer
- (2014) Peter Bronsert et al. SURGERY
- Cancer-associated fibroblasts induce epithelial–mesenchymal transition of breast cancer cells through paracrine TGF-β signalling
- (2013) Y Yu et al. BRITISH JOURNAL OF CANCER
- TGF- Modulates Ovarian Cancer Invasion by Upregulating CAF-Derived Versican in the Tumor Microenvironment
- (2013) T.-L. Yeung et al. CANCER RESEARCH
- Cancer cell bioenergetics and pH regulation influence breast cancer cell resistance to paclitaxel and doxorubicin
- (2013) Diana Tavares-Valente et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A
- (2013) Fiorenza Lotti et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Arginase II Expressed in Cancer-Associated Fibroblasts Indicates Tissue Hypoxia and Predicts Poor Outcome in Patients with Pancreatic Cancer
- (2013) Yoshinori Ino et al. PLoS One
- Candidate Markers That Associate with Chemotherapy Resistance in Breast Cancer through the Study on Taxotere-Induced Damage to Tumor Microenvironment and Gene Expression Profiling of Carcinoma-Associated Fibroblasts (CAFs)
- (2013) Guohua Rong et al. PLoS One
- Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment
- (2013) X Sui et al. Cell Death & Disease
- Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels
- (2013) Vikash P. Chauhan et al. Nature Communications
- The Tumor Stroma as Mediator of Drug Resistance - A Potential Target to Improve Cancer Therapy?
- (2012) Susanne Sebens et al. CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- IL-17 promoted metastasis of non-small-cell lung cancer cells
- (2012) Qinchuan Li et al. IMMUNOLOGY LETTERS
- Autophagic tumor stroma: Mechanisms and roles in tumor growth and progression
- (2012) Xianda Zhao et al. INTERNATIONAL JOURNAL OF CANCER
- Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B
- (2012) Yu Sun et al. NATURE MEDICINE
- The tumor microenvironment modulates tamoxifen resistance in breast cancer: a role for soluble stromal factors and fibronectin through β1 integrin
- (2011) Osvaldo Pontiggia et al. BREAST CANCER RESEARCH AND TREATMENT
- Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression
- (2011) Paolo Cirri et al. CANCER AND METASTASIS REVIEWS
- Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells
- (2011) Ubaldo E. Martinez-Outschoorn et al. CANCER BIOLOGY & THERAPY
- Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO
- (2011) Tuanjie Li et al. CANCER LETTERS
- Pancreatic Stellate Cells Radioprotect Pancreatic Cancer Cells through 1-Integrin Signaling
- (2011) T. S. Mantoni et al. CANCER RESEARCH
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
- (2011) S. E. Polo et al. GENES & DEVELOPMENT
- Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner
- (2010) Neta Erez et al. CANCER CELL
- Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution
- (2010) Ubaldo E. Martinez-Outschoorn et al. CELL CYCLE
- Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein-
- (2010) M. Kraman et al. SCIENCE
- PDGF-C Mediates the Angiogenic and Tumorigenic Properties of Fibroblasts Associated with Tumors Refractory to Anti-VEGF Treatment
- (2009) Yongping Crawford et al. CANCER CELL
- Down-regulation of connective tissue growth factor by inhibition of transforming growth factor β blocks the tumor-stroma cross-talk and tumor progression in hepatocellular carcinoma
- (2009) Antonio Mazzocca et al. HEPATOLOGY
- Tumor Microenvironments Direct the Recruitment and Expansion of Human Th17 Cells
- (2009) X. Su et al. JOURNAL OF IMMUNOLOGY
- Snail1 Protein in the Stroma as a New Putative Prognosis Marker for Colon Tumours
- (2009) Clara Francí et al. PLoS One
- VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma
- (2008) B M Beckermann et al. BRITISH JOURNAL OF CANCER
- Nuclear factor-κB dependency of doxorubicin sensitivity in gastric cancer cells is determined by manganese superoxide dismutase expression
- (2008) Sung Jin Cho et al. CANCER SCIENCE
- Effective Immunoconjugate Therapy in Cancer Models Targeting a Serine Protease of Tumor Fibroblasts
- (2008) E. Ostermann et al. CLINICAL CANCER RESEARCH
- The tumor microenvironment and its contribution to tumor evolution toward metastasis
- (2008) Girieca Lorusso et al. HISTOCHEMISTRY AND CELL BIOLOGY
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