Blood‐brain barrier transport using a high affinity, brain‐selective VNAR antibody targeting transferrin receptor 1

Brain delivery of biologics using a cross‐species reactive transferrin receptor 1 VNAR shuttle

(2020) Dag Sehlin et al.   FASEB JOURNAL

Plasma Pharmacokinetics of High-Affinity Transferrin Receptor Antibody-Erythropoietin Fusion Protein is a Function of Effector Attenuation in Mice

(2019) Jiahong Sun et al.   MOLECULAR PHARMACEUTICS

Targeting the transferrin receptor for brain drug delivery

(2019) Kasper Bendix Johnsen et al.   PROGRESS IN NEUROBIOLOGY

Neuroprotection by Therapeutic Hypothermia

(2019) Ying-Jian Sun et al.   Frontiers in Neuroscience

Transferrin and transferrin receptors update

(2018) Hiroshi Kawabata   FREE RADICAL BIOLOGY AND MEDICINE

Brain uptake of multivalent and multi-specific DVD-Ig proteins after systemic administration

(2018) Denise Karaoglu Hanzatian et al.   mAbs

Antibody pharmacokinetics in rat brain determined using microdialysis

(2018) Hsueh-Yuan Chang et al.   mAbs

Enhanced Delivery of Galanin Conjugates to the Brain through Bioengineering of the Anti-Transferrin Receptor Antibody OX26

(2018) George Thom et al.   MOLECULAR PHARMACEUTICS

Coupling brain perfusion screens and next generation sequencing to identify blood-brain barrier binding antibodies

(2018) Charles C. Stutz et al.   AICHE JOURNAL

Blood-Brain Barrier Transport, Plasma Pharmacokinetics, and Neuropathology Following Chronic Treatment of the Rhesus Monkey with a Brain Penetrating Humanized Monoclonal Antibody Against the Human Transferrin Receptor

(2018) William M. Pardridge et al.   MOLECULAR PHARMACEUTICS

Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice

(2017) Megan Lo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uptake of 111In-labeled fully human monoclonal antibody TSP-A18 reflects transferrin receptor expression in normal organs and tissues of mice

(2017) Aya Sugyo et al.   ONCOLOGY REPORTS

Enhanced delivery of IL-1 receptor antagonist to the central nervous system as a novel anti–transferrin receptor-IL-1RA fusion reverses neuropathic mechanical hypersensitivity

(2017) Carl I. Webster et al.   PAIN

Potential Pathways for CNS Drug Delivery Across the Blood-Cerebrospinal Fluid Barrier

(2016) Nathalie Strazielle et al.   CURRENT PHARMACEUTICAL DESIGN

Transferrin receptor 1: a target for antibody-mediated cancer therapy

(2016) Tracy R Daniels-Wells et al.   Immunotherapy

Pharmacologically induced hypothermia attenuates traumatic brain injury in neonatal rats

(2015) Xiaohuan Gu et al.   EXPERIMENTAL NEUROLOGY

Cargo Delivery into the Brain by in vivo identified Transport Peptides

(2015) Eduard Urich et al.   Scientific Reports

In vivo phage display screen for peptide sequences that cross the blood–cerebrospinal-fluid barrier

(2014) Jingwei Li et al.   AMINO ACIDS

Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties

(2014) Michel Demeule et al.   JOURNAL OF CLINICAL INVESTIGATION

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants

(2014) Nga Bien-Ly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle

(2014) Jens Niewoehner et al.   NEURON

Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates

(2014) Y. J. Yu et al.   Science Translational Medicine

Study of the transcytosis of an anti-transferrin receptor antibody with a Fab′ cargo across the blood–brain barrier in mice

(2013) Gemma Manich et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier

(2013) J. A. Couch et al.   Science Translational Medicine

Peptide sequences mediating tropism to intact blood–brain barrier: An in vivo biodistribution study using phage display

(2012) Mathew W. Smith et al.   PEPTIDES

In Vivo Labeling of Brain Capillary Endothelial Cells after Intravenous Injection of Monoclonal Antibodies Targeting the Transferrin Receptor

(2011) S. Paris-Robidas et al.   MOLECULAR PHARMACOLOGY

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

(2011) Y. J. Yu et al.   Science Translational Medicine

The role of neurotensin in physiologic and pathologic processes

(2011) W Conan Mustain et al.   Current Opinion in Endocrinology Diabetes and Obesity

Binding and uptake of H-ferritin are mediated by human transferrin receptor-1

(2010) Li Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single domain antibodies: promising experimental and therapeutic tools in infection and immunity

(2009) Janusz Wesolowski et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Engineering and expression of a chimeric transferrin receptor monoclonal antibody for blood-brain barrier delivery in the mouse

(2008) Ruben J. Boado et al.   BIOTECHNOLOGY AND BIOENGINEERING

Identification of nose-to-brain homing peptide through phage display

(2008) Xiao-Mei Wan et al.   PEPTIDES

Restricted transport of anti-transferrin receptor antibody (OX26) through the blood-brain barrier in the rat

(2003) Torben Moos et al.   JOURNAL OF NEUROCHEMISTRY