Cancer-Specific Telomerase Reverse Transcriptase (TERT) Promoter Mutations: Biological and Clinical Implications

AcquiredTERTpromoter mutations stimulateTERTtranscription in mantle cell lymphoma

(2016) Julieta Panero et al.   AMERICAN JOURNAL OF HEMATOLOGY

Clinicopathological significance of TERT promoter mutation in papillary thyroid carcinomas: a systematic review and meta-analysis

(2016) De-tao Yin et al.   CLINICAL ENDOCRINOLOGY

TERTpromoter mutations are a major indicator of recurrence and death due to papillary thyroid carcinomas

(2016) Martyn Bullock et al.   CLINICAL ENDOCRINOLOGY

Clinical utility of TERT promoter mutations and ALK rearrangement in thyroid cancer patients with a high prevalence of the BRAF V600E mutation

(2016) Ja Seong Bae et al.   Diagnostic Pathology

The Sensitive Detection of Telomerase Reverse Transcriptase Promoter Mutation by Amplification Refractory Mutation System-PCR

(2016) Jinbo Liu et al.   Genetic Testing and Molecular Biomarkers

Telomerase reverse transcriptase (TERT) promoter mutation analysis of benign, malignant and reactive urothelial lesions reveals a subpopulation of inverted papilloma with immortalizing genetic change

(2016) Liang Cheng et al.   HISTOPATHOLOGY

TERTpromoter mutations in melanoma survival

(2016) Eduardo Nagore et al.   INTERNATIONAL JOURNAL OF CANCER

Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers

(2016) Iñigo Landa et al.   JOURNAL OF CLINICAL INVESTIGATION

Varying Mutational Alterations in Multiple Primary Melanomas

(2016) Friederike Egberts et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

TERTpromoter mutations associate with fast-growing melanoma

(2016) Eduardo Nagore et al.   Pigment Cell & Melanoma Research

An interaction proteomics survey of transcription factor binding at recurrent TERT promoter mutations

(2016) Matthew M. Makowski et al.   PROTEOMICS

The genetic difference between Western and Chinese urothelial cell carcinomas: infrequent FGFR3 mutation in Han Chinese patients

(2016) Xiaotian Yuan et al.   Oncotarget

The association between the TERT rs2736100 AC genotype and reduced risk of upper tract urothelial carcinomas in a Han Chinese population

(2016) Xiaotian Yuan et al.   Oncotarget

Telomerase reverse transcriptase promoter mutations in hepatitis B virus-associated hepatocellular carcinoma

(2016) Xunjun Yang et al.   Oncotarget

TERT Promoter Mutations and Tumor Persistence/Recurrence in Papillary Thyroid Cancer

(2016) Jae Kyung Myung et al.   Cancer Research and Treatment

Telomere and Telomerase Therapeutics in Cancer

(2016) Yucheng Xu et al.   Genes

Telomerase Activity is Downregulated Early During Human Brain Development

(2016) Abbas Ishaq et al.   Genes

Telomerase reverse transcriptase promoter mutations in glandular lesions of the urinary bladder

(2015) Eric Vail et al.   Annals of Diagnostic Pathology

Heterogeneity of TERT promoter mutations status in squamous cell carcinomas of different anatomical sites

(2015) Katherine A. Cheng et al.   Annals of Diagnostic Pathology

TERT promoter mutations are frequent and show association with MED12 mutations in phyllodes tumors of the breast

(2015) Masayuki Yoshida et al.   BRITISH JOURNAL OF CANCER

TERTpromoter mutations in periocular carcinomas: implications of ultraviolet light in pathogenesis

(2015) Shih-Yao Lin et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Tall cell papillary thyroid carcinoma: new diagnostic criteria and mutations in BRAF and TERT

(2015) M. S Dettmer et al.   ENDOCRINE-RELATED CANCER

TERT promoter mutations are associated with distant metastases in papillary thyroid carcinoma

(2015) G. Gandolfi et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Mutation of theTERTpromoter, switch to active chromatin, and monoallelicTERTexpression in multiple cancers

(2015) Josh Lewis Stern et al.   GENES & DEVELOPMENT

Preoperative Assessment of TERT Promoter Mutation on Thyroid Core Needle Biopsies Supports Diagnosis of Malignancy and Addresses Surgical Strategy

(2015) A. Crescenzi et al.   HORMONE AND METABOLIC RESEARCH

Mutations inTERTpromoter andFGFR3and telomere length in bladder cancer

(2015) Ismail Hosen et al.   INTERNATIONAL JOURNAL OF CANCER

Association of TERT Promoter Mutation, But Not BRAF Mutation, With Increased Mortality in PTC

(2015) Jonathan R. George et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Association ofTERTPromoter Mutation 1,295,228 C>T WithBRAFV600E Mutation, Older Patient Age, and Distant Metastasis in Anaplastic Thyroid Cancer

(2015) Xiaoguang Shi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Clinical and Molecular Features of Hürthle Cell Carcinoma of the Thyroid

(2015) Ana-Maria Chindris et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Coexistence of TERT Promoter and BRAF Mutations in Papillary Thyroid Carcinoma: Added Value in Patient Prognosis?

(2015) Miguel Melo et al.   JOURNAL OF CLINICAL ONCOLOGY

TERT promoter mutation during development of hepatoblastoma to hepatocellular carcinoma

(2015) Rui Dong et al.   JOURNAL OF HEPATOLOGY

TERT promoter mutations and rs2853669 polymorphism: prognostic impact and interactions with common alterations in glioblastomas

(2015) Umberto Nencha et al.   JOURNAL OF NEURO-ONCOLOGY

TERT Promoter Mutations and Risk of Recurrence in Meningioma

(2015) Felix Sahm et al.   JNCI-Journal of the National Cancer Institute

Association of Telomerase Reverse Transcriptase Promoter Mutations with the Prognosis of Glioma Patients: a Meta-Analysis

(2015) Xiaogang Wang et al.   MOLECULAR NEUROBIOLOGY

Prognostic quality of activating TERT promoter mutations in glioblastoma: interaction with the rs2853669 polymorphism and patient age at diagnosis

(2015) Sabine Spiegl-Kreinecker et al.   NEURO-ONCOLOGY

Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors

(2015) Jeanette E. Eckel-Passow et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Genetic Evolution of Melanoma from Precursor Lesions

(2015) A. Hunter Shain et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas

(2015)   NEW ENGLAND JOURNAL OF MEDICINE

TERT Promoter Mutations and TERT mRNA but Not FGFR3 Mutations Are Urinary Biomarkers in Han Chinese Patients With Urothelial Bladder Cancer

(2015) K. Wang et al.   ONCOLOGIST

Frequency of TERT Promoter Mutations in Prostate Cancer

(2015) Robert Stoehr et al.   PATHOBIOLOGY

The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer

(2015) R. J. A. Bell et al.   SCIENCE

TERTPromoter Mutations in Papillary Thyroid Microcarcinomas

(2015) Dario de Biase et al.   THYROID

TERT promoter hot spot mutations are frequent in Indian cervical and oral squamous cell carcinomas

(2015) Vilvanathan Vinothkumar et al.   TUMOR BIOLOGY

Coexistence of TERT promoter and BRAF mutations in cutaneous melanoma is associated with more clinicopathological features of aggressiveness

(2015) Elisabetta Macerola et al.   VIRCHOWS ARCHIV

Common telomerase reverse transcriptase promoter mutations in hepatocellular carcinomas from different geographical locations

(2015) Dilek Cevik   WORLD JOURNAL OF GASTROENTEROLOGY

ARID1A and TERT promoter mutations in dedifferentiated meningioma

(2015) Malak S. Abedalthagafi et al.   Cancer Genetics

The DNA methylation inhibitor induces telomere dysfunction and apoptosis of leukemia cells that is attenuated by telomerase over-expression

(2015) Xiaolu Zhang et al.   Oncotarget

Bortezomib-mediated down-regulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells

(2015) Xinyu Ci et al.   Oncotarget

TERT promoter mutations and telomere length in adult malignant gliomas and recurrences

(2015) Barbara Heidenreich et al.   Oncotarget

TERT Promoter Mutations Are Predictive of Aggressive Clinical Behavior in Patients with Spitzoid Melanocytic Neoplasms

(2015) Seungjae Lee et al.   Scientific Reports

Cancer-associated TERT promoter mutations abrogate telomerase silencing

(2015) Kunitoshi Chiba et al.   eLife

TERT Promoter Mutations and Risk of Recurrence in Meningioma

(2015) Felix Sahm et al.   JNCI-Journal of the National Cancer Institute

Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas

(2015) Patrick J. Killela et al.   Oncotarget

TERT promoter mutations in renal cell carcinomas and upper tract urothelial carcinomas

(2015) Kun Wang et al.   Oncotarget

TERT promoter mutations and gene amplification: Promoting TERT expression in Merkel cell carcinoma

(2015) Hong Xie et al.   Oncotarget

TERT promoter mutations are associated with distant metastases in upper tract urothelial carcinomas and serve as urinary biomarkers detected by a sensitive castPCR

(2015) Kun Wang et al.   Oncotarget

TCEAL7 Inhibition of c-Myc Activity in Alternative Lengthening of Telomeres Regulates hTERT Expression

(2015) Kyle Lafferty-Whyte et al.   NEOPLASIA

TERT promoter mutations in gliomas, genetic associations and clinico-pathological correlations

(2014) M Labussière et al.   BRITISH JOURNAL OF CANCER

TERTpromoter mutation as an early genetic event activating telomerase in follicular thyroid adenoma (FTA) and atypical FTA

(2014) Na Wang et al.   CANCER

Extra-telomeric Functions of Human Telomerase: Cancer, Mitochondria and Oxidative Stress

(2014) G. Saretzki   CURRENT PHARMACEUTICAL DESIGN

Diagnostic and prognostic TERT promoter mutations in thyroid fine-needle aspiration biopsy

(2014) R. Liu et al.   ENDOCRINE-RELATED CANCER

The activating TERT promoter mutation C228T is recurrent in subsets of adrenal tumors

(2014) Tiantian Liu et al.   ENDOCRINE-RELATED CANCER

Low frequency of TERT promoter mutations in gastrointestinal stromal tumors (GISTs)

(2014) Nathália C Campanella et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The absence of TERT promoter mutations in primary gastric cancer

(2014) Tiantian Liu et al.   GENE

TERTpromoter mutations predict worse survival in laryngeal cancer patients

(2014) Yiping Qu et al.   INTERNATIONAL JOURNAL OF CANCER

Telomerase-Dependent and Independent Telomere Maintenance and its Clinical Implications in Medullary Thyroid Carcinoma

(2014) Na Wang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

TERTPromoter Mutations and Their Association withBRAFV600E Mutation and Aggressive Clinicopathological Characteristics of Thyroid Cancer

(2014) Xiaoli Liu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

TERT Promoter Mutations Are a Major Indicator of Poor Outcome in Differentiated Thyroid Carcinomas

(2014) Miguel Melo et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

BRAF V600E and TERT Promoter Mutations Cooperatively Identify the Most Aggressive Papillary Thyroid Cancer With Highest Recurrence

(2014) Mingzhao Xing et al.   JOURNAL OF CLINICAL ONCOLOGY

A primary melanoma and its asynchronous metastasis highlight the role ofBRAF,CDKN2A, andTERT

(2014) Gregory A. Hosler et al.   JOURNAL OF CUTANEOUS PATHOLOGY

TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities

(2014) Christian Koelsche et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

TERT Promoter Mutation Status as an Independent Prognostic Factor in Cutaneous Melanoma

(2014) Klaus G. Griewank et al.   JNCI-Journal of the National Cancer Institute

Melanomas of unknown primary frequently harbor TERT-promoter mutations

(2014) Friederike Egberts et al.   MELANOMA RESEARCH

Molecular alterations in endometrial and ovarian clear cell carcinomas: clinical impacts of telomerase reverse transcriptase promoter mutation

(2014) Hsien-Neng Huang et al.   MODERN PATHOLOGY

TERT promoter mutations: a novel independent prognostic factor in primary glioblastomas

(2014) Matthias Simon et al.   NEURO-ONCOLOGY

Combined analysis of TERT, EGFR, and IDH status defines distinct prognostic glioblastoma classes

(2014) M. Labussiere et al.   NEUROLOGY

TERT Promoter Mutations Lead to High Transcriptional Activity under Hypoxia and Temozolomide Treatment and Predict Poor Prognosis in Gliomas

(2014) Chen Chen et al.   PLoS One

Telomerase as a “stemness” enzyme

(2014) Feng Kong et al.   Science China-Life Sciences

Telomerase reverse transcriptase promoter mutations in primary cutaneous melanoma

(2014) Barbara Heidenreich et al.   Nature Communications

TERT promoter mutation in resectable hepatocellular carcinomas: A strong association with hepatitis C infection and absence of hepatitis B infection

(2014) Yu-Ling Chen et al.   International Journal of Surgery

TERT promoter mutations rather than methylation are the main mechanism for TERT upregulation in adult gliomas

(2013) Hideyuki Arita et al.   ACTA NEUROPATHOLOGICA

TERT promoter mutations in primary and secondary glioblastomas

(2013) Naosuke Nonoguchi et al.   ACTA NEUROPATHOLOGICA

Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss

(2013) Hideyuki Arita et al.   ACTA NEUROPATHOLOGICA

Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system

(2013) Christian Koelsche et al.   ACTA NEUROPATHOLOGICA

High Incidence of ActivatingTERTPromoter Mutations in Meningiomas Undergoing Malignant Progression

(2013) Stéphane Goutagny et al.   BRAIN PATHOLOGY

Telomerase reverse transcriptase inhibition stimulates cyclooxygenase 2 expression in cancer cells and synergizes with celecoxib to exert anti-cancer effects

(2013) T Liu et al.   BRITISH JOURNAL OF CANCER

Highly prevalentTERTpromoter mutations in bladder cancer and glioblastoma

(2013) Xiaoli Liu et al.   CELL CYCLE

TERT promoter mutations in cancer development

(2013) Barbara Heidenreich et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Highly prevalent TERT promoter mutations in aggressive thyroid cancers

(2013) Xiaoli Liu et al.   ENDOCRINE-RELATED CANCER

Telomerase Reverse Transcriptase Gene Promoter Mutations Help Discern the Origin of Urogenital Tumors: A Genomic and Molecular Study

(2013) Song Wu et al.   EUROPEAN UROLOGY

Telomerase Reverse Transcriptase Promoter Mutations in Bladder Cancer: High Frequency Across Stages, Detection in Urine, and Lack of Association with Outcome

(2013) Yves Allory et al.   EUROPEAN UROLOGY

Comprehensive Mutation Analysis of the TERT Promoter in Bladder Cancer and Detection of Mutations in Voided Urine

(2013) Carolyn D. Hurst et al.   EUROPEAN UROLOGY

Human telomerase reverse transcriptase regulates MMP expression independently of telomerase activity via NF-κB-dependent transcription

(2013) Deqiang Ding et al.   FASEB JOURNAL

Frequent somatic mutations of the telomerase reverse transcriptase promoter in ovarian clear cell carcinoma but not in other major types of gynaecological malignancy

(2013) Ren-Chin Wu et al.   JOURNAL OF PATHOLOGY

Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study

(2013) Pedro Castelo-Branco et al.   LANCET ONCOLOGY

Mutations of the TERT promoter are common in basal cell carcinoma and squamous cell carcinoma

(2013) Glynis A Scott et al.   MODERN PATHOLOGY

TERT promoter mutations are frequent in atypical fibroxanthomas and pleomorphic dermal sarcomas

