Heme Peroxidases at Unperturbed and Inflamed Mucous Surfaces

Structural and Signaling Events Driving Aspergillus fumigatus-Induced Human Eosinophil Extracellular Trap Release

(2021) Marina Valente Barroso et al.   Frontiers in Microbiology

Deletion of the lactoperoxidase gene causes multisystem inflammation and tumors in mice

(2021) Jayden Yamakaze et al.   Scientific Reports

Binding of myeloperoxidase to the extracellular matrix of smooth muscle cells and subsequent matrix modification

(2020) Huan Cai et al.   Scientific Reports

The Role of Thiocyanate in Modulating Myeloperoxidase Activity during Disease

(2020) Patrick San Gabriel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cross-Talk Between Alveolar Macrophages and Lung Epithelial Cells is Essential to Maintain Lung Homeostasis

(2020) Elyse Y. Bissonnette et al.   Frontiers in Immunology

Myeloperoxidase-derived damage to human plasma fibronectin: Modulation by protein binding and thiocyanate ions (SCN−)

(2020) Siriluck Vanichkitrungruang et al.   Redox Biology

Epithelial cell–derived cytokines: more than just signaling the alarm

(2019) Florence Roan et al.   JOURNAL OF CLINICAL INVESTIGATION

Mucus, mucins, and cystic fibrosis

(2019) Cameron Bradley Morrison et al.   PEDIATRIC PULMONOLOGY

Hydrogen peroxide release by bacteria suppresses inflammasome-dependent innate immunity

(2019) Saskia F. Erttmann et al.   Nature Communications

Goblet cells: multifaceted players in immunity at mucosal surfaces

(2018) Kathryn A. Knoop et al.   Mucosal Immunology

Myeloperoxidase oxidation of methionine associates with early cystic fibrosis lung disease

(2018) Joshua D. Chandler et al.   EUROPEAN RESPIRATORY JOURNAL

Interleukin-33 is activated by allergen- and necrosis-associated proteolytic activities to regulate its alarmin activity during epithelial damage

(2018) Ian C. Scott et al.   Scientific Reports

Chlorination and oxidation of human plasma fibronectin by myeloperoxidase-derived oxidants, and its consequences for smooth muscle cell function

(2018) Tina Nybo et al.   Redox Biology

Pathological Mucus and Impaired Mucus Clearance in Cystic Fibrosis Patients Results from Increased Concentration, not altered pH

(2018) David B. Hill et al.   EUROPEAN RESPIRATORY JOURNAL

IL-33: biological properties, functions, and roles in airway disease

(2017) Li Yin Drake et al.   IMMUNOLOGICAL REVIEWS

Separation of Dual Oxidase 2 and Lactoperoxidase Expression in Intestinal Crypts and Species Differences May Limit Hydrogen Peroxide Scavenging During Mucosal Healing in Mice and Humans

(2017) Alice Rigoni et al.   INFLAMMATORY BOWEL DISEASES

The Significance of Hypothiocyanite Production via the Pendrin/DUOX/Peroxidase Pathway in the Pathogenesis of Asthma

(2017) Kenji Izuhara et al.   Oxidative Medicine and Cellular Longevity

Resistin-like molecule β is a bactericidal protein that promotes spatial segregation of the microbiota and the colonic epithelium

(2017) Daniel C. Propheter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Myeloperoxidase Activity in Cystic Fibrosis Sputum by Peptide Inhibitor of Complement C1 (PIC1)

(2017) Pamela S. Hair et al.   PLoS One

Respiratory manifestations of ANCA-associated vasculitis

(2016) Kerry Greenan et al.   Clinical Respiratory Journal

Eosinophils in Homeostasis and Their Contrasting Roles during Inflammation and Helminth Infections

(2016) Julia Strandmark et al.   CRITICAL REVIEWS IN IMMUNOLOGY

Flavonoids as promoters of the (pseudo-)halogenating activity of lactoperoxidase and myeloperoxidase

(2016) Jana Gau et al.   FREE RADICAL BIOLOGY AND MEDICINE

The potential for repositioning antithyroid agents as antiasthma drugs

(2016) Shoichi Suzuki et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma

(2016) Zeneng Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of Airway Allergic Inflammation by Hypothiocyanite via Epithelial Cells

(2016) Shoichi Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acidic pH increases airway surface liquid viscosity in cystic fibrosis

(2016) Xiao Xiao Tang et al.   JOURNAL OF CLINICAL INVESTIGATION

Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16

(2016) Joakim H. Bergström et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proximity does not contribute to activity enhancement in the glucose oxidase–horseradish peroxidase cascade

(2016) Yifei Zhang et al.   Nature Communications

Biopolymeric Mucin and Synthetic Polymer Analogs: Their Structure, Function and Role in Biomedical Applications

(2016) Sundar Authimoolam et al.   Polymers

Lactoperoxidase as a potential drug target

(2015) Jörg Flemmig et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Interaction of ceruloplasmin with eosinophil peroxidase as compared to its interplay with myeloperoxidase: Reciprocal effect on enzymatic properties

(2015) A. V. Sokolov et al.   FREE RADICAL RESEARCH

The 3 major types of innate and adaptive cell-mediated effector immunity

(2015) Francesco Annunziato et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Origins of Cystic Fibrosis Lung Disease

(2015) David A. Stoltz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oxidation increases mucin polymer cross-links to stiffen airway mucus gels

(2015) Shaopeng Yuan et al.   Science Translational Medicine

Alkalinity of Neutrophil Phagocytic Vacuoles Is Modulated by HVCN1 and Has Consequences for Myeloperoxidase Activity

(2015) Adam P. Levine et al.   PLoS One

IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy

(2014) Corinne Cayrol et al.   CURRENT OPINION IN IMMUNOLOGY

Assembly of the Respiratory Mucin MUC5B

(2014) Caroline Ridley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell–derived IFN-γ

(2014) Henner F. Farin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of Pendrin as a Common Mediator for Mucus Production in Bronchial Asthma and Chronic Obstructive Pulmonary Disease

(2014) Isao Nakao et al.   JOURNAL OF IMMUNOLOGY

The Epithelial Anion Transporter Pendrin Is Induced by Allergy and Rhinovirus Infection, Regulates Airway Surface Liquid, and Increases Airway Reactivity and Inflammation in an Asthma Model

(2014) Y. Nakagami et al.   JOURNAL OF IMMUNOLOGY

The urea decomposition product cyanate promotes endothelial dysfunction

(2014) Dalia El-Gamal et al.   KIDNEY INTERNATIONAL

Inhibiting lung lining fluid glutathione metabolism with GGsTop as a novel treatment for asthma

(2014) Marina Tuzova et al.   Frontiers in Pharmacology

The buffer capacity of airway epithelial secretions

(2014) Dusik Kim et al.   Frontiers in Physiology

Pattern recognition receptors in innate immunity, host defense, and immunopathology

(2013) Rahul Suresh et al.   ADVANCES IN PHYSIOLOGY EDUCATION

Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans

(2013) S. Ueki et al.   BLOOD

Mucus as a barrier to lipophilic drugs

(2013) Hakon H. Sigurdsson et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Selective Metabolism of Hypothiocyanous Acid by Mammalian Thioredoxin Reductase Promotes Lung Innate Immunity and Antioxidant Defense

(2013) Joshua D. Chandler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Risk Factors for Bronchiectasis in Children with Cystic Fibrosis

(2013) Peter D. Sly et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ceruloplasmin: Macromolecular Assemblies with Iron-Containing Acute Phase Proteins

(2013) Valeriya R. Samygina et al.   PLoS One

IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis

(2013) E. Hams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physiology of Epithelial Chloride and Fluid Secretion

(2013) R. A. Frizzell et al.   Cold Spring Harbor Perspectives in Medicine

Prevention of infection caused by immunosuppressive drugs in gastroenterology

(2013) Katarzyna Orlicka et al.   Therapeutic Advances in Chronic Disease

Glutathione peroxidases

(2012) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Allergic host defences

(2012) Noah W. Palm et al.   NATURE

Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung

(2012) Alejandro A. Pezzulo et al.   NATURE

A Periciliary Brush Promotes the Lung Health by Separating the Mucus Layer from Airway Epithelia

(2012) B. Button et al.   SCIENCE

Enhancement of Respiratory Mucosal Antiviral Defenses by the Oxidation of Iodide

(2011) Anthony J. Fischer et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pathogenesis of Antineutrophil Cytoplasmic Autoantibody–Associated Small-Vessel Vasculitis

(2011) J. Charles Jennette et al.   Annual Review of Pathology-Mechanisms of Disease

Selenium-containing amino acids are targets for myeloperoxidase-derived hypothiocyanous acid: determination of absolute rate constants and implications for biological damage

(2011) Ojia Skaff et al.   BIOCHEMICAL JOURNAL

Hypothiocyanous Acid: Benign or Deadly?

(2011) Tessa J. Barrett et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Concentration of the antibacterial precursor thiocyanate in cystic fibrosis airway secretions

(2011) Daniel Lorentzen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Urate as a Physiological Substrate for Myeloperoxidase

(2011) Flavia C. Meotti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acid and base secretion in freshly excised nasal tissue from cystic fibrosis patients with ΔF508 mutation

(2011) Do-Yeon Cho et al.   International Forum of Allergy & Rhinology

Human myeloperoxidase in innate and acquired immunity

(2010) Juergen Arnhold et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity

(2010) K. D. Metzler et al.   BLOOD

Identifying peroxidases and their oxidants in the early pathology of cystic fibrosis

(2010) Eline Thomson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Anti-interferon-γ autoantibody and opportunistic infections: case series and review of the literature

(2010) T. Kampitak et al.   INFECTION

Carbamylation-Dependent Activation of T Cells: A Novel Mechanism in the Pathogenesis of Autoimmune Arthritis

(2010) P. Mydel et al.   JOURNAL OF IMMUNOLOGY

Myeloperoxidase: Molecular Mechanisms of Action and Their Relevance to Human Health and Disease

(2009) Betty S. van der Veen et al.   ANTIOXIDANTS & REDOX SIGNALING

(–)-Epicatechin enhances the chlorinating activity of human myeloperoxidase

(2009) Tina Kirchner et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Hypothiocyanous acid reactivity with low-molecular-mass and protein thiols: absolute rate constants and assessment of biological relevance

(2009) Ojia Skaff et al.   BIOCHEMICAL JOURNAL

Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

(2009) S Yousefi et al.   CELL DEATH AND DIFFERENTIATION

Kinetics and Mechanisms of the Reaction of Hypothiocyanous Acid with 5-Thio-2-nitrobenzoic Acid and Reduced Glutathione

(2009) Péter Nagy et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Functional extracellular eosinophil granules: novel implications in eosinophil immunobiology

(2009) Josiane S Neves et al.   CURRENT OPINION IN IMMUNOLOGY

The role of hypothiocyanous acid (HOSCN) in biological systems

(2009) Clare L. Hawkins   FREE RADICAL RESEARCH

The antioxidant role of thiocyanate in the pathogenesis of cystic fibrosis and other inflammation-related diseases

(2009) Y. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NETs: a new strategy for using old weapons

(2009) Venizelos Papayannopoulos et al.   TRENDS IN IMMUNOLOGY

Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans

(2009) Constantin F. Urban et al.   PLoS Pathogens

Cellular Defenses against Superoxide and Hydrogen Peroxide

(2008) James A. Imlay   Annual Review of Biochemistry

Mammalian Heme Peroxidases: From Molecular Mechanisms to Health Implications

(2008) Michael J. Davies et al.   ANTIOXIDANTS & REDOX SIGNALING

Kinetic evidence for rapid oxidation of (–)-epicatechin by human myeloperoxidase

(2008) Holger Spalteholz et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intramolecular Electron Transfer versus Substrate Oxidation in Lactoperoxidase: Investigation of Radical Intermediates by Stopped-Flow Absorption Spectrophotometry and (9−285 GHz) Electron Paramagnetic Resonance Spectroscopy†

(2008) Alistair J. Fielding et al.   BIOCHEMISTRY

Airway epithelial cells modify immune responses by inducing an anti-inflammatory microenvironment

(2008) Anja K. Mayer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Ceruloplasmin and myeloperoxidase in complex affect the enzymatic properties of each other

(2008) Alexej V. Sokolov et al.   FREE RADICAL RESEARCH

Crystal Structure of Lactoperoxidase at 2.4 Å Resolution

(2008) Amit Kumar Singh et al.   JOURNAL OF MOLECULAR BIOLOGY

Salivary histatin-5 and oral fungal colonisation in HIV+ individuals

(2008) Sandra R. Torres et al.   MYCOSES

Structure and Function of the Polymeric Mucins in Airways Mucus

(2007) David J. Thornton et al.   Annual Review of Physiology