Mitochondrial free radical theory of aging: Who moved my premise?

Superoxide anion radicals activate hepatic stellate cells after entry through chloride channels: A new target in liver fibrosis

(2014) Gertjan J.M. den Hartog et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Dual roles of vascular-derived reactive oxygen species—With a special reference to hydrogen peroxide and cyclophilin A—

(2014) Kimio Satoh et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The human peroxisome in health and disease: The story of an oddity becoming a vital organelle

(2013) Joseph Vamecq et al.   BIOCHIMIE

Oxidative damage to macromolecules in human Parkinson disease and the rotenone model

(2013) Laurie H. Sanders et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondria are targets for peroxisome-derived oxidative stress in cultured mammalian cells

(2013) Bo Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of vitamin E as a lipid-soluble peroxyl radical scavenger: in vitro and in vivo evidence

(2013) Etsuo Niki   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

(2013) Laura A. Sena et al.   IMMUNITY

Altered Activities of Antioxidant Enzymes in Patients with Metabolic Syndrome

(2013) Lucie Vávrová et al.   Obesity Facts

Endothelial Peroxisomal Dysfunction and Impaired Pexophagy Promotes Oxidative Damage in Lipopolysaccharide-Induced Acute Kidney Injury

(2012) Radovan Vasko et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of Lifespan by the Mitochondrial Electron Transport Chain: Reactive Oxygen Species-Dependent and Reactive Oxygen Species-Independent Mechanisms

(2012) Filippo Scialo et al.   ANTIOXIDANTS & REDOX SIGNALING

Peroxisomes, cell senescence, and rates of aging

(2012) Courtney R. Giordano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondria-targeted antioxidants and metabolic modulators as pharmacological interventions to slow ageing

(2012) Jan Gruber et al.   BIOTECHNOLOGY ADVANCES

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Catalase Deficiency Accelerates Diabetic Renal Injury Through Peroxisomal Dysfunction

(2012) I. Hwang et al.   DIABETES

Role of reactive oxygen species in the regulation of HIF-1 by prolyl hydroxylase 2 under mild hypoxia

(2012) Helene Niecknig et al.   FREE RADICAL RESEARCH

The peroxisome: an update on mysteries

(2012) Markus Islinger et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Superoxide flashes: Elemental events of mitochondrial ROS signaling in the heart

(2012) Xianhua Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Peroxisome deficiency but not the defect in ether lipid synthesis causes activation of the innate immune system and axonal loss in the central nervous system

(2012) Astrid Bottelbergs et al.   Journal of Neuroinflammation

A complex dietary supplement modulates nitrative stress in normal mice and in a new mouse model of nitrative stress and cognitive aging

(2012) Jiangang Long et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The Impact of Peroxisomes on Cellular Aging and Death

(2012) Selvambigai Manivannan et al.   Frontiers in Oncology

Activities of DNA base excision repair enzymes in liver and brain correlate with body mass, but not lifespan

(2011) Melissa M. Page et al.   AGE

A complex dietary supplement augments spatial learning, brain mass, and mitochondrial electron transport chain activity in aging mice

(2011) Vadim Aksenov et al.   AGE

Role of peroxisomes in ROS/RNS-metabolism: Implications for human disease

(2011) Marc Fransen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Regulation of Yeast Chronological Life Span by TORC1 via Adaptive Mitochondrial ROS Signaling

(2011) Yong Pan et al.   Cell Metabolism

Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals

(2011) Huaqiang Fang et al.   CELL RESEARCH

A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity

(2011) Celia M. Kassmann et al.   FEBS LETTERS

Extending life span by increasing oxidative stress

(2011) Michael Ristow et al.   FREE RADICAL BIOLOGY AND MEDICINE

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

Heme Oxygenase-1 Protects Human Melanocytes from H2O2-Induced Oxidative Stress via the Nrf2-ARE Pathway

(2011) Zhe Jian et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

There is no evidence that mitochondria are the main source of reactive oxygen species in mammalian cells

(2011) Guy C. Brown et al.   MITOCHONDRION

Intraperoxisomal redox balance in mammalian cells: oxidative stress and interorganellar cross-talk

(2011) Oksana Ivashchenko et al.   MOLECULAR BIOLOGY OF THE CELL

Hydroxyl Radical and Its Scavengers in Health and Disease

(2011) Boguslaw Lipinski   Oxidative Medicine and Cellular Longevity

Mitochondrial Changes in Ageing Caenorhabditis elegans – What Do We Learn from Superoxide Dismutase Knockouts?

