Development of human alveolar epithelial cell models to study distal lung biology and disease

Directed induction of alveolar type I cells derived from pluripotent stem cells via Wnt signaling inhibition

(2021) Shuhei Kanagaki et al.   STEM CELLS

Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo

(2021) Danielle R. Little et al.   Nature Communications

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Addressing variability in iPSC-derived models of human disease: guidelines to promote reproducibility

(2020) Viola Volpato et al.   Disease Models & Mechanisms

Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis

(2020) Maximilian Strunz et al.   Nature Communications

Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis

(2020) Taylor S. Adams et al.   Science Advances

Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis

(2020) Arun C. Habermann et al.   Science Advances

The Idiopathic Pulmonary Fibrosis Cell Atlas

(2020) Nir Neumark et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Single Nucleus RNASeq Profiling of Mouse Lung: Reduced Dissociation Bias and Improved Rare Cell Type Detection Compared with Single Cell RNASeq

(2020) Jeffrey R. Koenitzer et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Human lung stem cell-based alveolospheres provide insights into SARS-CoV-2 mediated interferon responses and pneumocyte dysfunction

(2020) Hiroaki Katsura et al.   Cell Stem Cell

PANTHER version 16: a revised family classification, tree-based classification tool, enhancer regions and extensive API

(2020) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

Immortalisation of primary human alveolar epithelial lung cells using a non-viral vector to study respiratory bioreactivity in vitro

(2020) Alberto Katsumiti et al.   Scientific Reports

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Proliferating SPP1/MERTK-expressing macrophages in idiopathic pulmonary fibrosis

(2019) Christina Morse et al.   EUROPEAN RESPIRATORY JOURNAL

Transcriptional control of lung alveolar type 1 cell development and maintenance by NK homeobox 2-1

(2019) Danielle R. Little et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human lung branching morphogenesis is orchestrated by the spatiotemporal distribution of ACTA2, SOX2, and SOX9

(2018) Soula Danopoulos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Claudin-18–mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis

(2018) Beiyun Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms and functions of cellular senescence

(2018) Nicolás Herranz et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Pulmonary alveolar type I cell population consists of two distinct subtypes that differ in cell fate

(2018) Yanjie Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells

(2018) Ahmad N. Nabhan et al.   SCIENCE

Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium

(2018) Katherine B. McCauley et al.   Stem Cell Reports

Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor

(2018) William J. Zacharias et al.   NATURE

Positional integration of lung adenocarcinoma susceptibility loci with primary human alveolar epithelial cell epigenomes

(2018) Chenchen Yang et al.   Epigenomics

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

(2018) Paul A Reyfman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

CLDN18.1 attenuates malignancy and related signaling pathways of lung adenocarcinoma in vivo and in vitro

(2018) Jiao Luo et al.   INTERNATIONAL JOURNAL OF CANCER

Long-term expansion of alveolar stem cells derived from human iPS cells in organoids

(2017) Yuki Yamamoto et al.   NATURE METHODS

DBTSS/DBKERO for integrated analysis of transcriptional regulation

(2017) Ayako Suzuki et al.   NUCLEIC ACIDS RESEARCH

The Encyclopedia of DNA elements (ENCODE): data portal update

(2017) Carrie A Davis et al.   NUCLEIC ACIDS RESEARCH

Conditionally reprogrammed primary airway epithelial cells maintain morphology, lineage and disease specific functional characteristics

(2017) Kelly M. Martinovich et al.   Scientific Reports

Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro

(2017) Bryan A. Hassell et al.   Cell Reports

Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids

(2017) Marko Z Nikolić et al.   eLife

Human embryonic and induced pluripotent stem cells maintain phenotype but alter their metabolism after exposure to ROCK inhibitor

(2017) Spyros I. Vernardis et al.   Scientific Reports

Combinations of differentiation markers distinguish subpopulations of alveolar epithelial cells in adult lung

(2016) Janice M. Liebler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Regenerative potential of human airway stem cells in lung epithelial engineering

(2016) Sarah E. Gilpin et al.   BIOMATERIALS

One-step immortalization of primary human airway epithelial cells capable of oncogenic transformation

(2016) Jordan L. Smith et al.   Cell and Bioscience

Plasticity of Hopx+ type I alveolar cells to regenerate type II cells in the lung

(2015) Rajan Jain et al.   Nature Communications

In vitro generation of human pluripotent stem cell derived lung organoids

(2015) Briana R Dye et al.   eLife

Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq

(2014) Barbara Treutlein et al.   NATURE

The effect of Rho kinase inhibition on long-term keratinocyte proliferation is rapid and conditional

(2014) Sandra Chapman et al.   Stem Cell Research & Therapy

Generation of Alveolar Epithelial Spheroids via Isolated Progenitor Cells from Human Pluripotent Stem Cells

(2014) Shimpei Gotoh et al.   Stem Cell Reports

Rho-Associated Protein Kinase Inhibition Enhances Airway Epithelial Basal-Cell Proliferation and Lentivirus Transduction

(2013) Amjad Horani et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Breaking theIn VitroAlveolar Type II Cell Proliferation Barrier while Retaining Ion Transport Properties

(2013) Peter F. Bove et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Type 2 alveolar cells are stem cells in adult lung

(2013) Christina E. Barkauskas et al.   JOURNAL OF CLINICAL INVESTIGATION

Lung epithelial branching program antagonizes alveolar differentiation

(2013) D. R. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sox9 plays multiple roles in the lung epithelium during branching morphogenesis

(2013) B. E. Rockich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrated Transcriptomic and Epigenomic Analysis of Primary Human Lung Epithelial Cell Differentiation

(2013) Crystal N. Marconett et al.   PLoS Genetics

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Building and maintaining the epithelium of the lung

(2012) Craig R. Rackley et al.   JOURNAL OF CLINICAL INVESTIGATION

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells

(2012) F. A. Suprynowicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ROCK Inhibitor and Feeder Cells Induce the Conditional Reprogramming of Epithelial Cells

(2011) Xuefeng Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

Epithelial Progenitor Cells in Lung Development, Maintenance, Repair, and Disease

(2011) Jason R. Rock et al.   Annual Review of Cell and Developmental Biology

Oncogene-Mediated Human Lung Epithelial Cell Transformation Produces Adenocarcinoma Phenotypes In Vivo

(2011) K. Sasai et al.   CANCER RESEARCH

The three R’s of lung health and disease: repair, remodeling, and regeneration

(2011) Michael F. Beers et al.   JOURNAL OF CLINICAL INVESTIGATION

FoxM1 mediates the progenitor function of type II epithelial cells in repairing alveolar injury induced byPseudomonas aeruginosa

(2011) Yuru Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Synergistic Effect of Medium, Matrix, and Exogenous Factors on the Adhesion and Growth of Human Pluripotent Stem Cells Under Defined, Xeno-Free Conditions

(2011) Guoliang Meng et al.   STEM CELLS AND DEVELOPMENT

Regulated gene expression in cultured type II cells of adult human lung

(2010) Philip L. Ballard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

HTII-280, a Biomarker Specific to the Apical Plasma Membrane of Human Lung Alveolar Type II Cells

(2010) Robert F. Gonzalez et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

ROCK inhibition enhances the recovery and growth of cryopreserved human embryonic stem cells and human induced pluripotent stem cells

(2009) David A. Claassen et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

GSK3: a multifaceted kinase in Wnt signaling

(2009) Dianqing Wu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Immortalization of Human Alveolar Epithelial Cells to Investigate Nanoparticle Uptake

(2008) Sarah J. Kemp et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A Multicolor Panel of Novel Lentiviral “Gene Ontology” (LeGO) Vectors for Functional Gene Analysis

(2008) Kristoffer Weber et al.   MOLECULAR THERAPY