Pan-mTOR inhibitors sensitize the senolytic activity of navitoclax via mTORC2 inhibition-mediated apoptotic signaling

Identification of GL-V9 as a novel senolytic agent against senescent breast cancer cells

(2021) Dawei Yang et al.   LIFE SCIENCES

Temporal trends in pulmonary arterial hypertension: Results from the COMPERA registry

(2021) Marius M. Hoeper et al.   EUROPEAN RESPIRATORY JOURNAL

Analysing the fitness cost of antibiotic resistance to identify targets for combination antimicrobials

(2021) Aviram Rasouly et al.   Nature Microbiology

Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice

(2020) Marcelo B. Cavalcante et al.   Aging-US

Recent advances in the combination delivery of drug for leukemia and other cancers

(2020) Thikrayat Al-Attar et al.   Expert Opinion on Drug Delivery

BCL-XL expression is essential for human erythropoiesis and engraftment of hematopoietic stem cells

(2020) Sehar Afreen et al.   Cell Death & Disease

Corrigendum to ‘Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease’ EBioMedicine 47 (2019) 446–456

(2020) LaTonya J. Hickson et al.   EBioMedicine

Galacto‐conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity

(2020) Estela González‐Gualda et al.   AGING CELL

Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice

(2020) Yusheng Cai et al.   CELL RESEARCH

Navitoclax (ABT263) reduces inflammation and promotes chondrogenic phenotype by clearing senescent osteoarthritic chondrocytes in osteoarthritis

(2020) Hao Yang et al.   Aging-US

Regulation of Platelet Production and Life Span: Role of Bcl-xL and Potential Implications for Human Platelet Diseases

(2020) Emma C. Josefsson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The curcumin analog EF24 is a novel senolytic agent

(2019) Wen Li et al.   Aging-US

Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes

(2019) Cristina Aguayo-Mazzucato et al.   Cell Metabolism

Targeting BCL2 in Chronic Lymphocytic Leukemia and Other Hematologic Malignancies

(2019) Fevzi F. Yalniz et al.   DRUGS

Combination of fenretinide and ABT-263 induces apoptosis through NOXA for head and neck squamous cell carcinoma treatment

(2019) Erin L. Britt et al.   PLoS One

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

(2019) LaTonya J. Hickson et al.   EBioMedicine

Identification and characterization of Cardiac Glycosides as senolytic compounds

(2019) Francisco Triana-Martínez et al.   Nature Communications

A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity

(2019) Sajid Khan et al.   NATURE MEDICINE

Recent developments of nanotherapeutics for targeted and long-acting, combination HIV chemotherapy

(2018) Yu Gao et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Inhibition of mTORC2 enhances UVB-induced apoptosis in keratinocytes through a mechanism dependent on the FOXO3a transcriptional target NOXA but independent of TRAIL

(2018) Robert P. Feehan et al.   CELLULAR SIGNALLING

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Fisetin is a senotherapeutic that extends health and lifespan

(2018) Matthew J. Yousefzadeh et al.   EBioMedicine

Epigallocatechin gallate suppresses premature senescence of preadipocytes by inhibition of PI3K/Akt/mTOR pathway and induces senescent cell death by regulation of Bax/Bcl-2 pathway

(2018) Ravi Kumar et al.   BIOGERONTOLOGY

Impaired immune surveillance accelerates accumulation of senescent cells and aging

(2018) Yossi Ovadya et al.   Nature Communications

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration

(2017) Birgit Ritschka et al.   GENES & DEVELOPMENT

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Identification of HSP90 inhibitors as a novel class of senolytics

(2017) Heike Fuhrmann-Stroissnigg et al.   Nature Communications

A Novel Indication for Panobinostat as a Senolytic Drug in NSCLC and HNSCC

(2017) Leleesha Samaraweera et al.   Scientific Reports

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

(2016) Carolyn M. Roos et al.   AGING CELL

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

(2016) Yi Zhu et al.   AGING CELL

Discovery of piperlongumine as a potential novel lead for the development of senolytic agents

(2016) Yingying Wang et al.   Aging-US

mTORC2 Signaling Regulates Nox4-Induced Podocyte Depletion in Diabetes

(2016) Stéphanie Eid et al.   ANTIOXIDANTS & REDOX SIGNALING

Cisplatin-induced apoptosis in non-small-cell lung cancer cells is dependent on Bax- and Bak-induction pathway and synergistically activated by BH3-mimetic ABT-263 in p53 wild-type and mutant cells

(2016) Masaru Matsumoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

BCKA down-regulates mTORC2-Akt signal and enhances apoptosis susceptibility in cardiomyocytes

(2016) Xiong Guo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice

(2016) Ming Xu et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Combination with vorinostat overcomes ABT-263 (navitoclax) resistance of small cell lung cancer

(2015) Wataru Nakajima et al.   CANCER BIOLOGY & THERAPY

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

(2015) Edgar Pérez-Herrero et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

HTLV-1-associated adult T cell leukemia is highly susceptible to Navitoclax due to enhanced Bax expression

(2015) Mathias Witzens-Harig et al.   INTERNATIONAL JOURNAL OF CANCER

ABT-199 (venetoclax) and BCL-2 inhibitors in clinical development

(2015) Shundong Cang et al.   Journal of Hematology & Oncology

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy

(2015) Joel D. Leverson et al.   Science Translational Medicine

ABT-263 induces apoptosis and synergizes with chemotherapy by targeting stemness pathways in esophageal cancer

(2015) Qiongrong Chen et al.   Oncotarget

Cellular senescence and the senescent secretory phenotype in age-related chronic diseases

(2014) Yi Zhu et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Targeting BCL2 for the Treatment of Lymphoid Malignancies

(2014) Mary Ann Anderson et al.   SEMINARS IN HEMATOLOGY

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Bim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppression

(2011) D Mérino et al.   ONCOGENE

Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

(2010) Wyndham H Wilson et al.   LANCET ONCOLOGY

Cellular senescence: Its role in tumor suppression and aging

(2009) Naoko Ohtani et al.   CANCER SCIENCE