Opening up the DNA methylome of dementia

The Alzheimer's Disease Mitochondrial Cascade Hypothesis

(2017) Russell H. Swerdlow et al.   JOURNAL OF ALZHEIMERS DISEASE

Molecular genetics of early-onset Alzheimer's disease revisited

(2016) Rita Cacace et al.   Alzheimers & Dementia

Epigenetic Mechanisms of Longevity and Aging

(2016) Payel Sen et al.   CELL

Distribution and Load of Amyloid-β Pathology in Parkinson Disease and Dementia with Lewy Bodies

(2016) Dagmar H. Hepp et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Epigenetics of dementia: understanding the disease as a transformation rather than a state

(2016) Bryan Maloney et al.   LANCET NEUROLOGY

DNA methylation on N6-adenine in mammalian embryonic stem cells

(2016) Tao P. Wu et al.   NATURE

Parkinsonism, movement disorders and genetics in frontotemporal dementia

(2016) José Fidel Baizabal-Carvallo et al.   Nature Reviews Neurology

TREM2 variants: new keys to decipher Alzheimer disease pathogenesis

(2016) Marco Colonna et al.   NATURE REVIEWS NEUROSCIENCE

Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases

(2016) Rita Guerreiro et al.   NEUROBIOLOGY OF AGING

Prevalence, characteristics, and survival of frontotemporal lobar degeneration syndromes

(2016) Ian T.S. Coyle-Gilchrist et al.   NEUROLOGY

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Epigenome Editing: State of the Art, Concepts, and Perspectives

(2016) Goran Kungulovski et al.   TRENDS IN GENETICS

On the Origin of CRISPR-Cas Technology: From Prokaryotes to Mammals

(2016) Francisco J.M. Mojica et al.   TRENDS IN MICROBIOLOGY

Validation of a DNA methylation microarray for 850,000 CpG sites of the human genome enriched in enhancer sequences

(2016) Sebastian Moran et al.   Epigenomics

Molecular Pathways Bridging Frontotemporal Lobar Degeneration and Psychiatric Disorders

(2016) Roberta Zanardini et al.   Frontiers in Aging Neuroscience

Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer’s disease

(2016) Corey T. Watson et al.   Genome Medicine

TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer’s disease hippocampus

(2016) Naiara Celarain et al.   Clinical Epigenetics

Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns

(2016) J V Sanchez-Mut et al.   Translational Psychiatry

The C9orf72 repeat expansion itself is methylated in ALS and FTLD patients

(2015) Zhengrui Xi et al.   ACTA NEUROPATHOLOGICA

Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer’s disease related cognitive functioning

(2015) Morgan E Levine et al.   Aging-US

Increased epigenetic age and granulocyte counts in the blood of Parkinson's disease patients

(2015) Steve Horvath et al.   Aging-US

Parkinson’s disease dementia: a neural networks perspective

(2015) James Gratwicke et al.   BRAIN

An Adenine Code for DNA: A Second Life for N6-Methyladenine

(2015) Holger Heyn et al.   CELL

Aberrant epigenome in iPSC-derived dopaminergic neurons from Parkinson's disease patients

(2015) R. Fernandez-Santiago et al.   EMBO Molecular Medicine

5-Hydroxymethylcytosine: A new player in brain disorders?

(2015) Ying Cheng et al.   EXPERIMENTAL NEUROLOGY

Prevalence of Amyloid PET Positivity in Dementia Syndromes

(2015) Rik Ossenkoppele et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Lewy body dementias

(2015) Zuzana Walker et al.   LANCET

Frontotemporal dementia

(2015) Jee Bang et al.   LANCET

The burden of disease in older people and implications for health policy and practice

(2015) Martin J Prince et al.   LANCET

The C9orf72 repeat size correlates with onset age of disease, DNA methylation and transcriptional downregulation of the promoter

(2015) I Gijselinck et al.   MOLECULAR PSYCHIATRY

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease

(2015) Elizabeta Gjoneska et al.   NATURE

Single-cell epigenomics: techniques and emerging applications

(2015) Omer Schwartzman et al.   NATURE REVIEWS GENETICS

Pathogenesis of Parkinson disease—the gut–brain axis and environmental factors

(2015) Lisa Klingelhoefer et al.   Nature Reviews Neurology

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Spatial Distribution of 5-Hydroxymethyl Cytosine in Rat Brain and Temporal Distribution in Striatum

(2015) Tingting Zheng et al.   NEUROCHEMICAL RESEARCH

C9orf72 promoter hypermethylation is neuroprotective: Neuroimaging and neuropathologic evidence

(2015) C. T. McMillan et al.   NEUROLOGY

Reading the unique DNA methylation landscape of the brain: Non-CpG methylation, hydroxymethylation, and MeCP2

(2015) Benyam Kinde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The epigenetics of aging and neurodegeneration

(2015) Roy Lardenoije et al.   PROGRESS IN NEUROBIOLOGY

Mitochondrial epigenetics: an overlooked layer of regulation?

(2015) Monique G.P. van der Wijst et al.   TRENDS IN GENETICS

Epigenetic mechanisms underlying learning and the inheritance of learned behaviors

(2015) Brian G. Dias et al.   TRENDS IN NEUROSCIENCES

Epigenetic Alterations in Alzheimer’s Disease

(2015) Jose V. Sanchez-Mut et al.   Frontiers in Behavioral Neuroscience

Association of Brain DNA Methylation inSORL1,ABCA7,HLA-DRB5,SLC24A4, andBIN1With Pathological Diagnosis of Alzheimer Disease

(2015) Lei Yu et al.   JAMA Neurology

Hypermethylation of repeat expanded C9orf72 is a clinical and molecular disease modifier

(2014) Jenny Russ et al.   ACTA NEUROPATHOLOGICA

C9orf72 hypermethylation protects against repeat expansion-associated pathology in ALS/FTD

(2014) Elaine Y. Liu et al.   ACTA NEUROPATHOLOGICA

Characterization of DNA hypermethylation in the cerebellum of c9FTD/ALS patients

(2014) Veronique V. Belzil et al.   BRAIN RESEARCH

Epigenetic memory: the Lamarckian brain

(2014) A. Fischer   EMBO JOURNAL

From development to diseases: The role of 5hmC in brain

(2014) Wenjia Sun et al.   GENOMICS

Promoter hypermethylation of the phosphatase DUSP22 mediates PKA-dependent TAU phosphorylation and CREB activation in Alzheimer's disease

(2014) Jose Vicente Sanchez-Mut et al.   HIPPOCAMPUS

Hypermethylation of the CpG-island near the C9orf72 G4C2-repeat expansion in FTLD patients

(2014) Zhengrui Xi et al.   HUMAN MOLECULAR GENETICS

The prevalence of Parkinson's disease: A systematic review and meta-analysis

(2014) Tamara Pringsheim et al.   MOVEMENT DISORDERS

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

(2014) Mike A Nalls et al.   NATURE GENETICS

Single-cell genome-wide bisulfite sequencing for assessing epigenetic heterogeneity

(2014) Sébastien A Smallwood et al.   NATURE METHODS

Decoding neural transcriptomes and epigenomes via high-throughput sequencing

(2014) Jaehoon Shin et al.   NATURE NEUROSCIENCE

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

(2014) Katie Lunnon et al.   NATURE NEUROSCIENCE

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

(2014) Philip L De Jager et al.   NATURE NEUROSCIENCE

Classifying neurocognitive disorders: the DSM-5 approach

(2014) Perminder S. Sachdev et al.   Nature Reviews Neurology

Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain

(2014) Daniel Condliffe et al.   NEUROBIOLOGY OF AGING

Epigenome-Wide Association Study for Parkinson’s Disease

(2014) Kerry Moore et al.   NEUROMOLECULAR MEDICINE

Human population reduction is not a quick fix for environmental problems

(2014) Corey J. A. Bradshaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetics reloaded: the single-cell revolution

(2014) Poonam Bheda et al.   TRENDS IN CELL BIOLOGY

Accounting for cellular heterogeneity is critical in epigenome-wide association studies

(2014) Andrew E Jaffe et al.   GENOME BIOLOGY

Hypermethylation of the CpG Island Near the G4C2 Repeat in ALS with a C9orf72 Expansion

(2013) Zhengrui Xi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

DNA methylation map of mouse and human brain identifies target genes in Alzheimer’s disease

(2013) Jose V. Sanchez-Mut et al.   BRAIN

Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

(2013) Jing L. Guo et al.   CELL

New sequencing technologies

(2013) Ivo Glynne Gut   Clinical & Translational Oncology

The Control Region of Mitochondrial DNA Shows an Unusual CpG and Non-CpG Methylation Pattern

(2013) D. Bellizzi et al.   DNA RESEARCH

Distinctive patterns of DNA methylation associated with Parkinson disease

(2013) Eliezer Masliah et al.   Epigenetics

DNA methylation contributes to natural human variation

(2013) H. Heyn et al.   GENOME RESEARCH

Altered CpG methylation in sporadic Alzheimer's disease is associated with APP and MAPT dysregulation

(2013) Atsushi Iwata et al.   HUMAN MOLECULAR GENETICS

Epigenetic changes in the progression of Alzheimer's disease

(2013) M.A. Bradley-Whitman et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

(2013) J Chapuis et al.   MOLECULAR PSYCHIATRY

Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain

(2013) Junjie U Guo et al.   NATURE NEUROSCIENCE

Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies

(2013) David J. Irwin et al.   NATURE REVIEWS NEUROSCIENCE

Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients

(2013) Leonidas Chouliaras et al.   NEUROBIOLOGY OF AGING

Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain

(2013) Natacha Coppieters et al.   NEUROBIOLOGY OF AGING

Insulin growth factor binding protein 7 is a novel target to treat dementia

(2013) Hope Y. Agbemenyah et al.   NEUROBIOLOGY OF DISEASE

The Emerging Field of Neuroepigenetics

(2013) J. David Sweatt   NEURON

The Function of α-Synuclein

(2013) Jacob T. Bendor et al.   NEURON

Global Epigenomic Reconfiguration During Mammalian Brain Development

(2013) R. Lister et al.   SCIENCE

Epigenetic Determinants of Healthy and Diseased Brain Aging and Cognition

(2013) Schahram Akbarian et al.   JAMA Neurology

Clinic, neuropathology and molecular genetics of frontotemporal dementia: a mini-review

(2013) Xiao-dong Pan et al.   Translational Neurodegeneration

Promoter DNA methylation regulates progranulin expression and is altered in FTLD

(2013) Julia Banzhaf-Strathmann et al.   Acta Neuropathologica Communications

Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study

(2012) Elisa Majounie et al.   LANCET NEUROLOGY

Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study

(2012) Eric M Reiman et al.   LANCET NEUROLOGY

Effect of aging on 5-hydroxymethylcytosine in brain mitochondria

(2012) Svetlana Dzitoyeva et al.   NEUROBIOLOGY OF AGING

Oxidative stress induces DNA demethylation and histone acetylation in SH-SY5Y cells: potential epigenetic mechanisms in gene transcription in Aβ production

(2012) Xinling Gu et al.   NEUROBIOLOGY OF AGING

Epigenetic regulation of BACE1 in Alzheimer’s disease patients and in transgenic mice

(2012) S.C.F. Marques et al.   NEUROSCIENCE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Distinct DNA methylomes of newborns and centenarians

(2012) H. Heyn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aging effects on DNA methylation modules in human brain and blood tissue

(2012) Steve Horvath et al.   GENOME BIOLOGY

Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients

(2012) J S Rao et al.   Translational Psychiatry

Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain

(2011) Junjie U. Guo et al.   CELL

A hippocampal insulin-growth factor 2 pathway regulates the extinction of fear memories

(2011) Roberto Carlos Agis-Balboa et al.   EMBO JOURNAL

α-Synuclein Sequesters Dnmt1 from the Nucleus

(2011) Paula Desplats et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DLB and PDD: a role for mutations in dementia and Parkinson disease genes?

(2011) Bram Meeus et al.   NEUROBIOLOGY OF AGING

Next-Generation Sequencing Reveals Regional Differences of the α-Synuclein Methylation State Independent of Lewy Body Disease

(2011) L. de Boni et al.   NEUROMOLECULAR MEDICINE

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

Promoter methylation analysis of seven clock genes in Parkinson's disease

(2011) Qingling Lin et al.   NEUROSCIENCE LETTERS

DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria

(2011) Lisa S. Shock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of CREB signaling in Alzheimer’s disease and other cognitive disorders

(2011) Carlos A. Saura et al.   REVIEWS IN THE NEUROSCIENCES

A Two-Stage Meta-Analysis Identifies Several New Loci for Parkinson's Disease

(2011) et al.   PLoS Genetics

IGF-I and the aging mammalian brain

(2010) J. Piriz et al.   EXPERIMENTAL GERONTOLOGY

Methylation Regulates Alpha-Synuclein Expression and Is Decreased in Parkinson's Disease Patients' Brains

(2010) A. Jowaed et al.   JOURNAL OF NEUROSCIENCE

The use of PET in Alzheimer disease

(2010) Agneta Nordberg et al.   Nature Reviews Neurology

CpG Demethylation Enhances Alpha-Synuclein Expression and Affects the Pathogenesis of Parkinson's Disease

(2010) Lumine Matsumoto et al.   PLoS One

Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates

(2010) Daniel Globisch et al.   PLoS One

Sex differences in brain epigenetics

(2010) Yannick Menger et al.   Epigenomics

REM sleep behavior disorder

(2009) Bradley F. Boeve   Annals of the New York Academy of Sciences

Formation and development of Lewy pathology: a critical update

(2009) Kurt A. Jellinger   JOURNAL OF NEUROLOGY

DNA Methylation of Alzheimer Disease and Tauopathy-Related Genes in Postmortem Brain

(2009) Marta Barrachina et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria

(2009) Dennis W Dickson et al.   LANCET NEUROLOGY

Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies

(2009) Rocio G Urdinguio et al.   LANCET NEUROLOGY

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases

(2009) D K Lahiri et al.   MOLECULAR PSYCHIATRY

Human DNA methylomes at base resolution show widespread epigenomic differences

(2009) Ryan Lister et al.   NATURE

Brain-derived neurotrophic factor in neurodegenerative diseases

(2009) Chiara Zuccato et al.   Nature Reviews Neurology

The heritability and genetics of frontotemporal lobar degeneration

(2009) J. D. Rohrer et al.   NEUROLOGY

In vivo methylation of mtDNA reveals the dynamics of protein–mtDNA interactions

(2009) Adriana P. Rebelo et al.   NUCLEIC ACIDS RESEARCH

Epigenetic Differences in Cortical Neurons from a Pair of Monozygotic Twins Discordant for Alzheimer's Disease

(2009) Diego Mastroeni et al.   PLoS One

Epigenetic codes in cognition and behaviour

(2008) Johannes Gräff et al.   BEHAVIOURAL BRAIN RESEARCH

Neuronal gene expression correlates of Parkinson's disease with dementia

(2008) Chelsea Stamper et al.   MOVEMENT DISORDERS

A pilot study for circadian gene disturbance in dementia patients

(2008) Hsing-Cheng Liu et al.   NEUROSCIENCE LETTERS

Elevated α-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease

(2008) Jan Gründemann et al.   NUCLEIC ACIDS RESEARCH

Age-Specific Epigenetic Drift in Late-Onset Alzheimer's Disease

(2008) Sun-Chong Wang et al.   PLoS One