TERT Promoter Mutations Increase Sense and Antisense Transcription from the TERT Promoter

The Solo Play of TERT Promoter Mutations

(2020) François Hafezi et al.   Cells

Allele‐specific proximal promoter hypomethylation of the telomerase reverse transcriptase gene ( TERT ) associates with TERT expression in multiple cancers

(2020) Teisha J. Rowland et al.   Molecular Oncology

Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players

(2019) Xiaotian Yuan et al.   ONCOGENE

Distinct profiles of TERT promoter mutations and telomerase expression in head and neck cancer and cervical carcinoma

(2018) Clorinda Annunziata et al.   INTERNATIONAL JOURNAL OF CANCER

Telomere Maintenance Mechanisms in Cancer

(2018) Tiago Bordeira Gaspar et al.   Genes

Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner

(2018) Andrew Mancini et al.   CANCER CELL

Telomere length, telomerase reverse transcriptase promoter mutations, and melanoma risk

(2018) Sivaramakrishna Rachakonda et al.   GENES CHROMOSOMES & CANCER

TERT promoter mutation subtypes and survival in stage I and II melanoma patients

(2018) Juan J. Andrés-Lencina et al.   INTERNATIONAL JOURNAL OF CANCER

DNA hypermethylation within TERT promoter upregulates TERT expression in cancer

(2018) Donghyun D. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

TERT promoter wild-type glioblastomas show distinct clinical features and frequent PI3K pathway mutations

(2018) Erik A. Williams et al.   Acta Neuropathologica Communications

TERTbiology and function in cancer: beyond immortalisation

(2017) Ana Pestana et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

TERT promoter mutations in telomere biology

(2017) Barbara Heidenreich et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Systematic analysis of telomere length and somatic alterations in 31 cancer types

(2017) Floris P Barthel et al.   NATURE GENETICS

Mutations in the promoter of the telomerase geneTERTcontribute to tumorigenesis by a two-step mechanism

(2017) Kunitoshi Chiba et al.   SCIENCE

Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes

(2017) Josh Lewis Stern et al.   Cell Reports

High incidence of TERT mutation in brain tumor cell lines

(2016) Tanner M. Johanns et al.   Brain Tumor Pathology

Prognostic effects ofTERTpromoter mutations are enhanced by coexistence withBRAForRASmutations and strengthen the risk prediction by the ATA or TNM staging system in differentiated thyroid cancer patients

(2016) Young Shin Song et al.   CANCER

Reactivation of telomerase in cancer

(2016) Semih Can Akincilar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Clinical utility of TERT promoter mutations and ALK rearrangement in thyroid cancer patients with a high prevalence of the BRAF V600E mutation

(2016) Ja Seong Bae et al.   Diagnostic Pathology

The prognostic impact of TERT promoter mutations in glioblastomas is modified by the rs2853669 single nucleotide polymorphism

(2016) Rui Batista et al.   INTERNATIONAL JOURNAL OF CANCER

Distribution of TERT promoter mutations in primary and metastatic melanomas in Austrian patients

(2016) Richard Ofner et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

High prevalence of TERT promoter mutations in primary squamous cell carcinoma of the urinary bladder

(2016) Morgan Cowan et al.   MODERN PATHOLOGY

Classification based on mutations ofTERTpromoter andIDHcharacterizes subtypes in grade II/III gliomas

(2016) Pei Yang et al.   NEURO-ONCOLOGY

High prevalence of TERT promoter mutations in micropapillary urothelial carcinoma

(2016) Doreen Nguyen et al.   VIRCHOWS ARCHIV

Long-Range Chromatin Interactions Drive Mutant TERT Promoter Activation

(2016) S. C. Ak nc lar et al.   Cancer Discovery

Tumor specific mutations in TERT promoter and CTNNB1 gene in hepatitis B and hepatitis C related hepatocellular carcinoma

(2016) Francesca Pezzuto et al.   Oncotarget

Telomerase reverse transcriptase promoter mutations in hepatitis B virus-associated hepatocellular carcinoma

(2016) Xunjun Yang et al.   Oncotarget

Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene

(2016) Muhammad Ramlee et al.   Genes

Cancer-Specific Telomerase Reverse Transcriptase (TERT) Promoter Mutations: Biological and Clinical Implications

(2016) Tiantian Liu et al.   Genes

A combination of TERT promoter mutation and MGMT methylation status predicts clinically relevant subgroups of newly diagnosed glioblastomas

(2016) Hideyuki Arita et al.   Acta Neuropathologica Communications

Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation

(2015) Dong-Sheng Huang et al.   EUROPEAN JOURNAL OF CANCER

Mutation of theTERTpromoter, switch to active chromatin, and monoallelicTERTexpression in multiple cancers

(2015) Josh Lewis Stern et al.   GENES & DEVELOPMENT

Mutations inTERTpromoter andFGFR3and telomere length in bladder cancer

(2015) Ismail Hosen et al.   INTERNATIONAL JOURNAL OF CANCER

Association of TERT Promoter Mutation, But Not BRAF Mutation, With Increased Mortality in PTC

(2015) Jonathan R. George et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Association ofTERTPromoter Mutation 1,295,228 C>T WithBRAFV600E Mutation, Older Patient Age, and Distant Metastasis in Anaplastic Thyroid Cancer

(2015) Xiaoguang Shi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity

(2015) Cheryl M. Koh et al.   JOURNAL OF CLINICAL INVESTIGATION

Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features

(2015) Fukiko Kawai-Kitahata et al.   JOURNAL OF GASTROENTEROLOGY

Telomerase in differentiated thyroid cancer: Promoter mutations, expression and localization

(2015) Marina Muzza et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation

(2015) Yinghui Li et al.   NATURE CELL BIOLOGY

Prognostic quality of activating TERT promoter mutations in glioblastoma: interaction with the rs2853669 polymorphism and patient age at diagnosis

(2015) Sabine Spiegl-Kreinecker et al.   NEURO-ONCOLOGY

Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors

(2015) Jeanette E. Eckel-Passow et al.   NEW ENGLAND JOURNAL OF MEDICINE

The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer

(2015) R. J. A. Bell et al.   SCIENCE

TERT promoter hot spot mutations are frequent in Indian cervical and oral squamous cell carcinomas

(2015) Vilvanathan Vinothkumar et al.   TUMOR BIOLOGY

Common telomerase reverse transcriptase promoter mutations in hepatocellular carcinomas from different geographical locations

(2015) Dilek Cevik   WORLD JOURNAL OF GASTROENTEROLOGY

Human telomerase reverse transcriptase (hTERT) promotes gastric cancer invasion through cooperating with c-Myc to upregulate heparanase expression

(2015) Bo Tang et al.   Oncotarget

TERT promoter mutations and polymorphisms as prognostic factors in primary glioblastoma

(2015) Mohamed Ali Mosrati et al.   Oncotarget

The C228T mutation of TERT promoter frequently occurs in bladder cancer stem cells and contributes to tumorigenesis of bladder cancer

(2015) Chong Li et al.   Oncotarget

Cancer-associated TERT promoter mutations abrogate telomerase silencing

(2015) Kunitoshi Chiba et al.   eLife

TERT promoter mutations and monoallelic activation of TERT in cancer

(2015) F W Huang et al.   Oncogenesis

Expression level of hTERT is regulated by somatic mutation and common single nucleotide polymorphism at promoter region in glioblastoma

(2015) Chul-Kee Park et al.   Oncotarget

Noncanonical Functions of Telomerase: Implications in Telomerase-Targeted Cancer Therapies

(2014) Yinghui Li et al.   CANCER RESEARCH

TERTPromoter Mutations and Their Association withBRAFV600E Mutation and Aggressive Clinicopathological Characteristics of Thyroid Cancer

(2014) Xiaoli Liu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

TERT Promoter Mutations Are a Major Indicator of Poor Outcome in Differentiated Thyroid Carcinomas

(2014) Miguel Melo et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

TERT Promoter Mutations in Skin Cancer: The Effects of Sun Exposure and X-Irradiation

(2014) Helena Pópulo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Telomere-Regulating Genes and the Telomere Interactome in Familial Cancers

(2014) Carla Daniela Robles-Espinoza et al.   MOLECULAR CANCER RESEARCH

Trans-ancestry mutational landscape of hepatocellular carcinoma genomes

(2014) Yasushi Totoki et al.   NATURE GENETICS

TERT promoter mutations: a novel independent prognostic factor in primary glioblastomas

(2014) Matthias Simon et al.   NEURO-ONCOLOGY

TERT Promoter Mutations Lead to High Transcriptional Activity under Hypoxia and Temozolomide Treatment and Predict Poor Prognosis in Gliomas

(2014) Chen Chen et al.   PLoS One

Telomerase reverse transcriptase promoter mutations in primary cutaneous melanoma

(2014) Barbara Heidenreich et al.   Nature Communications

TERT promoter mutation in resectable hepatocellular carcinomas: A strong association with hepatitis C infection and absence of hepatitis B infection

(2014) Yu-Ling Chen et al.   International Journal of Surgery

TERT promoter mutations rather than methylation are the main mechanism for TERT upregulation in adult gliomas

(2013) Hideyuki Arita et al.   ACTA NEUROPATHOLOGICA

Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss

(2013) Hideyuki Arita et al.   ACTA NEUROPATHOLOGICA

TERT promoter mutations in ocular melanoma distinguish between conjunctival and uveal tumours

(2013) K G Griewank et al.   BRITISH JOURNAL OF CANCER

Highly prevalentTERTpromoter mutations in bladder cancer and glioblastoma

(2013) Xiaoli Liu et al.   CELL CYCLE

Telomerase Reverse Transcriptase Promoter Mutations in Bladder Cancer: High Frequency Across Stages, Detection in Urine, and Lack of Association with Outcome

(2013) Yves Allory et al.   EUROPEAN UROLOGY

Human telomerase reverse transcriptase regulates MMP expression independently of telomerase activity via NF-κB-dependent transcription

(2013) Deqiang Ding et al.   FASEB JOURNAL

Frequent SomaticTERTPromoter Mutations in Thyroid Cancer: Higher Prevalence in Advanced Forms of the Disease

(2013) Iñigo Landa et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mutations of the TERT promoter are common in basal cell carcinoma and squamous cell carcinoma

(2013) Glynis A Scott et al.   MODERN PATHOLOGY

The age- and shorter telomere-dependent TERT promoter mutation in follicular thyroid cell-derived carcinomas

(2013) T Liu et al.   ONCOGENE

TERT Promoter Mutations Are Frequent in Cutaneous Basal Cell Carcinoma and Squamous Cell Carcinoma

(2013) Klaus G. Griewank et al.   PLoS One

TERT promoter mutations in bladder cancer affect patient survival and disease recurrence through modification by a common polymorphism

(2013) P. S. Rachakonda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

(2013) P. J. Killela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TERT Promoter Mutations in Familial and Sporadic Melanoma

(2013) S. Horn et al.   SCIENCE

Highly Recurrent TERT Promoter Mutations in Human Melanoma

(2013) F. W. Huang et al.   SCIENCE

Frequency of TERT promoter mutations in human cancers

(2013) João Vinagre et al.   Nature Communications

High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions

(2013) Jean Charles Nault et al.   Nature Communications

Telomerase directly regulates NF-κB-dependent transcription

(2012) Arkasubhra Ghosh et al.   NATURE CELL BIOLOGY

Telomerase reverse transcriptase promotes epithelial–mesenchymal transition and stem cell-like traits in cancer cells

(2012) Z Liu et al.   ONCOGENE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Separation of telomerase functions by reverse genetics

(2011) S. Mukherjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

hTERT promoter activity and CpG methylation in HPV-induced carcinogenesis

(2010) Jillian de Wilde et al.   BMC CANCER

Telomerase modulates Wnt signalling by association with target gene chromatin

(2009) Jae-Il Park et al.   NATURE