(2013) Klaus G Griewank et al.   MODERN PATHOLOGY

Prognostic significance of telomerase-associated parameters in glioblastoma: effect of patient age

(2013) Daniela Lötsch et al.   NEURO-ONCOLOGY

Overexpression and promoter mutation of the TERT gene in malignant pleural mesothelioma

(2013) A Tallet et al.   ONCOGENE

The age- and shorter telomere-dependent TERT promoter mutation in follicular thyroid cell-derived carcinomas

(2013) T Liu et al.   ONCOGENE

Mitochondrial Telomerase Protects Cancer Cells from Nuclear DNA Damage and Apoptosis

(2013) Chatchawan Singhapol et al.   PLoS One

TERT Promoter Mutations Are Frequent in Cutaneous Basal Cell Carcinoma and Squamous Cell Carcinoma

(2013) Klaus G. Griewank et al.   PLoS One

TERT promoter mutations in bladder cancer affect patient survival and disease recurrence through modification by a common polymorphism

(2013) P. S. Rachakonda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

(2013) P. J. Killela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TERT Promoter Mutations in Familial and Sporadic Melanoma

(2013) S. Horn et al.   SCIENCE

Highly Recurrent TERT Promoter Mutations in Human Melanoma

(2013) F. W. Huang et al.   SCIENCE

Telomerase at the intersection of cancer and aging

(2013) Bruno Bernardes de Jesus et al.   TRENDS IN GENETICS

Frequency of TERT promoter mutations in human cancers

(2013) João Vinagre et al.   Nature Communications

High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions

(2013) Jean Charles Nault et al.   Nature Communications

Human Telomerase Reverse Transcriptase (hTERT) Is a Novel Target of the Wnt/β-Catenin Pathway in Human Cancer

(2012) Yong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Telomerase reverse transcriptase promotes epithelial–mesenchymal transition and stem cell-like traits in cancer cells

(2012) Z Liu et al.   ONCOGENE

Wnt/ -Catenin Signaling Regulates Telomerase in Stem Cells and Cancer Cells

(2012) K. Hoffmeyer et al.   SCIENCE

Chromatin and epigenetic regulation of the telomerase reverse transcriptase gene

(2010) Jiyue Zhu et al.   Protein & Cell

Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression

(2009) Yuanyuan Li et al.   FASEB JOURNAL

Chromatin remodeling: recruitment of histone demethylase RBP2 by Mad1 for transcriptional repression of a Myc target gene, telomerase reverse transcriptase

(2009) Zheng Ge et al.   FASEB JOURNAL

The PTEN regulator DJ-1 is associated with hTERT expression in clear cell renal cell carcinoma

(2009) Raviprakash T. Sitaram et al.   INTERNATIONAL JOURNAL OF CANCER

FoxM1is up-regulated in gastric cancer and its inhibition leads to cellular senescence, partially dependent onp27kip1

(2009) Jiping Zeng et al.   JOURNAL OF PATHOLOGY

Activation of Telomerase by Human Cytomegalovirus

(2009) K. Straat et al.   JNCI-Journal of the National Cancer Institute

Central role of PI3K in transcriptional activation of hTERT in HTLV-I-infected cells

(2008) M. Bellon et al.   BLOOD

Bone Morphogenetic Protein-7 Inhibits Telomerase Activity, Telomere Maintenance, and Cervical Tumor Growth

(2008) L. Cassar et al.   CANCER RESEARCH

Ets2 Maintains hTERT Gene Expression and Breast Cancer Cell Proliferation by Interacting with c-Myc

(2008) Dakang Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Telomerase and Telomeres: Human Tumor Viruses Take Control

(2008) M. Bellon et al.   JNCI-Journal of the National Cancer Institute

TERT promotes cellular and organismal survival independently of telomerase activity

(2008) J Lee et al.   ONCOGENE

HPV E7 contributes to the telomerase activity of immortalized and tumorigenic cells and augments E6-induced hTERT promoter function

(2008) Xuefeng Liu et al.   VIROLOGY