Dimethyl itaconate, an itaconate derivative, exhibits immunomodulatory effects on neuroinflammation in experimental autoimmune encephalomyelitis

Sinomenine Attenuates Traumatic Spinal Cord Injury by Suppressing Oxidative Stress and Inflammation via Nrf2 Pathway

(2019) Lilian Zhang et al.   NEUROCHEMICAL RESEARCH

Sageretia thea Inhibits Inflammation through Suppression of NF-κB and MAPK and Activation of Nrf2/HO-1 Signaling Pathways in RAW264.7 Cells

(2019) Ha Na Kim et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β

(2019) Juliana Komuczki et al.   IMMUNITY

Microglia-mediated neuroinflammation in neurodegenerative diseases

(2019) Charannya Sozheesvari Subhramanyam et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Dimethyl itaconate protects against lippolysacchride-induced mastitis in mice by activating MAPKs and Nrf2 and inhibiting NF-κB signaling pathways

(2019) Caijun Zhao et al.   MICROBIAL PATHOGENESIS

Dithiolethione ACDT suppresses neuroinflammation and ameliorates disease severity in experimental autoimmune encephalomyelitis

(2018) Ping-Chang Kuo et al.   BRAIN BEHAVIOR AND IMMUNITY

Effective combination of methylprednisolone and interferon β-secreting mesenchymal stem cells in a model of multiple sclerosis

(2018) Mi Jin Kim et al.   JOURNAL OF NEUROIMMUNOLOGY

Granulocyte-macrophage colony-stimulating factor as a mediator of autoimmunity in multiple sclerosis

(2018) Milos Kostic et al.   JOURNAL OF NEUROIMMUNOLOGY

Dimethyl fumarate attenuates reactive microglia and long-term memory deficits following systemic immune challenge

(2018) Hallel C. Paraiso et al.   Journal of Neuroinflammation

D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization

(2018) Martin Böttcher et al.   OncoImmunology

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

(2018) Monika Bambouskova et al.   NATURE

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity

(2018) Jorge Domínguez-Andrés et al.   Cell Metabolism

Hydrogen-Rich Saline Ameliorates Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice Via the Nrf2-ARE Signaling Pathway

(2018) Yaping Liu et al.   INFLAMMATION

The novel Nrf2 inducer TFM-735 ameliorates experimental autoimmune encephalomyelitis in mice

(2017) Chika Higashi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Kv1.3 channel blocker (ImKTx88) maintains blood–brain barrier in experimental autoimmune encephalomyelitis

(2017) Jie Huang et al.   Cell and Bioscience

3H-1,2-dithiole-3-thione as a novel therapeutic agent for the treatment of experimental autoimmune encephalomyelitis

(2016) Ping-Chang Kuo et al.   BRAIN BEHAVIOR AND IMMUNITY

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

(2016) Thekla Cordes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo and in vitro effects of multiple sclerosis immunomodulatory therapeutics on glutamatergic excitotoxicity

(2016) Dirk Luchtman et al.   JOURNAL OF NEUROCHEMISTRY

Advances in the immunopathogenesis of multiple sclerosis

(2015) Sudhir K. Yadav et al.   CURRENT OPINION IN NEUROLOGY

IL-12-polarized Th1 cells produce GM-CSF and induce EAE independent of IL-23

(2015) Heather M. Grifka-Walk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Role of Matrix Metalloproteinase 3 and 9 in the Pathogenesis of Acute Neuroinflammation. Implications for Disease Modifying Therapy

(2015) Srdjan Ljubisavljevic et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE

(2015) Ian L. McWilliams et al.   Journal of Neuroinflammation

GM-CSF in Neuroinflammation: Licensing Myeloid Cells for Tissue Damage

(2015) Andrew L. Croxford et al.   TRENDS IN IMMUNOLOGY

Therapeutic uses of anti- 4-integrin (anti-VLA-4) antibodies in multiple sclerosis

(2014) N. Schwab et al.   INTERNATIONAL IMMUNOLOGY

ApoE-Deficient Promotes Blood–Brain Barrier Disruption in Experimental Autoimmune Encephalomyelitis via Alteration of MMP-9

(2014) Minghua Zheng et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Sulforaphane ameliorates the development of experimental autoimmune encephalomyelitis by antagonizing oxidative stress and Th17-related inflammation in mice

(2013) Bin Li et al.   EXPERIMENTAL NEUROLOGY

CD8+ T cell help is required for efficient induction of EAE in Lewis rats

(2013) Monika Camara et al.   JOURNAL OF NEUROIMMUNOLOGY

Succinate: a metabolic signal in inflammation

(2013) Evanna Mills et al.   TRENDS IN CELL BIOLOGY

The Mechanism of Action of Interferon-β in Relapsing Multiple Sclerosis

(2011) Bernd C. Kieseier   CNS DRUGS

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

T cells in multiple sclerosis and experimental autoimmune encephalomyelitis

(2010) J. M. Fletcher et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Cognitive deficits in experimental autoimmune encephalomyelitis: neuroinflammation and synaptic degeneration

(2010) G. Mandolesi et al.   NEUROLOGICAL SCIENCES

Th1, Th17, and Th9 Effector Cells Induce Experimental Autoimmune Encephalomyelitis with Different Pathological Phenotypes

(2009) A. Jager et al.   JOURNAL OF IMMUNOLOGY

Association of MMP1, MMP3, MMP9, and MMP12 polymorphisms with risk and clinical course of multiple sclerosis in a Polish population

(2009) Dagmara Mirowska-Guzel et al.   JOURNAL OF NEUROIMMUNOLOGY

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice

(2008) Beichu Guo et al.   JOURNAL OF CLINICAL INVESTIGATION