(2011) Jan Gruber et al.   PLoS One

Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice

(2011) A. Safdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Taking a “good” look at free radicals in the aging process

(2011) Siegfried Hekimi et al.   TRENDS IN CELL BIOLOGY

Enhanced protein repair and recycling are not correlated with longevity in 15 vertebrate endotherm species

(2010) Kurtis D. Salway et al.   AGE

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Multi-mechanisms are involved in reactive oxygen species regulation of mTORC1 signaling

(2010) Ming Li et al.   CELLULAR SIGNALLING

Dietary amelioration of locomotor, neurotransmitter and mitochondrial aging

(2010) Vadim Aksenov et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

(2010) Michael Ristow et al.   EXPERIMENTAL GERONTOLOGY

NADPH oxidases in cardiovascular disease

(2010) Ralf P. Brandes et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of NRF2 by Nitrosative Agents and H2O2Involves KEAP1 Disulfide Formation

(2010) Simon Fourquet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemistry and genetics of inherited disorders of peroxisomal fatty acid metabolism

(2010) Paul P. Van Veldhoven   JOURNAL OF LIPID RESEARCH

Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells

(2010) Long Chen et al.   LABORATORY INVESTIGATION

Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity

(2010) A. Mesquita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peroxisome Metabolism and Cellular Aging

(2010) Vladimir I. Titorenko et al.   TRAFFIC

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

(2010) Wen Yang et al.   PLOS BIOLOGY

Hydrogen Peroxide as a Cell-Survival Signaling Molecule

(2009) Gillian Groeger et al.   ANTIOXIDANTS & REDOX SIGNALING

Peroxisomes Are Oxidative Organelles

(2009) Vasily D. Antonenkov et al.   ANTIOXIDANTS & REDOX SIGNALING

Hydrogen peroxide induced oxidation of peroxisomal malate synthase and catalase

(2009) Pria Anand et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Reactive oxygen species and peroxisomes: Struggling for balance

(2009) Nina A. Bonekamp et al.   BIOFACTORS

Oxygen Sensors at the Crossroad of Metabolism

(2009) Julián Aragonés et al.   Cell Metabolism

When a theory of aging ages badly

(2009) Jérôme Lapointe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Biogenesis of peroxisomes and mitochondria: linked by division

(2009) Hannah K. Delille et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Elevated Mitochondrial Reactive Oxygen Species Generation Affects the Immune Response via Hypoxia-Inducible Factor-1  in Long-Lived Mclk1+/- Mouse Mutants

(2009) D. Wang et al.   JOURNAL OF IMMUNOLOGY

Mice Deficient in Both Mn Superoxide Dismutase and Glutathione Peroxidase-1 Have Increased Oxidative Damage and a Greater Incidence of Pathology but No Reduction in Longevity

(2009) Y. Zhang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A bad boy comes good

(2009) Ulrich Theopold   NATURE

Aspects of antioxidant foods and supplements in health and disease

(2009) Emilio Herrera et al.   NUTRITION REVIEWS

Antioxidants prevent health-promoting effects of physical exercise in humans

(2009) M. Ristow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans

(2009) Jeremy M. Van Raamsdonk et al.   PLoS Genetics

S13.38 A vicious cycle-mitochondrial dysfunction leads to beta-amyloid accumulation

(2008) Tanja Schütt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Cargo-Selected Transport from the Mitochondria to Peroxisomes Is Mediated by Vesicular Carriers

(2008) Margaret Neuspiel et al.   CURRENT BIOLOGY

Loss of peroxisome function triggers necrosis

(2008) Helmut Jungwirth et al.   FEBS LETTERS

The mitochondrial free radical theory of ageing - Where do we stand?

(2008) Jan Gruber   Frontiers in Bioscience-Landmark

Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rats

(2008) Jiejie Hao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Organelle dynamics and dysfunction: A closer link between peroxisomes and mitochondria

(2008) F. Camões et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Vitamins C and E and Beta Carotene Supplementation and Cancer Risk: A Randomized Controlled Trial

(2008) J. Lin et al.   JNCI-Journal of the National Cancer Institute

Mitochondrial Decay in the Brains of Old Rats: Ameliorating Effect of Alpha-Lipoic Acid and Acetyl-l-carnitine

(2008) Jiangang Long et al.   NEUROCHEMICAL RESEARCH

A Combination of Nutriments Improves Mitochondrial Biogenesis and Function in Skeletal Muscle of Type 2 Diabetic Goto–Kakizaki Rats

(2008) Weili Shen et al.   PLoS One

Progeric effects of catalase inactivation in human cells

(2008) Jay I. Koepke et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY