Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish

mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53

(2018) Seung Hee Jung et al.   ONCOGENE

Metformin Synergizes with BCL-XL/BCL-2 Inhibitor ABT-263 to Induce Apoptosis Specifically in p53-Defective Cancer Cells

(2017) Xinzhe Li et al.   MOLECULAR CANCER THERAPEUTICS

P16INK4a upregulation mediated by TBK1 induces retinal ganglion cell senescence in ischemic injury

(2017) L u Li et al.   Cell Death & Disease

Telomeres in aging and disease: lessons from zebrafish

(2016) Madalena C. Carneiro et al.   Disease Models & Mechanisms

Crosstalk between the IGF-1R/AKT/mTORC1 pathway and the tumor suppressors p53 and p27 determines cisplatin sensitivity and limits the effectiveness of an IGF-1R pathway inhibitor

(2016) Batzaya Davaadelger et al.   Oncotarget

Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging

(2016) Tongyuan Li et al.   Oncotarget

Short Telomeres in Key Tissues Initiate Local and Systemic Aging in Zebrafish

(2016) Madalena C. Carneiro et al.   PLoS Genetics

The IGF-1R/AKT pathway determines cell fate in response to p53

(2016) Lei Duan et al.   Translational Cancer Research

Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin

(2016) Michael C. Velarde et al.   Aging-US

Of Flies, Mice, and Men: Evolutionarily Conserved Tissue Damage Responses and Aging

(2015) Joana Neves et al.   DEVELOPMENTAL CELL

Akt inhibition improves irinotecan treatment and prevents cell emergence by switching the senescence response to apoptosis

(2015) Alexandra Vétillard et al.   Oncotarget

Senescence and apoptosis: dueling or complementary cell fates?

(2014) B. G. Childs et al.   EMBO REPORTS

Crosstalk between the Rb Pathway and AKT Signaling Forms a Quiescence-Senescence Switch

(2014) Yoshinori Imai et al.   Cell Reports

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

CDK4/6-inhibiting drug substitutes for p21 and p16 in senescence: Duration of cell cycle arrest and MTOR activity determine geroconversion

(2013) Olga V. Leontieva et al.   CELL CYCLE

Polyploidization and Cell Fusion Contribute to Wound Healing in the Adult Drosophila Epithelium

(2013) Vicki P. Losick et al.   CURRENT BIOLOGY

Tissue Repair through Cell Competition and Compensatory Cellular Hypertrophy in Postmitotic Epithelia

(2013) Yoichiro Tamori et al.   DEVELOPMENTAL CELL

Premature aging in telomerase-deficient zebrafish

(2013) M. Anchelin et al.   Disease Models & Mechanisms

Compensatory cellular hypertrophy: the other strategy for tissue homeostasis

(2013) Yoichiro Tamori et al.   TRENDS IN CELL BIOLOGY

Telomerase Is Required for Zebrafish Lifespan

(2013) Catarina M. Henriques et al.   PLoS Genetics

mTORC1 and p53

(2012) Paul Hasty et al.   CELL CYCLE

Akt Phosphorylates the Transcriptional Repressor Bmi1 to Block Its Effects on the Tumor-Suppressing Ink4a-Arf Locus

(2012) Y. Liu et al.   Science Signaling

Haploinsufficiency of Target of Rapamycin Attenuates Cardiomyopathies in Adult Zebrafish

(2011) Yonghe Ding et al.   CIRCULATION RESEARCH

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

(2011) Adam Freund et al.   EMBO JOURNAL

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

Behaviour of Telomere and Telomerase during Aging and Regeneration in Zebrafish

(2011) Monique Anchelin et al.   PLoS One

Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue

(2010) Nicolai Treiber et al.   AGING CELL

The p53 tumor suppressor: A master regulator of diverse cellular processes and therapeutic target in cancer

(2010) Marianne Farnebo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Deciphering the intricate regulatory mechanisms for the cellular choice between cell repair, apoptosis or senescence in response to damaging signals

(2010) Adnan Erol   CELLULAR SIGNALLING

Transforming growth factor-beta induces senescence in hepatocellular carcinoma cells and inhibits tumor growth

(2010) Serif Senturk et al.   HEPATOLOGY

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

Akt Activation Synergizes with Trp53 Loss in Oral Epithelium to Produce a Novel Mouse Model for Head and Neck Squamous Cell Carcinoma

(2009) M. Moral et al.   CANCER RESEARCH

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis

(2008) Veronique Nogueira et al.   CANCER CELL

A complex barcode underlies the heterogeneous response of p53 to stress

(2008) Fiona Murray-Zmijewski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Telomeres and Aging

(2008) Geraldine Aubert et al.   PHYSIOLOGICAL REVIEWS

Apoptosis-induced compensatory proliferation. The Cell is dead. Long live the Cell!

(2008) Yun Fan et al.   TRENDS IN CELL BIOLOGY

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY

The Identification of Zebrafish Mutants Showing Alterations in Senescence-Associated Biomarkers

(2008) Shuji Kishi et al.   PLoS Genetics