The role of the cell surface glycocalyx in drug delivery to and through the endothelium

A Systems View of the Heparan Sulfate Interactome

(2021) Alejandro Gómez Toledo et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Strong Reduction of the Chain Rigidity of Hyaluronan by Selective Binding of Ca2+ Ions

(2021) Giulia Giubertoni et al.   MACROMOLECULES

Cationic lipids for gene delivery: many players, one goal

(2021) Federica Ponti et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Macrophages bind LDL using heparan sulfate and the perlecan protein core

(2021) Chun-yi Ng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ion Pairing and Dielectric Decrement in Glycosaminoglycan Brushes

(2021) James D. Sterling et al.   JOURNAL OF PHYSICAL CHEMISTRY B

An improved in vitro model for studying the structural and functional properties of the endothelial glycocalyx in arteries, capillaries and veins

(2021) Erika M. J. Siren et al.   FASEB JOURNAL

Studying the Endothelial Glycocalyx in vitro: What Is Missing?

(2021) Andrew B. Haymet et al.   Frontiers in Cardiovascular Medicine

Lipid Nanoparticles—From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement

(2021) Rumiana Tenchov et al.   ACS Nano

Lipid nanoparticles for mRNA delivery

(2021) Xucheng Hou et al.   Nature Reviews Materials

The Endothelial Glycocalyx: Physiology and Pathology in Neonates, Infants and Children

(2021) Alexandra Puchwein-Schwepcke et al.   Frontiers in Cell and Developmental Biology

Glycocalyx Impairment in Vascular Disease: Focus on Inflammation

(2021) Jing Qu et al.   Frontiers in Cell and Developmental Biology

Targeted Intravenous Nanoparticle Delivery: Role of Flow and Endothelial Glycocalyx Integrity

(2020) Ming J. Cheng et al.   ANNALS OF BIOMEDICAL ENGINEERING

Syndecan-3 in Inflammation and Angiogenesis

(2020) Samantha Arokiasamy et al.   Frontiers in Immunology

Cationic Arginine-Rich Peptides (CARPs): A Novel Class of Neuroprotective Agents With a Multimodal Mechanism of Action

(2020) Bruno P. Meloni et al.   Frontiers in Neurology

The Influence of Nanoparticle Shape on Protein Corona Formation

(2020) Rahul Madathiparambil Visalakshan et al.   Small

The Emerging Role of the Mammalian Glycocalyx in Functional Membrane Organization and Immune System Regulation

(2020) Leonhard Möckl   Frontiers in Cell and Developmental Biology

Targeting drug delivery in the vascular system: Focus on endothelium

(2020) Patrick M. Glassman et al.   ADVANCED DRUG DELIVERY REVIEWS

The need to freeze—Dehydration during specimen preparation for electron microscopy collapses the endothelial glycocalyx regardless of fixation method

(2020) Casper Hempel et al.   MICROCIRCULATION

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

(2020) Thomas Mandel Clausen et al.   CELL

Three-dimensional electron microscopy for endothelial glycocalyx observation using Alcian blue with silver enhancement

(2020) Shumpei Mukai et al.   Medical Molecular Morphology

Metabolic precision labeling enables selective probing of O-linkedN-acetylgalactosamine glycosylation

(2020) Marjoke F. Debets et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping and identification of soft corona proteins at nanoparticles and their impact on cellular association

(2020) Hossein Mohammad-Beigi et al.   Nature Communications

Nanoparticle delivery in vivo: A fresh look from intravital imaging

(2020) Qiaoya Lin et al.   EBioMedicine

Overview of the Assessment of Endothelial Function in Humans

(2020) Po Ying Chia et al.   Frontiers in Medicine

Endothelial glycocalyx as an important factor in composition of blood‐brain barrier

(2020) Fangfang Zhao et al.   CNS Neuroscience & Therapeutics

Metabolic glycan labelling for cancer-targeted therapy

(2020) Hua Wang et al.   Nature Chemistry

Engineering precision nanoparticles for drug delivery

(2020) Michael J. Mitchell et al.   NATURE REVIEWS DRUG DISCOVERY

Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin

(2020) Courtney J. Mycroft-West et al.   THROMBOSIS AND HAEMOSTASIS

Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies

(2020) Lena Claesson-Welsh et al.   TRENDS IN MOLECULAR MEDICINE

Equilibrium Modeling of the Mechanics and Structure of the Cancer Glycocalyx

(2019) Jay G. Gandhi et al.   BIOPHYSICAL JOURNAL

Ultrasmall gold nanorods: synthesis and glycocalyx-related permeability in human endothelial cells

(2019) Ming J Cheng et al.   International Journal of Nanomedicine

Glycosylation in health and disease

(2019) Colin Reily et al.   Nature Reviews Nephrology

In Vitro Activity of a Novel Glycopolymer against Biofilms of Burkholderia cepacia Complex Cystic Fibrosis Clinical Isolates

(2019) Vidya P. Narayanaswamy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Physical Principles of Membrane Shape Regulation by the Glycocalyx

(2019) Carolyn R. Shurer et al.   CELL

Quantitative Super-Resolution Microscopy of the Mammalian Glycocalyx

(2019) Leonhard Möckl et al.   DEVELOPMENTAL CELL

Thrombin-cleaved syndecan-3/-4 ectodomain fragments mediate endothelial barrier dysfunction

(2019) Melanie Jannaway et al.   PLoS One

The role of endothelial glycocalyx in health and disease

(2019) Onur Yilmaz et al.   Clinical Kidney Journal

Corona Composition Can Affect the Mechanisms Cells Use to Internalize Nanoparticles

(2019) Valentina Francia et al.   ACS Nano

Hallmarks of Endothelial Cell Metabolism in Health and Disease

(2019) Xuri Li et al.   Cell Metabolism

Membrane tension regulates syndecan-1 expression through actin remodelling

(2019) Weiqi Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Tumor targeting via EPR: Strategies to enhance patient responses

(2018) Susanne K. Golombek et al.   ADVANCED DRUG DELIVERY REVIEWS

Endothelial Glycocalyx as a Shield Against Diabetic Vascular ComplicationsHighlights

(2018) Sophie Dogné et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Surface-Enhanced Raman Spectroscopy for Bioanalysis: Reliability and Challenges

(2018) Cheng Zong et al.   CHEMICAL REVIEWS

Niosomes decorated with dual ligands targeting brain endothelial transporters increase cargo penetration across the blood-brain barrier

(2018) Mária Mészáros et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

A Continuum Model of Mucosa with Glycan-Ion Pairing

(2018) James D. Sterling et al.   MACROMOLECULAR THEORY AND SIMULATIONS

Structure and elasticity of bush and brush-like models of the endothelial glycocalyx

(2018) Aleksei Kabedev et al.   Scientific Reports

Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization

(2018) Susan Hua et al.   Frontiers in Pharmacology

Adapting liposomes for oral drug delivery

(2018) Haisheng He et al.   Acta Pharmaceutica Sinica B

The GAGOme: a cell-based library of displayed glycosaminoglycans

(2018) Yen-Hsi Chen et al.   NATURE METHODS

Novel Glycopolymer Eradicates Antibiotic- and CCCP-Induced Persister Cells in Pseudomonas aeruginosa

(2018) Vidya P. Narayanaswamy et al.   Frontiers in Microbiology

Cellular uptake of modified aminoglycosides

(2017) Kaivin Hadidi et al.   JOURNAL OF ANTIBIOTICS

Endothelial glycocalyx as a critical signalling platform integrating the extracellular haemodynamic forces and chemical signalling

(2017) Ye Zeng   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Therapeutic Restoration of Endothelial Glycocalyx in Sepsis

(2017) J.W. Song et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Evidence of Ion-Pairing in Cationic Brushes from Evaluation of Brush Charging and Structure by Electrokinetic and Surface Conductivity Analysis

(2017) Ralf Zimmermann et al.   Journal of Physical Chemistry C

In vivo Imaging of the Cerebral Endothelial Glycocalyx in Mice

(2017) Jin-Hui Yoon et al.   JOURNAL OF VASCULAR RESEARCH

Structure-Activity Relationships of Bioengineered Heparin/Heparan Sulfates Produced in Different Bioreactors

(2017) et al.   MOLECULES

The glycocalyx regulates the uptake of nanoparticles by human endothelial cells in vitro

(2017) Leonhard Möckl et al.   Nanomedicine

Inflammation-induced brain endothelial activation leads to uptake of electrostatically stabilized iron oxide nanoparticles via sulfated glycosaminoglycans

