The role of ferroptosis in lung cancer

Tumor heterogeneity in autophagy-dependent ferroptosis

(2021) Jingbo Li et al.   Autophagy

Oxygenated phosphatidylethanolamine navigates phagocytosis of ferroptotic cells by interacting with TLR2

(2021) Xiang Luo et al.   CELL DEATH AND DIFFERENTIATION

Cellular degradation systems in ferroptosis

(2021) Xin Chen et al.   CELL DEATH AND DIFFERENTIATION

Characteristics and Biomarkers of Ferroptosis

(2021) Xin Chen et al.   Frontiers in Cell and Developmental Biology

Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS‐mitochondrial fission‐mitophagy axis

(2021) Ming Liu et al.   Molecular Oncology

Broadening horizons: the role of ferroptosis in cancer

(2021) Xin Chen et al.   Nature Reviews Clinical Oncology

The deubiquitinase USP11 regulates cell proliferation and ferroptotic cell death via stabilization of NRF2 USP11 deubiquitinates and stabilizes NRF2

(2021) Chunjie Meng et al.   ONCOGENE

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

(2021) Yilei Zhang et al.   Nature Communications

NUPR1 is a critical repressor of ferroptosis

(2021) Jiao Liu et al.   Nature Communications

Curcumin induces ferroptosis in non‐small‐cell lung cancer via activating autophagy

(2021) Xin Tang et al.   Thoracic Cancer

PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis

(2021) Xinxin Song et al.   Cell Reports

miR-324-3p reverses cisplatin resistance by inducing GPX4-mediated ferroptosis in lung adenocarcinoma cell line A549

(2021) Shi-hua Deng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ferroptosis in infection, inflammation, and immunity

(2021) Xin Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

(2021) Chao Mao et al.   NATURE

Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity

(2021) Guang Lei et al.   ONCOGENE

CREB stimulates GPX4 transcription to inhibit ferroptosis in lung adenocarcinoma

(2021) Zhixian Wang et al.   ONCOLOGY REPORTS

Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes

(2021) Christina M. Bebber et al.   Nature Communications

Targeting histone deacetylase enhances the therapeutic effect of Erastin-induced ferroptosis in EGFR-activating mutant lung adenocarcinoma

(2021) Tuo Zhang et al.   Translational Lung Cancer Research

Ferroptosis is involved in the progression of hepatocellular carcinoma through the circ0097009/miR-1261/SLC7A11 axis

(2021) Ning Lyu et al.   Annals of Translational Medicine

Iron-Bound Lipocalin-2 Protects Renal Cell Carcinoma from Ferroptosis

(2021) Julia K. Meier et al.   Metabolites

Deubiquitinase USP35 modulates ferroptosis in lung cancer via targeting ferroportin

(2021) Zheng Tang et al.   Clinical and Translational Medicine

Local anesthetic levobupivacaine induces ferroptosis and inhibits progression by up-regulating p53 in non-small cell lung cancer

(2021) Minghua Meng et al.   Aging-US

Inhibition of GPX4 or mTOR overcomes resistance to Lapatinib via promoting ferroptosis in NSCLC cells

(2021) Jiangwei Ni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dihydroisotanshinone I induced ferroptosis and apoptosis of lung cancer cells

(2021) Ching-Yuan Wu et al.   BIOMEDICINE & PHARMACOTHERAPY

MicroRNA-302a-3p induces ferroptosis of non-small cell lung cancer cells via targeting ferroportin

(2021) Dong Wei et al.   FREE RADICAL RESEARCH

Lipocalin 2 expression promotes tumor progression and therapy resistance by inhibiting ferroptosis in colorectal cancer

(2021) Nazia Chaudhary et al.   INTERNATIONAL JOURNAL OF CANCER

Exosomal miR-4443 promotes cisplatin resistance in non-small cell lung carcinoma by regulating FSP1 m6A modification-mediated ferroptosis

(2021) Zhiyu Song et al.   LIFE SCIENCES

Anticancer effects of Cryptotanshinone against lung cancer cells through ferroptosis

(2021) Xiaoping Li et al.   Arabian Journal of Chemistry

Lidocaine Promoted Ferroptosis by Targeting miR-382-5p /SLC7A11 Axis in Ovarian and Breast Cancer

(2021) Dan Sun et al.   Frontiers in Pharmacology

Orlistat induces ferroptosis-like cell death of lung cancer cells

(2021) Wenjing Zhou et al.   Frontiers of Medicine

Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers

(2020) Ling F. Ye et al.   ACS Chemical Biology

AIFM2 blocks ferroptosis independent of ubiquinol metabolism

(2020) Enyong Dai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers

(2020) Suman Mukhopadhyay et al.   CANCER RESEARCH

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

(2020) Guang Lei et al.   CELL RESEARCH

Maintaining protein stability of ∆Np63 via USP 28 is required by squamous cancer cells

(2020) Cristian Prieto‐Garcia et al.   EMBO Molecular Medicine

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

(2020) Yilong Zou et al.   Nature Chemical Biology

Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death

(2020) Changfeng Li et al.   Autophagy

Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

(2020) John K. Eaton et al.   Nature Chemical Biology

Cysteine depletion induces pancreatic tumor ferroptosis in mice

(2020) Michael A. Badgley et al.   SCIENCE

The X-linked trichothiodystrophy-causing gene RNF113A links the spliceosome to cell survival upon DNA damage

(2020) Kateryna Shostak et al.   Nature Communications

Jdp2-deficient granule cell progenitors in the cerebellum are resistant to ROS-mediated apoptosis through xCT/Slc7a11 activation

(2020) Chia-Chen Ku et al.   Scientific Reports

Transferrin Receptor Is a Specific Ferroptosis Marker

(2020) Huizhong Feng et al.   Cell Reports

NRF2-GPX4/SOD2 axis imparts resistance to EGFR-tyrosine kinase inhibitors in non-small-cell lung cancer cells

(2020) Chun-shuang Ma et al.   ACTA PHARMACOLOGICA SINICA

Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers

(2020) Mariluz Soula et al.   Nature Chemical Biology

Broad Spectrum Deubiquitinase Inhibition Induces Both Apoptosis and Ferroptosis in Cancer Cells

(2020) Li Yang et al.   Frontiers in Oncology

ATF2 inhibits ani-tumor effects of BET inhibitor in a negative feedback manner by attenuating ferroptosis

(2020) Lina Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NEDD4L-mediated LTF protein degradation limits ferroptosis

(2020) Yuan Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR wild-type non-small-cell lung cancer

(2020) Jian-Shu Lou et al.   PHYTOMEDICINE

Dihydroartemisinin Inhibits the Proliferation, Colony Formation and Induces Ferroptosis of Lung Cancer Cells by Inhibiting PRIM2/SLC7A11 Axis

(2020) Bing Yuan et al.   OncoTargets and Therapy

MT1DP loaded by folate-modified liposomes sensitizes erastin-induced ferroptosis via regulating miR-365a-3p/NRF2 axis in non-small cell lung cancer cells

(2020) Chengcheng Gai et al.   Cell Death & Disease

Iron Metabolism in Ferroptosis

(2020) Xin Chen et al.   Frontiers in Cell and Developmental Biology

Ferroptotic pores induce Ca2+ fluxes and ESCRT-III activation to modulate cell death kinetics

(2020) Lohans Pedrera et al.   CELL DEATH AND DIFFERENTIATION

Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1

(2020) Bo Yan et al.   MOLECULAR CELL

Effective ferroptotic small-cell lung cancer cell death from SLC7A11 inhibition by sulforaphane

(2020) Yuko Iida et al.   Oncology Letters

Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway

(2020) Enyong Dai et al.   Nature Communications

Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer

(2020) Corrin A. Wohlhieter et al.   Cell Reports

Ferroptosis is a type of autophagy-dependent cell death

(2019) Borong Zhou et al.   SEMINARS IN CANCER BIOLOGY

Chaperone-mediated autophagy is involved in the execution of ferroptosis

(2019) Zheming Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA

(2019) Min Wang et al.   CELL DEATH AND DIFFERENTIATION

The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11

(2019) Tong Liu et al.   CANCER RESEARCH

The release and activity of HMGB1 in ferroptosis

(2019) Qirong Wen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

(2019) Bo Chu et al.   NATURE CELL BIOLOGY

Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance

(2019) Jonathan K. M. Lim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ferritinophagy is required for the induction of ferroptosis by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cells

(2019) Shiyao Sui et al.   Cell Death & Disease

ATF3 promotes erastin-induced ferroptosis by suppressing system Xc–

(2019) Liyuan Wang et al.   CELL DEATH AND DIFFERENTIATION

The Relationship between Ferroptosis and Tumors - A Novel Landscape for Therapeutic Approach

(2019) Xiaojun Xia et al.   CURRENT GENE THERAPY

LSH interacts with and stabilizes GINS4 transcript that promotes tumourigenesis in non-small cell lung cancer

(2019) Rui Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

(2019) Jiao Wu et al.   NATURE

Progressive study of effects of erianin on anticancer activity

(2019) Yuying Zhang et al.   OncoTargets and Therapy

Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis

(2019) Masahiro Yoshida et al.   Nature Communications

STYK1/NOK correlates with ferroptosis in non-small cell lung carcinoma

(2019) Yuanyang Lai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Acetaminophen sensitizing erastin‐induced ferroptosis via modulation of Nrf2/heme oxygenase‐1 signaling pathway in non‐small‐cell lung cancer

(2019) Chengcheng Gai et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inhibition of tumor propellant glutathione peroxidase 4 induces ferroptosis in cancer cells and enhances anticancer effect of cisplatin

(2019) Xuefei Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels

(2019) Gloria E. Villalpando-Rodriguez et al.   Oxidative Medicine and Cellular Longevity

Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11

(2019) Xueting Lang et al.   Cancer Discovery

STYK1 promotes autophagy through enhancing the assembly of autophagy-specific class III phosphatidylinositol 3-kinase complex I

(2019) Cefan Zhou et al.   Autophagy

ESCRT-III–dependent membrane repair blocks ferroptosis

(2019) Enyong Dai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Biomarkers for immune checkpoint inhibition in non–small cell lung cancer (NSCLC)

(2019) J. Nicholas Bodor et al.   CANCER

A TAZ–ANGPTL4–NOX2 Axis Regulates Ferroptotic Cell Death and Chemoresistance in Epithelial Ovarian Cancer

(2019) Wen-Hsuan Yang et al.   MOLECULAR CANCER RESEARCH

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Initiation of human mammary cell tumorigenesis by mutant KRAS requires YAP inactivation

(2019) Sylvain Lefort et al.   ONCOGENE

Aberrantly High Expression Of NOK/STYK1 Is Tightly Associated With The Activation Of The AKT/GSK3β/N-Cadherin Pathway In Non-Small Cell Lung Cancer

(2019) Zhao Huang et al.   OncoTargets and Therapy

DNA methylation modifier LSH inhibits p53 ubiquitination and transactivates p53 to promote lipid metabolism

(2019) Ling Chen et al.   Epigenetics & Chromatin

Erastin/sorafenib induces cisplatin‑resistant non‑small cell lung cancer cell ferroptosis through inhibition of the Nrf2/xCT pathway

(2019) Yu Li et al.   Oncology Letters

Upregulation of the chromatin remodeler HELLS is mediated by YAP1 in Sonic Hedgehog Medulloblastoma

(2019) M. Hope Robinson et al.   Scientific Reports

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

(2019) Vanessa A. N. Kraft et al.   ACS Central Science

Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma

(2019) Kewen Hu et al.   JOURNAL OF CLINICAL INVESTIGATION

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis

(2018) Rui Kang et al.   Cell Host & Microbe

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

(2018) Michael M. Gaschler et al.   Nature Chemical Biology

xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression

(2018) Xiangming Ji et al.   ONCOGENE

Low tumor glutathione level as a sensitivity marker for glutamate‑cysteine ligase inhibitors

(2018) Satoru Nishizawa et al.   Oncology Letters

Ferroptosis: A Novel Anti-tumor Action for Cisplatin

(2018) Jipeng Guo et al.   Cancer Research and Treatment

YAP and TAZ in Lung Cancer: Oncogenic Role and Clinical Targeting

(2018) Federica Lo Sardo et al.   Cancers

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

(2018) Xinxin Song et al.   CURRENT BIOLOGY

A pharmacological probe identifies cystathionine β-synthase as a new negative regulator for ferroptosis

(2018) Li Wang et al.   Cell Death & Disease

Lipid storage and lipophagy regulates ferroptosis

(2018) Yuansong Bai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Whole cigarette smoke condensates induce ferroptosis in human bronchial epithelial cells

(2018) Eun-Jung Park et al.   TOXICOLOGY LETTERS

DHA inhibits proliferation and induces ferroptosis of leukemia cells through autophagy dependent degradation of ferritin

(2018) Jing Du et al.   FREE RADICAL BIOLOGY AND MEDICINE

NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression

(2017) Delin Chen et al.   MOLECULAR CELL

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

(2017) Samantha W. Alvarez et al.   NATURE

A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair

(2017) Joshua R. Brickner et al.   NATURE

ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner

(2017) D Chen et al.   ONCOGENE

EGLN1/c-Myc Induced Lymphoid-Specific Helicase Inhibits Ferroptosis through Lipid Metabolic Gene Expression Changes

(2017) Yiqun Jiang et al.   Theranostics

ΔNp63 Inhibits Oxidative Stress-Induced Cell Death, Including Ferroptosis, and Cooperates with the BCL-2 Family to Promote Clonogenic Survival

(2017) Gary X. Wang et al.   Cell Reports

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

(2017) Yangchun Xie et al.   Cell Reports

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Identification of ACSL4 as a biomarker and contributor of ferroptosis

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

Activation ofSAT1engages polyamine metabolism with p53-mediated ferroptotic responses

(2016) Yang Ou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression

(2016) Shang-Jui Wang et al.   Cell Reports

Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors

(2015) O. Canli et al.   BLOOD

YAP enhances the pro‐proliferative transcriptional activity of mutant p53 proteins

(2015) Silvia Di Agostino et al.   EMBO REPORTS

Lung cancer: Prevalent trends & emerging concepts

(2015) Vinod Raina et al.   INDIAN JOURNAL OF MEDICAL RESEARCH

Transformation from non-small-cell lung cancer to small-cell lung cancer: molecular drivers and cells of origin

(2015) Matthew G Oser et al.   LANCET ONCOLOGY

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Dihydroartemisinin and its derivative induce apoptosis in acute myeloid leukemia through Noxa-mediated pathway requiring iron and endoperoxide moiety

(2015) Xuan Zhao et al.   Oncotarget

Clinicopathologic features and prognostic implications of NOK/STYK1 protein expression in non-small cell lung cancer

(2014) Peng Chen et al.   BMC CANCER

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

A requirement for wild-type Ras isoforms in mutant KRas-driven signalling and transformation

(2013) Carolyn Bentley et al.   BIOCHEMICAL JOURNAL

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Dihydroartemisinin induces autophagy and inhibits the growth of iron-loaded human myeloid leukemia K562 cells via ROS toxicity

(2012) Zeng Wang et al.   FEBS Open Bio

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

(2009) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY