SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response
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Title
SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response
Authors
Keywords
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Journal
iScience
Volume 25, Issue 1, Pages 103562
Publisher
Elsevier BV
Online
2021-12-04
DOI
10.1016/j.isci.2021.103562
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Note: Only part of the references are listed.- SARS-CoV-2 nucleocapsid protein phase separates with G3BPs to disassemble stress granules and facilitate viral production
- (2021) Lingling Luo et al. Science Bulletin
- SARS-CoV-2 nucleocapsid protein undergoes liquid–liquid phase separation into stress granules through its N-terminal intrinsically disordered region
- (2021) Jia Wang et al. Cell Discovery
- Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
- (2021) Ryan A. Flynn et al. CELL
- Inhibition of anti-viral stress granule formation by coronavirus endoribonuclease nsp15 ensures efficient virus replication
- (2021) Bo Gao et al. PLoS Pathogens
- The SARS-CoV-2 RNA interactome
- (2021) Sungyul Lee et al. MOLECULAR CELL
- Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV
- (2021) Alexey Stukalov et al. NATURE
- Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication
- (2021) Ting Cai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SARS-CoV-2 nucleocapsid protein impairs stress granule formation to promote viral replication
- (2021) Zhou-Qin Zheng et al. Cell Discovery
- SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA
- (2021) Amanda Jack et al. PLOS BIOLOGY
- A pneumonia outbreak associated with a new coronavirus of probable bat origin
- (2020) Peng Zhou et al. NATURE
- Improved protein structure prediction using predicted interresidue orientations
- (2020) Jianyi Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2
- (2020) Qihui Wang et al. CELL
- Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization
- (2020) David W. Sanders et al. CELL
- G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules
- (2020) Peiguo Yang et al. CELL
- Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
- (2020) Daniel Blanco-Melo et al. CELL
- Evaluation of Nucleocapsid and Spike Protein-Based Enzyme-Linked Immunosorbent Assays for Detecting Antibodies against SARS-CoV-2
- (2020) Wanbing Liu et al. JOURNAL OF CLINICAL MICROBIOLOGY
- A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
- (2020) David E. Gordon et al. NATURE
- The HDOCK server for integrated protein–protein docking
- (2020) Yumeng Yan et al. Nature Protocols
- The RNA-Binding Protein Rasputin/G3BP Enhances the Stability and Translation of Its Target mRNAs
- (2020) John D. Laver et al. Cell Reports
- Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites
- (2020) Sisi Kang et al. Acta Pharmaceutica Sinica B
- Biochemical characterization of SARS-CoV-2 nucleocapsid protein
- (2020) Weihong Zeng et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- A proposed role for the SARS‐CoV‐2 nucleocapsid protein in the formation and regulation of biomolecular condensates
- (2020) Sean M. Cascarina et al. FASEB JOURNAL
- Architecture and self‐assembly of the SARS‐CoV ‐2 nucleocapsid protein
- (2020) Qiaozhen Ye et al. PROTEIN SCIENCE
- Liquid–liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA
- (2020) Hui Chen et al. CELL RESEARCH
- Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms
- (2020) David E. Gordon et al. SCIENCE
- SARS‐CoV‐2 nucleocapsid protein phase‐separates with RNA and with human hnRNPs
- (2020) Theodora Myrto Perdikari et al. EMBO JOURNAL
- Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions
- (2020) Christopher R. Carlson et al. MOLECULAR CELL
- Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2
- (2020) Ryan M. Hekman et al. MOLECULAR CELL
- Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid
- (2020) Christiane Iserman et al. MOLECULAR CELL
- Translational control of coronaviruses
- (2020) Sylvain de Breyne et al. NUCLEIC ACIDS RESEARCH
- Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates
- (2020) Adriana Savastano et al. Nature Communications
- The SARS-CoV-2 RNA–protein interactome in infected human cells
- (2020) Nora Schmidt et al. Nature Microbiology
- System-wide Profiling of RNA-Binding Proteins Uncovers Key Regulators of Virus Infection
- (2019) Manuel Garcia-Moreno et al. MOLECULAR CELL
- Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates
- (2019) Simon Alberti et al. CELL
- Viral Regulation of RNA Granules in Infected Cells
- (2019) Qiang Zhang et al. VIROLOGICA SINICA
- Stress granule: a promising target for cancer treatment
- (2019) Xiaomeng Gao et al. BRITISH JOURNAL OF PHARMACOLOGY
- Phosphorylation of G3BP1-S149 does not influence stress granule assembly
- (2019) Marc D. Panas et al. JOURNAL OF CELL BIOLOGY
- Properties of Stress Granule and P-Body Proteomes
- (2019) Ji-Young Youn et al. MOLECULAR CELL
- ShinyGO: a graphical gene-set enrichment tool for animals and plants
- (2019) Steven Xijin Ge et al. BIOINFORMATICS
- G3BP1 inhibits RNA virus replication by positively regulating RIG-I-mediated cellular antiviral response
- (2019) Wenping Yang et al. Cell Death & Disease
- The hepatitis C viral nonstructural protein 5A stabilizes growth-regulatory human transcripts
- (2018) Liang Guo et al. NUCLEIC ACIDS RESEARCH
- Rasputin a decade on and more promiscuous than ever? A review of G3BPs
- (2018) Umber Alam et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Phase Separation in Biology and Disease
- (2018) Julie D. Forman-Kay et al. JOURNAL OF MOLECULAR BIOLOGY
- Inhibition of Stress Granule Formation by Middle East Respiratory Syndrome Coronavirus 4a Accessory Protein Facilitates Viral Translation, Leading to Efficient Virus Replication
- (2018) Keisuke Nakagawa et al. JOURNAL OF VIROLOGY
- Reovirus infection induces stabilization and up-regulation of cellular transcripts that encode regulators of TGF-β signaling
- (2018) Liang Guo et al. PLoS One
- GENCODE reference annotation for the human and mouse genomes
- (2018) Adam Frankish et al. NUCLEIC ACIDS RESEARCH
- Interplay between coronavirus, a cytoplasmic RNA virus, and nonsense-mediated mRNA decay pathway
- (2018) Masami Wada et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An atlas of alternative splicing profiles and functional associations reveals new regulatory programs and genes that simultaneously express multiple major isoforms
- (2017) Javier Tapial et al. GENOME RESEARCH
- UMI-tools: modeling sequencing errors in Unique Molecular Identifiers to improve quantification accuracy
- (2017) Tom Smith et al. GENOME RESEARCH
- Zika Virus Hijacks Stress Granule Proteins and Modulates the Host Stress Response
- (2017) Shangmei Hou et al. JOURNAL OF VIROLOGY
- P-Body Purification Reveals the Condensation of Repressed mRNA Regulons
- (2017) Arnaud Hubstenberger et al. MOLECULAR CELL
- Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors
- (2017) Hong Han et al. MOLECULAR CELL
- ProHits-viz: a suite of web tools for visualizing interaction proteomics data
- (2017) James D R Knight et al. NATURE METHODS
- Splicing and transcription touch base: co-transcriptional spliceosome assembly and function
- (2017) Lydia Herzel et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis
- (2017) Raghu R Edupuganti et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis
- (2017) Raghu R Edupuganti et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Proteomic approaches to uncovering virus–host protein interactions during the progression of viral infection
- (2016) Krystal K Lum et al. Expert Review of Proteomics
- Multiparameter functional diversity of human C2H2 zinc finger proteins
- (2016) Frank W. Schmitges et al. GENOME RESEARCH
- Mechanistic insights into mammalian stress granule dynamics
- (2016) Marc D. Panas et al. JOURNAL OF CELL BIOLOGY
- G3BP–Caprin1–USP10 complexes mediate stress granule condensation and associate with 40S subunits
- (2016) Nancy Kedersha et al. JOURNAL OF CELL BIOLOGY
- Preferential binding of a stable G3BP ribonucleoprotein complex to intron-retaining transcripts in mouse brain and modulation of their expression in the cerebellum
- (2016) Sophie Martin et al. JOURNAL OF NEUROCHEMISTRY
- Casein Kinase 2 Is Linked to Stress Granule Dynamics through Phosphorylation of the Stress Granule Nucleating Protein G3BP1
- (2016) Lucas C. Reineke et al. MOLECULAR AND CELLULAR BIOLOGY
- MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets
- (2016) Sudhir Kumar et al. MOLECULAR BIOLOGY AND EVOLUTION
- Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP)
- (2016) Eric L Van Nostrand et al. NATURE METHODS
- The MaxQuant computational platform for mass spectrometry-based shotgun proteomics
- (2016) Stefka Tyanova et al. Nature Protocols
- CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL
- (2016) Paulina Bartuzi et al. Nature Communications
- Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses
- (2016) Huib H. Rabouw et al. PLoS Pathogens
- New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes
- (2016) Dal Young Kim et al. PLoS Pathogens
- G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA
- (2015) Anaïs Aulas et al. JOURNAL OF CELL BIOLOGY
- Loss of Clcc1 Results in ER Stress, Misfolded Protein Accumulation, and Neurodegeneration
- (2015) Y. Jia et al. JOURNAL OF NEUROSCIENCE
- The MEME Suite
- (2015) Timothy L. Bailey et al. NUCLEIC ACIDS RESEARCH
- The SARS coronavirus nucleocapsid protein – Forms and functions
- (2014) Chung-ke Chang et al. ANTIVIRAL RESEARCH
- The Coronavirus Nucleocapsid Is a Multifunctional Protein
- (2014) Ruth McBride et al. Viruses-Basel
- Human-Chromatin-Related Protein Interactions Identify a Demethylase Complex Required for Chromosome Segregation
- (2014) Edyta Marcon et al. Cell Reports
- G3BP1, G3BP2 and CAPRIN1 Are Required for Translation of Interferon Stimulated mRNAs and Are Targeted by a Dengue Virus Non-coding RNA
- (2014) Katell Bidet et al. PLoS Pathogens
- SAINTexpress: Improvements and additional features in Significance Analysis of INTeractome software
- (2013) Guoci Teo et al. Journal of Proteomics
- iCLIP: Protein–RNA interactions at nucleotide resolution
- (2013) Ina Huppertz et al. METHODS
- Alternative cleavage and polyadenylation: extent, regulation and function
- (2013) Ran Elkon et al. NATURE REVIEWS GENETICS
- Crystal Structures of the Human G3BP1 NTF2-Like Domain Visualize FxFG Nup Repeat Specificity
- (2013) Tina Vognsen et al. PLoS One
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- Both G3BP1 and G3BP2 contribute to stress granule formation
- (2012) Hideaki Matsuki et al. GENES TO CELLS
- clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
- (2012) Guangchuang Yu et al. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
- Ataxin-2-Like Is a Regulator of Stress Granules and Processing Bodies
- (2012) Christian Kaehler et al. PLoS One
- Regulation of stress granules in virus systems
- (2012) James P. White et al. TRENDS IN MICROBIOLOGY
- HHblits: lightning-fast iterative protein sequence searching by HMM-HMM alignment
- (2011) Michael Remmert et al. NATURE METHODS
- Viral-mediated stabilization of AU-rich element containing mRNA contributes to cell transformation
- (2011) T Kuroshima et al. ONCOGENE
- BEDTools: a flexible suite of utilities for comparing genomic features
- (2010) Aaron R. Quinlan et al. BIOINFORMATICS
- The chemotherapeutic agent bortezomib induces the formation of stress granules
- (2010) Marie-Josée Fournier et al. Cancer Cell International
- Turnover of AU-rich-containing mRNAs during stress: a matter of survival
- (2010) Christopher von Roretz et al. Wiley Interdisciplinary Reviews-RNA
- Eukaryotic Stress Granules: The Ins and Outs of Translation
- (2009) J. Ross Buchan et al. MOLECULAR CELL
- Activation of the Antiviral Kinase PKR and Viral Countermeasures
- (2009) Bianca Dauber et al. Viruses-Basel
- Conserved GU-Rich Elements Mediate mRNA Decay by Binding to CUG-Binding Protein 1
- (2008) Irina A. Vlasova et al. MOLECULAR CELL
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