Macrophages bind LDL using heparan sulfate and the perlecan protein core

Convenience versus Biological Significance: Are PMA-Differentiated THP-1 Cells a Reliable Substitute for Blood-Derived Macrophages When Studying in Vitro Polarization?

(2018) Serena Tedesco et al.   Frontiers in Pharmacology

Effect of Polarization and Chronic Inflammation on Macrophage Expression of Heparan Sulfate Proteoglycans and Biosynthesis Enzymes

(2018) Maarten Swart et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Chondroitin sulfate N-acetylgalactosaminyltransferase-2 deletion alleviates lipoprotein retention in early atherosclerosis and attenuates aortic smooth muscle cell migration

(2018) Imam Manggalya Adhikara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ginsenoside Rb1 enhances atherosclerotic plaque stability by skewing macrophages to the M2 phenotype

(2017) Xue Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The central role of arterial retention of cholesterol-rich apolipoprotein-B-containing lipoproteins in the pathogenesis of atherosclerosis

(2016) Jan Borén et al.   CURRENT OPINION IN LIPIDOLOGY

Bioengineered human heparin with anticoagulant activity

(2016) Megan S. Lord et al.   METABOLIC ENGINEERING

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

(2015) Renato V. Iozzo et al.   MATRIX BIOLOGY

The glycosylation-dependent interaction of perlecan core protein with LDL: implications for atherosclerosis

(2014) Yu-Xin Xu et al.   JOURNAL OF LIPID RESEARCH

A rapid increase in macrophage-derived versican and hyaluronan in infectious lung disease

(2014) Mary Y. Chang et al.   MATRIX BIOLOGY

The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling

(2014) Megan S. Lord et al.   MATRIX BIOLOGY

Macrophage subsets in atherosclerosis

(2014) Giulia Chinetti-Gbaguidi et al.   Nature Reviews Cardiology

Sulfation of the Bikunin Chondroitin Sulfate Chain Determines Heavy Chain·Hyaluronan Complex Formation

(2013) Megan S. Lord et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fluid-Phase Pinocytosis of Native Low Density Lipoprotein Promotes Murine M-CSF Differentiated Macrophage Foam Cell Formation

(2013) Manoj K. Barthwal et al.   PLoS One

Distribution of macrophage polarization markers in human atherosclerosis

(2012) J. Lauran Stöger et al.   ATHEROSCLEROSIS

Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells enhances binding of LDL to proteoglycans

(2012) Narin Osman et al.   CARDIOVASCULAR PATHOLOGY

Interleukin-13 protects from atherosclerosis and modulates plaque composition by skewing the macrophage phenotype

(2012) Larissa Cardilo-Reis et al.   EMBO Molecular Medicine

In Vitro Generation of Monocyte-Derived Macrophages under Serum-Free Conditions Improves Their Tumor Promoting Functions

(2012) Flora Rey-Giraud et al.   PLoS One

The use of THP-1 cells as a model for mimicking the function and regulation of monocytes and macrophages in the vasculature

(2011) Zhenyu Qin   ATHEROSCLEROSIS

Regulation of heparanase expression in coronary artery disease in diabetic, hyperlipidemic swine

(2010) Aaron B. Baker et al.   ATHEROSCLEROSIS

Macrophages exposed to hypoxia secrete proteoglycans for which LDL has higher affinity

(2010) Annika Asplund et al.   ATHEROSCLEROSIS

Oxidized LDL enhances pro-inflammatory responses of alternatively activated M2 macrophages: A crucial role for Krüppel-like factor 2

(2010) L.J.H. van Tits et al.   ATHEROSCLEROSIS

Endothelin-1 activates ETA receptors on human vascular smooth muscle cells to yield proteoglycans with increased binding to LDL

(2009) Mandy L. Ballinger et al.   ATHEROSCLEROSIS

Hypoxic regulation of secreted proteoglycans in macrophages

(2009) Annika Asplund et al.   GLYCOBIOLOGY

Hypoxia increases macrophage motility, possibly by decreasing the heparan sulfate proteoglycan biosynthesis

(2009) Annika Asplund et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Hyperelongated biglycan: the surreptitious initiator of atherosclerosis

(2008) Peter J Little et al.   CURRENT OPINION IN LIPIDOLOGY

Hypoxia, Hypoxia-Inducible Transcription Factor, and Macrophages in Human Atherosclerotic Plaques Are Correlated With Intraplaque Angiogenesis

(2008) Judith C. Sluimer et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark

Characterization and Purification of Glycosaminoglycans from Crude Biological Samples

(2007) N. P. Davies et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY