Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain

Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor–ligand complex

(2019) Emiko Uchikawa et al.   eLife

Visualization of ligand-induced transmembrane signaling in the full-length human insulin receptor

(2018) Theresia Gutmann et al.   JOURNAL OF CELL BIOLOGY

How ligand binds to the type 1 insulin-like growth factor receptor

(2018) Yibin Xu et al.   Nature Communications

Near-native, site-specific and purification-free protein labeling for quantitative protein interaction analysis by MicroScale Thermophoresis

(2018) Tanja Bartoschik et al.   Scientific Reports

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

A thing of beauty: Structure and function of insulin's “aromatic triplet”

(2018) Michael A. Weiss et al.   DIABETES OBESITY & METABOLISM

Structure of the insulin receptor–insulin complex by single-particle cryo-EM analysis

(2018) Giovanna Scapin et al.   NATURE

The signalling conformation of the insulin receptor ectodomain

(2018) Felix Weis et al.   Nature Communications

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

doGlycans–Tools for Preparing Carbohydrate Structures for Atomistic Simulations of Glycoproteins, Glycolipids, and Carbohydrate Polymers for GROMACS

(2017) Reinis Danne et al.   Journal of Chemical Information and Modeling

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

Structural Perspectives of Insulin Receptor Isoform-Selective Insulin Analogs

(2017) Jiří Jiráček et al.   Frontiers in Endocrinology

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Advances in the molecular dynamics flexible fitting method for cryo-EM modeling

(2016) Ryan McGreevy et al.   METHODS

Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain

(2016) Tristan I. Croll et al.   STRUCTURE

Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2

(2016) Dari Kimanius et al.   eLife

Structural Dynamics of Insulin Receptor and Transmembrane Signaling

(2015) Suren A. Tatulian   BIOCHEMISTRY

Insulin/receptor binding: The last piece of the puzzle?

(2015) Pierre De Meyts   BIOESSAYS

N-Glycosylation as determinant of epidermal growth factor receptor conformation in membranes

(2015) Karol Kaszuba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

(2014) A. Kleinridders et al.   DIABETES

Protective hinge in insulin opens to enable its receptor engagement

(2014) J. G. Menting et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging concepts in the regulation of the EGF receptor and other receptor tyrosine kinases

(2014) Nicholas F. Endres et al.   TRENDS IN BIOCHEMICAL SCIENCES

An Insulin-to-Insulin Regulatory Network Orchestrates Phenotypic Specificity in Development and Physiology

(2014) Diana Andrea Fernandes de Abreu et al.   PLoS Genetics

How IGF-1 activates its receptor

(2014) Jennifer M Kavran et al.   eLife

Insulin receptor-insulin interaction kinetics using multiplex surface plasmon resonance

(2013) Kannan Subramanian et al.   JOURNAL OF MOLECULAR RECOGNITION

How insulin engages its primary binding site on the insulin receptor

(2013) John G. Menting et al.   NATURE

Relaxation of backbone bond geometry improves protein energy landscape modeling

(2013) Patrick Conway et al.   PROTEIN SCIENCE

Real-space refinement with DireX: From global fitting to side-chain improvements

(2012) Zhe Wang et al.   BIOPOLYMERS

Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

(2012) Susanne A.I. Seidel et al.   METHODS

Insulin receptor and cancer

(2011) A. Belfiore et al.   ENDOCRINE-RELATED CANCER

RosettaScripts: A Scripting Language Interface to the Rosetta Macromolecular Modeling Suite

(2011) Sarel J. Fleishman et al.   PLoS One

Cell Membranes: The Lipid Perspective

(2011) Ünal Coskun et al.   STRUCTURE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor

(2010) Diego Alvarado et al.   CELL

Decoding the Cryptic Active Conformation of a Protein by Synthetic Photoscanning

(2009) Bin Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular dynamics flexible fitting: A practical guide to combine cryo-electron microscopy and X-ray crystallography

(2009) Leonardo G. Trabuco et al.   METHODS

Harmonic oscillator model of the insulin and IGF1 receptors’ allosteric binding and activation

(2009) Vladislav V Kiselyov et al.   Molecular Systems Biology

High-Affinity Insulin Binding: Insulin Interacts with Two Receptor Ligand Binding Sites†

(2008) Linda Whittaker et al.   BIOCHEMISTRY

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

A Comparative Structural Bioinformatics Analysis of the Insulin Receptor Family Ectodomain Based on Phylogenetic Information

(2008) Miguel E. Rentería et al.   PLoS One

N-linked glycans of the human insulin receptor and their distribution over the crystal structure

(2007) Lindsay G. Sparrow et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS