Regulation of Platelet Production and Life Span: Role of Bcl-xL and Potential Implications for Human Platelet Diseases

Macrophage galactose lectin is critical for Kupffer cells to clear aged platelets

(2020) Carsten Deppermann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

BCL-XL expression is essential for human erythropoiesis and engraftment of hematopoietic stem cells

(2020) Sehar Afreen et al.   Cell Death & Disease

Inherited thrombocytopenias: history, advances and perspectives

(2020) Alan T. Nurden et al.   HAEMATOLOGICA

Membrane budding is a major mechanism of in vivo platelet biogenesis

(2020) Kathryn S. Potts et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Single-cell lineage tracing unveils a role for TCF15 in haematopoiesis

(2020) Alejo E. Rodriguez-Fraticelli et al.   NATURE

Low Iron Promotes Megakaryocytic Commitment of Megakaryocytic-Erythroid Progenitors in Humans and Mice

(2019) Juliana Xavier-Ferrucio et al.   BLOOD

Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion

(2018) Irina Pleines et al.   BLOOD

Megakaryocyte and polyploidization

(2018) Stefania Mazzi et al.   EXPERIMENTAL HEMATOLOGY

Transient von Willebrand factor-mediated platelet influx stimulates liver regeneration after partial hepatectomy in mice

(2017) Marc Kirschbaum et al.   LIVER INTERNATIONAL

The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors

(2017) Emma Lefrançais et al.   NATURE

Genetic Alterations of the Thrombopoietin/MPL/JAK2 Axis Impacting Megakaryopoiesis

(2017) Isabelle Plo et al.   Frontiers in Endocrinology

Genetic basis and molecular pathophysiology of classical myeloproliferative neoplasms

(2016) William Vainchenker et al.   BLOOD

Loss of PUMA (BBC3) does not prevent thrombocytopenia caused by the loss of BCL-XL (BCL2L1)

(2016) Alex R. D. Delbridge et al.   BRITISH JOURNAL OF HAEMATOLOGY

Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia

(2016) Andrew W. Roberts et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of platelet lifespan by apoptosis

(2016) Marion Lebois et al.   PLATELETS

Platelet clearance by the hepatic Ashwell-Morrell receptor: mechanisms and biological significance

(2016) Karin M. Hoffmeister et al.   THROMBOSIS RESEARCH

Platelet secretion: From haemostasis to wound healing and beyond

(2015) Ewelina M. Golebiewska et al.   BLOOD REVIEWS

Megakaryocytic hyperplasia in myeloproliferative neoplasms is driven by disordered proliferative, apoptotic and epigenetic mechanisms

(2015) Jacques A J Malherbe et al.   JOURNAL OF CLINICAL PATHOLOGY

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy

(2015) Joel D. Leverson et al.   Science Translational Medicine

BCL-2 is dispensable for thrombopoiesis and platelet survival

(2015) M A Debrincat et al.   Cell Death & Disease

Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan

(2014) Z.-J. Liu et al.   BLOOD

Loss of Bak enhances lymphocytosis but does not ameliorate thrombocytopaenia in BCL-2 transgenic mice

(2014) C J Vandenberg et al.   CELL DEATH AND DIFFERENTIATION

Pre-activated blood platelets and a pro-thrombotic phenotype in APP23 mice modeling Alzheimer's disease

(2014) Andrea Jarre et al.   CELLULAR SIGNALLING

Platelets Effects on Tumor Growth

(2014) Hadi A. Goubran et al.   SEMINARS IN ONCOLOGY

Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL

(2014) Michael F. T. Koehler et al.   ACS Medicinal Chemistry Letters

Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity

(2014) Zhi-Fu Tao et al.   ACS Medicinal Chemistry Letters

Mutations of cytochrome c identified in patients with thrombocytopenia THC4 affect both apoptosis and cellular bioenergetics

(2013) Daniela De Rocco et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

CD41 expression marks myeloid-biased adult hematopoietic stem cells and increases with age

(2013) C. Gekas et al.   BLOOD

Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life

(2013) Paul R. Hess et al.   JOURNAL OF CLINICAL INVESTIGATION

Structure-guided design of a selective BCL-XL inhibitor

(2013) Guillaume Lessene et al.   Nature Chemical Biology

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice

(2012) E. Ottina et al.   BLOOD

Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival

(2012) M. A. Debrincat et al.   BLOOD

Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages

(2012) T Kodama et al.   CELL DEATH AND DIFFERENTIATION

Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury

(2012) Axelle Caudrillier et al.   JOURNAL OF CLINICAL INVESTIGATION

Platelets: active players in the pathogenesis of arthritis and SLE

(2012) Eric Boilard et al.   Nature Reviews Rheumatology

Can the analysis of BH3-only protein knockout mice clarify the issue of ‘direct versus indirect’ activation of Bax and Bak?

(2011) A Villunger et al.   CELL DEATH AND DIFFERENTIATION

Essential in vivo roles of the platelet activation receptor CLEC-2 in tumour metastasis, lymphangiogenesis and thrombus formation

(2011) Katsue Suzuki-Inoue   JOURNAL OF BIOCHEMISTRY

BH3-only Activator Proteins Bid and Bim Are Dispensable for Bak/Bax-dependent Thrombocyte Apoptosis Induced by Bcl-xL Deficiency

(2011) Takahiro Kodama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease

(2011) Andrew W. Roberts et al.   JOURNAL OF CLINICAL ONCOLOGY

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets

(2011) Emma C. Josefsson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The role of blood platelets in tumor angiogenesis

(2010) Siamack Sabrkhany et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development

(2010) P N Kelly et al.   CELL DEATH AND DIFFERENTIATION

Cytoskeletal mechanics of proplatelet maturation and platelet release

(2010) Jonathan N. Thon et al.   JOURNAL OF CELL BIOLOGY

The Proapoptotic G41S Mutation to Human CytochromecAlters the Heme Electronic Structure and Increases the Electron Self-Exchange Rate

(2010) Matthew D. Liptak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

(2010) D. Ren et al.   SCIENCE

Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function

(2009) S. M. Schoenwaelder et al.   BLOOD

Platelets in defense against bacterial pathogens

(2009) Michael R. Yeaman   CELLULAR AND MOLECULAR LIFE SCIENCES

The glycoprotein Ibα-von Willebrand factor interaction induces platelet apoptosis

(2009) S. LI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia

(2008) Ian M Morison et al.   NATURE GENETICS