Coupling Heme and Iron Metabolism via Ferritin H Chain

Lactoferrin Decreases Inflammatory Response by Cystic Fibrosis Bronchial Cells Invaded with Burkholderia Cenocepacia Iron-Modulated Biofilm

(2017) P. Valenti et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Interplay Between Heme Oxygenase-1 and miR-378 Affects Non-Small Cell Lung Carcinoma Growth, Vascularization, and Metastasis

(2013) Klaudia Skrzypek et al.   ANTIOXIDANTS & REDOX SIGNALING

TNF Dually Mediates Resistance and Susceptibility to Mycobacteria via Mitochondrial Reactive Oxygen Species

(2013) Francisco J. Roca et al.   CELL

Iron in Infection and Immunity

(2013) James E. Cassat et al.   Cell Host & Microbe

HRG1 Is Essential for Heme Transport from the Phagolysosome of Macrophages during Erythrophagocytosis

(2013) Carine White et al.   Cell Metabolism

Heme transport and erythropoiesis

(2013) Xiaojing Yuan et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Heme Catabolism by Heme Oxygenase-1 Confers Host Resistance to Mycobacterium Infection

(2013) Sandro Silva-Gomes et al.   INFECTION AND IMMUNITY

Nitric oxide–mediated regulation of ferroportin-1 controls macrophage iron homeostasis and immune function in Salmonella infection

(2013) Manfred Nairz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural insight into the lactoferrin receptors from pathogenic Neisseria

(2013) Nicholas Noinaj et al.   JOURNAL OF STRUCTURAL BIOLOGY

Lysosomal Iron, Iron Chelation, and Cell Death

(2012) Alexei Terman et al.   ANTIOXIDANTS & REDOX SIGNALING

Ferroportin expression in haem oxygenase 1-deficient mice

(2012) Rafał R. Starzyński et al.   BIOCHEMICAL JOURNAL

Lactoferrin, a bird’s eye view

(2012) Hans J. Vogel   Biochemistry and Cell Biology

Hepcidin and iron homeostasis

(2012) Tomas Ganz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The triumph of good over evil: protection by the sickle gene against malaria

(2012) H. F. Bunn   BLOOD

Pretreatment with CO-releasing molecules suppresses hepcidin expression during inflammation and endoplasmic reticulum stress through inhibition of the STAT3 and CREBH pathways

(2012) D.-Y. Shin et al.   BLOOD

Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production

(2012) G. B. Fortes et al.   BLOOD

Metabolic Adaptation to Tissue Iron Overload Confers Tolerance to Malaria

(2012) Raffaella Gozzelino et al.   Cell Host & Microbe

The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation

(2012) Deborah Chiabrando et al.   JOURNAL OF CLINICAL INVESTIGATION

Slc11a1 (Nramp1) impairs growth of Salmonella enterica serovar typhimurium in macrophages via stimulation of lipocalin-2 expression

(2012) Gernot Fritsche et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The catalytic center of ferritin regulates iron storage via Fe(II)-Fe(III) displacement

(2012) Kourosh Honarmand Ebrahimi et al.   Nature Chemical Biology

ABCB6 is dispensable for erythropoiesis and specifies the new blood group system Langereis

(2012) Virginie Helias et al.   NATURE GENETICS

Null alleles of ABCG2 encoding the breast cancer resistance protein define the new blood group system Junior

(2012) Carole Saison et al.   NATURE GENETICS

Iron Overload in Human Disease

(2012) Robert E. Fleming et al.   NEW ENGLAND JOURNAL OF MEDICINE

Shifting the Paradigm: The Putative Mitochondrial Protein ABCB6 Resides in the Lysosomes of Cells and in the Plasma Membrane of Erythrocytes

(2012) Katalin Kiss et al.   PLoS One

Hepcidin and the Iron-Infection Axis

(2012) H. Drakesmith et al.   SCIENCE

Disease Tolerance as a Defense Strategy

(2012) R. Medzhitov et al.   SCIENCE

Insulin/IGF-1 and Hypoxia Signaling Act in Concert to Regulate Iron Homeostasis in Caenorhabditis elegans

(2012) Daniel Ackerman et al.   PLoS Genetics

Heme Cytotoxicity and the Pathogenesis of Immune-Mediated Inflammatory Diseases

(2012) Rasmus Larsen et al.   Frontiers in Pharmacology

Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation

(2011) Chia Chi Sun et al.   AMERICAN JOURNAL OF HEMATOLOGY

Hepcidin and iron regulation, 10 years later

(2011) T. Ganz   BLOOD

Ironing Out Cancer

(2011) S. V. Torti et al.   CANCER RESEARCH

Sickle Hemoglobin Confers Tolerance to Plasmodium Infection

(2011) Ana Ferreira et al.   CELL

Cell sensitivity to oxidative stress is influenced by ferritin autophagy

(2011) Tino Kurz et al.   FREE RADICAL BIOLOGY AND MEDICINE

Heme oxygenase 1 is induced by miR-155 via reduced BACH1 translation in endothelial cells

(2011) Kati H. Pulkkinen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice

(2011) Emilio Ramos et al.   HEPATOLOGY

Haem oxygenase-1 dictates intrauterine fetal survival in mice via carbon monoxide

(2011) Maria Laura Zenclussen et al.   JOURNAL OF PATHOLOGY

Iron metabolism and the innate immune response to infection

(2011) Erin E. Johnson et al.   MICROBES AND INFECTION

Distinct Mechanisms of Ferritin Delivery to Lysosomes in Iron-Depleted and Iron-Replete Cells

(2011) T. Asano et al.   MOLECULAR AND CELLULAR BIOLOGY

Lessons from Sickle Cell Disease in the Treatment and Control of Malaria

(2011) Philip J. Rosenthal   NEW ENGLAND JOURNAL OF MEDICINE

Structural analysis of heme proteins: implications for design and prediction

(2011) Ting Li et al.   BMC STRUCTURAL BIOLOGY

Mutations in FLVCR1 Cause Posterior Column Ataxia and Retinitis Pigmentosa

(2010) Anjali M. Rajadhyaksha et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Hepcidin and Disorders of Iron Metabolism

(2010) Tomas Ganz et al.   Annual Review of Medicine

Mechanisms of Cell Protection by Heme Oxygenase-1

(2010) Raffaella Gozzelino et al.   Annual Review of Pharmacology and Toxicology

Redox properties of heme peroxidases

(2010) Gianantonio Battistuzzi et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

miR-122-induced down-regulation of HO-1 negatively affects miR-122-mediated suppression of HBV

(2010) Lipeng Qiu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cytosolic and mitochondrial ferritins in the regulation of cellular iron homeostasis and oxidative damage

(2010) Paolo Arosio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Dysfunction of the heme recycling system in heme oxygenase 1-deficient mice: effects on macrophage viability and tissue iron distribution

(2010) G. Kovtunovych et al.   BLOOD

Role of ferritin alterations in human breast cancer cells

(2010) Svitlana I. Shpyleva et al.   BREAST CANCER RESEARCH AND TREATMENT

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

Intestinal Ferritin H Is Required for an Accurate Control of Iron Absorption

(2010) Liviu Vanoaica et al.   Cell Metabolism

Regulation of Heme Oxygenase-1 Protein Expression by miR-377 in Combination with miR-217

(2010) Joan D. Beckman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Yeast Homolog of Heme Oxygenase-1 Affords Cellular Antioxidant Protection via the Transcriptional Regulation of Known Antioxidant Genes

(2010) Emma J. Collinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepcidin in human iron disorders: Therapeutic implications

(2010) Antonello Pietrangelo   JOURNAL OF HEPATOLOGY

The Fowler Syndrome-Associated Protein FLVCR2 Is an Importer of Heme

(2010) S. P. Duffy et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol

(2010) D. R. Richardson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ferroportin and Iron Regulation in Breast Cancer Progression and Prognosis

(2010) Z. K. Pinnix et al.   Science Translational Medicine

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

(2010) R. Larsen et al.   Science Translational Medicine

Lipocalin-2 Resistance Confers an Advantage to Salmonella enterica Serotype Typhimurium for Growth and Survival in the Inflamed Intestine

(2009) Manuela Raffatellu et al.   Cell Host & Microbe

Iron in innate immunity: starve the invaders

(2009) Tomas Ganz   CURRENT OPINION IN IMMUNOLOGY

Immunoregulatory effects of HO-1: how does it work?

(2009) Miguel P Soares et al.   CURRENT OPINION IN PHARMACOLOGY

Bilirubin and glutathione have complementary antioxidant and cytoprotective roles

(2009) T. W. Sedlak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heme oxygenase-1 affords protection against noncerebral forms of severe malaria

(2009) E. Seixas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heme oxygenase-1: from biology to therapeutic potential

(2009) Miguel P. Soares et al.   TRENDS IN MOLECULAR MEDICINE

The biochemistry of heme biosynthesis

(2008) Ilka U. Heinemann et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Forging a field: the golden age of iron biology

(2008) N. C. Andrews   BLOOD

Functional identification of HugZ, a heme oxygenase from Helicobacter pylori

(2008) Ying Guo et al.   BMC MICROBIOLOGY

Nramp1 drives an accelerated inflammatory response duringSalmonella-induced colitis in mice

(2008) Yanet Valdez et al.   CELLULAR MICROBIOLOGY

Role and regulation of ferritin H in rotenone-mediated mitochondrial oxidative stress

(2008) Elizabeth L. MacKenzie et al.   FREE RADICAL BIOLOGY AND MEDICINE

A central role for free heme in the pathogenesis of severe malaria: the missing link?

(2008) Ana Ferreira et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Regulation of Mitochondrial Iron Import through Differential Turnover of Mitoferrin 1 and Mitoferrin 2

(2008) P. N. Paradkar et al.   MOLECULAR AND CELLULAR BIOLOGY

Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins

(2008) Abbhirami Rajagopal et al.   NATURE

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

A Heme Export Protein Is Required for Red Blood Cell Differentiation and Iron Homeostasis

(2008) S. B. Keel et al.   SCIENCE

The Regulation of Hepcidin and Its Effects on Systemic and Cellular Iron Metabolism

(2008) M. D. Fleming   Hematology-American Society of Hematology Education Program