LOXL1 Is Regulated by Integrin α11 and Promotes Non-Small Cell Lung Cancer Tumorigenicity

Collagen remodeling in the hypoxic tumor-mesothelial niche promotes ovarian cancer metastasis

(2019) Suchitra Natarajan et al.   CANCER RESEARCH

Characterization of Distinct Populations of Carcinoma-Associated Fibroblasts from Non–Small Cell Lung Carcinoma Reveals a Role for ST8SIA2 in Cancer Cell Invasion

(2019) Jing Hao et al.   NEOPLASIA

Regulation of PD-L1 expression by matrix stiffness in lung cancer cells

(2018) Ayako Miyazawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lysyl oxidase in cancer inhibition and metastasis

(2018) Kathryn A. Johnston et al.   CANCER LETTERS

Matrix stiffness-upregulated LOXL2 promotes fibronectin production, MMP9 and CXCL12 expression and BMDCs recruitment to assist pre-metastatic niche formation

(2018) Sifan Wu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Silibinin Inhibits NSCLC Metastasis by Targeting the EGFR/LOX Pathway

(2018) Xiaoying Hou et al.   Frontiers in Pharmacology

Knockdown of LOXL1 inhibits TGF-β1-induced proliferation and fibrogenesis of hepatic stellate cells by inhibition of Smad2/3 phosphorylation

(2018) Li Ma et al.   BIOMEDICINE & PHARMACOTHERAPY

Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy

(2018) Thomas Bertero et al.   Cell Metabolism

The lysyl oxidase like 2/3 enzymatic inhibitor, PXS‐5153A, reduces crosslinks and ameliorates fibrosis

(2018) Heidi Schilter et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility

(2018) Amanpreet Kaur et al.   Cancer Discovery

LOX-1 is a poor prognostic indicator and induces epithelial-mesenchymal transition and metastasis in pancreatic cancer patients

(2017) Jie Zhang et al.   CELLULAR ONCOLOGY

Tumor Cell Invasion Can Be Blocked by Modulators of Collagen Fibril Alignment That Control Assembly of the Extracellular Matrix

(2016) Moran Grossman et al.   CANCER RESEARCH

Localized LoxL3-Dependent Fibronectin Oxidation Regulates Myofiber Stretch and Integrin-Mediated Adhesion

(2016) Ortal Kraft-Sheleg et al.   DEVELOPMENTAL CELL

ZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis

(2016) D H Peng et al.   ONCOGENE

Oriented collagen fibers direct tumor cell intravasation

(2016) Weijing Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysyl oxidase family activity promotes resistance of pancreatic ductal adenocarcinoma to chemotherapy by limiting the intratumoral anticancer drug distribution

(2016) Benjamin Le Calvé et al.   Oncotarget

LOXL2 Is Highly Expressed in Cancer-Associated Fibroblasts and Associates to Poor Colon Cancer Survival

(2015) S. Torres et al.   CLINICAL CANCER RESEARCH

Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression

(2015) A. Martin et al.   EMBO JOURNAL

Reduced Granulation Tissue and Wound Strength in the Absence of α11β1 Integrin

(2015) Jan-Niklas Schulz et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Integrin α11β1 regulates cancer stromal stiffness and promotes tumorigenicity and metastasis in non-small cell lung cancer

(2015) R Navab et al.   ONCOGENE

Integrated analysis of DNA methylation and mRNA expression profiling reveals candidate genes associated with cisplatin resistance in non-small cell lung cancer

(2014) You-Wei Zhang et al.   Epigenetics

A new role for LOX and LOXL2 proteins in transcription regulation

(2014) Ane Iturbide et al.   FEBS Journal

Comprehensive molecular profiling of lung adenocarcinoma

(2014) Eric A. Collisson et al.   NATURE

Fibroblast α11β1 Integrin Regulates Tensional Homeostasis in Fibroblast/A549 Carcinoma Heterospheroids

(2014) Ning Lu et al.   PLoS One

Molecular composition and function of integrin-based collagen glues—Introducing COLINBRIs

(2013) Cédric Zeltz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis

(2013) T. R. Cox et al.   CANCER RESEARCH

MCF-7 Cells Expressing Nuclear Associated Lysyl Oxidase-like 2 (LOXL2) Exhibit an Epithelial-to-Mesenchymal Transition (EMT) Phenotype and Are Highly Invasivein Vitro

(2013) Hee-Jung Moon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Validation of a Histology-Independent Prognostic Gene Signature for Early-Stage, Non–Small-Cell Lung Cancer Including Stage IA Patients

(2013) Sandy D. Der et al.   Journal of Thoracic Oncology

Controlled collagen crosslinking process in tissue-engineered fibroblast sheets for preventing scar contracture on the surface of lungs

(2012) Masato Kanzaki et al.   Journal of Tissue Engineering and Regenerative Medicine

Experimental investigation of collagen waviness and orientation in the arterial adventitia using confocal laser scanning microscopy

(2011) R. Rezakhaniha et al.   Biomechanics and Modeling in Mechanobiology

Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer

(2011) R. Navab et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

(2011) C. C.-L. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Motility and Mechanics in Three-Dimensional Collagen Matrices

(2010) Frederick Grinnell et al.   Annual Review of Cell and Developmental Biology

Lysyl oxidase: A lung adenocarcinoma biomarker of invasion and survival

(2010) May-Lin Wilgus et al.   CANCER

Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche

(2009) Janine T. Erler et al.   CANCER CELL

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

The human α11 integrin promoter drives fibroblast-restricted expression in vivo and is regulated by TGF-β1 in a Smad- and Sp1-dependent manner

(2009) Ning Lu et al.   MATRIX BIOLOGY

Lysyl Oxidase-Like 2 as a New Poor Prognosis Marker of Squamous Cell Carcinomas

(2008) H. Peinado et al.   CANCER RESEARCH

Prediction of Recurrence-Free Survival in Postoperative Non-Small Cell Lung Cancer Patients by Using an Integrated Model of Clinical Information and Gene Expression

(2008) E.-S. Lee et al.   CLINICAL CANCER RESEARCH