The Isolated Brain Microvessel: A Versatile Experimental Model of the Blood-Brain Barrier

Identification of a combination of transcription factors that synergistically increases endothelial cell barrier resistance

(2020) Filip Roudnicky et al.   Scientific Reports

Interindividual and Regional Variability in Drug Transporter Abundance at the Human Blood–Brain Barrier Measured by Quantitative Targeted Proteomics

(2019) Sarah Billington et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

PECAM-1 Stabilizes Blood-Brain Barrier Integrity and Favors Paracellular T-Cell Diapedesis Across the Blood-Brain Barrier During Neuroinflammation

(2019) Isabella Wimmer et al.   Frontiers in Immunology

Distinct roles of ezrin, radixin and moesin in maintaining the plasma membrane localizations and functions of human blood–brain barrier transporters

(2019) Yutaro Hoshi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons

(2019) Scott G. Canfield et al.   Fluids and Barriers of the CNS

Abundant expression of OCT2, MATE1, OAT1, OAT3, PEPT2, BCRP, MDR1 and xCT transporters in blood-arachnoid barrier of pig, and polarized localizations at CSF- and blood-facing plasma membranes

(2019) Yasuo Uchida et al.   DRUG METABOLISM AND DISPOSITION

Asymmetric functions of a binuclear metal center within the transport pathway of a human zinc transporter ZIP4

(2019) Tuo Zhang et al.   FASEB JOURNAL

Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood–brain barrier dysfunction module

(2019) Roeben Nocon Munji et al.   NATURE NEUROSCIENCE

Cholesterol Metabolism in the Brain and Its Association with Parkinson’s Disease

(2019) Uram Jin et al.   Experimental Neurobiology

Cytosolic phospholipase A2 is a key regulator of blood–brain barrier function in epilepsy

(2019) Anika M. S. Hartz et al.   FASEB JOURNAL

The amyloid-β degradation intermediate Aβ34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer’s disease

(2019) Tunahan Kirabali et al.   Acta Neuropathologica Communications

Identification and Quantification of Blood-Brain Barrier Transporters in Isolated Rat Brain Microvessels

(2018) Hajar Al Feteisi et al.   JOURNAL OF NEUROCHEMISTRY

Dynamic Remodeling of Pericytes In Vivo Maintains Capillary Coverage in the Adult Mouse Brain

(2018) Andrée-Anne Berthiaume et al.   Cell Reports

Targeting pericytes for therapeutic approaches to neurological disorders

(2018) Jinping Cheng et al.   ACTA NEUROPATHOLOGICA

Gene Expression Profiling in Alzheimer's Disease Brain Microvessels

(2018) Shu Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Blood-Brain Barrier Transport, Plasma Pharmacokinetics, and Neuropathology Following Chronic Treatment of the Rhesus Monkey with a Brain Penetrating Humanized Monoclonal Antibody Against the Human Transferrin Receptor

(2018) William M. Pardridge et al.   MOLECULAR PHARMACEUTICS

Contributions of the glycocalyx, endothelium, and extravascular compartment to the blood–brain barrier

(2018) Nikolay Kutuzov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isolation and differential transcriptome of vascular smooth muscle cells and mid-capillary pericytes from the rat brain

(2018) Stéphanie Chasseigneaux et al.   Scientific Reports

Cluster of Differentiation 46 Is the Major Receptor in Human Blood–Brain Barrier Endothelial Cells for Uptake of Exosomes Derived from Brain-Metastatic Melanoma Cells (SK-Mel-28)

(2018) Hiroki Kuroda et al.   MOLECULAR PHARMACEUTICS

Impact of Zn2+ on ABC Transporter Function in Intact Isolated Rat Brain Microvessels, Human Brain Capillary Endothelial Cells, and in Rat in Vivo

(2018) Alexander Zaremba et al.   MOLECULAR PHARMACEUTICS

Brain-Specific Ultrastructure of Capillary Endothelial Glycocalyx and Its Possible Contribution for Blood Brain Barrier

(2018) Yoshiaki Ando et al.   Scientific Reports

Astrocytic endfoot Ca2+ correlates with parenchymal vessel responses during 4-AP induced epilepsy: An in vivo two-photon lifetime microscopy study

(2017) Cong Zhang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

An isogenic blood-brain barrier model comprising brain endothelial cells, astrocytes, and neurons derived from human induced pluripotent stem cells

(2017) Scott G. Canfield et al.   JOURNAL OF NEUROCHEMISTRY

Evaluation of [ 14 C] and [ 13 C]Sucrose as Blood–Brain Barrier Permeability Markers

