Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth
Authors
Keywords
-
Journal
Nature Communications
Volume 7, Issue -, Pages 12321
Publisher
Springer Nature
Online
2016-08-05
DOI
10.1038/ncomms12321
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer
- (2015) Lukas E. Dow et al. CELL
- Bending Gradients: How the Intestinal Stem Cell Gets Its Home
- (2015) Amy E. Shyer et al. CELL
- Stromal Indian Hedgehog Signaling Is Required for Intestinal Adenoma Formation in Mice
- (2015) Nikè V.J.A. Büller et al. GASTROENTEROLOGY
- Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer
- (2015) Daniel V.T. Catenacci et al. JOURNAL OF CLINICAL ONCOLOGY
- Colon carcinogenesis in wild type and immune compromised mice after treatment with azoxymethane, and azoxymethane with dextran sodium sulfate
- (2015) Ryan D. Whetstone et al. MOLECULAR CARCINOGENESIS
- Stromal contribution to the colorectal cancer transcriptome
- (2015) Claudio Isella et al. NATURE GENETICS
- limma powers differential expression analyses for RNA-sequencing and microarray studies
- (2015) Matthew E. Ritchie et al. NUCLEIC ACIDS RESEARCH
- Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms
- (2015) Michael Cohen et al. Nature Communications
- The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer
- (2015) Tapati Mazumdar et al. Oncotarget
- Hedgehog Signaling Restrains Bladder Cancer Progression by Eliciting Stromal Production of Urothelial Differentiation Factors
- (2014) Kunyoo Shin et al. CANCER CELL
- Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
- (2014) Andrew D. Rhim et al. CANCER CELL
- Colorectal Cancer Stem Cells: From the Crypt to the Clinic
- (2014) Ann Zeuner et al. Cell Stem Cell
- Growth and differentiation factor 10 (Gdf10) is involved in Bergmann glial cell development underShhregulation
- (2014) Nora Mecklenburg et al. GLIA
- GLI2 is a novel therapeutic target for metastasis of osteosarcoma
- (2014) Hiroko Nagao-Kitamoto et al. INTERNATIONAL JOURNAL OF CANCER
- Fibroblast heterogeneity in the cancer wound
- (2014) Daniel Öhlund et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche
- (2014) Hayley Davis et al. NATURE MEDICINE
- Loss of Sonic Hedgehog Leads to Alterations in Intestinal Secretory Cell Maturation and Autophagy
- (2014) Jessica Gagné-Sansfaçon et al. PLoS One
- Real-Time Assessment of Tissue Hypoxia In Vivo with Combined Photoacoustics and High-Frequency Ultrasound
- (2014) Marco Gerling et al. Theranostics
- The Gastrointestinal Tumor Microenvironment
- (2013) Michael Quante et al. GASTROENTEROLOGY
- New cast for a new era: preclinical cancer drug development revisited
- (2013) Grit S. Herter-Sprie et al. JOURNAL OF CLINICAL INVESTIGATION
- Inferring tumour purity and stromal and immune cell admixture from expression data
- (2013) Kosuke Yoshihara et al. Nature Communications
- Sonic Hedgehog Promotes Tumor Cell Survival by Inhibiting CDON Pro-Apoptotic Activity
- (2013) Céline Delloye-Bourgeois et al. PLOS BIOLOGY
- Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation
- (2012) Alexandre Calon et al. CANCER CELL
- Hedgehog Signaling Blockade Delays Hepatocarcinogenesis Induced by Hepatitis B Virus X Protein
- (2012) A. Arzumanyan et al. CANCER RESEARCH
- Tumor Suppressor Function of the Plasma Glutathione Peroxidase Gpx3 in Colitis-Associated Carcinoma
- (2012) C. W. Barrett et al. CANCER RESEARCH
- A Randomized Phase II Trial of Vismodegib versus Placebo with FOLFOX or FOLFIRI and Bevacizumab in Patients with Previously Untreated Metastatic Colorectal Cancer
- (2012) J. Berlin et al. CLINICAL CANCER RESEARCH
- Risk of Colorectal Cancer in Patients With Ulcerative Colitis: A Meta-analysis of Population-Based Cohort Studies
- (2012) Tine Jess et al. Clinical Gastroenterology and Hepatology
- The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers
- (2012) Javier Muñoz et al. EMBO JOURNAL
- Inactivation of Patched1 in Mice Leads to Development of Gastrointestinal Stromal-Like Tumors That Express Pdgfrα but Not Kit
- (2012) Penelope Pelczar et al. GASTROENTEROLOGY
- Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1
- (2012) Emma Jaeger et al. NATURE GENETICS
- Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma
- (2012) Aleksandar Sekulic et al. NEW ENGLAND JOURNAL OF MEDICINE
- Hedgehog Signaling and Maintenance of Homeostasis in the Intestinal Epithelium
- (2012) Nikè V. J. A. Büller et al. PHYSIOLOGY
- Hedgehog-responsive mesenchymal clusters direct patterning and emergence of intestinal villi
- (2012) K. D. Walton et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.
- (2012) Ethan Cerami et al. Cancer Discovery
- RNAscope
- (2011) Fay Wang et al. JOURNAL OF MOLECULAR DIAGNOSTICS
- Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells
- (2011) W. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes
- (2011) M. Kasper et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hedgehog beyond medulloblastoma and basal cell carcinoma
- (2010) Stephan Teglund et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Hedgehog Signaling Drives Cellular Survival in Human Colon Carcinoma Cells
- (2010) T. Mazumdar et al. CANCER RESEARCH
- Loss of Indian Hedgehog Activates Multiple Aspects of a Wound Healing Response in the Mouse Intestine
- (2010) Willemijn A. van Dop et al. GASTROENTEROLOGY
- Hedgehog Is an Anti-Inflammatory Epithelial Signal for the Intestinal Lamina Propria
- (2010) William J. Zacharias et al. GASTROENTEROLOGY
- Indian Hedgehog Regulates Intestinal Stem Cell Fate Through Epithelial−Mesenchymal Interactions During Development
- (2010) Cynthia Kosinski et al. GASTROENTEROLOGY
- Differential expression analysis for sequence count data
- (2010) Simon Anders et al. GENOME BIOLOGY
- Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion
- (2009) Frédéric Varnat et al. EMBO Molecular Medicine
- Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling
- (2009) Frédéric Varnat et al. MECHANISMS OF DEVELOPMENT
- Detection of K-ras mutations in azoxymethane-induced aberrant crypt foci in mice using LNA-mediated real-time PCR clamping and mutant-specific probes
- (2009) Ying Hu et al. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
- Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
- (2009) Suzie J. Scales et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- FoxF1 and FoxL1 Link Hedgehog Signaling and the Control of Epithelial Proliferation in the Developing Stomach and Intestine
- (2008) Blair B. Madison et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A paracrine requirement for hedgehog signalling in cancer
- (2008) Robert L. Yauch et al. NATURE
- The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer
- (2007) Liudmila L. Kodach et al. CANCER
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started