Article
Oncology
Yusuke Yoshida, Yoshitsugu Nakanishi, Tomoko Mitsuhashi, Hiroyuki Yamamoto, Mariko O. O. Hayashi, Mitsunobu Oba, Takeo Nitta, Takashi Ueno, Toru Yamada, Masato Ono, Shota Kuwabara, Yutaka Hatanaka, Satoshi Hirano
Summary: This study aimed to investigate the impact of different pathological reaction categories on the prognosis of patients with extrahepatic cholangiocarcinomas (EHCCs). The results showed that the pathological reaction category was significantly associated with tumor invasiveness, as well as overall survival and relapse-free survival rates.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Hideki Ueno, Yoshiki Kajiwara, Yoich Ajioka, Tamotsu Sugai, Shigeki Sekine, Megumi Ishiguro, Atsuo Takashima, Yukihide Kanemitsu
Summary: This study investigates the diagnostic criteria for the desmoplastic reaction classification being used in the JCOG1805 study, which aims to elucidate the value of adjuvant chemotherapy in stage II colorectal cancer patients with pathological risk factors of recurrence.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2021)
Review
Cell Biology
Martina Bedeschi, Noemi Marino, Elena Cavassi, Filippo Piccinini, Anna Tesei
Summary: Prostate cancer is a common cancer in European males and androgen deprivation therapy is the standard treatment. However, resistance to this therapy has led to cancer progression and long-term side effects. Studies have shown that cancer-associated fibroblasts (CAFs) play a crucial role in the tumor microenvironment (TME) and targeting them could be a potential therapeutic approach to overcome therapy resistance in prostate cancer.
Article
Pharmacology & Pharmacy
Yingpinyapat Kittirat, Manida Suksawat, Suyanee Thongchot, Sureerat Padthaisong, Jutarop Phetcharaburanin, Arporn Wangwiwatsin, Poramate Klanrit, Sakkarn Sangkhamanon, Attapol Titapun, Watcharin Loilome, Hideyuki Saya, Nisana Namwat
Summary: Cancer-associated fibroblasts (CAFs) play a role in promoting gemcitabine resistance and enhancing cell viability in cholangiocarcinoma (CCA) cells through the activation of IL-6/STAT3 signaling. High expression of IL-6R is associated with poor overall survival rate and gemcitabine resistance in CCA.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Akihiro Sakai, Yuichiro Nakashima, Yu Miyashita, Tadakazu Ao, Yasue Kimura, Eiji Shinto, Eiji Oki, Mototsugu Shimokawa, Hideki Ueno, Yoshinao Oda, Masaki Mori
Summary: This study evaluated the prognostic value of desmoplastic reaction (DR) categorisation in esophageal squamous cell carcinoma (OSCC) patients. The results showed that immature DR was an independent poor prognostic factor in OSCC patients, while the mature DR group had the best survival rates.
Review
Medicine, General & Internal
Michele Montori, Chiara Scorzoni, Maria Eva Argenziano, Daniele Balducci, Federico De Blasio, Francesco Martini, Tiziana Buono, Antonio Benedetti, Marco Marzioni, Luca Maroni
Summary: Cholangiocarcinoma is an aggressive cancer with a desmoplastic stroma, where cancer-associated fibroblasts play a crucial role in modulating cancer microenvironments.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Yuanke Li, Zhen Zhao, Chien-Yu Lin, Yanli Liu, Kevin F. Staveley-OCarroll, Guangfu Li, Kun Cheng
Summary: This study investigated silencing the PCBP2 gene through siRNA to reverse the accumulation of type I collagen in PDAC tumor stroma. The use of nanocomplex significantly reduced ECM production and enhanced drug penetration through desmoplastic tumor stroma. In a mouse model, the combination of PCBP2 siRNA nanocomplex with gemcitabine effectively suppressed tumor progression.
Article
Oncology
Hideki Ueno, Megumi Ishiguro, Eiji Nakatani, Toshiaki Ishikawa, Hiroyuki Uetake, Kenta Murotani, Shigeyuki Matsui, Satoshi Teramukai, Tamotsu Sugai, Yoichi Ajioka, Hirotoshi Maruo, Masahito Kotaka, Masaki Tsujie, Yoshinori Munemoto, Takashi Yamaguchi, Hisashi Kuroda, Mutsumi Fukunaga, Naohiro Tomita, Kenichi Sugihara
Summary: The study validated the prognostic value of desmoplastic reaction (DR) in colorectal cancer and found that DR classification is an independent prognostic factor. Histological categorisation of DR provides important prognostic information for efficient selection of colon cancer patients who would benefit from postoperative adjuvant therapy.
BRITISH JOURNAL OF CANCER
(2021)
Article
Engineering, Biomedical
Xiaobei Luo, Eliza Li Shan Fong, Chaojun Zhu, Quy Xiao Xuan Lin, Man Xiong, Aimin Li, Tingting Li, Touati Benoukraf, Hanry Yu, Side Liu
Summary: This study developed a comprehensive three-dimensional model by establishing in vitro conditions for co-culturing colorectal cancer PDO and patient-derived CAFs, which helps to maintain the characteristics of tumor cells. Ultimately, this model is suitable for evaluating standard-of-care drugs and potentially useful for personalized cancer medicine.
ACTA BIOMATERIALIA
(2021)
Review
Oncology
Mo Zhang, Zhixian Chen, Yan Wang, Hongbo Zhao, Yan Du
Summary: This review focuses on the important role of cancer-associated fibroblasts (CAFs) in the ovarian cancer tumor microenvironment. Different subtypes of CAFs have specific functions in tumor pathogenesis and can be potential treatment targets. Several clinical or preclinical trials have targeted CAFs to enhance ovarian cancer treatment outcomes.
Article
Oncology
Noriyuki Nishiwaki, Kazuhiro Noma, Toshiaki Ohara, Tomoyoshi Kunitomo, Kento Kawasaki, Masaaki Akai, Teruki Kobayashi, Toru Narusaka, Hajime Kashima, Hiroaki Sato, Satoshi Komoto, Takuya Kato, Naoaki Maeda, Satoru Kikuchi, Shunsuke Tanabe, Hiroshi Tazawa, Yasuhiro Shirakawa, Toshiyoshi Fujiwara
Summary: Cancer-associated fibroblasts (CAFs) play a critical role in tumor progression by inducing tumor immunosuppression via IL-6. IL-6 induces tumor immunosuppression by enhancing glucose uptake by cancer cells and competing for glucose with immune cells. Anti-IL-6 receptor antibody could overcome tumor immunosuppression and inhibit tumor progression.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Engineering, Biomedical
Yan Liu, Xiaodi Wu, Feifan Chen, Hao Li, Tao Wang, Ningning Liu, Kang Sun, Guangdong Zhou, Ke Tao
Summary: In this study, we found that nanoparticle-based photodynamic therapy disrupted the tumor-stroma crosstalk in pancreatic tumor models, leading to persistent inhibition of extracellular matrix secretion and enhanced therapeutic effect. By down-regulating TGF beta signaling pathways, this therapy decreased drug resistance, proliferation, and migration of cancer cells. Furthermore, it inactivated pancreatic stellate cells and hindered ECM secretion. The disruption of tumor-stroma crosstalk also improved tumor penetration in stroma-rich pancreatic tumor models, enhancing subsequent therapy outcomes.
Review
Biochemistry & Molecular Biology
Maosen Xu, Tao Zhang, Ruolan Xia, Yuquan Wei, Xiawei Wei
Summary: Tumors are composed of cancer cells and the surrounding stromal components, and there are important interactions between the stromal components and tumor cells. Significant progress has been made in the study of tumor stroma, and clinical trials targeting the tumor stroma are ongoing. This review summarizes the latest research on the interaction between stromal components and tumor cells, and proposes potential novel approaches for tumor-stroma-based therapeutic targeting.
Review
Oncology
Linh-Huyen Truong, Siim Pauklin
Summary: Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers with no effective treatment currently available. The complexity and dynamics of the tumor microenvironment (TME) play a crucial role in PDAC treatment resistance, emphasizing the need for a detailed understanding of the TME. Insights into the heterogeneous TME composition and interplay among its components are essential for developing more efficient therapeutic approaches for PDAC.
Article
Biochemistry & Molecular Biology
Renjie Yang, Dong Wang, Shen Han, Yichao Gu, Zhi Li, Lei Deng, Aihong Yin, Yun Gao, Xiangcheng Li, Yue Yu, Xuehao Wang
Summary: Intrahepatic cholangiocarcinoma (iCCA) is a highly malignant subtype of cholangiocarcinoma (CCA) with poor prognosis. This study found that miR-206 is downregulated in iCCA tissues and its overexpression can inhibit cell proliferation, migration and invasion. Normal fibroblast cells can transform into cancer-associated fibroblast cells (CAFs) and promote malignant behavior and drug resistance in cancer cells. Overexpressing miR-206 can inhibit this mutual promoting effect and suppress tumor deterioration through exosomes.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Charupong Saengboonmee, Marutpong Detarya, Sakkarn Sangkhamanon, Kanlayanee Sawanyawisuth, Wunchana Seubwai, Sopit Wongkham
Summary: The study demonstrates that high glucose can induce the expression of cell cycle machinery proteins in CCA cells, especially cyclin A, and that hyperglycemia is associated with significantly increased nuclear cyclin A levels in tumor tissues from CCA patients, leading to a shorter post-operative survival period of less than 5 months. Silencing cyclin A expression enhances the sensitivity of CCA cells to pan-CDKs inhibitors, suggesting a potential alternative treatment approach for CCA patients with diabetes mellitus.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Integrative & Complementary Medicine
Chiara Vidoni, Andrea Fuzimoto, Alessandra Ferraresi, Ciro Isidoro
Summary: Autophagy is a process that regulates internal homeostasis and energy balance by degrading redundant or damaged cellular components. During virus infection, autophagy can be triggered to destroy virion particles or activate immune responses. However, some viruses can exploit autophagy for their own benefit. This study reports on natural products that can interfere with SARS-CoV-2 infection and replication by targeting autophagy. These natural products may serve as adjuvant therapeutics to prevent virus infection and mitigate disease progression in COVID-19.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Waritta Kunprom, Chaiwat Aphivatanasiri, Prakasit Sa-ngiamwibool, Sakkarn Sangkhamanon, Piyapharom Intarawichian, Walailak Bamrungkit, Malinee Thanee, Piya Prajumwongs, Watcharin Loilome, Narong Khuntikeo, Attapol Titapun, Apiwat Jareanrat, Vasin Thanasukarn, Tharatip Srisuk, Vor Luvira, Kulyada Eurboonyanun, Julaluck Promsorn, Supinda Koonmee
Summary: This study aims to identify a prognostic factor that can improve the performance stratification and influence the outcome of patients with distal cholangiocarcinoma (dCCA) after curative resection. The study found that growth pattern and distant metastasis were independent factors. Classifying patients based on growth pattern can better predict their survival rates.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Gastroenterology & Hepatology
Prakasit Sa-Ngiamwibool, Chaiwat Aphivatanasiri, Sakkarn Sangkhamanon, Piyapharom Intarawichian, Waritta Kunprom, Malinee Thanee, Piya Prajumwongs, Watcharin Loilome, Narong Khuntikeo, Attapol Titapun, Apiwat Jareanrat, Vasin Thanasukarn, Tharatip Srisuk, Vor Luvira, Kulyada Eurboonyanun, Julaluck Promsom, Aileen Wee, Supinda Koonmee
Summary: This study aimed to improve prognostic prediction and patient stratification for iCCA by creating the KKU staging system. The incorporation of growth patterns as independent prognostic factors and modification of AJCC stages in the KKU staging system resulted in better prediction of patient survival. The KKU staging system may serve as an alternative model for iCCA staging to enhance the accuracy of survival prognostication.
Article
Multidisciplinary Sciences
Sirinya Sitthirak, Manida Suksawat, Jutarop Phetcharaburanin, Arporn Wangwiwatsin, Poramate Klanrit, Nisana Namwat, Narong Khuntikeo, Attapol Titapun, Apiwat Jarearnrat, Sakkarn Sangkhamanon, Watcharin Loilome
Summary: This study investigated the association between the intratumoral microbiome and chemotherapeutic resistance in cholangiocarcinoma tissues using 16S rRNA sequencing and 1H NMR spectroscopic analysis. The results showed that specific bacteria and metabolites were significantly different between resistance and sensitive groups, suggesting their potential use as predictive markers for drug responses.
Article
Public, Environmental & Occupational Health
Supinda Koonmee, Sakkarn Sangkhamanon, Piyapharom Intarawichian, Chaiwat Aphivatanasiri, Waritta Kunprom, Prakasit Sa-ngiamwibool, Suwit Balthaisong, Chitsakul Phuyao, Piya Prajumwongs, Reza Alaghehbandan, Malinee Thanee
Summary: This study compared the use of the CASCAP container with the conventional method for examining CCA specimens, and found that the CASCAP container significantly improved tissue quality and the immunohistochemical expression of CK19, a prognostic marker for CCA.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Thin Su Kyaw, Manatsaphon Sukmak, Kanokwan Nahok, Amod Sharma, Atit Silsirivanit, Worachart Lert-itthiporn, Nichapa Sansurin, Vichai Senthong, Sirirat Anutrakulchai, Sakkarn Sangkhamanon, Somchai Pinlaor, Carlo Selmi, Bruce D. Hammock, Ubon Cha'on
Summary: The study suggests that prolonged high dose consumption of monosodium glutamate (MSG) may lead to TMAO accumulation in the blood by reducing renal excretion, resulting in acute kidney injury.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Yingpinyapat Kittirat, Manida Suksawat, Suyanee Thongchot, Sureerat Padthaisong, Jutarop Phetcharaburanin, Arporn Wangwiwatsin, Poramate Klanrit, Sakkarn Sangkhamanon, Attapol Titapun, Watcharin Loilome, Hideyuki Saya, Nisana Namwat
Summary: Cancer-associated fibroblasts (CAFs) play a role in promoting gemcitabine resistance and enhancing cell viability in cholangiocarcinoma (CCA) cells through the activation of IL-6/STAT3 signaling. High expression of IL-6R is associated with poor overall survival rate and gemcitabine resistance in CCA.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Chaiwat Aphivatanasiri, Prakasit Sa-Ngiamwibool, Sakkarn Sangkhamanon, Piyapharom Intarawichian, Waritta Kunprom, Malinee Thanee, Piya Prajumwongs, Narong Khuntikeo, Attapol Titapun, Apiwat Jareanrat, Vasin Thanasukarn, Tharatip Srisuk, Vor Luvira, Kulyada Eurboonyanun, Julaluck Promsorn, Watcharin Loilome, Aileen Wee, Supinda Koonmee
Summary: This study aims to improve the classification performance of the eighth American Joint Committee on Cancer (AJCC) staging system for perihilar cholangiocarcinoma (pCCA) by proposing the Khon Kaen University (KKU) staging system developed in cholangiocarcinoma-prevalent Northeast Thailand. The results show that the new KKU staging system is able to better classify and predict the prognosis of pCCA patients, improving the accuracy of classification and survival prognosis.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Piyapharom Intarawichian, Sirada Sangpaibool, Piya Prajumwongs, Prakasit Sa-Ngiamwibool, Sakkarn Sangkhamanon, Waritta Kunprom, Malinee Thanee, Watcharin Loilome, Narong Khuntikeo, Attapol Titapun, Apiwat Jareanrat, Vasin Thanasukarn, Tharatip Srisuk, Vor Luvira, Kulyada Eurboonyanun, Julaluck Promsorn, Supinda Koonmee, Aileen Wee, Chaiwat Aphivatanasiri
Summary: The study found that tumor-infiltrating lymphocytes (TILs) are an independent factor for predicting the prognosis of patients with distal cholangiocarcinoma (dCCA). By assessing TILs and growth patterns, patients can be stratified more effectively, leading to improved prognostication capabilities.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Rujikorn Treeriya, Phuc N. Ho, Attapol Titapun, Poramate Klanrit, Manida Suksawat, Thanaporn Kulthawatsiri, Suphasarang Sirirattanakul, Watcharin Loilome, Nisana Namwat, Arporn Wangwiwatsin, Nittaya Chamadol, Narong Khuntikeo, Jutarop Phetcharaburanin
Summary: In this study, nuclear magnetic resonance (NMR) metabolomics was used to investigate the fecal metabolic phenotypes of different study groups, including normal bile duct, periductal fibrosis (PDF), and cholangiocarcinoma (CCA) patients. The results revealed distinct fecal metabolic patterns in PDF and CCA patients compared to the normal bile duct group, indicating the involvement of various metabolic pathways in PDF and CCA progression. The study also highlighted the role of gut-microbial host metabolic crosstalk in PDF and/or CCA patients.
Article
Medicine, Research & Experimental
Sakkarn Sangkhamanon, Natcha Kotano, Wichien Sirithanaphol, Ukrit Rompsaithong, Pakorn Kiatsopit, Aumkhae Sookprasert, Kosin Wirasorn, Prin Twinprai, Piyakarn Watcharenwong, Jarin Chindaprasirt
Summary: The study aimed to analyze PD-L1 expression in penile cancer patients and its correlation with clinicopathological parameters. Eighteen percent of patients were found to have PD-L1 positive expression and it was associated with early T stage. Patients with positive PD-L1 expression showed a trend towards longer survival. Lymph node involvement and tumor location were independent prognostic factors.
BIOMEDICAL REPORTS
(2023)
Article
Gastroenterology & Hepatology
Charupong Saengboonmee, Supannika Sorin, Sakkarn Sangkhamanon, Surang Chomphoo, Somsiri Indramanee, Wunchana Seubwai, Kanyarat Thithuan, Ching-Feng Chiu, Seiji Okada, Marie-Claude Gingras, Sopit Wongkham
Summary: This study investigated the effects of hyperglycemia on GABBR2 expression and its potential as a therapeutic target for cholangiocarcinoma (CCA). The results showed that GABBR2 expression was upregulated in CCA cells under high glucose conditions and in tumor tissues from patients with diabetes mellitus and hyperglycemia. Baclofen, a GABA-B receptor agonist, significantly suppressed CCA cell proliferation and clonogenicity. GABBR2 may regulate GSK3/ss-beta-catenin and STAT3 signaling pathways to affect CCA cell proliferation. Therefore, GABBR2 holds promise as a therapeutic target for CCA treatment.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Sarassawan Kananuraks, Pornprapha Sophonritthidet, Wisansanee Karoonbooyanan, Sakkarn Sangkhamanon
