DNA methylation signature of human hippocampus in Alzheimer’s disease is linked to neurogenesis

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

(2019) Elena P. Moreno-Jiménez et al.   NATURE MEDICINE

Genetic ablation of tau in postnatal neurons rescues decreased adult hippocampal neurogenesis in a tauopathy model

(2019) Sarah Houben et al.   NEUROBIOLOGY OF DISEASE

Molecular profiling of aged neural progenitors identifies Dbx2 as a candidate regulator of age-associated neurogenic decline

(2018) Giuseppe Lupo et al.   AGING CELL

Genome-Wide DNA Methylation Differences Between Late-Onset Alzheimer's Disease and Cognitively Normal Controls in Human Frontal Cortex

(2018) Kelly M. Bakulski et al.   JOURNAL OF ALZHEIMERS DISEASE

Opening up the DNA methylome of dementia

(2017) R Delgado-Morales et al.   MOLECULAR PSYCHIATRY

The epigenome in Alzheimer’s disease: current state and approaches for a new path to gene discovery and understanding disease mechanism

(2016) Hans-Ulrich Klein et al.   ACTA NEUROPATHOLOGICA

Novel function of Tau in regulating the effects of external stimuli on adult hippocampal neurogenesis

(2016) Noemí Pallas‐Bazarra et al.   EMBO JOURNAL

Defeating Alzheimer's disease and other dementias: a priority for European science and society

(2016) Bengt Winblad et al.   LANCET NEUROLOGY

Polygenic risk of Alzheimer disease is associated with early- and late-life processes

(2016) Elizabeth C. Mormino et al.   NEUROLOGY

CRTC1 gene is differentially methylated in the human hippocampus in Alzheimer’s disease

(2016) Maite Mendioroz et al.   Alzheimers Research & Therapy

Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer’s disease

(2016) Corey T. Watson et al.   Genome Medicine

TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer’s disease hippocampus

(2016) Naiara Celarain et al.   Clinical Epigenetics

Chromatin remodeling and bivalent histone modifications in embryonic stem cells

(2015) A. Harikumar et al.   EMBO REPORTS

Imprinting control regions (ICRs) are marked by mono-allelic bivalent chromatin when transcriptionally inactive

(2015) Stéphanie Maupetit-Méhouas et al.   NUCLEIC ACIDS RESEARCH

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Epigenetic Alterations in Alzheimer’s Disease

(2015) Jose V. Sanchez-Mut et al.   Frontiers in Behavioral Neuroscience

Association of Brain DNA Methylation inSORL1,ABCA7,HLA-DRB5,SLC24A4, andBIN1With Pathological Diagnosis of Alzheimer Disease

(2015) Lei Yu et al.   JAMA Neurology

Differences among brain tumor stem cell types and fetal neural stem cells in focal regions of histone modifications and DNA methylation, broad regions of modifications, and bivalent promoters

(2014) Sally Yoo et al.   BMC GENOMICS

Temporal dynamics of hippocampal neurogenesis in chronic neurodegeneration

(2014) Diego Gomez-Nicola et al.   BRAIN

Promoter hypermethylation of the phosphatase DUSP22 mediates PKA-dependent TAU phosphorylation and CREB activation in Alzheimer's disease

(2014) Jose Vicente Sanchez-Mut et al.   HIPPOCAMPUS

Composition of a Neuromere and Its Segmental Diversification under the Control ofHoxGenes in the Embryonic CNS ofDrosophila

(2014) Gerhard M. Technau et al.   JOURNAL OF NEUROGENETICS

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

(2014) Katie Lunnon et al.   NATURE NEUROSCIENCE

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

(2014) Philip L De Jager et al.   NATURE NEUROSCIENCE

Dynamic regulation of epigenomic landscapes during hematopoiesis

(2013) Brian J Abraham et al.   BMC GENOMICS

A data-driven approach to preprocessing Illumina 450K methylation array data

(2013) Ruth Pidsley et al.   BMC GENOMICS

Dynamics of Hippocampal Neurogenesis in Adult Humans

(2013) Kirsty L. Spalding et al.   CELL

A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression

(2013) Jerry Guintivano et al.   Epigenetics

Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray

(2013) Yi-an Chen et al.   Epigenetics

Roles ofHoxgenes in the patterning of the central nervous system ofDrosophila

(2013) Alicia Estacio-Gómez et al.   FLY

Additional annotation enhances potential for biologically-relevant analysis of the Illumina Infinium HumanMethylation450 BeadChip array

(2013) Magda E Price et al.   Epigenetics & Chromatin

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

OSAT: a tool for sample-to-batch allocations in genomics experiments

(2012) Li Yan et al.   BMC GENOMICS

Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients

(2012) J S Rao et al.   Translational Psychiatry

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome

(2011) Juan Sandoval et al.   Epigenetics

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Adult hippocampal neurogenesis and its role in Alzheimer's disease

(2011) Yangling Mu et al.   Molecular Neurodegeneration

The Human Epigenome Browser at Washington University

(2011) Xin Zhou et al.   NATURE METHODS

Epidemiology of Alzheimer disease

(2011) Christiane Reitz et al.   Nature Reviews Neurology

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions

(2011) Guo-li Ming et al.   NEURON

Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis

(2011) O. Karalay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The pathological process underlying Alzheimer’s disease in individuals under thirty

(2010) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Molecular mechanisms of neurodegeneration in Alzheimer's disease

(2010) L. Crews et al.   HUMAN MOLECULAR GENETICS

GREAT improves functional interpretation of cis-regulatory regions

(2010) Cory Y McLean et al.   NATURE BIOTECHNOLOGY

Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study

(2009) G. Lace et al.   BRAIN

Management of a twenty-first century brain bank: experience in the BrainNet Europe consortium

(2008) Jeanne E. Bell et al.   ACTA NEUROPATHOLOGICA

Failure of Neuronal Maturation in Alzheimer Disease Dentate Gyrus

(2008) Bin Li et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

QUMA: quantification tool for methylation analysis

(2008) Y. Kumaki et al.   NUCLEIC ACIDS RESEARCH