Kinetics of Blood–Brain Barrier Transport of Monoclonal Antibodies Targeting the Insulin Receptor and the Transferrin Receptor

Iduronate-2-sulfatase fused with anti-hTfR antibody, pabinafusp alfa, for MPS-II: A phase 2 trial in Brazil

(2021) Roberto Giugliani et al.   MOLECULAR THERAPY

Understanding insulin and its receptor from their three-dimensional structure

(2021) Michael C. Lawrence   Molecular Metabolism

Mathematical Models of Blood-Brain Barrier Transport of Monoclonal Antibodies Targeting the Transferrin Receptor and the Insulin Receptor

(2021) William M. Pardridge et al.   Pharmaceuticals

Enzyme Replacement Therapy with Pabinafusp Alfa for Neuronopathic Mucopolysaccharidosis II: An Integrated Analysis of Preclinical and Clinical Data

(2021) Roberto Giugliani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transferrin: a blood coagulation modifier

(2020) Alvin H. Schmaier   CELL RESEARCH

An Affibody Molecule Is Actively Transported into the Cerebrospinal Fluid via Binding to the Transferrin Receptor

(2020) Sebastian W. Meister et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A TfR-Binding Cystine-Dense Peptide Promotes Blood–Brain Barrier Penetration of Bioactive Molecules

(2020) Zachary R. Crook et al.   JOURNAL OF MOLECULAR BIOLOGY

Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys

(2020) Mihalis S. Kariolis et al.   Science Translational Medicine

Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice

(2020) Julie C. Ullman et al.   Science Translational Medicine

The Isolated Brain Microvessel: A Versatile Experimental Model of the Blood-Brain Barrier

(2020) William M. Pardridge   Frontiers in Physiology

Brain delivery of biologics using a cross‐species reactive transferrin receptor 1 VNAR shuttle

(2020) Dag Sehlin et al.   FASEB JOURNAL

A Phase 2/3 Trial of Pabinafusp Alfa, IDS Fused with Anti-Human Transferrin Receptor Antibody, Targeting Neurodegeneration in MPS-II

(2020) Torayuki Okuyama et al.   MOLECULAR THERAPY

SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-β antibody in a mouse model of Alzheimer’s disease

(2020) Tobias Gustavsson et al.   Translational Neurodegeneration

Acute and Chronic Dosing of a High-Affinity Rat/Mouse Chimeric Transferrin Receptor Antibody in Mice

(2020) Demi M. Castellanos et al.   Pharmaceutics

Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain

(2020) Stina Syvänen et al.   ACS Chemical Neuroscience

Blood‐brain barrier transport using a high affinity, brain‐selective VNAR antibody targeting transferrin receptor 1

(2020) Pawel Stocki et al.   FASEB JOURNAL

Tetravalent Bispecific Tandem Antibodies Improve Brain Exposure and Efficacy in an Amyloid Transgenic Mouse Model

(2020) Tuan-Minh Do et al.   Molecular Therapy-Methods & Clinical Development

Surface plasmon resonance analysis of complex formation of therapeutic recombinant lysosomal enzymes with domain 9 of human cation-independent mannose 6-phosphate receptor

(2020) Minori Kanzaki et al.   Molecular Genetics and Metabolism Reports

Modulating the antibody density changes the uptake and transport at the blood-brain barrier of both transferrin receptor-targeted gold nanoparticles and liposomal cargo

(2019) Kasper Bendix Johnsen et al.   JOURNAL OF CONTROLLED RELEASE

Engineered antibodies: new possibilities for brain PET?

(2019) Dag Sehlin et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Enhancement of binding avidity by bivalent binding enables PrPSc-specific detection by anti-PrP monoclonal antibody 132

(2019) Akio Suzuki et al.   PLoS One

Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor–ligand complex

(2019) Emiko Uchikawa et al.   eLife

Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain

(2019) Theresia Gutmann et al.   JOURNAL OF CELL BIOLOGY

Evaluation of Targeted Delivery to the Brain Using Magnetic Immunoliposomes and Magnetic Force

(2019) Louiza Bohn Thomsen et al.   Materials

Transferrin Receptors TfR1 and TfR2 Bind Transferrin through Differing Mechanisms

(2018) Mark D. Kleven et al.   BIOCHEMISTRY

Receptor-mediated PLGA nanoparticles for glioblastoma multiforme treatment

(2018) M.J. Ramalho et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Brain uptake of multivalent and multi-specific DVD-Ig proteins after systemic administration

(2018) Denise Karaoglu Hanzatian et al.   mAbs

Enhanced Delivery of Galanin Conjugates to the Brain through Bioengineering of the Anti-Transferrin Receptor Antibody OX26

(2018) George Thom et al.   MOLECULAR PHARMACEUTICS

A Blood-Brain-Barrier-Penetrating Anti-human Transferrin Receptor Antibody Fusion Protein for Neuronopathic Mucopolysaccharidosis II

(2018) Hiroyuki Sonoda et al.   MOLECULAR THERAPY

Neurocognitive and somatic stabilization in pediatric patients with severe Mucopolysaccharidosis Type I after 52 weeks of intravenous brain-penetrating insulin receptor antibody-iduronidase fusion protein (valanafusp alpha): an open label phase 1-2 trial

(2018) Roberto Giugliani et al.   Orphanet Journal of Rare Diseases

Transferrin receptor 1 is a reticulocyte-specific receptor forPlasmodium vivax

(2018) Jakub Gruszczyk et al.   SCIENCE

Cerebral Blood Flow Measurements in Adults: A Review on the Effects of Dietary Factors and Exercise

(2018) Peter Joris et al.   Nutrients

Unique pharmacology of a novel allosteric agonist/sensitizer insulin receptor monoclonal antibody

(2018) Simon A. Hinke et al.   Molecular Metabolism

Quantification of kinetic rate constants for transcytosis of polymeric nanoparticle through blood-brain barrier

(2018) Aminul Islam Khan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Blood-Brain Barrier Transport, Plasma Pharmacokinetics, and Neuropathology Following Chronic Treatment of the Rhesus Monkey with a Brain Penetrating Humanized Monoclonal Antibody Against the Human Transferrin Receptor

(2018) William M. Pardridge et al.   MOLECULAR PHARMACEUTICS

Structure of the insulin receptor–insulin complex by single-particle cryo-EM analysis

(2018) Giovanna Scapin et al.   NATURE

Tissue Physiology of Cynomolgus Monkeys: Cross-Species Comparison and Implications for Translational Pharmacology

(2018) Danielle Mandikian et al.   AAPS Journal

Evaluation of brain-targeted chitosan nanoparticles through blood–brain barrier cerebral microvessel endothelial cells

(2017) Adem Sahin et al.   JOURNAL OF MICROENCAPSULATION

Brain and Organ Uptake in the Rhesus Monkey in Vivo of Recombinant Iduronidase Compared to an Insulin Receptor Antibody–Iduronidase Fusion Protein

(2017) Ruben J. Boado et al.   MOLECULAR PHARMACEUTICS

Enhanced delivery of IL-1 receptor antagonist to the central nervous system as a novel anti–transferrin receptor-IL-1RA fusion reverses neuropathic mechanical hypersensitivity

(2017) Carl I. Webster et al.   PAIN

Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor

(2017) Greta Hultqvist et al.   Theranostics

Impact of Antigen Density on the Binding Mechanism of IgG Antibodies

(2017) Maya Hadzhieva et al.   Scientific Reports

Pharmacokinetics, biodistribution and brain retention of a bispecific antibody-based PET radioligand for imaging of amyloid-β

(2017) Dag Sehlin et al.   Scientific Reports

Use of PEGylated Immunoliposomes to Deliver Dopamine Across the Blood-Brain Barrier in a Rat Model of Parkinson's Disease

(2016) Young-Sook Kang et al.   CNS Neuroscience & Therapeutics

Cellular uptake of PLGA nanoparticles targeted with anti-amyloid and anti-transferrin receptor antibodies for Alzheimer’s disease treatment

(2016) Joana A. Loureiro et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Novel Antitransferrin Receptor Antibodies Improve the Blood–Brain Barrier Crossing Efficacy of Immunoliposomes

(2016) Maria Gregori et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Very High Plasma Concentrations of a Monoclonal Antibody against the Human Insulin Receptor Are Produced by Subcutaneous Injection in the Rhesus Monkey

(2016) Ruben J. Boado et al.   MOLECULAR PHARMACEUTICS

Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer’s disease

(2016) Dag Sehlin et al.   Nature Communications

Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle

(2014) Jens Niewoehner et al.   NEURON

Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates

(2014) Y. J. Yu et al.   Science Translational Medicine

Insulin and insulin like growth factor II endocytosis and signaling via insulin receptor B

(2013) Jimena Giudice et al.   Cell Communication and Signaling

How insulin engages its primary binding site on the insulin receptor

(2013) John G. Menting et al.   NATURE

Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier

(2013) J. A. Couch et al.   Science Translational Medicine

IgG-Enzyme Fusion Protein: Pharmacokinetics and Anti-Drug Antibody Response in Rhesus Monkeys

(2012) Ruben J. Boado et al.   BIOCONJUGATE CHEMISTRY

An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses

(2012) G. Helguera et al.   JOURNAL OF VIROLOGY

The intracellular trafficking pathway of transferrin

(2011) Kristine M. Mayle et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Fructose-Fed Rhesus Monkeys: A Nonhuman Primate Model of Insulin Resistance, Metabolic Syndrome, and Type 2 Diabetes

(2011) Andrew A. Bremer et al.   CTS-Clinical and Translational Science

An Antibody-based Multifaceted Approach Targeting the Human Transferrin Receptor for the Treatment of B-cell Malignancies

(2011) Tracy R. Daniels et al.   JOURNAL OF IMMUNOTHERAPY

Brain tissue volumes in the general population of the elderly

(2011) Sigurdur Sigurdsson et al.   NEUROIMAGE

How the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pH

(2011) Brian E. Eckenroth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

(2011) Y. J. Yu et al.   Science Translational Medicine

Landmarks in Insulin Research

(2011) Colin W. Ward et al.   Frontiers in Endocrinology

The role of transferrin receptor 1 and 2 in transferrin-bound iron uptake in human hepatoma cells

(2009) Carly E. Herbison et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A loop in theN-lobe of human serum transferrin is critical for binding to the transferrin receptor as revealed by mutagenesis, isothermal titration calorimetry, and epitope mapping

(2009) Anne B. Mason et al.   JOURNAL OF MOLECULAR RECOGNITION

Diffusion in Brain Extracellular Space

(2008) Eva Syková et al.   PHYSIOLOGICAL REVIEWS