Analysing the fitness cost of antibiotic resistance to identify targets for combination antimicrobials

Rapid inference of antibiotic resistance and susceptibility by genomic neighbour typing

(2020) Karel Břinda et al.   Nature Microbiology

Tuberculosis

(2019) Jennifer Furin et al.   LANCET

Pervasive and diverse collateral sensitivity profiles inform optimal strategies to limit antibiotic resistance

(2019) Jeff Maltas et al.   PLOS BIOLOGY

High-resolution RNA 3′-ends mapping of bacterial Rho-dependent transcripts

(2018) Daniel Dar et al.   NUCLEIC ACIDS RESEARCH

Altered Mycobacterium tuberculosis Cell Wall Metabolism and Physiology Associated With RpoB Mutation H526D

(2018) Victoria L. Campodónico et al.   Frontiers in Microbiology

Same-Day Diagnostic and Surveillance Data for Tuberculosis via Whole-Genome Sequencing of Direct Respiratory Samples

(2017) Antonina A. Votintseva et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Expanding Proteome Coverage with CHarge Ordered Parallel Ion aNalysis (CHOPIN) Combined with Broad Specificity Proteolysis

(2017) Simon Davis et al.   JOURNAL OF PROTEOME RESEARCH

Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition

(2017) Wei Lin et al.   MOLECULAR CELL

Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found inMycobacterium tuberculosis

(2017) Vadim Molodtsov et al.   MOLECULAR MICROBIOLOGY

Tuberculosis: Just the FAQs

(2017) Kristine M. Guinn et al.   mBio

Rifabutin and rifampin resistance levels and associated rpoB mutations in clinical isolates of Mycobacterium tuberculosis complex

(2016) Zenda L. Berrada et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

(2016) Stefka Tyanova et al.   Nature Protocols

ppGpp couples transcription to DNA repair in E. coli

(2016) V. Kamarthapu et al.   SCIENCE

The Complex Mechanism of Antimycobacterial Action of 5-Fluorouracil

(2015) Vinayak Singh et al.   CHEMISTRY & BIOLOGY

Systematic discovery of drug interaction mechanisms

(2015) G. Chevereau et al.   Molecular Systems Biology

Multidrug evolutionary strategies to reverse antibiotic resistance

(2015) M. Baym et al.   SCIENCE

The no-SCAR (Scarless Cas9 Assisted Recombineering) system for genome editing in Escherichia coli

(2015) Chris R. Reisch et al.   Scientific Reports

UvrD facilitates DNA repair by pulling RNA polymerase backwards

(2014) Vitaly Epshtein et al.   NATURE

A pause sequence enriched at translation start sites drives transcription dynamics in vivo

(2014) M. H. Larson et al.   SCIENCE

Bacterial evolution of antibiotic hypersensitivity

(2013) V. Lazar et al.   Molecular Systems Biology

Use of Collateral Sensitivity Networks to Design Drug Cycling Protocols That Avoid Resistance Development

(2013) L. Imamovic et al.   Science Translational Medicine

Antibiotic Sensitivity Profiles Determined with an Escherichia coli Gene Knockout Collection: Generating an Antibiotic Bar Code

(2010) A. Liu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phenotypic Landscape of a Bacterial Cell

(2010) Robert J. Nichols et al.   CELL

Silent Mischief: Bacteriophage Mu Insertions Contaminate Products of Escherichia coli Random Mutagenesis Performed Using Suicidal Transposon Delivery Plasmids Mobilized by Broad-Host-Range RP4 Conjugative Machinery

(2010) L. Ferrieres et al.   JOURNAL OF BACTERIOLOGY

A22 Disrupts the Bacterial Actin Cytoskeleton by Directly Binding and Inducing a Low-Affinity State in MreB

(2009) G. J. Bean et al.   BIOCHEMISTRY

Identifying Genetic Determinants Needed to Establish a Human Gut Symbiont in Its Habitat

(2009) Andrew L. Goodman et al.   Cell Host & Microbe

Similar and Divergent Effects of ppGpp and DksA Deficiencies on Transcription in Escherichia coli

(2009) A. Aberg et al.   JOURNAL OF BACTERIOLOGY

Tn-seq: high-throughput parallel sequencing for fitness and genetic interaction studies in microorganisms

(2009) Tim van Opijnen et al.   NATURE METHODS

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS