DNA Methylation: A Promising Approach in Management of Alzheimer’s Disease and Other Neurodegenerative Disorders

Neuroprotective potential of cinnamon and its metabolites in Parkinson's disease: Mechanistic insights, limitations, and novel therapeutic opportunities

(2021) Efthalia Angelopoulou et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Cell-Type Specific Changes in DNA Methylation of SNCA Intron 1 in Synucleinopathy Brains

(2021) Jeffrey Gu et al.   Frontiers in Neuroscience

DNA Methylation in Huntington’s Disease

(2021) Nóra Zsindely et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroprotective Potential of Chrysin: Mechanistic Insights and Therapeutic Potential for Neurological Disorders

(2021) Awanish Mishra et al.   MOLECULES

CpG and non-CpG Presenilin1 methylation pattern in course of neurodevelopment and neurodegeneration is associated with gene expression in human and murine brain

(2020) Noemi Monti et al.   Epigenetics

Psychosis-associated DNA methylomic variation in Alzheimer's disease cortex

(2020) Ehsan Pishva et al.   NEUROBIOLOGY OF AGING

DNA Methylation in Neurodegenerative and Cerebrovascular Disorders

(2020) Olaia Martínez-Iglesias et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DNA Methylation Biomarkers in Aging and Age-Related Diseases

(2020) Yasmeen Salameh et al.   Frontiers in Genetics

Genome-wide epigenetic analyses in Japanese immigrant plantation workers with Parkinson’s disease and exposure to organochlorines reveal possible involvement of glial genes and pathways involved in neurotoxicity

(2020) Rodney C. P. Go et al.   BMC NEUROSCIENCE

Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms

(2020) Linfeng Gao et al.   Nature Communications

Lower DNA methylation levels in CpG island shores of CR1, CLU, and PICALM in the blood of Japanese Alzheimer’s disease patients

(2020) Risa Mitsumori et al.   PLoS One

Epigenetics: Recent Advances and Its Role in the Treatment of Alzheimer's Disease

(2020) Xuewen Xiao et al.   Frontiers in Neurology

Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer’s disease

(2019) Adam R. Smith et al.   Clinical Epigenetics

Integrated DNA methylation and gene expression analysis in the pathogenesis of coronary artery disease

(2019) Liu Miao et al.   Aging-US

Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer’s disease pathology and cognitive symptoms

(2019) Peipei Li et al.   Nature Communications

DNA methylation signature of human hippocampus in Alzheimer’s disease is linked to neurogenesis

(2019) Miren Altuna et al.   Clinical Epigenetics

Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology

(2018) Rebecca G. Smith et al.   Alzheimers & Dementia

PICALM Gene Methylation in Blood of Alzheimer’s Disease Patients Is Associated with Cognitive Decline

(2018) Roberta Mercorio et al.   JOURNAL OF ALZHEIMERS DISEASE

Pyrosequencing analysis of methylation levels of clock genes in leukocytes from Parkinson’s disease patients

(2018) Wei Mao et al.   NEUROSCIENCE LETTERS

Epigenetic Regulation in Neurodegenerative Diseases

(2018) Amit Berson et al.   TRENDS IN NEUROSCIENCES

Altered Regulation of KIAA0566, and Katanin Signaling Expression in the Locus Coeruleus With Neurofibrillary Tangle Pathology

(2018) Pol Andrés-Benito et al.   Frontiers in Cellular Neuroscience

Elevated methylation of OPRM1 and OPRL1 genes in Alzheimer's disease

(2018) Chunshuang Xu et al.   Molecular Medicine Reports

Mitochondrial DNA copy number and D-loop region methylation in carriers of amyotrophic lateral sclerosis gene mutations

(2018) Andrea Stoccoro et al.   Epigenomics

PLD3 epigenetic changes in the hippocampus of Alzheimer’s disease

(2018) Idoia Blanco-Luquin et al.   Clinical Epigenetics

DNA Methylation Profiles in Whole Blood of Huntington's Disease Patients

(2018) Maja Zadel et al.   Frontiers in Neurology

Pharmacoepigenomic Interventions as Novel Potential Treatments for Alzheimer’s and Parkinson’s Diseases

(2018) Oscar Teijido et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DNA Hypomethylation in Blood Links B3GALT4 and ZADH2 to Alzheimer’s Disease

(2018) Andy Madrid et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's disease DNA methylome of pyramidal layers in frontal cortex: laser-assisted microdissection study

(2018) Hernán Guillermo Hernández et al.   Epigenomics

A cross-brain regions study of ANK1 DNA methylation in different neurodegenerative diseases

(2018) Adam R. Smith et al.   NEUROBIOLOGY OF AGING

DNA methylation variability in Alzheimer's disease

(2018) Zhiguang Huo et al.   NEUROBIOLOGY OF AGING

Higher Peripheral TREM2 mRNA Levels Relate to Cognitive Deficits and Hippocampal Atrophy in Alzheimer’s Disease and Amnestic Mild Cognitive Impairment

(2017) Yi Jayne Tan et al.   JOURNAL OF ALZHEIMERS DISEASE

Opening up the DNA methylome of dementia

(2017) R Delgado-Morales et al.   MOLECULAR PSYCHIATRY

The role of BDNF in Alzheimer's disease

(2017) Heikki Tanila   NEUROBIOLOGY OF DISEASE

Association of OPRK1 and OPRM1 methylation with mild cognitive impairment in Xinjiang Han and Uygur populations

(2017) Guili Liu et al.   NEUROSCIENCE LETTERS

Parkinson’s disease is associated with DNA methylation levels in human blood and saliva

(2017) Yu-Hsuan Chuang et al.   Genome Medicine

Hypomethylation of intron1 of α-synuclein gene does not correlate with Parkinson’s disease

(2017) Subhrangshu Guhathakurta et al.   Molecular Brain

Implications of DNA Methylation in Parkinson’s Disease

(2017) Ernesto Miranda-Morales et al.   Frontiers in Molecular Neuroscience

Altered Mitochondrial DNA Methylation Pattern in Alzheimer Disease–Related Pathology and in Parkinson Disease

(2016) Marta Blanch et al.   AMERICAN JOURNAL OF PATHOLOGY

5-Hydroxymethylation-associated epigenetic modifiers of Alzheimer’s disease modulate Tau-induced neurotoxicity

(2016) Alison I. Bernstein et al.   HUMAN MOLECULAR GENETICS

Elevated mRNA Expression and Low Methylation of SNCA in Japanese Alzheimer’s Disease Subjects

(2016) Yuta Yoshino et al.   JOURNAL OF ALZHEIMERS DISEASE

DNA methylation in Parkinson's disease

(2016) Ullrich Wüllner et al.   JOURNAL OF NEUROCHEMISTRY

Association of gene expression and methylation of UQCRC1 to the predisposition of Alzheimer's disease in a Chinese population

(2016) Suk Ling Ma et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Neurofilament-labeled pyramidal neurons and astrocytes are deficient in DNA methylation marks in Alzheimer's disease

(2016) Andrew J. Phipps et al.   NEUROBIOLOGY OF AGING

Dose-dependent progression of parkinsonism in manganese-exposed welders

(2016) Brad A. Racette et al.   NEUROLOGY

DNA methylation in Huntington’s disease: Implications for transgenerational effects

(2016) Elizabeth A. Thomas   NEUROSCIENCE LETTERS

DNA methylation changes atSNCAintron 1 in patients with dementia with Lewy bodies

(2016) Yu Funahashi et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

CRTC1 gene is differentially methylated in the human hippocampus in Alzheimer’s disease

(2016) Maite Mendioroz et al.   Alzheimers Research & Therapy

TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer’s disease hippocampus

(2016) Naiara Celarain et al.   Clinical Epigenetics

Epigenetic Research of Neurodegenerative Disorders Using Patient iPSC-Based Models

(2016) Rubén Fernández-Santiago et al.   Stem Cells International

Methylation status of DJ-1 in leukocyte DNA of Parkinson’s disease patients

(2016) Yuyan Tan et al.   Translational Neurodegeneration

Role of the Long Non-Coding RNA MAPT-AS1 in Regulation of Microtubule Associated Protein Tau (MAPT) Expression in Parkinson's Disease

(2016) Kirsten G. Coupland et al.   PLoS One

Inhibition of DNA Methyltransferases Blocks Mutant Huntingtin-Induced Neurotoxicity

(2016) Yanchun Pan et al.   Scientific Reports

Understanding the function of ABCA7 in Alzheimer's disease

(2015) H. Li et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Function and information content of DNA methylation

(2015) Dirk Schübeler   NATURE

Alterations in global DNA methylation and hydroxymethylation are not detected in Alzheimer's disease

(2015) Tammaryn Lashley et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Inducible nitric oxide synthase gene methylation and parkinsonism in manganese-exposed welders

(2015) Susan Searles Nielsen et al.   PARKINSONISM & RELATED DISORDERS

Exploring the Epigenetics of Alzheimer Disease

(2015) Bryan J. Traynor et al.   JAMA Neurology

Association of Brain DNA Methylation inSORL1,ABCA7,HLA-DRB5,SLC24A4, andBIN1With Pathological Diagnosis of Alzheimer Disease

(2015) Lei Yu et al.   JAMA Neurology

PGC−1α Promoter Methylation in Parkinson’s Disease

(2015) Xiaomin Su et al.   PLoS One

The Role of H3K4me3 in Transcriptional Regulation Is Altered in Huntington’s Disease

(2015) Xianjun Dong et al.   PLoS One

Highly sensitive targeted methylome sequencing by post-bisulfite adaptor tagging

(2014) Fumihito Miura et al.   DNA RESEARCH

Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains

(2014) Guang Bai et al.   HUMAN MOLECULAR GENETICS

PLD3 in Alzheimer’s Disease

(2014) Jun Wang et al.   MOLECULAR NEUROBIOLOGY

Epigenome-Wide Association Study for Parkinson’s Disease

(2014) Kerry Moore et al.   NEUROMOLECULAR MEDICINE

Elevation of Peripheral BDNF Promoter Methylation Links to the Risk of Alzheimer's Disease

(2014) Lan Chang et al.   PLoS One

Striatal adenosine A2A receptor expression is controlled by S-adenosyl-L-methionine-mediated methylation

(2014) Izaskun Villar-Menéndez et al.   Purinergic Signalling

Epigenetic mechanisms in Alzheimer's disease: Implications for pathogenesis and therapy

(2013) Jun Wang et al.   AGEING RESEARCH REVIEWS

A DNA Methyltransferase Inhibitor, 5-Aza-2′-Deoxycytidine, Exacerbates Neurotoxicity and Upregulates Parkinson's Disease-Related Genes in Dopaminergic Neurons

(2013) Yong Wang et al.   CNS Neuroscience & Therapeutics

Distinctive patterns of DNA methylation associated with Parkinson disease

(2013) Eliezer Masliah et al.   Epigenetics

Amyloid precursor protein expression is enhanced in human platelets from subjects with Alzheimer's disease and frontotemporal lobar degeneration: A Real-time PCR study

(2013) Arianna Vignini et al.   EXPERIMENTAL GERONTOLOGY

Hypomethylation of long interspersed nuclear element-1 (LINE-1) leads to activation of proto-oncogenes in human colorectal cancer metastasis

(2013) Keun Hur et al.   GUT

Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease

(2013) Fengli Wang et al.   HUMAN MOLECULAR GENETICS

Epigenetic changes in the progression of Alzheimer's disease

(2013) M.A. Bradley-Whitman et al.   MECHANISMS OF AGEING AND DEVELOPMENT

DNA methylation of theMAPTgene in Parkinson's disease cohorts and modulation by vitamin EIn Vitro

(2013) Kirsten G. Coupland et al.   MOVEMENT DISORDERS

Altered DNA methylation and RNA splicing could be key mechanisms in Huntington disease

(2013) Heather Wood   Nature Reviews Neurology

Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients

(2013) Leonidas Chouliaras et al.   NEUROBIOLOGY OF AGING

Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain

(2013) Natacha Coppieters et al.   NEUROBIOLOGY OF AGING

Increased 5-Methylcytosine and Decreased 5-Hydroxymethylcytosine Levels are Associated with Reduced Striatal A2AR Levels in Huntington’s Disease

(2013) Izaskun Villar-Menéndez et al.   NEUROMOLECULAR MEDICINE

Epigenetic Mechanisms of Neurodegeneration in Huntington’s Disease

(2013) Junghee Lee et al.   Neurotherapeutics

Aberrant Regulation of DNA Methylation in Amyotrophic Lateral Sclerosis: A New Target of Disease Mechanisms

(2013) Lee J. Martin et al.   Neurotherapeutics

Monetary Costs of Dementia in the United States

(2013) Michael D. Hurd et al.   NEW ENGLAND JOURNAL OF MEDICINE

Peptidylarginine deiminase and protein citrullination in prion diseases

(2013) Byungki Jang et al.   Prion

Extensive changes in DNA methylation are associated with expression of mutant huntingtin

(2013) C. W. Ng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease

(2013) Meng-Shan Tan et al.   TRENDS IN MOLECULAR MEDICINE

Changes in methylation patterns of multiple genes from peripheral blood leucocytes of Alzheimer's disease patients

(2012) Yaping Hou et al.   ACTA NEUROPSYCHIATRICA

DNA methylation at promoter regions of interleukin 1B, interleukin 6, and interleukin 8 in non-small cell lung cancer

(2012) Xavier Tekpli et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Global Methylation Profiling for Risk Prediction of Prostate Cancer

(2012) S. Mahapatra et al.   CLINICAL CANCER RESEARCH

Genome-scale methylation analysis of Parkinson's disease patients' brains reveals DNA hypomethylation and increased mRNA expression of cytochrome P450 2E1

(2012) Oliver Kaut et al.   NEUROGENETICS

DNA Methylation and Its Basic Function

(2012) Lisa D Moore et al.   NEUROPSYCHOPHARMACOLOGY

Identification of Epigenetically Altered Genes in Sporadic Amyotrophic Lateral Sclerosis

(2012) Claudia Figueroa-Romero et al.   PLoS One

Histone tails regulate DNA methylation by allosterically activating de novo methyltransferase

(2011) Bin-Zhong Li et al.   CELL RESEARCH

Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson’s disease

(2011) Giuseppa Mudò et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Study of Methylation Levels of Parkin Gene Promoter in Parkinson's Disease Patients

(2011) Miao Cai et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Epigenetic Regulation of Motor Neuron Cell Death through DNA Methylation

(2011) B. A. Chestnut et al.   JOURNAL OF NEUROSCIENCE

Neuronal activity modifies the DNA methylation landscape in the adult brain

(2011) Junjie U Guo et al.   NATURE NEUROSCIENCE

Loss of activity-induced phosphorylation of MeCP2 enhances synaptogenesis, LTP and spatial memory

(2011) Hongda Li et al.   NATURE NEUROSCIENCE

Gene expression profiling of R6/2 transgenic mice with different CAG repeat lengths reveals genes associated with disease onset and progression in Huntington's disease

(2011) Bin Tang et al.   NEUROBIOLOGY OF DISEASE

Next-Generation Sequencing Reveals Regional Differences of the α-Synuclein Methylation State Independent of Lewy Body Disease

(2011) L. de Boni et al.   NEUROMOLECULAR MEDICINE

Genome-Wide Activity-Dependent MeCP2 Phosphorylation Regulates Nervous System Development and Function

(2011) Sonia Cohen et al.   NEURON

Promoter methylation analysis of seven clock genes in Parkinson's disease

(2011) Qingling Lin et al.   NEUROSCIENCE LETTERS

PGC-1α at the intersection of bioenergetics regulation and neuron function: From Huntington's disease to Parkinson's disease and beyond

(2011) Taiji Tsunemi et al.   PROGRESS IN NEUROBIOLOGY

The decrease of β-synuclein in cortical brain areas defines a molecular subgroup of dementia with Lewy bodies

(2010) Katrin Beyer et al.   BRAIN

Methylation Regulates Alpha-Synuclein Expression and Is Decreased in Parkinson's Disease Patients' Brains

(2010) A. Jowaed et al.   JOURNAL OF NEUROSCIENCE

Clinical spectrum of Kufor-Rakeb syndrome in the Chilean kindred with ATP13A2 mutations

(2010) Maria I. Behrens et al.   MOVEMENT DISORDERS

Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons

(2010) Jian Feng et al.   NATURE NEUROSCIENCE

Principles and challenges of genome-wide DNA methylation analysis

(2010) Peter W. Laird   NATURE REVIEWS GENETICS

Origin and evolution of peptide-modifying dioxygenases and identification of the wybutosine hydroxylase/hydroperoxidase

(2010) L. M. Iyer et al.   NUCLEIC ACIDS RESEARCH

CpG Demethylation Enhances Alpha-Synuclein Expression and Affects the Pathogenesis of Parkinson's Disease

(2010) Lumine Matsumoto et al.   PLoS One

Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates

(2010) Daniel Globisch et al.   PLoS One

Active DNA Demethylation Mediated by DNA Glycosylases

(2009) Jian-Kang Zhu   Annual Review of Genetics

Alterations of Zinc Transporter Proteins ZnT-1, ZnT-4 and ZnT-6 in Preclinical Alzheimer's Disease Brain

(2009) Ganna Lyubartseva et al.   BRAIN PATHOLOGY

A Unifying Model for the Selective Regulation of Inducible Transcription by CpG Islands and Nucleosome Remodeling

(2009) Vladimir R. Ramirez-Carrozzi et al.   CELL

Expression of clock genesPer1andBmal1in total leukocytes in health and Parkinson’s disease

(2009) Y. Cai et al.   EUROPEAN JOURNAL OF NEUROLOGY

Dynamic expression of the Slit-Robo GTPase activating protein genes during development of the murine nervous system

(2009) Claire Bacon et al.   JOURNAL OF COMPARATIVE NEUROLOGY

DNA Methylation of Alzheimer Disease and Tauopathy-Related Genes in Postmortem Brain

(2009) Marta Barrachina et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Human DNA methylomes at base resolution show widespread epigenomic differences

(2009) Ryan Lister et al.   NATURE

Genome-wide association study reveals genetic risk underlying Parkinson's disease

(2009) Javier Simón-Sánchez et al.   NATURE GENETICS

Linking DNA methylation and histone modification: patterns and paradigms

(2009) Howard Cedar et al.   NATURE REVIEWS GENETICS

Epigenetic regulation of nervous system development by DNA methylation and histone deacetylation

(2009) Jessica L. MacDonald et al.   PROGRESS IN NEUROBIOLOGY

Cellular distribution of the C-type II lectin dendritic cell immunoreceptor (DCIR) and its expression in the rheumatic joint: identification of a subpopulation of DCIR+ T cells

(2008) C Eklow et al.   ANNALS OF THE RHEUMATIC DISEASES

Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines

(2008) Christopher J. Henry et al.   BRAIN BEHAVIOR AND IMMUNITY

Epigenetic Regulation of bdnf Gene Transcription in the Consolidation of Fear Memory

(2008) F. D. Lubin et al.   JOURNAL OF NEUROSCIENCE

Runx transcription factors in neuronal development

(2008) Ken-ichi Inoue et al.   Neural Development

Different methylation of the TNF-alpha promoter in cortex and substantia nigra: Implications for selective neuronal vulnerability

(2008) Heike C. Pieper et al.   NEUROBIOLOGY OF DISEASE

Age-Specific Epigenetic Drift in Late-Onset Alzheimer's Disease

(2008) Sun-Chong Wang et al.   PLoS One