Translational control of coronaviruses

An interactive web-based dashboard to track COVID-19 in real time

(2020) Ensheng Dong et al.   LANCET INFECTIOUS DISEASES

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

No-Go Decay mRNA cleavage in the ribosome exit tunnel produces 5′-OH ends phosphorylated by Trl1

(2020) Albertas Navickas et al.   Nature Communications

The Architecture of SARS-CoV-2 Transcriptome

(2020) Dongwan Kim et al.   CELL

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Mechanisms, regulation and functions of the unfolded protein response

(2020) Claudio Hetz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human Type I Interferon Antiviral Effects in Respiratory and Reemerging Viral Infections

(2020) Patricio L. Acosta et al.   Journal of Immunology Research

The Global Phosphorylation Landscape of SARS-CoV-2 Infection

(2020) Mehdi Bouhaddou et al.   CELL

The molecular virology of Coronaviruses

(2020) Ella Hartenian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and functional conservation of the programmed −1 ribosomal frameshift signal of SARS coronavirus 2 (SARS-CoV-2)

(2020) Jamie A. Kelly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gcn2 eIF2α kinase mediates combinatorial translational regulation through nucleotide motifs and uORFs in target mRNAs

(2020) Yuji Chikashige et al.   NUCLEIC ACIDS RESEARCH

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

(2020) Matthias Thoms et al.   SCIENCE

A molecular pore spans the double membrane of the coronavirus replication organelle

(2020) Georg Wolff et al.   SCIENCE

Double-Membrane Vesicles as Platforms for Viral Replication

(2020) Georg Wolff et al.   TRENDS IN MICROBIOLOGY

SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses

(2020) Abhik K. Banerjee et al.   CELL

Mammalian stress granules and P bodies at a glance

(2020) Claire L. Riggs et al.   JOURNAL OF CELL SCIENCE

The coding capacity of SARS-CoV-2

(2020) Yaara Finkel et al.   NATURE

SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation

(2020) Katharina Schubert et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

N6-methyladenosine regulates PEDV replication and host gene expression

(2020) Jianing Chen et al.   VIROLOGY

Dance with the Devil: Stress Granules and Signaling in Antiviral Responses

(2020) Nina Eiermann et al.   Viruses-Basel

New insights into no-go, non-stop and nonsense-mediated mRNA decay complexes

(2020) Kyle T Powers et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Interplay between Influenza Virus and the Host RNA Polymerase II Transcriptional Machinery

(2019) Alexander P. Walker et al.   TRENDS IN MICROBIOLOGY

The Molecular Basis of Viral Inhibition of IRF- and STAT-Dependent Immune Responses

(2019) Hao-Sen Chiang et al.   Frontiers in Immunology

Identification and characterization of a human coronavirus 229E nonstructural protein 8-associated RNA 3′-terminal adenylyltransferase activity

(2019) Jana Tvarogová et al.   JOURNAL OF VIROLOGY

SARS coronavirus protein nsp1 disrupts localization of Nup93 from the nuclear pore complex

(2019) Garret N. Gomez et al.   Biochemistry and Cell Biology

Translational Control under Stress: Reshaping the Translatome

(2019) Vivek M. Advani et al.   BIOESSAYS

The Organizing Principles of Eukaryotic Ribosome Recruitment

(2019) Jerry Pelletier et al.   Annual Review of Biochemistry

Human Coronavirus: Host-Pathogen Interaction

(2019) To Sing Fung et al.   Annual Review of Microbiology

A conserved region of nonstructural protein 1 from alphacoronaviruses inhibits host gene expression and is critical for viral virulence

(2019) Zhou Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Hsp70 chaperone network

(2019) Rina Rosenzweig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of Viral Infection by the RNA Modification N6-methyladenosine

(2019) Graham D. Williams et al.   Annual Review of Virology

Direct RNA nanopore sequencing of full-length coronavirus genomes provides novel insights into structural variants and enables modification analysis

(2019) Adrian Viehweger et al.   GENOME RESEARCH

Extensions, Extra Factors, and Extreme Complexity: Ribosomal Structures Provide Insights into Eukaryotic Translation

(2019) Melanie Weisser et al.   Cold Spring Harbor Perspectives in Biology

The C-terminal domain of the MERS coronavirus M protein contains a trans-Golgi network localization signal

(2019) Anabelle Perrier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Porcine Deltacoronavirus Replication Organelle Comprises Double-Membrane Vesicles and Zippered Endoplasmic Reticulum with Double-Membrane Spherules

(2019) Nicole Doyle et al.   Viruses-Basel

Adapted formaldehyde gradient cross-linking protocol implicates human eIF3d and eIF3c, k and l subunits in the 43S and 48S pre-initiation complex assembly, respectively

(2019) Anna Herrmannová et al.   NUCLEIC ACIDS RESEARCH

Potential roles of the poly(A)-binding proteins in translational regulation during spermatogenesis

(2018) Saffet OZTURK et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Role of eIF2α Kinases in Translational Control and Adaptation to Cellular Stress

(2018) Ronald C. Wek   Cold Spring Harbor Perspectives in Biology

Protein Synthesis Initiation in Eukaryotic Cells

(2018) William C. Merrick et al.   Cold Spring Harbor Perspectives in Biology

Phosphorylation and Signal Transduction Pathways in Translational Control

(2018) Christopher G. Proud   Cold Spring Harbor Perspectives in Biology

Noncanonical Translation Initiation in Eukaryotes

(2018) Thaddaeus Kwan et al.   Cold Spring Harbor Perspectives in Biology

Translation initiation by cap-dependent ribosome recruitment: Recent insights and open questions

(2018) Nikolay E. Shirokikh et al.   Wiley Interdisciplinary Reviews-RNA

The endonucleolytic RNA cleavage function of nsp1 of Middle East respiratory syndrome coronavirus promotes the production of infectious virus particles in specific human cell lines

(2018) Keisuke Nakagawa et al.   JOURNAL OF VIROLOGY

Interplay between the poly(A) tail, poly(A)-binding protein and coronavirus nucleocapsid protein regulates gene expression of the coronavirus and host cell

(2018) Tsung-Lin Tsai et al.   JOURNAL OF VIROLOGY

Inhibition of Stress Granule Formation by Middle East Respiratory Syndrome Coronavirus 4a Accessory Protein Facilitates Viral Translation, Leading to Efficient Virus Replication

(2018) Keisuke Nakagawa et al.   JOURNAL OF VIROLOGY

Stress Granules and Processing Bodies in Translational Control

(2018) Pavel Ivanov et al.   Cold Spring Harbor Perspectives in Biology

Structural Basis for the Inhibition of Host Gene Expression by Porcine Epidemic Diarrhea Virus nsp1

(2017) Zhou Shen et al.   JOURNAL OF VIROLOGY

Classification and function of small open reading frames

(2017) Juan-Pablo Couso et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Virus taxonomy: the database of the International Committee on Taxonomy of Viruses (ICTV)

(2017) Elliot J Lefkowitz et al.   NUCLEIC ACIDS RESEARCH

MODOMICS: a database of RNA modification pathways. 2017 update

(2017) Pietro Boccaletto et al.   NUCLEIC ACIDS RESEARCH

Dynamics of IRES-mediated translation

(2017) Alex G. Johnson et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages

(2017) Xufang Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MERS coronavirus nsp1 participates in an efficient propagation through a specific interaction with viral RNA

(2017) Yutaka Terada et al.   VIROLOGY

Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA Replication

(2017) Diede Oudshoorn et al.   mBio

Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5

(2017) Eiji Obayashi et al.   Cell Reports

Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication

(2017) Eveline Kindler et al.   PLoS Pathogens

Upstream ORFs are prevalent translational repressors in vertebrates

(2016) Timothy G Johnstone et al.   EMBO JOURNAL

Infectious Bronchitis Coronavirus Limits Interferon Production by Inducing a Host Shutoff That Requires Accessory Protein 5b

(2016) Joeri Kint et al.   JOURNAL OF VIROLOGY

Post-transcriptional gene regulation by mRNA modifications

(2016) Boxuan Simen Zhao et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An RNA trapping mechanism in Alphavirus mRNA promotes ribosome stalling and translation initiation

(2016) René Toribio et al.   NUCLEIC ACIDS RESEARCH

SRAMP: prediction of mammalian N6-methyladenosine (m6A) sites based on sequence-derived features

(2016) Yuan Zhou et al.   NUCLEIC ACIDS RESEARCH

Tuning Specific Translation in Cancer Metastasis and Synaptic Memory: Control at the MNK–eIF4E Axis

(2016) Clive R. Bramham et al.   TRENDS IN BIOCHEMICAL SCIENCES

Principles and Properties of Stress Granules

(2016) David S.W. Protter et al.   TRENDS IN CELL BIOLOGY

Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses

(2016) Huib H. Rabouw et al.   PLoS Pathogens

High-Resolution Analysis of Coronavirus Gene Expression by RNA Sequencing and Ribosome Profiling

(2016) Nerea Irigoyen et al.   PLoS Pathogens

Characterization of the Role of Hexamer AGUAAA and Poly(A) Tail in Coronavirus Polyadenylation

(2016) Yu-Hui Peng et al.   PLoS One

Middle East Respiratory Syndrome Coronavirus nsp1 Inhibits Host Gene Expression by Selectively Targeting mRNAs Transcribed in the Nucleus while Sparing mRNAs of Cytoplasmic Origin

(2015) Kumari G. Lokugamage et al.   JOURNAL OF VIROLOGY

Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex

(2015) Jose L. Llácer et al.   MOLECULAR CELL

Probing the closed-loop model of mRNA translation in living cells

(2015) Stuart K Archer et al.   RNA Biology

SHAPE analysis of the RNA secondary structure of the Mouse Hepatitis Virus 5’ untranslated region and N-terminal nsp1 coding sequences

(2015) Dong Yang et al.   VIROLOGY

Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression

(2015) Krishna Narayanan et al.   VIRUS RESEARCH

The structure and functions of coronavirus genomic 3′ and 5′ ends

(2015) Dong Yang et al.   VIRUS RESEARCH

Cryo-EM structure of Hepatitis C virus IRES bound to the human ribosome at 3.9-Å resolution

(2015) Nick Quade et al.   Nature Communications

Continuous and Discontinuous RNA Synthesis in Coronaviruses

(2015) Isabel Sola et al.   Annual Review of Virology

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Poly(A)-binding proteins are required for diverse biological processes in metazoans

(2014) Richard W.P. Smith et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Single-Molecule Kinetics of the Eukaryotic Initiation Factor 4AI upon RNA Unwinding

(2014) Yingjie Sun et al.   STRUCTURE

Regulation of coronaviral poly(A) tail length during infection is not coronavirus species- or host cell-specific

(2014) Jui-Hung Shien et al.   VIRUS GENES

Comparative analysis of the activation of unfolded protein response by spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus HKU1

(2014) Kam-Leung Siu et al.   Cell and Bioscience

Two-Stage Translational Control of Dentate Gyrus LTP Consolidation Is Mediated by Sustained BDNF-TrkB Signaling to MNK

(2014) Debabrata Panja et al.   Cell Reports

A new paradigm: innate immune sensing of viruses via the unfolded protein response

(2014) Judith A. Smith   Frontiers in Microbiology

Cytoplasmic RNA Granules and Viral Infection

(2014) Wei-Chih Tsai et al.   Annual Review of Virology

Roles of helicases in translation initiation: A mechanistic view

(2013) Assen Marintchev   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The mechanism of translation initiation on Type 1 picornavirus IRESs

(2013) Trevor R Sweeney et al.   EMBO JOURNAL

MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-  treatment

(2013) A. H. de Wilde et al.   JOURNAL OF GENERAL VIROLOGY

Eukaryotic mRNA Decay: Methodologies, Pathways, and Links to Other Stages of Gene Expression

(2013) José E. Pérez-Ortín et al.   JOURNAL OF MOLECULAR BIOLOGY

Reselection of a Genomic Upstream Open Reading Frame in Mouse Hepatitis Coronavirus 5'-Untranslated-Region Mutants

(2013) H.-Y. Wu et al.   JOURNAL OF VIROLOGY

Antibiotic re-frames decoding

(2013) John F. Atkins et al.   NATURE

Identification of Residues of SARS-CoV nsp1 That Differentially Affect Inhibition of Gene Expression and Antiviral Signaling

(2013) Andrew R. Jauregui et al.   PLoS One

Regulation of Coronaviral Poly(A) Tail Length during Infection

(2013) Hung-Yi Wu et al.   PLoS One

Stress granules and cell signaling: more than just a passing phase?

(2013) Nancy Kedersha et al.   TRENDS IN BIOCHEMICAL SCIENCES

Severe Acute Respiratory Syndrome Coronavirus Protein nsp1 Is a Novel Eukaryotic Translation Inhibitor That Represses Multiple Steps of Translation Initiation

(2012) K. G. Lokugamage et al.   JOURNAL OF VIROLOGY

Severe Acute Respiratory Syndrome Coronavirus nsp1 Facilitates Efficient Propagation in Cells through a Specific Translational Shutoff of Host mRNA

(2012) T. Tanaka et al.   JOURNAL OF VIROLOGY

A Common Strategy for Host RNA Degradation by Divergent Viruses

(2012) M. M. Gaglia et al.   JOURNAL OF VIROLOGY

A Novel 4EHP-GIGYF2 Translational Repressor Complex Is Essential for Mammalian Development

(2012) M. Morita et al.   MOLECULAR AND CELLULAR BIOLOGY

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS-like virus in the Middle East: A truly bat-related coronavirus causing human diseases

(2012) Guangwen Lu et al.   Protein & Cell

Mechanisms and implications of programmed translational frameshifting

(2012) Jonathan D. Dinman   Wiley Interdisciplinary Reviews-RNA

Cytoplasmic polyadenylation and translational control

(2011) Ana Villalba et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Human Coronavirus-Induced Neuronal Programmed Cell Death Is Cyclophilin D Dependent and Potentially Caspase Dispensable

(2011) D. J. Favreau et al.   JOURNAL OF VIROLOGY

Blocking eIF4E-eIF4G Interaction as a Strategy To Impair Coronavirus Replication

(2011) R. Cencic et al.   JOURNAL OF VIROLOGY

Viral subversion of the host protein synthesis machinery

(2011) Derek Walsh et al.   NATURE REVIEWS MICROBIOLOGY

RNA-RNA and RNA-protein interactions in coronavirus replication and transcription

(2011) Isabel Sola et al.   RNA Biology

The Structure of the Eukaryotic Ribosome at 3.0 A Resolution

(2011) A. Ben-Shem et al.   SCIENCE

SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA Cleavage

(2011) Cheng Huang et al.   PLoS Pathogens

Organelle-Like Membrane Compartmentalization of Positive-Strand RNA Virus Replication Factories

(2010) Johan A. den Boon et al.   Annual Review of Microbiology

Coronaviruses Hijack the LC3-I-Positive EDEMosomes, ER-Derived Vesicles Exporting Short-Lived ERAD Regulators, for Replication

(2010) Fulvio Reggiori et al.   Cell Host & Microbe

Qualitative and quantitative ultrastructural analysis of the membrane rearrangements induced by coronavirus

(2010) Mustafa Ulasli et al.   CELLULAR MICROBIOLOGY

Nsp1 proteins of group I and SARS coronaviruses share structural and functional similarities

(2010) Yongjin Wang et al.   INFECTION GENETICS AND EVOLUTION

Alphacoronavirus Transmissible Gastroenteritis Virus nsp1 Protein Suppresses Protein Translation in Mammalian Cells and in Cell-Free HeLa Cell Extracts but Not in Rabbit Reticulocyte Lysate

(2010) C. Huang et al.   JOURNAL OF VIROLOGY

Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F

(2010) R. Cencic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Group-specific structural features of the 5′-proximal sequences of coronavirus genomic RNAs

(2010) Shih-Cheng Chen et al.   VIROLOGY

Structural and functional diversity of viral IRESes

(2009) Laurent Balvay et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Suppression of Host Gene Expression by nsp1 Proteins of Group 2 Bat Coronaviruses

(2009) Y. Tohya et al.   JOURNAL OF VIROLOGY

Severe Acute Respiratory Syndrome Coronavirus Nonstructural Protein 2 Interacts with a Host Protein Complex Involved in Mitochondrial Biogenesis and Intracellular Signaling

(2009) C. T. Cornillez-Ty et al.   JOURNAL OF VIROLOGY

A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein

(2009) Wataru Kamitani et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The SARS Coronavirus 3a Protein Causes Endoplasmic Reticulum Stress and Induces Ligand-Independent Downregulation of the Type 1 Interferon Receptor

(2009) Rinki Minakshi et al.   PLoS One

Translational control of the subgenomic RNAs of severe acute respiratory syndrome coronavirus

(2009) Yaling Yang et al.   VIRUS GENES

Translational control by cytoplasmic polyadenylation in Xenopus oocytes

(2008) Helois E. Radford et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Phosphorylation of the arginine/serine dipeptide-rich motif of the severe acute respiratory syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization

(2008) Tsui-Yi Peng et al.   FEBS Journal

The role of programmed-1 ribosomal frameshifting in coronavirus propagation

(2008) Ewan et al.   Frontiers in Bioscience-Landmark

Severe acute respiratory syndrome coronavirus 3a protein activates the mitochondrial death pathway through p38 MAP kinase activation

(2008) K. Padhan et al.   JOURNAL OF GENERAL VIROLOGY

The Nucleocapsid Protein of Severe Acute Respiratory Syndrome Coronavirus Inhibits Cell Cytokinesis and Proliferation by Interacting with Translation Elongation Factor 1 

(2008) B. Zhou et al.   JOURNAL OF VIROLOGY

Severe Acute Respiratory Syndrome Coronavirus Triggers Apoptosis via Protein Kinase R but Is Resistant to Its Antiviral Activity

(2008) V. Krahling et al.   JOURNAL OF VIROLOGY

Severe Acute Respiratory Syndrome Coronavirus nsp1 Suppresses Host Gene Expression, Including That of Type I Interferon, in Infected Cells

(2008) K. Narayanan et al.   JOURNAL OF VIROLOGY

Coronavirus Spike Protein Inhibits Host Cell Translation by Interaction with eIF3f

(2008) Han Xiao et al.   PLoS One

Stress granules: the Tao of RNA triage

(2008) Paul Anderson et al.   TRENDS IN BIOCHEMICAL SCIENCES

Modulation of enteroviral proteinase cleavage of poly(A)-binding protein (PABP) by conformation and PABP-associated factors

(2008) Carlos I. Rivera et al.   VIROLOGY

Cleavage of eukaryotic initiation factor eIF5B by enterovirus 3C proteases

(2008) Sylvain de Breyne et al.   VIROLOGY

Frameshifting RNA pseudoknots: Structure and mechanism

(2008) David P. Giedroc et al.   VIRUS RESEARCH

SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic Reticulum

(2008) Kèvin Knoops et al.   PLOS BIOLOGY

Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine: Involvement of p38 MAPK and ERK

(2007) Masakazu Kono et al.   ANTIVIRAL RESEARCH