(2017) Dominique Berndt et al.   Nanomedicine-Nanotechnology Biology and Medicine

Stromal Versican Regulates Tumor Growth by Promoting Angiogenesis

(2017) Keiichi Asano et al.   Scientific Reports

Glycosaminoglycan and Proteoglycan-Based Biomaterials: Current Trends and Future Perspectives

(2017) Jelena Rnjak-Kovacina et al.   Advanced Healthcare Materials

Personalized protein corona on nanoparticles and its clinical implications

(2017) Claudia Corbo et al.   Biomaterials Science

Regeneration of glycocalyx by heparan sulfate and sphingosine 1-phosphate restores inter-endothelial communication

(2017) Solomon A. Mensah et al.   PLoS One

Loss ofBiglycanEnhances Thrombin Generation inApolipoprotein E-Deficient MiceSignificance

(2016) Maria Grandoch et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial glycocalyx, apoptosis and inflammation in an atherosclerotic mouse model

(2016) Limary M. Cancel et al.   ATHEROSCLEROSIS

A novel 72-kDa leukocyte-derived osteoglycin enhances the activation of toll-like receptor 4 and exacerbates cardiac inflammation during viral myocarditis

(2016) Marieke Rienks et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The “in and out” of glucosamine 6-O-sulfation: the 6th sense of heparan sulfate

(2016) Rana El Masri et al.   GLYCOCONJUGATE JOURNAL

Endothelial glycocalyx conditions influence nanoparticle uptake for passive targeting

(2016) Eno Ebong et al.   International Journal of Nanomedicine

Uptake of citrate-coated iron oxide nanoparticles into atherosclerotic lesions in mice occurs via accelerated transcytosis through plaque endothelial cells

(2016) Wolfram C. Poller et al.   Nano Research

Controlled Immobilization Strategies to Probe Short Hyaluronan-Protein Interactions

(2016) Burcu Baykal Minsky et al.   Scientific Reports

Transport of Gold Nanoparticles by Vascular Endothelium from Different Human Tissues

(2016) Radka Gromnicova et al.   PLoS One

The intracellular trafficking mechanism of Lipofectamine-based transfection reagents and its implication for gene delivery

(2016) Francesco Cardarelli et al.   Scientific Reports

Combinatorial Biomolecular Nanopatterning for High-Throughput Screening of Stem-Cell Behavior

(2015) Yacoub Y. I. Amin et al.   ADVANCED MATERIALS

Protein Corona of Nanoparticles: Distinct Proteins Regulate the Cellular Uptake

(2015) Sandra Ritz et al.   BIOMACROMOLECULES

Heparin desulfation modulates VEGF release and angiogenesis in diabetic wounds

(2015) Uwe Freudenberg et al.   JOURNAL OF CONTROLLED RELEASE

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

(2015) Renato V. Iozzo et al.   MATRIX BIOLOGY

Insoluble drug delivery strategies: review of recent advances and business prospects

(2015) Sandeep Kalepu et al.   Acta Pharmaceutica Sinica B

The endothelial glycocalyx: a review of the vascular barrier

(2014) C. S. Alphonsus et al.   ANAESTHESIA

Shear-induced endothelial NOS activation and remodeling via heparan sulfate, glypican-1, and syndecan-1

(2014) Eno E. Ebong et al.   Integrative Biology

Secondary Structure of Corona Proteins Determines the Cell Surface Receptors Used by Nanoparticles

(2014) Candace C. Fleischer et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling

(2014) Megan S. Lord et al.   MATRIX BIOLOGY

Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions

(2014) Hana Kolářová et al.   MEDIATORS OF INFLAMMATION

Personalized protein coronas: a “key” factor at the nanobiointerface

(2014) Mohammad J. Hajipour et al.   Biomaterials Science

Engineered nanoparticles interacting with cells: size matters

(2014) Li Shang et al.   JOURNAL OF NANOBIOTECHNOLOGY

ADAMTS-4 and Biglycan are Expressed at High Levels and Co-Localize to Podosomes During Endothelial Cell Tubulogenesis In Vitro

(2013) Masanari Obika et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Reactive Oxygen Species Modulate the Barrier Function of the Human Glomerular Endothelial Glycocalyx

(2013) Anurag Singh et al.   PLoS One

Sialic Acid Associated with αvβ3Integrin Mediates HIV-1 Tat Protein Interaction and Endothelial Cell Proangiogenic Activation

(2012) Paola Chiodelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Doxil® — The first FDA-approved nano-drug: Lessons learned

(2012) Yechezkel (Chezy) Barenholz   JOURNAL OF CONTROLLED RELEASE

Spatio-temporal development of the endothelial glycocalyx layer and its mechanical property in vitro

(2012) K. Bai et al.   Journal of the Royal Society Interface

The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis

(2012) Eric P Schmidt et al.   NATURE MEDICINE

Endothelial Glycocalyx: Permeability Barrier and Mechanosensor

(2011) F. E. Curry et al.   ANNALS OF BIOMEDICAL ENGINEERING

A High Admission Syndecan-1 Level, A Marker of Endothelial Glycocalyx Degradation, Is Associated With Inflammation, Protein C Depletion, Fibrinolysis, and Increased Mortality in Trauma Patients

(2011) Pär I. Johansson et al.   ANNALS OF SURGERY

Imaging the Endothelial Glycocalyx In Vitro by Rapid Freezing/Freeze Substitution Transmission Electron Microscopy

(2011) Eno E. Ebong et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Multivalent Binding of Nanocarrier to Endothelial Cells under Shear Flow

(2011) Jin Liu et al.   BIOPHYSICAL JOURNAL

Extensive Determination of Glycan Heterogeneity Reveals an Unusual Abundance of High Mannose Glycans in Enriched Plasma Membranes of Human Embryonic Stem Cells

(2011) Hyun Joo An et al.   MOLECULAR & CELLULAR PROTEOMICS

Regulation of Endothelial Permeability via Paracellular and Transcellular Transport Pathways

(2010) Yulia Komarova et al.   Annual Review of Physiology

Endothelial glycocalyx and coronary vascular permeability: the fringe benefit

(2010) Bernhard F. Becker et al.   BASIC RESEARCH IN CARDIOLOGY

Effect of sulodexide on endothelial glycocalyx and vascular permeability in patients with type 2 diabetes mellitus

(2010) L. N. Broekhuizen et al.   DIABETOLOGIA

Proteoglycans in host–pathogen interactions: molecular mechanisms and therapeutic implications

(2010) Allison H. Bartlett et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Endocytosis of nanomedicines

(2010) Gaurav Sahay et al.   JOURNAL OF CONTROLLED RELEASE

Influence of nanoscale surface topography on protein adsorption and cellular response

(2010) Megan S. Lord et al.   Nano Today

Metabolic manipulation of glycosylation disorders in humans and animal models

(2010) Hudson H. Freeze et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

GLYCOCALYX PROTECTION REDUCES LEUKOCYTE ADHESION AFTER ISCHEMIA/REPERFUSION

(2010) Daniel Chappell et al.   SHOCK

The use of an endothelium-targeted cationic copolymer to enhance the barrier function of lung capillary endothelial monolayers

(2009) Kristina M. Giantsos et al.   BIOMATERIALS

Antithrombin reduces shedding of the endothelial glycocalyx following ischaemia/reperfusion

(2009) D. Chappell et al.   CARDIOVASCULAR RESEARCH

The Recovery Time Course of the Endothelial Cell Glycocalyx In Vivo and Its Implications In Vitro

(2009) Daniel R. Potter et al.   CIRCULATION RESEARCH

Arginine-rich cell-penetrating peptides

(2009) Nathan Schmidt et al.   FEBS LETTERS

Role of glycocalyx in flow-induced production of nitric oxide and reactive oxygen species

(2009) Robert Kumagai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Syndecan proteoglycan contributions to cytoskeletal organization and contractility

(2009) E. Okina et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

TNF-α induced shedding of the endothelial glycocalyx is prevented by hydrocortisone and antithrombin

(2008) Daniel Chappell et al.   BASIC RESEARCH IN CARDIOLOGY

Diverse Cell Signaling Events Modulated by Perlecan†

(2008) John M. Whitelock et al.   BIOCHEMISTRY

From shell to cell: neutron scattering studies of biological water dynamics and coupling to activity

(2008) A. Frölich et al.   FARADAY DISCUSSIONS

The design of guanidinium-rich transporters and their internalization mechanisms

(2007) Paul A. Wender et al.   ADVANCED DRUG DELIVERY REVIEWS