Modulation of Oxidative Stress and Inflammation in the Aged Lacrimal Gland

Immune - Goblet cell interaction in the conjunctiva

(2020) Jehan Alam et al.   Ocular Surface

Parity Attenuates Intraepithelial Corneal Sensory Nerve Loss in Female Mice

(2020) Mary Ann Stepp et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Calcineurin Inhibitor Voclosporin Preserves Corneal Barrier and Conjunctival Goblet Cells in Experimental Dry Eye

(2020) Jehan Alam et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells

(2019) Fang Bian et al.   Mucosal Immunology

Evaluation of vascular endothelial growth factor levels in tears and serum among diabetic patients

(2019) Wen Jeat Ang et al.   PLoS One

Involvement of adiponectin in age-related increases in tear production in mice

(2019) Yosuke Shikama et al.   Aging-US

Polydatin Inhibits NLRP3 Inflammasome in Dry Eye Disease by Attenuating Oxidative Stress and Inhibiting the NF-κB Pathway

(2019) Bongkyun Park et al.   Nutrients

Reduced intraepithelial corneal nerve density and sensitivity accompany desiccating stress and aging in C57BL/6 mice

(2018) Mary Ann Stepp et al.   EXPERIMENTAL EYE RESEARCH

Nrf2 protects human lens epithelial cells against H 2 O 2 -induced oxidative and ER stress: The ATF4 may be involved

(2018) Tian-ju Ma et al.   EXPERIMENTAL EYE RESEARCH

Shifting the IGF-axis: An age-related decline in human tear IGF-1 correlates with clinical signs of dry eye

(2018) Roshni Patel et al.   GROWTH HORMONE & IGF RESEARCH

Goblet cell produced retinoic acid suppresses CD86 expression and IL-12 production in bone marrow derived cells

(2018) Yangyan Xiao et al.   INTERNATIONAL IMMUNOLOGY

Suppression of Th1-Mediated Keratoconjunctivitis Sicca by Lifitegrast

(2018) Rodrigo Guimaraes de Souza et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

The Eye, Oxidative Damage and Polyunsaturated Fatty Acids

(2018) Sergio Saccà et al.   Nutrients

The Role of Reactive Oxygen Species in Regulating T Cell-mediated Immunity and Disease

(2018) Emily L. Yarosz et al.   Immune Network

Goblet Cells Contribute to Ocular Surface Immune Tolerance—Implications for Dry Eye Disease

(2017) Flavia Barbosa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Systemic Activation of NRF2 Alleviates Lethal Autoimmune Inflammation in Scurfy Mice

(2017) Takuma Suzuki et al.   MOLECULAR AND CELLULAR BIOLOGY

Interferon-γ–Induced Unfolded Protein Response in Conjunctival Goblet Cells as a Cause of Mucin Deficiency in Sjögren Syndrome

(2016) Terry G. Coursey et al.   AMERICAN JOURNAL OF PATHOLOGY

Repression of the Antioxidant NRF2 Pathway in Premature Aging

(2016) Nard Kubben et al.   CELL

Expression of Lipid Peroxidation Markers in the Tear Film and Ocular Surface of Patients with Non-Sjogren Syndrome: Potential Biomarkers for Dry Eye Disease

(2016) Won Choi et al.   CURRENT EYE RESEARCH

Men and mice: Relating their ages

(2016) Sulagna Dutta et al.   LIFE SCIENCES

Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells

(2016) T G Coursey et al.   Mucosal Immunology

Therapeutic Efficacy of Topically Applied Antioxidant Medicinal Plant Extracts in a Mouse Model of Experimental Dry Eye

(2016) Won Choi et al.   Oxidative Medicine and Cellular Longevity

Interferon-gamma deficiency protects against aging-related goblet cell loss

(2016) Eugene A. Volpe et al.   Oncotarget

Blueberry Component Pterostilbene Protects Corneal Epithelial Cells from Inflammation via Anti-oxidative Pathway

(2016) Jin Li et al.   Scientific Reports

The Effect of Nrf2 Knockout on Ocular Surface Protection from Acute Tobacco Smoke Exposure

(2015) Takashi Kojima et al.   AMERICAN JOURNAL OF PATHOLOGY

Comparison of human Nrf2 antibodies: A tale of two proteins

(2015) Zachary A. Kemmerer et al.   TOXICOLOGY LETTERS

Altered balance of interleukin-13/interferon-gamma contributes to lacrimal gland destruction and secretory dysfunction in CD25 knockout model of Sjögren’s syndrome

(2015) Fang Bian et al.   ARTHRITIS RESEARCH & THERAPY

Immunomodulatory Cross-Talk between Conjunctival Goblet Cells and Dendritic Cells

(2015) Laura Contreras-Ruiz et al.   PLoS One

Oxidative Stress Markers Induced by Hyperosmolarity in Primary Human Corneal Epithelial Cells

(2015) Ruzhi Deng et al.   PLoS One

Ocular Surface Disease and Dacryoadenitis in Aging C57BL/6 Mice

(2014) Andrew J. McClellan et al.   AMERICAN JOURNAL OF PATHOLOGY

Evaluation of oxidative stress levels in the conjunctival epithelium of patients with or without dry eye, and dry eye patients treated with preservative-free hyaluronic acid 0.15 % and vitamin B12 eye drops

(2014) Angelo Macri et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Desiccating Stress–Induced Chemokine Expression in the Epithelium Is Dependent on Upregulation of NKG2D/RAE-1 and Release of IFN-γ in Experimental Dry Eye

(2014) Terry G. Coursey et al.   JOURNAL OF IMMUNOLOGY

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

(2014) Diana Jurk et al.   Nature Communications

Tear proteomic analysis of Sjögren syndrome patients with dry eye syndrome by two-dimensional-nano-liquid chromatography coupled with tandem mass spectrometry

(2014) Bing Li et al.   Scientific Reports

Tear Cathepsin S as a Candidate Biomarker for Sjögren's Syndrome

(2014) Sarah F. Hamm-Alvarez et al.   Arthritis & Rheumatology

Oxidative stress and its downstream signaling in aging eyes

(2014) Maria Pinazo-duran et al.   Clinical Interventions in Aging

CD8+ cells regulate the T helper-17 response in an experimental murine model of Sjögren syndrome

(2013) X Zhang et al.   Mucosal Immunology

Age-Related Dysfunction of the Lacrimal Gland and Oxidative Stress

(2012) Takashi Kojima et al.   AMERICAN JOURNAL OF PATHOLOGY

A New Mouse Model of Dry Eye Disease

(2012) Yuichi Uchino et al.   CORNEA

NK Cells Promote Th-17 Mediated Corneal Barrier Disruption in Dry Eye

(2012) Xiaobo Zhang et al.   PLoS One

Oxidative Stress Induced Inflammation Initiates Functional Decline of Tear Production

(2012) Yuichi Uchino et al.   PLoS One

Age-Related Retinopathy in NRF2-Deficient Mice

(2011) Zhenyang Zhao et al.   PLoS One

Disruption of TGF-β Signaling Improves Ocular Surface Epithelial Disease in Experimental Autoimmune Keratoconjunctivitis Sicca

(2011) Cintia S. De Paiva et al.   PLoS One

Reversal of aging by NFκB blockade

(2010) Adam S. Adler et al.   CELL CYCLE

Homeostatic control of conjunctival mucosal goblet cells by NKT-derived IL-13

(2010) C S De Paiva et al.   Mucosal Immunology

Anti-NGF-antibody administration as collyrium reduces the presence of NGF and enhances the expression of VEGF in the retina, lacrimal gland and hippocampus

(2009) Valeria Colafrancesco et al.   NEUROSCIENCE LETTERS

Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans

(2008) Luigi Fontana et al.   AGING CELL

Tear Cytokine Profiles in Dysfunctional Tear Syndrome

(2008) Helene Lam et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Upregulation of cathepsin S in the aging and pathological nervous system of mice

(2008) Wiebke Wendt et al.   BRAIN RESEARCH

The Nrf2 Activator Oltipraz Also Activates the Constitutive Androstane Receptor

(2008) M. D. Merrell et al.   DRUG METABOLISM AND DISPOSITION