(2017) Mohammad K. Miah et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

In vivo Imaging of the Cerebral Endothelial Glycocalyx in Mice

(2017) Jin-Hui Yoon et al.   JOURNAL OF VASCULAR RESEARCH

Effects of hepatic ischemia-reperfusion injury on the blood-brain barrier permeability to [14C] and [13C]sucrose

(2017) Mohammad K. Miah et al.   METABOLIC BRAIN DISEASE

Quantification of Transporter and Receptor Proteins in Dog Brain Capillaries and Choroid Plexus: Relevance for the Distribution in Brain and CSF of Selected BCRP and P-gp Substrates

(2017) Clemens Braun et al.   MOLECULAR PHARMACEUTICS

Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents

(2017) Choi-Fong Cho et al.   Nature Communications

Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination

(2017) Alerie Guzman De La Fuente et al.   Cell Reports

A Novel Cervical Spinal Cord Window Preparation Allows for Two-Photon Imaging of T-Cell Interactions with the Cervical Spinal Cord Microvasculature during Experimental Autoimmune Encephalomyelitis

(2017) Neda Haghayegh Jahromi et al.   Frontiers in Immunology

Directed differentiation of human pluripotent stem cells to blood-brain barrier endothelial cells

(2017) Tongcheng Qian et al.   Science Advances

Translation in astrocyte distal processes sets molecular heterogeneity at the gliovascular interface

(2017) Anne- Cécile Boulay et al.   Cell Discovery

Endothelin-1 is Elevated in Alzheimer's Disease Brain Microvessels and is Neuroprotective

(2017) Jinhua Luo et al.   JOURNAL OF ALZHEIMERS DISEASE

The SLC28 (CNT) and SLC29 (ENT) nucleoside transporter families: a 30-year collaborative odyssey

(2016) J. D. Young   BIOCHEMICAL SOCIETY TRANSACTIONS

Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder

(2016) Dora C. Tărlungeanu et al.   CELL

Dynamic mRNA Transport and Local Translation in Radial Glial Progenitors of the Developing Brain

(2016) Louis-Jan Pilaz et al.   CURRENT BIOLOGY

CSF, blood-brain barrier, and brain drug delivery

(2016) William M. Pardridge   Expert Opinion on Drug Delivery

Novel method to study pericyte contractility and responses to ischaemia in vitro using electrical impedance

(2016) Ain A Neuhaus et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

PPAR-α, a lipid-sensing transcription factor, regulates blood–brain barrier efflux transporter expression

(2016) Vijay R More et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Equilibrative nucleoside transporters—A review

(2016) Rebba C. Boswell-Casteel et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Alpha-Smooth Muscle Actin mRNA and Protein Are Increased in Isolated Brain Vessel Extracts of Alzheimer Mice

(2016) Bianca Hutter-Schmid et al.   PHARMACOLOGY

Coordination of Protein Phosphorylation and Dephosphorylation in Synaptic Plasticity

(2015) Kevin M. Woolfrey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative Determination of Luminal and Abluminal Membrane Distributions of Transporters in Porcine Brain Capillaries by Plasma Membrane Fractionation and Quantitative Targeted Proteomics

(2015) Yoshiyuki Kubo et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes

(2015) Robert A. Hill et al.   NEURON

Cholesterol metabolites exported from human brain

(2015) Luigi Iuliano et al.   STEROIDS

A Novel Dynamic Neonatal Blood-Brain Barrier on a Chip

(2015) Sudhir P. Deosarkar et al.   PLoS One

Quantitative targeted proteomics for understanding the blood–brain barrier: towards pharmacoproteomics

(2014) Sumio Ohtsuki et al.   Expert Review of Proteomics

Nrf2 Upregulates ATP Binding Cassette Transporter Expression and Activity at the Blood-Brain and Blood-Spinal Cord Barriers

(2014) X. Wang et al.   JOURNAL OF NEUROSCIENCE

A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells

(2014) Romeo Cecchelli et al.   PLoS One

Drowning stars: reassessing the role of astrocytes in brain edema

(2014) Alexander S. Thrane et al.   TRENDS IN NEUROSCIENCES

A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources

(2014) Ethan S. Lippmann et al.   Scientific Reports

“You Shall Not Pass”—tight junctions of the blood brain barrier

(2014) Hans-Christian Bauer et al.   Frontiers in Neuroscience

Oxysterols decrease apical-to-basolateral transport of Aß peptides via an ABCB1-mediated process in an in vitro Blood-brain barrier model constituted of bovine brain capillary endothelial cells

(2013) Julien Saint-Pol et al.   BRAIN RESEARCH

Retinoic Acid Induces Blood-Brain Barrier Development

(2013) M. R. Mizee et al.   JOURNAL OF NEUROSCIENCE

Quantitative Atlas of Blood–Brain Barrier Transporters, Receptors, and Tight Junction Proteins in Rats and Common Marmoset

(2013) Yutaro Hoshi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Multicellular Self-Assembled Spheroidal Model of the Blood Brain Barrier

(2013) Eduard Urich et al.   Scientific Reports

Retinoic acid and hydrocortisone strengthen the barrier function of human RPMI 2650 cells, a model for nasal epithelial permeability

(2012) Levente Kürti et al.   CYTOTECHNOLOGY

Drug Transport across the Blood–Brain Barrier

(2012) William M Pardridge   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

(2012) Ross Booth et al.   LAB ON A CHIP

SyM-BBB: a microfluidic blood brain barrier model

(2012) Balabhaskar Prabhakarpandian et al.   LAB ON A CHIP

Cerebrovascular Remodeling and Epilepsy

(2012) Nicola Marchi et al.   NEUROSCIENTIST

Transcriptional Profiling of Human Brain Endothelial Cells Reveals Key Properties Crucial for Predictive In Vitro Blood-Brain Barrier Models

(2012) Eduard Urich et al.   PLoS One

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues

(2012) Alicia Lundby et al.   Nature Communications

Na+-dependent transport of taurine is found only on the abluminal membrane of the blood–brain barrier

(2011) Hector Rasgado-Flores et al.   EXPERIMENTAL NEUROLOGY

Obligate Role for Ketone Body Oxidation in Neonatal Metabolic Homeostasis

(2011) David G. Cotter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Proteome of Mouse Brain Microvessel Membranes and Basal Lamina

(2011) Hyun Bae Chun et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

(2011) Yasuo Uchida et al.   JOURNAL OF NEUROCHEMISTRY

A Transgenic Approach to Identify Thyroxine Transporter-Expressing Structures in Brain Development

(2011) M.-F. Lang et al.   JOURNAL OF NEUROENDOCRINOLOGY

Transcriptomic and Quantitative Proteomic Analysis of Transporters and Drug Metabolizing Enzymes in Freshly Isolated Human Brain Microvessels

(2011) Ramzi Shawahna et al.   MOLECULAR PHARMACEUTICS

The Immunopathophysiology of Multiple Sclerosis

(2011) Gregory F. Wu et al.   NEUROLOGIC CLINICS

The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction

(2010) Thomas Misje Mathiisen et al.   GLIA

Activation of PKC Isoform βI at the Blood–Brain Barrier Rapidly Decreases P-Glycoprotein Activity and Enhances Drug Delivery to the Brain

(2010) Robert R Rigor et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Rapid, Reversible Modulation of Blood-Brain BarrierP-Glycoprotein Transport Activity by Vascular Endothelial Growth Factor

(2010) B. T. Hawkins et al.   JOURNAL OF NEUROSCIENCE

Tumor Microvasculature and Microenvironment: Novel Insights Through Intravital Imaging in Pre-Clinical Models

(2010) DAI FUKUMURA et al.   MICROCIRCULATION

Endothelin-converting enzyme-1 in Alzheimer's disease and vascular dementia

(2010) J. C. Palmer et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The Mouse Blood-Brain Barrier Transcriptome: A New Resource for Understanding the Development and Function of Brain Endothelial Cells

(2010) Richard Daneman et al.   PLoS One

Structural basis for recognition of phosphodiester-containing lysosomal enzymes by the cation-independent mannose 6-phosphate receptor

(2010) Linda J. Olson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vascular pathology in Alzheimer's disease

(2010) Taihei MIYAKAWA   Psychogeriatrics

Inhibition of Src activity decreases tyrosine phosphorylation of occludin in brain capillaries and attenuates increase in permeability of the blood–brain barrier after transient focal cerebral ischemia

(2009) Yuji Takenaga et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Identification and expression profiling of blood–brain barrier membrane proteins

(2009) Nitin Agarwal et al.   JOURNAL OF NEUROCHEMISTRY

Human myelin proteome and comparative analysis with mouse myelin

(2009) A. Ishii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiplex expression cloning of blood-brain barrier membrane proteins

(2009) Nitin Agarwal et al.   PROTEOMICS

Analysis of mouse brain microvascular endothelium using immuno‐laser capture microdissection coupled to a hybrid linear ion trap with Fourier transform‐mass spectrometry proteomics platform

(2008) Qiaozhen Lu et al.   ELECTROPHORESIS

Claudin 2 mRNA and Protein Are Present in Human Keratinocytes and May Be Regulated by All-trans-Retinoic Acid

(2008) D. Telgenhoff et al.   SKIN PHARMACOLOGY AND PHYSIOLOGY