Acute and Chronic Dosing of a High-Affinity Rat/Mouse Chimeric Transferrin Receptor Antibody in Mice

Blood-Brain Barrier and Delivery of Protein and Gene Therapeutics to Brain

(2020) William M. Pardridge   Frontiers in Aging Neuroscience

Modulating the antibody density changes the uptake and transport at the blood-brain barrier of both transferrin receptor-targeted gold nanoparticles and liposomal cargo

(2019) Kasper Bendix Johnsen et al.   JOURNAL OF CONTROLLED RELEASE

Plasma Pharmacokinetics of High-Affinity Transferrin Receptor Antibody-Erythropoietin Fusion Protein is a Function of Effector Attenuation in Mice

(2019) Jiahong Sun et al.   MOLECULAR PHARMACEUTICS

Targeting the transferrin receptor for brain drug delivery

(2019) Kasper Bendix Johnsen et al.   PROGRESS IN NEUROBIOLOGY

2018 Alzheimer's disease facts and figures

(2018)   Alzheimers & Dementia

First Infusion Reactions are Mediated by FcγRIIIb and Neutrophils

(2018) Felix Weber et al.   PHARMACEUTICAL RESEARCH

Brain Shuttle Antibody for Alzheimer’s Disease with Attenuated Peripheral Effector Function due to an Inverted Binding Mode

(2018) Felix Weber et al.   Cell Reports

Blood-Brain Barrier Transport, Plasma Pharmacokinetics, and Neuropathology Following Chronic Treatment of the Rhesus Monkey with a Brain Penetrating Humanized Monoclonal Antibody Against the Human Transferrin Receptor

(2018) William M. Pardridge et al.   MOLECULAR PHARMACEUTICS

A Brain Penetrating Bifunctional Erythropoietin-Transferrin Receptor Antibody Fusion Protein for Alzheimer’s Disease

(2018) Rudy Chang et al.   MOLECULAR PHARMACEUTICS

Iduronate-2-Sulfatase with Anti-human Transferrin Receptor Antibody for Neuropathic Mucopolysaccharidosis II: A Phase 1/2 Trial

(2018) Torayuki Okuyama et al.   MOLECULAR THERAPY

The transferrin receptor: the cellular iron gate

(2017) Elena Gammella et al.   Metallomics

Blood–Brain Barrier Penetrating Biologic TNF-α Inhibitor for Alzheimer’s Disease

(2017) Rudy Chang et al.   MOLECULAR PHARMACEUTICS

Stress reticulocytes lose transferrin receptors by an extrinsic process involving spleen and macrophages

(2016) Melissa M. Rhodes et al.   AMERICAN JOURNAL OF HEMATOLOGY

CSF, blood-brain barrier, and brain drug delivery

(2016) William M. Pardridge   Expert Opinion on Drug Delivery

Lipopolysaccharide exacerbates infarct size and results in worsened post-stroke behavioral outcomes

(2015) Danielle N. Doll et al.   Behavioral and Brain Functions

Immunomodulation by IVIg and the Role of Fc-Gamma Receptors: Classic Mechanisms of Action after all?

(2015) Sietse Q. Nagelkerke et al.   Frontiers in Immunology

Blood–brain barrier drug delivery of IgG fusion proteins with a transferrin receptor monoclonal antibody

(2014) William M Pardridge   Expert Opinion on Drug Delivery

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants

(2014) Nga Bien-Ly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates

(2014) Y. J. Yu et al.   Science Translational Medicine

The role of Fc gamma receptors in the activity of immunomodulatory antibodies for cancer

(2014) Ross Stewart et al.   Journal for ImmunoTherapy of Cancer

Disaggregation of Amyloid Plaque in Brain of Alzheimer’s Disease Transgenic Mice with Daily Subcutaneous Administration of a Tetravalent Bispecific Antibody That Targets the Transferrin Receptor and the Abeta Amyloid Peptide

(2013) Rachita K. Sumbria et al.   MOLECULAR PHARMACEUTICS

Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier

(2013) J. A. Couch et al.   Science Translational Medicine

Brain Protection from Stroke with Intravenous TNFα Decoy Receptor-Trojan Horse Fusion Protein

(2012) Rachita K Sumbria et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

(2011) Y. J. Yu et al.   Science Translational Medicine

Pharmacokinetics and Brain Uptake of a Genetically Engineered Bifunctional Fusion Antibody Targeting the Mouse Transferrin Receptor

(2009) Ruben J. Boado et al.   MOLECULAR PHARMACEUTICS

Engineering and expression of a chimeric transferrin receptor monoclonal antibody for blood-brain barrier delivery in the mouse

(2008) Ruben J. Boado et al.   BIOTECHNOLOGY AND BIOENGINEERING