Neuroprotective Potential of Chrysin: Mechanistic Insights and Therapeutic Potential for Neurological Disorders

Neuroprotective potential of cinnamon and its metabolites in Parkinson's disease: Mechanistic insights, limitations, and novel therapeutic opportunities

(2021) Efthalia Angelopoulou et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

New approaches to symptomatic treatments for Alzheimer’s disease

(2021) Jeffrey Cummings   Molecular Neurodegeneration

Potential Role of Nanoparticles in Treating the Accumulation of Amyloid-Beta Peptide in Alzheimer’s Patients

(2021) Mohamed Abbas   Polymers

Anti-Inflammatory and Anti-Hyperuricemic Effects of Chrysin on a High Fructose Corn Syrup-Induced Hyperuricemia Rat Model via the Amelioration of Urate Transporters and Inhibition of NLRP3 Inflammasome Signaling Pathway

(2021) Yi-Hsien Chang et al.   Antioxidants

Neuroinflammation in neurological disorders: pharmacotherapeutic targets from bench to bedside

(2021) Awanish Mishra et al.   METABOLIC BRAIN DISEASE

Natural Phytochemicals as Novel Therapeutic Strategies to Prevent and Treat Parkinson’s Disease: Current Knowledge and Future Perspectives

(2021) Rengasamy Balakrishnan et al.   Oxidative Medicine and Cellular Longevity

Chrysin: Perspectives on Contemporary Status and Future Possibilities as Pro-Health Agent

(2021) Monika Stompor-Gorący et al.   Nutrients

The burden of neurological disorders across the states of India: the Global Burden of Disease Study 1990–2019

(2021) Gagandeep Singh et al.   Lancet Global Health

Caloric Restriction Mimetics in Nutrition and Clinical Trials

(2021) Sebastian J. Hofer et al.   Frontiers in Nutrition

Developing nutritional component chrysin as a therapeutic agent: Bioavailability and pharmacokinetics consideration, and ADME mechanisms

(2021) Song Gao et al.   BIOMEDICINE & PHARMACOTHERAPY

Neuroprotective Effects of Chrysin on Diclofenac-Induced Apoptosis in SH-SY5Y Cells

(2020) Ekrem Darendelioglu   NEUROCHEMICAL RESEARCH

Chrysin attenuates traumatic brain injury-induced recognition memory decline, and anxiety/depression-like behaviors in rats: Insights into underlying mechanisms

(2020) Masome Rashno et al.   PSYCHOPHARMACOLOGY

Involvement of GABAergic system in the antidepressant-like effects of chrysin (5,7-dihydroxyflavone) in ovariectomized rats in the forced swim test: comparison with neurosteroids

(2020) Jonathan Cueto-Escobedo et al.   BEHAVIOURAL BRAIN RESEARCH

Role of flavonoids in neurodegenerative diseases: Limitations and future perspectives

(2020) Gagandeep Maan et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Chrysin ameliorates aluminum p hosphide‐induced oxidative stress and mitochondrial damages in rat cardiomyocytes and isolated mitochondria

(2020) Saleh Khezri et al.   ENVIRONMENTAL TOXICOLOGY

Ten Unsolved Questions About Neuroinflammation in Parkinson's Disease

(2020) Etienne C. Hirsch et al.   MOVEMENT DISORDERS

Chrysin loaded lipid-core nanocapsules ameliorates neurobehavioral alterations induced by β-amyloid1-42 in aged female mice

(2020) Renata Giacomeli et al.   BEHAVIOURAL BRAIN RESEARCH

Effects of chrysin and its major conjugated metabolites chrysin-7-sulfate and chrysin-7-glucuronide on cytochrome P450 enzymes, and on OATP, P-gp, BCRP and MRP2 transporters

(2020) Violetta Mohos et al.   DRUG METABOLISM AND DISPOSITION

Modulation of glutamate levels and Na+,K+-ATPase activity contributes to the chrysin memory recovery in hypothyroidism mice

(2020) Vandreza Cardoso Bortolotto et al.   PHYSIOLOGY & BEHAVIOR

Chrysin Attenuates the NLRP3 Inflammasome Cascade to Reduce Synovitis and Pain in KOA Rats

(2020) Taiyang Liao et al.   Drug Design Development and Therapy

QbD-steered development of Biotin-Conjugated Nanostructured Lipid Carriers for Oral Delivery of Chrysin: Role of Surface Modification for Improving Biopharmaceutical Performance

(2020) Teenu Sharma et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Neuroprotective role of chrysin‐loaded poly(lactic‐co‐glycolic acid) nanoparticle against kindling‐induced epilepsy through Nrf2/ARE/HO‐1 pathway

(2020) Ying Zhang et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Quercetin, chrysin, caffeic acid and ferulic acid ameliorate cyclophosphamide-induced toxicities in SH-SY5Y cells

(2020) Adnan Ayna et al.   MOLECULAR BIOLOGY REPORTS

Flavonoids mitigate neurodegeneration in aged Caenorhabditis elegans by mitochondrial uncoupling

(2020) Injeong Cho et al.   Food Science & Nutrition

Chrysin reduces anxiety-like behavior through actions on GABAA receptors during metestrus-diestrus in the rat

(2020) Juan Francisco Rodríguez-Landa et al.   BEHAVIOURAL BRAIN RESEARCH

Chrysin protects against testicular toxicity caused by lead acetate in rats with its antioxidant, anti‐inflammatory, and antiapoptotic properties

(2020) Mustafa Ileriturk et al.   JOURNAL OF FOOD BIOCHEMISTRY

Revisiting the role of neurotransmitters in epilepsy: An updated review

(2020) Enes Akyuz et al.   LIFE SCIENCES

A20 as a novel target for the anti-neuroinflammatory effect of chrysin via inhibition of NF-κB signaling pathway

(2019) Zhipeng Li et al.   BRAIN BEHAVIOR AND IMMUNITY

Chrysin attenuates global cerebral ischemic reperfusion injury via suppression of oxidative stress, inflammation and apoptosis

(2019) Iman H. El Khashab et al.   BIOMEDICINE & PHARMACOTHERAPY

Chrysin prevents cognitive and hippocampal long-term potentiation deficits and inflammation in rat with cerebral hypoperfusion and reperfusion injury

(2019) Alireza Sarkaki et al.   LIFE SCIENCES

Therapeutic effects of chrysin in a rat model of traumatic brain injury: A behavioral, biochemical, and histological study

(2019) Masome Rashno et al.   LIFE SCIENCES

An Updated Review on Pharmaceutical Properties of Gamma-Aminobutyric Acid

(2019) Dai-Hung Ngo et al.   MOLECULES

Chrysin protects against behavioral, cognitive and neurochemical alterations in a 6-hydroxydopamine model of Parkinson's disease

(2019) Lucian Del Fabbro et al.   NEUROSCIENCE LETTERS

Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders

(2019) Muhammad Ayaz et al.   Frontiers in Aging Neuroscience

Chrysin restores MPTP induced neuroinflammation, oxidative stress and neurotrophic factors in an acute Parkinson’s disease mouse model

(2019) Alagudurai Krishnamoorthy et al.   NEUROSCIENCE LETTERS

Toxicological evaluation of a flavonoid, chrysin: morphological, behavioral, biochemical and histopathological assessments in rats

(2019) Wei Yao et al.   DRUG AND CHEMICAL TOXICOLOGY

Expression of extracellular peroxidases and catalases in mesophilic and thermophilic Chaetomia in response to environmental oxidative stress stimuli

(2019) Katarína Chovanová et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Chrysin suppress immune responses and protects from experimental autoimmune encephalomyelitis in mice

(2019) Lucian Del Fabbro et al.   JOURNAL OF NEUROIMMUNOLOGY

Chrysin ameliorates cerebral ischemia/reperfusion (I/R) injury in rats by regulating the PI3K/Akt/mTOR pathway

(2019) Teng-Fei Li et al.   NEUROCHEMISTRY INTERNATIONAL

Comparative pharmacokinetic study of the components in Alpinia oxyphylla Miq.-Schisandra chinensis (Turcz.) Baill. herb pair and its single herb between normal and Alzheimer’s disease rats by UPLC-MS/MS

(2019) Yu Qi et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Protective effects of Chrysin against memory impairment, cerebral hyperemia and oxidative stress after cerebral hypoperfusion and reperfusion in rats

(2019) Maryam Khombi Shooshtari et al.   METABOLIC BRAIN DISEASE

Protective role of chrysin on 6-hydroxydopamine-induced neurodegeneration a mouse model of Parkinson's disease: Involvement of neuroinflammation and neurotrophins

(2018) André T.R. Goes et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Chrysin reverses the depressive-like behavior induced by hypothyroidism in female mice by regulating hippocampal serotonin and dopamine

(2018) Vandreza Cardoso Bortolotto et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling

(2018) Ying Wang et al.   JOURNAL OF CELL BIOLOGY

Inhibition of human monoamine oxidase A and B by flavonoids isolated from two Algerian medicinal plants

(2018) Farida Larit et al.   PHYTOMEDICINE

Chrysin suppresses proliferation, migration, and invasion in glioblastoma cell lines via mediating the ERK/Nrf2 signaling pathway

(2018) Juan Wang et al.   Drug Design Development and Therapy

Reactive Oxygen and Nitrogen Species–Induced Protein Modifications: Implication in Carcinogenesis and Anticancer Therapy

(2018) Nurbubu T. Moldogazieva et al.   CANCER RESEARCH

Interaction of Chrysin and Its Main Conjugated Metabolites Chrysin-7-Sulfate and Chrysin-7-Glucuronide with Serum Albumin

(2018) Violetta Mohos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chrysin Attenuates VCAM-1 Expression and Monocyte Adhesion in Lipopolysaccharide-Stimulated Brain Endothelial Cells by Preventing NF-κB Signaling

(2017) Bo Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chrysin cocrystals: Characterization and evaluation

(2017) Renu Chadha et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Protective effect of 5, 7-dihydroxyflavone on brain of rats exposed to acrylamide or γ-radiation

(2017) Somaya Z. Mansour et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Chrysin isolated from Pyrus pashia fruit ameliorates convulsions in experimental animals

(2017) Priyanka Sharma et al.   NUTRITIONAL NEUROSCIENCE

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action

(2017) Renuka Mani et al.   PHYTOCHEMISTRY

Preparation and activity evaluation of chrysin-β-d-galactopyranoside

(2016) Zhen-Yuan Zhu et al.   ARCHIVES OF PHARMACAL RESEARCH

Chrysin exerts neuroprotective effects against 3-Nitropropionic acid induced behavioral despair—Mitochondrial dysfunction and striatal apoptosis via upregulating Bcl-2 gene and downregulating Bax—Bad genes in male wistar rats

(2016) Sumathi Thangarajan et al.   BIOMEDICINE & PHARMACOTHERAPY

Multifunction of Chrysin in Parkinson’s Model: Anti-Neuronal Apoptosis, Neuroprotection via Activation of MEF2D, and Inhibition of Monoamine Oxidase-B

(2016) Baojian Guo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Sodium Oleate-Based Nanoemulsion Enhances Oral Absorption of Chrysin through Inhibition of UGT-Mediated Metabolism

(2016) Dong Dong et al.   MOLECULAR PHARMACEUTICS

Mitigating effect of chrysin loaded solid lipid nanoparticles against Amyloid β25–35 induced oxidative stress in rat hippocampal region: An efficient formulation approach for Alzheimer's disease

(2016) Aishwarya Vedagiri et al.   NEUROPEPTIDES

Chronic 5-HT3 receptor antagonism ameliorates seizures and associated memory deficit in pentylenetetrazole-kindled mice

(2016) Awanish Mishra et al.   NEUROSCIENCE

Chrysin prevents brain damage caused by global cerebralischemia/reperfusion in a C57BL/J6 mouse model

(2016) Mehmet Akif DURAK et al.   Turkish Journal Of Medical Sciences

Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expression

(2015) Balbino L. Santos et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Regulation of three isoforms of SOD gene by environmental stresses in citrus red mite, Panonychus citri

(2015) Ying-Cai Feng et al.   EXPERIMENTAL AND APPLIED ACAROLOGY

Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson disease

(2015) Zaijun Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Determination of Pharmacokinetics of Chrysin and Its Conjugates in Wild-Type FVB and Bcrp1 Knockout Mice Using a Validated LC-MS/MS Method

(2015) Shufan Ge et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Chrysin suppresses human CD14+ monocyte-derived dendritic cells and ameliorates experimental autoimmune encephalomyelitis

(2015) Kai Zhang et al.   JOURNAL OF NEUROIMMUNOLOGY

Chronic unpredictable mild stress decreases BDNF and NGF levels and Na+,K+-ATPase activity in the hippocampus and prefrontal cortex of mice: Antidepressant effect of chrysin

(2015) C.B. Filho et al.   NEUROSCIENCE

Flavonoid Chrysin prevents age-related cognitive decline via attenuation of oxidative stress and modulation of BDNF levels in aged mouse brain

(2015) Leandro Cattelan Souza et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Chrysin-loaded PLGA-PEG nanoparticles designed for enhanced effect on the breast cancer cell line

(2015) Elham Anari et al.   Artificial Cells Nanomedicine and Biotechnology

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Chrysin alleviates acute doxorubicin cardiotoxicity in rats via suppression of oxidative stress, inflammation and apoptosis

(2014) Eman M. Mantawy et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Chrysin Protects against Focal Cerebral Ischemia/Reperfusion Injury in Mice through Attenuation of Oxidative Stress and Inflammation

(2014) Yang Yao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chrysin Suppressed Inflammatory Responses and the Inducible Nitric Oxide Synthase Pathway after Spinal Cord Injury in Rats

(2014) Yong Jiang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pine (Pinus morrisonicola Hayata) Needle Extracts Sensitize GBM8901 Human Glioblastoma Cells to Temozolomide by Downregulating Autophagy and O6-Methylguanine-DNA Methyltransferase Expression

(2014) Chia-Leng Liao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inflammasomes in the CNS

(2014) John G. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

(2014) Antonio Ayala et al.   Oxidative Medicine and Cellular Longevity

Propolis changes the anticancer activity of temozolomide in U87MG human glioblastoma cell line

(2013) Renata Markiewicz-Żukowska et al.   BMC Complementary and Alternative Medicine

Complexity of dopamine metabolism

(2013) Johannes Meiser et al.   Cell Communication and Signaling

Neuroinflammation: The role and consequences

(2013) Monty Lyman et al.   NEUROSCIENCE RESEARCH

Arsenic modulates heme oxygenase-1, interleukin-6, and vascular endothelial growth factor expression in endothelial cells: roles of ROS, NF-κB, and MAPK pathways

(2012) Lisu Wang et al.   ARCHIVES OF TOXICOLOGY

Chrysin improves cognitive deficits and brain damage induced by chronic cerebral hypoperfusion in rats

(2012) Xiao-Li He et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Evaluation of the structure–activity relationship of flavonoids as antioxidants and toxicants of zebrafish larvae

(2012) Yau-Hung Chen et al.   FOOD CHEMISTRY

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Christopher J L Murray et al.   LANCET

Kaempferol acts through mitogen-activated protein kinases and protein kinase B/AKT to elicit protection in a model of neuroinflammation in BV2 microglial cells

(2011) SE Park et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dual protective effect of Passiflora incarnata in epilepsy and associated post-ictal depression

(2011) Bhupinder Singh et al.   JOURNAL OF ETHNOPHARMACOLOGY

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Chrysin suppresses LPS-stimulated proinflammatory responses by blocking NF-κB and JNK activations in microglia cells

(2010) Sang Keun Ha et al.   NEUROSCIENCE LETTERS

Effects of blackberries on motor and cognitive function in aged rats

(2009) Barbara Shukitt-Hale et al.   NUTRITIONAL NEUROSCIENCE

Neuroinflammation and microglia: considerations and approaches for neurotoxicity assessment

(2008) Gaylia Jean Harry et al.   Expert Opinion on Drug Metabolism & Toxicology

Mechanisms of Microglia-Mediated Neurotoxicity in a New Model of the Stroke Penumbra

(2008) V. Kaushal et al.   JOURNAL OF NEUROSCIENCE